Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis.

abstract：:In this issue of Blood, Rowley et al report that noncoding RNAs precisely regulate the messenger RNA (mRNA) profile in platelets. Interfering in this process using genetically engineered mice affects hemostatic and thrombotic functions of platelets. ...

journal_title：Blood

authors： Boilard E,Belleannée C

更新日期：2016-04-07 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) exerts two separate effects on neutrophils, stimulating effector functions while simultaneously inducing apoptosis. We examined here the involvement of caspases in neutrophil apoptosis and the effect of TNF-alpha-induced apoptosis on reactive oxygen production. Immunoblotting an...

journal_title：Blood

authors： Yamashita K,Takahashi A,Kobayashi S,Hirata H,Mesner PW Jr,Kaufmann SH,Yonehara S,Yamamoto K,Uchiyama T,Sasada M

更新日期：1999-01-15 00:00:00

abstract：:In the majority of Philadelphia (Ph)-positive chronic myeloid leukemia (CML) patients, the c-abl gene is fused to the bcr gene, resulting in the transcription of an 8.5 kb chimeric bcr-abl mRNA, which is translated into a p210bcr-abl fusion protein. In about 50% of the Ph-positive acute lymphoid leukemias (ALL), the b...

journal_title：Blood

authors： Selleri L,von Lindern M,Hermans A,Meijer D,Torelli G,Grosveld G

更新日期：1990-03-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective tumor immunotherapy available. Although allo-HSCT provides beneficial graft-versus-tumor effects, acute GVHD (aGVHD) is the primary source of morbidity and mortality after HSCT. Diagnosis of aGVHD is typically based on clinical sympto...

journal_title：Blood

authors： Paczesny S

更新日期：2013-01-24 00:00:00

abstract：:We have investigated the interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis. Acidic FGF (aFGF) stimulated the proliferation of murine megakaryocytes and human erythroleukemia (HEL) cells in a concentration-dependent manner. The concentrations of aFGF required to elicit half-maximum and maximum eff...

journal_title：Blood

authors： Bikfalvi A,Han ZC,Fuhrmann G

更新日期：1992-10-15 00:00:00

abstract：:Although most investigators are well aware of the incredible success of brentuximab vedotin in the treatment of patients with Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL), the study by Jacobsen and colleagues in this issue of Blood demonstrates surprising activity of this agent in patients with B-ce...

journal_title：Blood

authors： Blum KA

更新日期：2015-02-26 00:00:00

abstract：:Uncontrolled activation of the complement system against endothelial and blood cells is central to the pathogenesis of atypical hemolytic uremic syndrome (aHUS). aHUS patients frequently carry mutations in the inhibitory complement regulator factor H (FH). Mutations cluster in domains 19 and 20 (FH19-20), which are cr...

journal_title：Blood

authors： Hyvärinen S,Meri S,Jokiranta TS

更新日期：2016-06-02 00:00:00

abstract：:We report here 7 new mutations in the ADAMTS13 gene responsible for Upshaw-Schulman syndrome (USS), a catastrophic phenotype of congenital thrombotic thrombocytopenic purpura, by analyzing 5 Japanese families. There were 3 mutations that occurred at exon-intron boundaries: 414+1G>A at intron 4, 686+1G>A at intron 6, a...

journal_title：Blood

authors： Matsumoto M,Kokame K,Soejima K,Miura M,Hayashi S,Fujii Y,Iwai A,Ito E,Tsuji Y,Takeda-Shitaka M,Iwadate M,Umeyama H,Yagi H,Ishizashi H,Banno F,Nakagaki T,Miyata T,Fujimura Y

更新日期：2004-02-15 00:00:00

abstract：:The introduction of immunosuppressive therapy for treatment of aplastic anemia has led to a considerable improvement in the prognosis of this disease. However, long-term follow-up of these patients showed a high incidence of "late" hematologic complications such as myelodysplasia and paroxysmal nocturnal hemoglobinuri...

journal_title：Blood

authors： Schubert J,Vogt HG,Zielinska-Skowronek M,Freund M,Kaltwasser JP,Hoelzer D,Schmidt RE

更新日期：1994-04-15 00:00:00

abstract：:Circulating IgG autoantibodies that produce cytoplasmic immunofluorescence staining of ethanol-fixed normal neutrophils have recently been found in a large percentage of patients with active Wegener's granulomatosis. Such autoantibodies are rarely found in other diseases and are therefore virtually diagnostic of Wegen...

journal_title：Blood

authors： Niles JL,McCluskey RT,Ahmad MF,Arnaout MA

更新日期：1989-11-01 00:00:00

abstract：:This study investigated the immunogenicity of Wilms tumor gene product 1 (WT1)-peptide vaccination in WT1-expressing acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients without curative treatment option. Vaccination consisted of granulocyte-macrophage colony-stimulating factor subcutaneously days ...

