Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1.

abstract：:Most anticancer chemotherapies are immunosuppressive and induce nonimmunogenic tumor cell death. Bortezomib, a specific inhibitor of 26S proteasome, has shown clinical activity in several human tumors, including myeloma. Here we show that the uptake of human myeloma cells by dendritic cells (DCs) after tumor cell deat...

journal_title：Blood

authors： Spisek R,Charalambous A,Mazumder A,Vesole DH,Jagannath S,Dhodapkar MV

更新日期：2007-06-01 00:00:00

abstract：:Mutations in the Bcr-Abl kinase domain may cause, or contribute to, resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia patients. Recommendations aimed to rationalize the use of BCR-ABL mutation testing in chronic myeloid leukemia have been compiled by a panel of experts appointed by the Europe...

journal_title：Blood

authors： Soverini S,Hochhaus A,Nicolini FE,Gruber F,Lange T,Saglio G,Pane F,Müller MC,Ernst T,Rosti G,Porkka K,Baccarani M,Cross NC,Martinelli G

更新日期：2011-08-04 00:00:00

abstract：:Plasma fibronectin (pFN) cross-linked to fibrin during the injury response provides a provisional matrix required for cells to begin tissue repair. Using a synthetic matrix of pFN and fibrin as a substrate for cell adhesion and spreading, we have determined that pFN covalently cross-linked to fibrin into a complex mul...

journal_title：Blood

authors： Corbett SA,Wilson CL,Schwarzbauer JE

更新日期：1996-07-01 00:00:00

abstract：:Different forms of interleukin-15 (IL-15) have been identified and shown to elicit different transduction pathways whose impact on hematopoiesis is poorly understood. We demonstrated herein that hematopoietic CD34+ cells constitutively produced endogenous secreted IL-15 (ES-IL-15) that activated different transcriptio...

journal_title：Blood

authors： Giron-Michel J,Caignard A,Fogli M,Brouty-Boyé D,Briard D,van Dijk M,Meazza R,Ferrini S,Lebousse-Kerdilès C,Clay D,Bompais H,Chouaib S,Péault B,Azzarone B

更新日期：2003-07-01 00:00:00

abstract：:The promyelocytic leukemia (PML) tumor suppressor of acute promyelocytic leukemia (APL) is essential for a number of proapoptotic and growth-suppressive pathways as well as for the activity of differentiating agents such as retinoic acid (RA). In human APL, the dose of PML is reduced to heterozygosity given that one a...

journal_title：Blood

authors： Gurrieri C,Nafa K,Merghoub T,Bernardi R,Capodieci P,Biondi A,Nimer S,Douer D,Cordon-Cardo C,Gallagher R,Pandolfi PP

更新日期：2004-03-15 00:00:00

abstract：:CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression. In the present study, we analy...

journal_title：Blood

authors： Tissino E,Pozzo F,Benedetti D,Caldana C,Bittolo T,Rossi FM,Bomben R,Nanni P,Chivilò H,Cattarossi I,Zaina E,Norris K,Polesel J,Gentile M,Tripepi G,Moia R,Santinelli E,Innocenti I,Olivieri J,D'Arena G,Laurenti L,Z

更新日期：2020-04-09 00:00:00

abstract：:AC133 is a member of a novel family of cell surface proteins with 5 transmembrane domains. The function of AC133 is unknown. Although AC133 mRNA is detected in different tissues, its expression in the hematopoietic system is restricted to CD34+ stem cells. AC133 is also expressed on stem cells of other tissues, includ...

journal_title：Blood

authors： Shmelkov SV,Jun L,St Clair R,McGarrigle D,Derderian CA,Usenko JK,Costa C,Zhang F,Guo X,Rafii S

更新日期：2004-03-15 00:00:00

abstract：:Chronic transfusion of packed red blood cells, in addition to other ongoing treatment with warfarin, acetyl salicylic acid, desferrioxamine, and other supportive measures, was given to a splenectomized hemoglobin E/beta-thalassemia woman with pulmonary arterial hypertension (PHT). Serial measurements of plasma thrombi...

