Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133.

abstract：:We have established four hybridoma cells that produce monoclonal antibodies (MoAbs) R2, R4, R6, and R12 directed toward recombinant human erythropoietin (rHuEPO). MoAbs R2, R4, and R6 bound to EPO with high affinities (kd = approximately 2, 4, and 1 nmol/L, respectively) but MoAb R12 had a low affinity (240 nmol/L). T...

journal_title：Blood

authors： Goto M,Murakami A,Akai K,Kawanishi G,Ueda M,Chiba H,Sasaki R

更新日期：1989-09-01 00:00:00

abstract：:We report the transient response of a patient with the ETV6-ABL fusion gene to imatinib mesylate (STI571). A 38-year-old man was referred with an erroneous diagnosis of Philadelphia-positive chronic myeloid leukemia in blastic transformation for treatment with the ABL tyrosine kinase inhibitor, STI571. Further investi...

journal_title：Blood

authors： O'Brien SG,Vieira SA,Connors S,Bown N,Chang J,Capdeville R,Melo JV

更新日期：2002-05-01 00:00:00

abstract：:Selectins are carbohydrate-binding adhesion molecules that play important roles in control of leukocyte traffic. Glycosyltransferases involved in selectin ligand biosynthesis include the alpha1,3-fucosyltransferases FucT-VII and FucT-IV, one or more sialyltransferases, and at least one O-linked branching enzyme. Previ...

journal_title：Blood

authors： Snapp KR,Heitzig CE,Ellies LG,Marth JD,Kansas GS

更新日期：2001-06-15 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated numbers of double-negative T (DNT) cells, and increased risk of lymphoma. Most cases of ALPS are associated with germline mutations of the FAS gene (type Ia), where...

journal_title：Blood

authors： Dowdell KC,Niemela JE,Price S,Davis J,Hornung RL,Oliveira JB,Puck JM,Jaffe ES,Pittaluga S,Cohen JI,Fleisher TA,Rao VK

更新日期：2010-06-24 00:00:00

abstract：:Marrow cells of myeloid lineage from 115 patients with myelodysplastic syndrome (MDS) were characterized by multidimensional flow cytometry and compared with findings in 104 patients with various disorders and 25 healthy donors. Based on phenotypic and scatter characteristics, a flow cytometric scoring system (FCSS) w...

journal_title：Blood

authors： Wells DA,Benesch M,Loken MR,Vallejo C,Myerson D,Leisenring WM,Deeg HJ

更新日期：2003-07-01 00:00:00

abstract：:To evaluate internal tandem duplication (ITD) insertion sites and length as well as their clinical impact in younger adult patients with FLT3-ITD-positive acute myeloid leukemia (AML), sequencing after DNA-based amplification was performed in diagnostic samples from 241 FLT3-ITD-mutated patients. All patients were tre...

journal_title：Blood

authors： Kayser S,Schlenk RF,Londono MC,Breitenbuecher F,Wittke K,Du J,Groner S,Späth D,Krauter J,Ganser A,Döhner H,Fischer T,Döhner K,German-Austrian AML Study Group (AMLSG).

更新日期：2009-09-17 00:00:00

abstract：:Stimulators of human erythroid burst-forming units (BFU-E) and multipotential colony-forming cells (CFU-GEMM) can be produced by a number of different cell types. A product of human peripheral blood monocytes, interleukin 1 (IL-1), was evaluated for its ability to stimulate fibroblast cultures to produce stimulators o...

journal_title：Blood

authors： Zucali JR,Broxmeyer HE,Dinarello CA,Gross MA,Weiner RS

更新日期：1987-01-01 00:00:00

abstract：:To obtain information relevant to the question of bone marrow transplantation, we examined the prognostic significance of disease features recorded at the time of diagnosis among 625 patients, aged 5 to 45, with Philadelphia chromosome-positive, nonblastic chronic granulocytic leukemia. The actuarial death rate for th...

journal_title：Blood

authors： Sokal JE,Baccarani M,Tura S,Fiacchini M,Cervantes F,Rozman C,Gomez GA,Galton DA,Canellos GP,Braun TJ

更新日期：1985-12-01 00:00:00

abstract：:The iron storage macrophage has been isolated from the marrow of Imferon-treated mice and studied in vitro by morphologic, histochemical, and functional tests and isotope labeling techniques. These macrophages on stained preparations are large, many times binucleate cells (up to 150 mu), and show Prussian blue reactiv...

journal_title：Blood

authors： Fedorko ME

更新日期：1975-03-01 00:00:00

abstract：:Transcriptional profiles of cultured primary human erythroid cells were examined to identify those genes involved in the control of erythroid growth during the terminal phase of maturation. Our in silico screening strategy indicated that a hypoxia-inducible proapoptotic member of the Bcl-2 gene family called Nix is ex...