journal_title：Blood

authors： Keilholz U,Letsch A,Busse A,Asemissen AM,Bauer S,Blau IW,Hofmann WK,Uharek L,Thiel E,Scheibenbogen C

更新日期：2009-06-25 00:00:00

abstract：:Autologous T cells engineered to express a CD19-specific chimeric antigen receptor (CAR) have produced impressive minimal residual disease-negative (MRD-negative) complete remission (CR) rates in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the factors associated with durable...

journal_title：Blood

authors： Hay KA,Gauthier J,Hirayama AV,Voutsinas JM,Wu Q,Li D,Gooley TA,Cherian S,Chen X,Pender BS,Hawkins RM,Vakil A,Steinmetz RN,Schoch G,Chapuis AG,Till BG,Kiem HP,Ramos JD,Shadman M,Cassaday RD,Acharya UH,Riddell SR

更新日期：2019-04-11 00:00:00

abstract：:Variations within proteasome β (PSMB) genes, which encode the β subunits of the 20S proteasome, may affect proteasome function, assembly, and/or binding of proteasome inhibitors. To investigate the potential association between PSMB gene variants and treatment-emergent resistance to bortezomib and/or long-term outcome...

journal_title：Blood

authors： Lichter DI,Danaee H,Pickard MD,Tayber O,Sintchak M,Shi H,Richardson PG,Cavenagh J,Bladé J,Façon T,Niesvizky R,Alsina M,Dalton W,Sonneveld P,Lonial S,van de Velde H,Ricci D,Esseltine DL,Trepicchio WL,Mulligan G,And

更新日期：2012-11-29 00:00:00

abstract：:A microperfusion system containing a glass capillary, the inner surface of which is coated with a phospholipid bilayer containing tissue factor, was used to explore the requirement for factors VIIa and Xa in the complex formed with the lipoprotein-associated coagulation inhibitor (LACI). Various combinations of factor...

journal_title：Blood

authors： Gemmell CH,Broze GJ Jr,Turitto VT,Nemerson Y

更新日期：1990-12-01 00:00:00

abstract：:Recombinant human interleukin-6 (IL-6) has previously been shown to increase platelet counts in normal and sublethally irradiated mice, dogs, and primates. To assess its tolerance and efficacy in clinical use, we performed a randomized phase Ib study in patients with ovarian carcinoma. IL-6 was administered during an ...

journal_title：Blood

authors： D'Hondt V,Humblet Y,Guillaume T,Baatout S,Chatelain C,Berlière M,Longueville J,Feyens AM,de Greve J,Van Oosterom A

更新日期：1995-05-01 00:00:00

abstract：:Malignant cells from 52 children with acute lymphocytic leukemia (ALL) were investigated for inactivation of the p15ink4B and p16ink4 genes and other genetic alterations on chromosome 9p21. Homozygous deletions of the p15ink4B and/or the p16ink4 genes were detected in 16 cases and a further 9 cases showed evidence of ...

journal_title：Blood

authors： Rasool O,Heyman M,Brandter LB,Liu Y,Grandér D,Söderhäll S,Einhorn S

更新日期：1995-06-15 00:00:00

abstract：:Mast cells may be cultured from human peripheral blood in the presence of recombinant human stem cell factor (rhSCF). The characteristics of the cells in peripheral blood that give rise to mast cells are unknown. Because mast cell precursors in human marrow are CD34+, human peripheral blood mononuclear cells from pati...

journal_title：Blood

authors： Rottem M,Okada T,Goff JP,Metcalfe DD

更新日期：1994-10-15 00:00:00

abstract：:The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity. Perturbations in either system can prompt primary pathological end points of hemorrhage or thrombosis with vessel occlusion. However, fibrin(ogen) and proteases controlling its deposition and clearance, including (pro)thro...

journal_title：Blood

authors： Luyendyk JP,Schoenecker JG,Flick MJ

更新日期：2019-02-07 00:00:00

abstract：:Interleukin-1 beta (IL-1 beta) converting enzyme (ICE) is a cysteine protease that specifically cleaves precursor IL-1 beta to its biologically active form. Recent studies have also implicated ICE in the induction of apoptosis in vertebrate cells. Because IL-1 plays a major role in acute myelogenous leukemia (AML) bla...

journal_title：Blood

authors： Estrov Z,Black RA,Sleath PR,Harris D,Van Q,LaPushin R,Estey EH,Talpaz M

更新日期：1995-12-15 00:00:00

abstract：:Elevated plasma clot lysis time (CLT) increases risk of venous and arterial thrombosis. It is unclear which fibrinolytic factors contribute to thrombosis risk. In 743 healthy control subjects we investigated determinants of CLT. By comparison with 770 thrombosis patients, we assessed plasma levels of fibrinolytic prot...

