Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder.

abstract：:Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia. However, the function of Gadd45a in hematopoietic stem cells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a(-/-)) mice showed a normal hematologic phenotype under homeostatic conditions. However, f...

journal_title：Blood

authors： Chen Y,Ma X,Zhang M,Wang X,Wang C,Wang H,Guo P,Yuan W,Rudolph KL,Zhan Q,Ju Z

更新日期：2014-02-06 00:00:00

abstract：:Polymorphonuclear neutrophils (PMN) contain multiple distinct secretory compartments that are sequentially mobilized during cell activation. Complement receptor type 1 (CR1) is a marker for a readily mobilizable secretory vesicle compartment, which can undergo exocytic fusion with the plasma membrane independently of ...

journal_title：Blood

authors： Jost C,Klickstein L,Wetzler E,Kumar A,Berger M

更新日期：1998-07-01 00:00:00

abstract：:This study aimed to evaluate whether gait speed and grip strength predicted clinical outcomes among older adults with blood cancers. We prospectively recruited 448 patients aged 75 years and older presenting for initial consultation at the myelodysplastic syndrome/leukemia, myeloma, or lymphoma clinic of a large terti...

journal_title：Blood

authors： Liu MA,DuMontier C,Murillo A,Hshieh TT,Bean JF,Soiffer RJ,Stone RM,Abel GA,Driver JA

更新日期：2019-07-25 00:00:00

abstract：:The underlying pathways that lead to relapse in childhood acute lymphoblastic leukemia (ALL) are unknown. To comprehensively characterize the molecular evolution of relapsed childhood B-precursor ALL, we used human 500K single-nucleotide polymorphism arrays to identify somatic copy number alterations (CNAs) in 20 diag...

journal_title：Blood

authors： Yang JJ,Bhojwani D,Yang W,Cai X,Stocco G,Crews K,Wang J,Morrison D,Devidas M,Hunger SP,Willman CL,Raetz EA,Pui CH,Evans WE,Relling MV,Carroll WL

更新日期：2008-11-15 00:00:00

abstract：:Posttranscriptional modification of histones by methylation plays an important role in regulating Ag-driven T-cell responses. We have recently drawn correlations between allogeneic T-cell responses and the histone methyltransferase Ezh2, which catalyzes histone H3 lysine 27 trimethylation. The functional relevance of ...

journal_title：Blood

authors： He S,Xie F,Liu Y,Tong Q,Mochizuki K,Lapinski PE,Mani RS,Reddy P,Mochizuki I,Chinnaiyan AM,Mineishi S,King PD,Zhang Y

更新日期：2013-12-12 00:00:00

abstract：:It was previously shown that patients with chronic myeloid leukemia (CML) have a rare but consistently detectable population of quiescent (G0) leukemic (Philadelphia chromosome-positive and BCR-ABL-positive [BCR-ABL+]) CD34+ cells. In the study described here, most such cells expressed a primitive phenotype (CD38-, CD...

journal_title：Blood

authors： Holyoake TL,Jiang X,Jorgensen HG,Graham S,Alcorn MJ,Laird C,Eaves AC,Eaves CJ

更新日期：2001-02-01 00:00:00

abstract：:Recent studies have reported that the pharmacokinetics of high-dose busulfan in bone marrow transplantation (BMT) are age-dependent: with the usual dosage of 16 mg/kg over 4 days, systemic exposure is two to four times lower in children than in adults. Data suggested that the dose of busulfan should rather be calculat...

journal_title：Blood

authors： Vassal G,Deroussent A,Challine D,Hartmann O,Koscielny S,Valteau-Couanet D,Lemerle J,Gouyette A

更新日期：1992-05-01 00:00:00

abstract：:Improved supportive care, more precise risk stratification, and personalized chemotherapy based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and pharmacogenetics) have pushed the cure rate of childhood acute lymphoblastic leukemia to near 90%. Further increase in cure rate can be expected f...

journal_title：Blood

authors： Pui CH,Mullighan CG,Evans WE,Relling MV

更新日期：2012-08-09 00:00:00

abstract：:When granulocytes are stimulated under certain clinical conditions, elastase is released therefrom and digests fibrin(ogen) independently of the plasmin system, which may also be mobilized simultaneously. Thus, discrimination of these 2 systems becomes urgent for the diagnosis and treatment of the underlying diseases....

journal_title：Blood

authors： Kohno I,Inuzuka K,Itoh Y,Nakahara K,Eguchi Y,Sugo T,Soe G,Sakata Y,Murayama H,Matsuda M

更新日期：2000-03-01 00:00:00

abstract：:The evidence for a regulatory role of acidic isoferritins on hemopoiesis is not entirely consistent with our knowledge of ferritin biochemistry, and no clear picture of this phenomeonon has emerged. In the present study, we have been unable to confirm a consistent effect of purified heart (acidic), spleen (basic), or ...