journal_title：Blood

authors： Aerbajinai W,Giattina M,Lee YT,Raffeld M,Miller JL

更新日期：2003-07-15 00:00:00

abstract：:Conditioned medium (CM) obtained from a human hepatoma cell line, SK-HEP-1, contains colony-stimulating factors (CSFs) active on murine and human bone marrow-derived granulocyte and macrophage colony-forming units (CFU-GM) and a factor capable of inducing granulocyte-macrophage differentiation (GM-DF) of murine myelom...

journal_title：Blood

authors： Gabrilove JL,Welte K,Lu L,Castro-Malaspina H,Moore MA

更新日期：1985-08-01 00:00:00

abstract：:Pediatric myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal disorders with an annual incidence of 1 to 4 cases per million, accounting for less than 5% of childhood hematologic malignancies. MDSs in children often occur in the context of inherited bone marrow failure syndromes, which represent a pec...

journal_title：Blood

authors： Locatelli F,Strahm B

更新日期：2018-03-29 00:00:00

abstract：:Pattern recognition receptors (PRRs) play an essential role in a macrophage's response to mycobacterial infections. However, how these receptors work in concert to promote this macrophage response remains unclear. In this study, we used bone marrow-derived macrophages isolated from mannose receptor (MR), complement re...

journal_title：Blood

authors： Yadav M,Schorey JS

更新日期：2006-11-01 00:00:00

abstract：:Surface receptors specific for either the C4b (CR1) or C3d (CR2) component of complement were examined on the neoplastic cells from 30 cases of non-Hodgkin's lymphoma of B-cell origin and on cells derived from 9 normal lymphoid tissues. Lymphocyte suspensions from non-neoplastic peripheral blood, tonsils, and lymph no...

journal_title：Blood

authors： Cossman J,Jaffe ES

更新日期：1981-07-01 00:00:00

abstract：:Thirty-two patients treated on consecutive Southwest Oncology Group (SWOG) protocols for malignant lymphoma were subsequently diagnosed as having lymphoblastic lymphoma. Combination chemistry, usually adriamycin-based, produced complete responses (CR) in 17 patients (53%). Median survival was 15 mo. Patients achieving...

journal_title：Blood

authors： Voakes JB,Jones SE,McKelvey EM

更新日期：1981-01-01 00:00:00

abstract：:Recombinant erythropoietin (EPO) and iron substitution are a standard of care for treatment of anemias associated with chronic inflammation, including anemia of chronic kidney disease. A black box warning for EPO therapy and concerns about negative side effects related to high-dose iron supplementation as well as the ...

journal_title：Blood

authors： Petzer V,Tymoszuk P,Asshoff M,Carvalho J,Papworth J,Deantonio C,Bayliss L,Wake MS,Seifert M,Brigo N,Valente de Souza L,Hilbe R,Grubwieser P,Demetz E,Dichtl S,Volani C,Berger S,Böhm F,Hoffmann A,Pfeifhofer-Obermair C

更新日期：2020-08-27 00:00:00

abstract：:Without a prior history of hemorrhagic disease, a 62-year-old man suffered recurrent episodes of bleeding. Solubility of the patient's clot in 5 mol/L urea indicated a problem with fibrin stabilization. The transamidase activity potential of factor XIII, measured by the incorporation of radioactive putrescine into N,N...

journal_title：Blood

authors： Lorand L,Velasco PT,Murthy SN,Lefebvre P,Green D

更新日期：1999-02-01 00:00:00

abstract：:Radioiodinated L-cell-derived colony-stimulating factor (CSF) was used to characterize the binding reaction to murine bone marrow cells. The major increment in cell-associated radioactivity occurred over 24 hr incubation at 37 degrees C, but virtually no binding was observed at 4 degrees C. The reaction was saturable ...

journal_title：Blood

authors： Pigoli G,Waheed A,Shadduck RK

更新日期：1982-02-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs), members of the transforming growth factor (TGF)-beta superfamily, are a group of related proteins that are capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines. We show in this report a novel function of BMPs in hematopoietic cell...

journal_title：Blood

authors： Kawamura C,Kizaki M,Yamato K,Uchida H,Fukuchi Y,Hattori Y,Koseki T,Nishihara T,Ikeda Y

更新日期：2000-09-15 00:00:00

abstract：:Circulating endothelial progenitor cells (EPCs) are thought to contribute to angiogenesis following vascular injury, stimulating interest in their ability to mediate therapeutic angiogenesis. However, the number of EPCs in the blood is low, limiting endogenous repair, and a method to rapidly mobilize EPCs has not been...

journal_title：Blood

authors： Shepherd RM,Capoccia BJ,Devine SM,Dipersio J,Trinkaus KM,Ingram D,Link DC

更新日期：2006-12-01 00:00:00

abstract：:In a series of 153 children with T-cell malignancies enrolled in 2 consecutive European Organization for Research and Treatment of Cancer (EORTC) trials, we assessed the HOX11L2 expression and/or the presence of a t(5;14)(q35;q32). Additionally, in 138 of these patients, HOX11 expression and SIL-TAL rearrangement were...