journal_title：Blood

authors： Meltzer ME,Lisman T,de Groot PG,Meijers JC,le Cessie S,Doggen CJ,Rosendaal FR

更新日期：2010-07-08 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q11.2), which results in the PML-RARA fusion gene. In previous studies, we demonstrated that expression of a human PML-RARA complementary DNA in murine granulocyte precursor cells initiated the development of leukemia. However, leukemogenesis by P...

journal_title：Blood

authors： Le Beau MM,Bitts S,Davis EM,Kogan SC

更新日期：2002-04-15 00:00:00

abstract：:Adherent cell layers and their associated extracellular matrices form when human marrow is incubated in cultures containing hydrocortisone and horse serum. These stromal layers contain cells positive for alkaline phosphatase; secrete collagens types I and III and fibronectin, bind the anti-actin monoclonal antibodies ...

journal_title：Blood

authors： Liesveld JL,Abboud CN,Duerst RE,Ryan DH,Brennan JK,Lichtman MA

更新日期：1989-05-15 00:00:00

abstract：:To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide upon silencing. Ribosomal pro...

journal_title：Blood

authors： Zhu YX,Yin H,Bruins LA,Shi CX,Jedlowski P,Aziz M,Sereduk C,Kortuem KM,Schmidt JE,Champion M,Braggio E,Keith Stewart A

更新日期：2015-01-15 00:00:00

abstract：:The pathologic hallmarks of thrombotic thrombocytopenic purpura (TTP) include endothelial cell proliferation and subendothelial hyalin deposits in the microvasculature leading to symptomatic thrombotic occlusions. Plasma or sera from three consecutive patients with TTP were subjected to multiple analyses to determine ...

journal_title：Blood

authors： Burns ER,Zucker-Franklin D

更新日期：1982-10-01 00:00:00

abstract：:Since the introduction of replacement therapy in the early 1960s by the infusion of plasma-derived factor VIII and IX preparations, important changes have occurred for hemophilia patients. We studied the medical and social developments over 30 years of hemophilia treatment. Since 1972, 5 cross-sectional national posta...

journal_title：Blood

authors： Plug I,van der Bom JG,Peters M,Mauser-Bunschoten EP,de Goede-Bolder A,Heijnen L,Smit C,Zwart-van Rijkom JE,Willemse J,Rosendaal FR

更新日期：2004-12-01 00:00:00

abstract：:Although receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) signaling has been shown to prolong the survival of mature dendritic cells (DCs), the association of RANKL pathway with Fas-mediated apoptosis is obscure. Here, we found that bone marrow-derived DCs (BMDCs) from the Fas-deficient strain MRL/lpr m...

journal_title：Blood

authors： Izawa T,Ishimaru N,Moriyama K,Kohashi M,Arakaki R,Hayashi Y

更新日期：2007-07-01 00:00:00

abstract：:Myeloperoxidase (MPO) catalyzes a reaction between chloride and hydrogen peroxide to generate hypochlorous acid and other reactive compounds that have been linked to DNA damage. The MPO gene is expressed at high levels in normal myeloid precursors and in acute myeloid leukemias (AMLs) which are clonal derivatives of m...

journal_title：Blood

authors： Reynolds WF,Chang E,Douer D,Ball ED,Kanda V

更新日期：1997-10-01 00:00:00

abstract：:The NADPH:O2 oxidoreductase catalyzing the respiratory burst in activated phagocytes from healthy individuals is not operative in phagocytes from patients with chronic granulomatous disease (CGD). In a microscopic slide test using the dye nitroblue tetrazolium (NBT), carriers of X-linked CGD can be recognized by a mos...

journal_title：Blood

authors： Verhoeven AJ,van Schaik ML,Roos D,Weening RS

更新日期：1988-02-01 00:00:00

abstract：:A large English pedigree in which heterocellular hereditary persistence of fetal hemoglobin (HPFH) segregates is described. beta-globin cluster deletions and gamma gene promoter mutations associated with HPFH have been excluded. Of particular importance in this pedigree is the absence of any cosegregating hemoglobinop...

journal_title：Blood

authors： Craig JE,Rochette J,Sampietro M,Wilkie AO,Barnetson R,Hatton CS,Demenais F,Thein SL

更新日期：1997-07-01 00:00:00

abstract：:Patients referred to tertiary care centers occasionally may have their diagnostic procedures repeated and have a final diagnosis that differs from that of the referring center. The aim of this study was to evaluate discordance rates and their clinical implications in the diagnosis of patients with myelodysplastic synd...

journal_title：Blood

authors： Naqvi K,Jabbour E,Bueso-Ramos C,Pierce S,Borthakur G,Estrov Z,Ravandi F,Faderl S,Kantarjian H,Garcia-Manero G

更新日期：2011-10-27 00:00:00