journal_title：Blood

authors： Atichartakarn V,Chuncharunee S,Chandanamattha P,Likittanasombat K,Aryurachai K

更新日期：2004-04-01 00:00:00

abstract：:The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hep...

journal_title：Blood

authors： Pippard MJ,Johnson DK,Finch CA

更新日期：1981-10-01 00:00:00

abstract：:Histone deacetylase (HDAC) enzymatic activity has been linked to the transcription of DNA in cancers including multiple myeloma (MM). Therefore, HDAC inhibitors used alone and in combination are being actively studied as novel therapies in MM. In the present study, we investigated the preclinical activity of ACY-1215,...

journal_title：Blood

authors： Santo L,Hideshima T,Kung AL,Tseng JC,Tamang D,Yang M,Jarpe M,van Duzer JH,Mazitschek R,Ogier WC,Cirstea D,Rodig S,Eda H,Scullen T,Canavese M,Bradner J,Anderson KC,Jones SS,Raje N

更新日期：2012-03-15 00:00:00

abstract：:Caveolin-1 (Cav-1) is a key organizer of membrane specializations and a scaffold protein that regulates signaling in multiple cell types. We found increased Cav-1 expression in human and murine T cells after allogeneic hematopoietic cell transplantation. Indeed, Cav-1(-/-)donor T cells caused less severe acute graft-v...

journal_title：Blood

authors： Schönle A,Hartl FA,Mentzel J,Nöltner T,Rauch KS,Prestipino A,Wohlfeil SA,Apostolova P,Hechinger AK,Melchinger W,Fehrenbach K,Guadamillas MC,Follo M,Prinz G,Ruess AK,Pfeifer D,del Pozo MA,Schmitt-Graeff A,Duyster J,H

更新日期：2016-04-14 00:00:00

abstract：:Active immunization with the idiotype of follicular lymphoma induces tumor-specific immunity. T cells induced in vivo by idiotype vaccination recognize human leukocyte antigen (HLA)--restricted hypervariable but not conserved idiotype peptides. We hypothesized that idiotype-directed T-cell immunity occurs naturally an...

journal_title：Blood

authors： Strothmeyer AM,Papaioannou D,Dühren-von Minden M,Navarrete M,Zirlik K,Heining-Mikesch K,Veelken H

更新日期：2010-09-09 00:00:00

abstract：:The bcl-2 gene is translocated into the Ig loci in about 80% of human follicular lymphomas and in 10% of B-type chronic lymphocytic leukemias (B-CLL), resulting in a high level of expression. We have compared the expression of bcl-2 transcripts and protein in B-CLL cells in their normal equivalent CD5+ B cells and in ...

journal_title：Blood

authors： Schena M,Larsson LG,Gottardi D,Gaidano G,Carlsson M,Nilsson K,Caligaris-Cappio F

更新日期：1992-06-01 00:00:00

abstract：:Children with Philadelphia chromosome (Ph+) acute lymphoblastic leukemia (ALL) have a poorer prognosis than do most pediatric patients with ALL. Because of this poor prognosis and the presence of the Ph chromosome, we have asked whether or not Ph + ALL involves a multipotential stem cell. We cultured hematopoietic pro...

journal_title：Blood

authors： Tachibana N,Raimondi SC,Lauer SJ,Sartain P,Dow LW

更新日期：1987-11-01 00:00:00

abstract：:The relationship between the level of retinoblastoma protein (RB) expression and the survival of 113 newly diagnosed acute myelogenous leukemia (AML) patients was studied. Western blotting was used to determine the level of RB protein present in peripheral blood leukemia cells and results were confirmed in 26 patients...

journal_title：Blood

authors： Kornblau SM,Xu HJ,Zhang W,Hu SX,Beran M,Smith TL,Hester J,Estey E,Benedict WF,Deisseroth AB

