The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypes.

abstract：:B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the progn...

journal_title：Blood

authors： Grabowski P,Hultdin M,Karlsson K,Tobin G,Aleskog A,Thunberg U,Laurell A,Sundström C,Rosenquist R,Roos G

更新日期：2005-06-15 00:00:00

abstract：:Protein S is a cofactor for tissue factor pathway inhibitor (TFPI), accelerating the inhibition of activated factor X (FXa). TFPI Kunitz domain 3 residue Glu226 is essential for enhancement of TFPI by protein S. To investigate the complementary functional interaction site on protein S, we screened 44 protein S point, ...

journal_title：Blood

authors： Reglińska-Matveyev N,Andersson HM,Rezende SM,Dahlbäck B,Crawley JT,Lane DA,Ahnström J

更新日期：2014-06-19 00:00:00

abstract：:Reticulocytes release small membrane vesicles termed exosomes during their maturation into erythrocytes. It has been suggested that reticulocytes remodel the plasma membrane of the immature red cell during erythropoiesis by specifically eliminating various proteins. We report here that exosome release is associated wi...

journal_title：Blood

authors： Blanc L,Barres C,Bette-Bobillo P,Vidal M

更新日期：2007-11-01 00:00:00

abstract：:GVHD is still one of the major complications after allogeneic stem cell transplantation. Whereas murine data have clearly shown the beneficial effects of regulatory T cells (Tregs) on the prevention of GVHD, data from the human system are rare. Here, we present a comparative dynamic analysis of CD4(+)CD25(hi)CD127(lo/...

journal_title：Blood

authors： Ukena SN,Velaga S,Geffers R,Grosse J,Baron U,Buchholz S,Stadler M,Bruder D,Ganser A,Franzke A

更新日期：2011-09-29 00:00:00

abstract：:Interferon (IFN) therapy has become widely used for the treatment of chronic myelogenous leukemia. Hematologic remissions can be induced in about 60% of patients. Moreover, in a small number of patients loss of the Philadelphia (Ph) chromosome and of the BCR-ABL rearrangement is observed. We have used genomic Southern...

journal_title：Blood

authors： Opalka B,Wandl UB,Becher R,Kloke O,Nagel-Hiemke M,Moritz T,Beer U,Seeber S,Niederle N

更新日期：1991-11-01 00:00:00

abstract：:The microbiota is known to influence the generation of hematopoietic progenitors, although the pathways underlying this process are still poorly understood. NOD1 and NOD2 are intracellular sensors for both Gram-positive and Gram-negative bacteria, but their role in steady-state hematopoiesis has never been characteriz...

journal_title：Blood

authors： Iwamura C,Bouladoux N,Belkaid Y,Sher A,Jankovic D

更新日期：2017-01-12 00:00:00

abstract：:The effects of the deoxygenation rate on the formation of irreversibly sickled cells (ISCs) were investigated by using metabolically replete sickle cells (SS cells). We found that the formation of ISCs required Ca2+ and that the amount formed depended on the rate of deoxygenation. When less dense SS discocytes were de...

journal_title：Blood

authors： Horiuchi K,Ballas SK,Asakura T

更新日期：1988-01-01 00:00:00

abstract：:Conflicting data have been reported on the risk for venous thrombosis in subjects with low free protein S levels. We performed a post-hoc analysis in a single-center retrospective thrombophilic family cohort, to define the optimal free protein S level that can identify subjects at risk for venous thrombosis. Relatives...

journal_title：Blood

authors： Lijfering WM,Mulder R,ten Kate MK,Veeger NJ,Mulder AB,van der Meer J

更新日期：2009-02-05 00:00:00

abstract：:Extracorporeal immunoadsorption of plasma to remove IgG and circulating immune complexes (CIC) was evaluated as a therapy for adults with treatment-resistant immune thrombocytopenic purpura (ITP). Seventy-two patients with initial platelet counts less than 50,000/microL who had failed at least two other therapies were...

journal_title：Blood

authors： Snyder HW Jr,Cochran SK,Balint JP Jr,Bertram JH,Mittelman A,Guthrie TH Jr,Jones FR