journal_title：Blood

authors： Cavé H,Suciu S,Preudhomme C,Poppe B,Robert A,Uyttebroeck A,Malet M,Boutard P,Benoit Y,Mauvieux L,Lutz P,Méchinaud F,Grardel N,Mazingue F,Dupont M,Margueritte G,Pages MP,Bertrand Y,Plouvier E,Brunie G,Bastard C,P

更新日期：2004-01-15 00:00:00

abstract：:Two new myeloid cell lines (K051 and K052) were established from a patient with multilineage CD7-positive acute leukemia. The K051 and K052 were established from the patient's bone marrow cells at diagnosis and at relapse, respectively. The K051 cell expressed myeloid-associated antigens (CD13 and CD33), a platelet-as...

journal_title：Blood

authors： Abo J,Inokuchi K,Dan K,Nomura T

更新日期：1993-11-01 00:00:00

abstract：:To analyze the structure of the murine erythropoietin receptor (EpoR), wild-type or mutant EpoR cDNAs were expressed in cell lines, and the proteins that cross-linked with 125I-labeled erythropoietin (Epo) were analyzed by immunoprecipitation using an antibody against the intracellular region of the cloned EpoR. COS-7...

journal_title：Blood

authors： Miura O,Ihle JN

更新日期：1993-04-01 00:00:00

abstract：:Immunosuppressive therapy can produce hematologic improvement in a large proportion of patients with severe aplastic anemia. Antithymocyte globulin (ATG) is the current treatment of choice for patients who do not have histocompatible sibling donors or who are otherwise inegligible for allogeneic bone marrow transplant...

journal_title：Blood

authors： Rosenfeld SJ,Kimball J,Vining D,Young NS

更新日期：1995-06-01 00:00:00

abstract：:Myelodysplastic syndromes (MDSs) are hematopoietic stem cell disorders in which recurrent mutations define clonal hematopoiesis. The origin of the phenotypic diversity of non-del(5q) MDS remains unclear. Here, we investigated the clonal architecture of the CD34+CD38- hematopoietic stem/progenitor cell (HSPC) compartme...

journal_title：Blood

authors： Chesnais V,Arcangeli ML,Delette C,Rousseau A,Guermouche H,Lefevre C,Bondu S,Diop M,Cheok M,Chapuis N,Legros L,Raynaud S,Willems L,Bouscary D,Lauret E,Bernard OA,Kosmider O,Pflumio F,Fontenay M

更新日期：2017-01-26 00:00:00

abstract：:Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, uni...

journal_title：Blood

authors： Kim YH,Willemze R,Pimpinelli N,Whittaker S,Olsen EA,Ranki A,Dummer R,Hoppe RT,ISCL and the EORTC.

更新日期：2007-07-15 00:00:00

abstract：:Cryoprecipitate has been demonstrated to correct the bleeding abnormality of patients with some congenital (storage pool disease) and acquired (uremia) platelet abnormalities, but the reason for this effect is unknown. We found significant platelet contamination in plasma harvested to prepare fresh frozen plasma and c...

journal_title：Blood

authors： George JN,Pickett EB,Heinz R

更新日期：1986-07-01 00:00:00

abstract：:Leukemic blasts from 774 children with newly diagnosed acute lymphocytic leukemia (ALL) have been phenotyped by microcytotoxicity testing with a panel of monoclonal antibodies and heteroantisera as part of a Pediatric Oncology Group classification study of acute leukemia. One hundred twenty-two cases, or 16% were desi...

journal_title：Blood

authors： Borowitz MJ,Dowell BL,Boyett JM,Falletta JM,Pullen DJ,Crist WM,Humphrey GB,Metzgar RS

更新日期：1985-04-01 00:00:00

abstract：:Folylpolyglutamate synthetase (FPGS) is responsible for the metabolism of natural folates and a broad range of folate antagonists to polyglutamate derivatives. Recent studies indicated increased accumulation of methotrexate (MTX) polyglutamates (MTX-PG) in blast cells as a predictor of favorable treatment outcome in c...

journal_title：Blood

authors： Barredo JC,Synold TW,Laver J,Relling MV,Pui CH,Priest DG,Evans WE

更新日期：1994-07-15 00:00:00

abstract：:von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of debate. In order to study the spectrum of type 1 VWD in the United States, the Zimmerman Program enrolled 482 subjects with a...

journal_title：Blood

authors： Flood VH,Christopherson PA,Gill JC,Friedman KD,Haberichter SL,Bellissimo DB,Udani RA,Dasgupta M,Hoffmann RG,Ragni MV,Shapiro AD,Lusher JM,Lentz SR,Abshire TC,Leissinger C,Hoots WK,Manco-Johnson MJ,Gruppo RA,Boggio LN

更新日期：2016-05-19 00:00:00