更新日期：1994-07-01 00:00:00

abstract：:Vascular calcification is a marker of increased cardiovascular risk. Vitamin K-dependent matrix Gla protein (MGP) is important in inhibiting calcification. Because MGP activation is vitamin K dependent, we performed a cross-sectional study investigating the relationship between the use of vitamin K antagonists and ext...

journal_title：Blood

authors： Rennenberg RJ,van Varik BJ,Schurgers LJ,Hamulyak K,Ten Cate H,Leiner T,Vermeer C,de Leeuw PW,Kroon AA

更新日期：2010-06-17 00:00:00

abstract：:We have applied a proteomics approach to analyze signaling cascades in human platelets stimulated by thrombin receptor activating peptide (TRAP). By analyzing basal and TRAP-activated platelets using 2-dimensional gel electrophoresis (2-DE), we detected 62 differentially regulated protein features. From these, 41 coul...

journal_title：Blood

authors： García A,Prabhakar S,Hughan S,Anderson TW,Brock CJ,Pearce AC,Dwek RA,Watson SP,Hebestreit HF,Zitzmann N

更新日期：2004-03-15 00:00:00

abstract：:Combination cytokine therapy continues to be evaluated in an effort to stimulate multilineage hematopoietic reconstitution after bone marrow myelosuppression. This study evaluated the efficacy of combination therapy with the synthetic interleukin-3 receptor agonist, Synthokine-SC55494, and recombinant methionyl human ...

journal_title：Blood

authors： MacVittie TJ,Farese AM,Herodin F,Grab LB,Baum CM,McKearn JP

更新日期：1996-05-15 00:00:00

abstract：:Membrane markers expressed by a transplantable granulocytic leukemia induced in inbred strain 13 guinea pigs by N-nitroso-N-butylurea have been investigated by serologic and immunochemical methods. Although the leukemic myeloblasts have no detectable surface immunoglobulin or Fc receptors, they have been found to synt...

journal_title：Blood

authors： Clement LT,Hu C,Shevach EM,Green I

更新日期：1980-02-01 00:00:00

abstract：:Recent molecular analyses of leukemic blasts from pretreatment marrow or blood of patients with acute myeloid leukemia (AML) and a normal karyotype, the largest cytogenetic subset (ie, 40%-49%) of AML, have revealed a striking heterogeneity with regard to the presence of acquired gene mutations and changes in gene exp...

journal_title：Blood

authors： Mrózek K,Marcucci G,Paschka P,Whitman SP,Bloomfield CD

更新日期：2007-01-15 00:00:00

abstract：:We describe the development of acute myeloid leukemia (AML) in an adult with CBL syndrome caused by a heterozygous de novo germline mutation in CBL codon D390. In the AML bone marrow, the mutated CBL allele was homozygous after copy number-neutral loss-of-heterozygosity and amplified through a chromosomal gain; moreov...

journal_title：Blood

authors： Becker H,Yoshida K,Blagitko-Dorfs N,Claus R,Pantic M,Abdelkarim M,Niemöller C,Greil C,Hackanson B,Shiraishi Y,Chiba K,Tanaka H,Miyano S,Döhner K,Schnittger S,Henneke P,Niemeyer CM,Flotho C,Pfeifer D,Ogawa S,Lübber

更新日期：2014-03-20 00:00:00

abstract：:Although chemotherapy can induce complete responses in patients with chronic lymphocytic leukemia (CLL), it is not considered curative. Treated patients generally develop recurrent disease requiring additional therapy, which can cause worsening immune dysfunction, myelosuppression, and selection for chemotherapy-resis...

journal_title：Blood

authors： Kater AP,van Oers MH,Kipps TJ

更新日期：2007-10-15 00:00:00

abstract：:We have amplified and sequenced the 5' flanking and the second intervening sequence (IVS-II) regions of both the G gamma- and A gamma-globin genes of the beta S chromosomes from sickle cell anemia (SS) patients with homozygosities for five different haplotypes. The sequencing data, compared with previously published s...

