Abstract:
:Membrane markers expressed by a transplantable granulocytic leukemia induced in inbred strain 13 guinea pigs by N-nitroso-N-butylurea have been investigated by serologic and immunochemical methods. Although the leukemic myeloblasts have no detectable surface immunoglobulin or Fc receptors, they have been found to synthesize and express membrane antigens encoded for by the I-region of the major histocompatibility complex. Despite the presence of Ia antigens, these cells do not stimulate allogeneic T lymphocytes in the mixed lymphocyte reaction nor are they able to present soluble antigen to immune T cells. The presence of Ia antigens on immature myeloid cells suggests that these proteins may be important in cellular functions beyond those identified in the cellular immune system.
journal_name
Bloodjournal_title
Bloodauthors
Clement LT,Hu C,Shevach EM,Green Isubject
Has Abstractpub_date
1980-02-01 00:00:00pages
304-10issue
2eissn
0006-4971issn
1528-0020journal_volume
55pub_type
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