journal_title：Blood

authors： Sala G,Worwood M,Jacobs A

更新日期：1986-02-01 00:00:00

abstract：:Human myeloma cells freshly isolated from 40 patients with IgG multiple myeloma (MM, 10 in stage I and 30 in stage III), were cultured for 48 hours with recombinant B cell stimulatory factor 2 (rBSF-2)/interleukin-6 (IL-6), which is considered a major growth factor for myeloma cells. Uptake of 3H-thymidine by these pu...

journal_title：Blood

authors： Asaoku H,Kawano M,Iwato K,Tanabe O,Tanaka H,Hirano T,Kishimoto T,Kuramoto A

更新日期：1988-08-01 00:00:00

abstract：:Internal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in 30% of acute myeloid leukemias (AMLs) and confers a poor prognosis. Thirteen relapsed or chemo-refractory FLT3-ITD(+) AML patients were treated with sorafenib (200-400 mg twice daily). Twelve patients showed clearance or near ...

journal_title：Blood

authors： Man CH,Fung TK,Ho C,Han HH,Chow HC,Ma AC,Choi WW,Lok S,Cheung AM,Eaves C,Kwong YL,Leung AY

更新日期：2012-05-31 00:00:00

abstract：:The value of a postremission treatment in acute myelogenous leukemia (AML), with alternating combinations of non-cross-resistant drugs, has been prospectively assessed. Of 515 evaluable patients, 347 (67.4%) entered into complete remission (CR), following induction treatment with daunorubicin (DNR), vincristine (VCR),...

journal_title：Blood

authors： Zittoun R,Jehn U,Fière D,Haanen C,Löwenberg B,Willemze R,Abels J,Bury J,Peetermans M,Hayat M

更新日期：1989-03-01 00:00:00

abstract：:Constitutively active JAK2V617F and thrombopoietin receptor (TpoR) W515L/K mutants are major determinants of human myeloproliferative neoplasms (MPNs). We show that a TpoRW515 mutation (W515A), which we detected in 2 myelofibrosis patients, and the Delta5TpoR active mutant, where the juxtamembrane R/KW(515)QFP motif i...

journal_title：Blood

authors： Pecquet C,Staerk J,Chaligné R,Goss V,Lee KA,Zhang X,Rush J,Van Hees J,Poirel HA,Scheiff JM,Vainchenker W,Giraudier S,Polakiewicz RD,Constantinescu SN

更新日期：2010-02-04 00:00:00

abstract：:Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy. We examined the expression of the flavoproteins and oxidative stress-promoting enzymes, NADPH oxidases (Nox's), in MKs because of their known role in promoting the cell cycle. Although the expression of Nox isoforms varies between cell type...

journal_title：Blood

authors： McCrann DJ,Eliades A,Makitalo M,Matsuno K,Ravid K

更新日期：2009-08-06 00:00:00

abstract：:The short-term beneficial effect of hydroxyurea (HU) in sickle cell disease (SCD) has been proven by randomized studies in children and adults. The Belgian registry of HU-treated SCD patients was created to evaluate its long-term efficacy and toxicity. The median follow-up of the 93 patients registered is 3.5 years; c...

journal_title：Blood

authors： Ferster A,Tahriri P,Vermylen C,Sturbois G,Corazza F,Fondu P,Devalck C,Dresse MF,Feremans W,Hunninck K,Toppet M,Philippet P,Van Geet C,Sariban E

更新日期：2001-06-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a malignant disease of the hematopoietic stem cell characterized by abnormal circulation and proliferation of malignant progenitors. In contrast to their normal counterparts, CML progenitors adhere poorly to bone marrow stroma or fibronectin (FN). Aside from anchoring progenitors ...

journal_title：Blood

authors： Lundell BI,McCarthy JB,Kovach NL,Verfaillie CM

更新日期：1996-03-15 00:00:00

abstract：:By using a cDNA clone of the myeloperoxidase (MPO) gene, we have studied, by Northern blot analysis, the level of MPO mRNA in eight cases of acute lymphoblastic leukemia (ALL). The blast cell populations studied were characterized by morphologic, cytochemical, immunochemical, and molecular criteria. With all the metho...

journal_title：Blood

authors： Ferrari S,Mariano MT,Tagliafico E,Sarti M,Ceccherelli G,Selleri L,Merli F,Narni F,Donelli A,Torelli G

更新日期：1988-09-01 00:00:00

abstract：:Defective function of dendritic cells (DC) in cancer has been recently described and may represent one of the mechanisms of tumor evasion from immune system control. We have previously shown in vitro that vascular endothelial growth factor (VEGF), produced by almost all tumors, is one of the tumor-derived factors resp...

journal_title：Blood

authors： Gabrilovich D,Ishida T,Oyama T,Ran S,Kravtsov V,Nadaf S,Carbone DP

更新日期：1998-12-01 00:00:00

abstract：:As B-cell chronic lymphocytic leukemia (B-CLL) progresses, malignant cells extravasate and infiltrate lymphoid tissues. Several molecules, including gelatinase B/MMP-9, contribute to these processes. Although mainly a secreted protease, some MMP-9 is present at the B-CLL cell surface and the function, mode of anchorin...