journal_title：Blood

authors： Lanclos KD,Oner C,Dimovski AJ,Gu YC,Huisman TH

更新日期：1991-06-01 00:00:00

abstract：:Nasal natural killer (NK) cell lymphoma is rare, so that its optimal therapy, long-term outcome, and prognostic factors are unclear. Data on 52 men and 15 women with well-characterized nasal NK cell lymphomas were analyzed retrospectively to define the impact of primary therapy on remission and long-term outcome and t...

journal_title：Blood

authors： Chim CS,Ma SY,Au WY,Choy C,Lie AK,Liang R,Yau CC,Kwong YL

更新日期：2004-01-01 00:00:00

abstract：:The expression and function of a glycoprotein Ib (GPIb) complex on human umbilical vein endothelial cells (HUVECs) is still a matter of controversy. We characterized HUVEC GPIb using viper venom proteins: alboaggregins A and B, echicetin, botrocetin, and echistatin. Echicetin is an antagonist, and alboaggregins act as...

journal_title：Blood

authors： Tan L,Kowalska MA,Romo GM,Lopez JA,Darzynkiewicz Z,Niewiarowski S

更新日期：1999-04-15 00:00:00

abstract：:The CXC-chemokines interleukin-8 (IL-8), neutrophil-activating peptide-2 (NAP-2), and melanoma growth-stimulatory activity (MGSA) are chemoattractants with high selectivity for neutrophils. Although IL-8 has been shown to act as an extremely potent mediator, reports on NAP-2 and MGSA are still contradictory. Here we s...

journal_title：Blood

authors： Ludwig A,Petersen F,Zahn S,Götze O,Schröder JM,Flad HD,Brandt E

更新日期：1997-12-01 00:00:00

abstract：:Protein kinase C (PKC) activity has a recognized role in mediating apoptosis. However, the role of individual PKC isoforms in apoptosis is poorly defined. Therefore, we investigated the translocation of individual PKC isoforms during radiation-induced apoptosis with and without rescue from apoptosis by granulocyte-mac...

journal_title：Blood

authors： Kelly ML,Tang Y,Rosensweig N,Clejan S,Beckman BS

更新日期：1998-07-15 00:00:00

abstract：:Exposure to HIV-1 does not necessarily result in infection and progression toward disease, thus suggesting that the control of viral infection may be achieved. Antibodies to CCR5 have been detected in HIV-exposed but uninfected subjects (ESNs); thus, these antibodies could be involved in HIV protection. To assess whet...

journal_title：Blood

authors： Pastori C,Weiser B,Barassi C,Uberti-Foppa C,Ghezzi S,Longhi R,Calori G,Burger H,Kemal K,Poli G,Lazzarin A,Lopalco L

更新日期：2006-06-15 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an autoimmune prothrombotic disorder in association with autoantibodies to phospholipid (PL)-binding plasma proteins, such as beta(2)-glycoprotein I (beta(2)GPI). We have recently found that CD4(+) T cells autoreactive to beta(2)GPI in patients with APS preferentially recognize a cry...

journal_title：Blood

authors： Kuwana M,Matsuura E,Kobayashi K,Okazaki Y,Kaburaki J,Ikeda Y,Kawakami Y

更新日期：2005-02-15 00:00:00

abstract：:Chronic myelocytic leukemia (CML) is a common neoplasm of hematopoietic pluripotent stem cells. Although the evolution from chronic phase to blast crisis (BC) in CML patients is an inevitable clinical feature, little is understood about the mechanisms responsible for the transformation. We have previously performed al...

journal_title：Blood

authors： Mori N,Morosetti R,Spira S,Lee S,Ben-Yehuda D,Schiller G,Landolfi R,Mizoguchi H,Koeffler HP

更新日期：1998-11-01 00:00:00