Abstract:
:Human myeloma cells freshly isolated from 40 patients with IgG multiple myeloma (MM, 10 in stage I and 30 in stage III), were cultured for 48 hours with recombinant B cell stimulatory factor 2 (rBSF-2)/interleukin-6 (IL-6), which is considered a major growth factor for myeloma cells. Uptake of 3H-thymidine by these purified myeloma cells was measured, and BSF-2 response was evaluated by stimulation index and delta cpm induced by rBSF-2. Myeloma cells from cases in stage I responded to rBSF-2 better than those in stage III. Moreover rBSF-2 responders also showed better response to chemotherapy. Therefore, these results suggest that in vitro response of myeloma cells to BSF-2 correlates with disease progression and clinical response in patients of MM.
journal_name
Bloodjournal_title
Bloodauthors
Asaoku H,Kawano M,Iwato K,Tanabe O,Tanaka H,Hirano T,Kishimoto T,Kuramoto Asubject
Has Abstractpub_date
1988-08-01 00:00:00pages
429-32issue
2eissn
0006-4971issn
1528-0020journal_volume
72pub_type
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