journal_title：Blood

authors： Redondo-Muñoz J,Ugarte-Berzal E,García-Marco JA,del Cerro MH,Van den Steen PE,Opdenakker G,Terol MJ,García-Pardo A

更新日期：2008-07-01 00:00:00

abstract：:Adhesive interactions between circulating sickle red blood cells (RBCs), leukocytes, and endothelial cells are major pathophysiologic events in sickle cell disease (SCD). To develop new therapeutics that efficiently inhibit adhesive interactions, we generated an anti-P-selectin aptamer and examined its effects on cell...

journal_title：Blood

authors： Gutsaeva DR,Parkerson JB,Yerigenahally SD,Kurz JC,Schaub RG,Ikuta T,Head CA

更新日期：2011-01-13 00:00:00

abstract：:Immunosuppression resulting in impaired Epstein-Barr virus (EBV)-specific T-cell immunity is involved in the pathogenesis of EBV-positive post-transplantation lymphoproliferative disorder (EBV(+) PTLD). Restoration of EBV-specific T-cell immunity by adoptive immunotherapy can induce remission. EBV-nuclear antigen-1 (E...

journal_title：Blood

authors： Jones K,Nourse JP,Morrison L,Nguyen-Van D,Moss DJ,Burrows SR,Gandhi MK

更新日期：2010-09-30 00:00:00

abstract：:The PI3K/AKT signaling is activated in various hematologic malignancies. We evaluated the effect of a novel, pan-AKT kinase inhibitor, GSK690693, on the proliferation of 112 cell lines representing different hematologic neoplasia. Fifty-five percent of all cell lines tested were sensitive to AKT inhibitor (EC(50)<1 mi...

journal_title：Blood

authors： Levy DS,Kahana JA,Kumar R

更新日期：2009-02-19 00:00:00

abstract：:Although numerous studies have shown a higher risk of acquiring HIV infection in the presence of other sexually transmitted diseases, the biologic mechanisms responsible for enhanced HIV acquisition are unclear. Because Langerhans cells (LCs) are suspected to be the initial HIV targets after sexual exposure, we studie...

journal_title：Blood

authors： Ogawa Y,Kawamura T,Kimura T,Ito M,Blauvelt A,Shimada S

更新日期：2009-05-21 00:00:00

abstract：:We have used (cryo) electron tomography to provide a 3-dimensional (3D) map of the intracellular membrane organization of human platelets at high spatial resolution. Our study shows that the open canalicular system and dense tubular system are highly intertwined and form close associations in specialized membrane regi...

journal_title：Blood

authors： van Nispen tot Pannerden H,de Haas F,Geerts W,Posthuma G,van Dijk S,Heijnen HF

更新日期：2010-08-19 00:00:00

abstract：:The thrombolytic efficacy of recombinant unglycosylated full length single chain urokinase-type plasminogen activator (rscu-PA, saruplase), applied either as single intravenous bolus or as a continuous infusion over 60 minutes, was studied in 5 randomized blinded groups of 5 dogs with combined copper coil induced coro...

journal_title：Blood

authors： Rapold HJ,Wu ZM,Stassen T,Van de Werf F,Collen D

更新日期：1990-10-15 00:00:00

abstract：:We used restriction endonuclease analysis to determine the incidence of alpha-thalassemia in two Mediterranean islands. In a random population sample, the gene frequency of deletion-type alpha-thalassemia-2 (-alpha) was 0.18 in Sardinians and 0.07 in Greek Cypriots. All cases were the rightward crossover type. From th...

journal_title：Blood

authors： Pirastu M,Lee KY,Dozy AM,Kan YW,Stamatoyannopoulos G,Hadjiminas MG,Zachariades Z,Angius A,Furbetta M,Rosatelli C,Cao A

更新日期：1982-08-01 00:00:00

abstract：:Although the potential role of Pim2 as a cooperative oncogene has been well described in lymphoma, its role in leukemia has remained largely unexplored. Here we show that high expression of Pim2 is observed in patients with acute promyelocytic leukemia (APL). To further characterize the cooperative role of Pim2 with p...

journal_title：Blood

authors： Agrawal-Singh S,Koschmieder S,Gelsing S,Stocking C,Stehling M,Thiede C,Thoennissen NH,Köhler G,Valk PJ,Delwel R,Mills K,Bäumer N,Tickenbrock L,Hansen K,Berdel WE,Müller-Tidow C,Serve H

更新日期：2010-06-03 00:00:00

abstract：:In a study of the relationship between thrombocytopenia and increased vascular fragility, changes in the endothelium of capillaries and postcapillary venules of the tongue were examined by electron microscopy. Adult male albino rabbits (4 kg) were maintained thrombocytopenic (platelets less than 20,000/cu mm) up to 24...

journal_title：Blood

authors： Kitchens CS,Weiss L

更新日期：1975-10-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal disorder characterized by the overactivation of T cells and macrophages that excessively produce proinflammatory cytokines, including interferon-γ (IFN-γ). Previously, we reported that the JAK inhibitor ruxolitinib dampens T-cell activation and lessens inflamm...

journal_title：Blood

authors： Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE

更新日期：2019-07-11 00:00:00