更新日期：1992-05-01 00:00:00

abstract：:Fibronectin is an adhesive protein that can promote phagocytosis and endothelial cell adhesion. Plasma fibronectin declines following burn in animals and patients, potentially due to its complexing with circulating collagenous debris as well as its rapid binding to sites of tissue injury. Such depletion of fibronectin...

journal_title：Blood

authors： La Celle P,Blumenstock FA,Saba TM

更新日期：1991-05-01 00:00:00

abstract：:Using the technique of differential cDNA library screening, we have molecularly cloned a gene that is highly expressed in an undifferentiated myeloid multipotent and growth factor-dependent stem cell line (FDCP-Mix) and that downregulates as these cells are induced to differentiate along monocytic, granulocytic, and e...

journal_title：Blood

authors： Hampson IN,Cross MA,Heyworth CM,Fairbairn L,Spooncer E,Cowling GJ,Dexter TM

更新日期：1992-12-15 00:00:00

abstract：:We report a novel chromosome translocation--t(2;5)(p23;q35) or its variant, t(2;5;13)(p23;q35;q12)--in 3 patients with peripheral T-cell lymphoma. All 3 were female children who had peripheral lymphadenopathy without organomegaly and underwent complete remission with or without chemotherapy. Their tumors were characte...

journal_title：Blood

authors： Kaneko Y,Frizzera G,Edamura S,Maseki N,Sakurai M,Komada Y,Sakurai M,Tanaka H,Sasaki M,Suchi T

更新日期：1989-02-15 00:00:00

abstract：:Anaplastic large cell lymphoma represents a subset of neoplasms caused by translocations that juxtapose the anaplastic lymphoma kinase (ALK) to dimerization partners. The constitutive activation of ALK fusion proteins leads to cellular transformation through a complex signaling network. To elucidate the ALK pathways s...

journal_title：Blood

authors： Boccalatte FE,Voena C,Riganti C,Bosia A,D'Amico L,Riera L,Cheng M,Ruggeri B,Jensen ON,Goss VL,Lee K,Nardone J,Rush J,Polakiewicz RD,Comb MJ,Chiarle R,Inghirami G

更新日期：2009-03-19 00:00:00

abstract：:Identification of genes involved in in vitro differentiation induction of embryonic stem cells (ESCs) into hematopoietic stem cells (HSCs) has been challenged during last decade. To date, a homeobox transcription factor Hoxb4 has been only demonstrated to possess such an effect in mice. Here, we show that HSC-like cel...

journal_title：Blood

authors： Kitajima K,Minehata K,Sakimura K,Nakano T,Hara T

更新日期：2011-04-07 00:00:00

abstract：:The fibrinogen structural variant, Marburg (A alpha 1-460B beta gamma)2, is comprised of normal B beta and gamma chains but contains severely truncated A alpha chains that are missing approximately one half of their factor XIIIa cross-linking domain. Immunochemical studies of fibrin(ogen) Marburg were conducted to cha...

journal_title：Blood

authors： Sobel JH,Trakht I,Wu HQ,Rudchenko S,Egbring R

更新日期：1995-08-01 00:00:00

abstract：:The effects of transforming growth factor-beta 1 (TGF-beta 1) on proliferation and hemoglobinization in K-562 cells, a human multipotential hematopoietic cell line, were studied. We found that TGF-beta 1 could induce hemoglobin accumulation in K-562 cells. Various clones were selected on the basis of the inducibility ...

journal_title：Blood

authors： Chen LL,Dean A,Jenkinson T,Mendelsohn J

更新日期：1989-11-15 00:00:00

abstract：:The study of the molecular bases of thrombophilia in a large family with 4 symptomatic members is reported. Three thrombophilic genetic components (FV R506Q, FV H1299R, and PT 20210G/A), all affecting the activity of the prothrombinase complex, were detected alone and in combination in various family members. In addit...

journal_title：Blood

authors： Castoldi E,Simioni P,Kalafatis M,Lunghi B,Tormene D,Girelli D,Girolami A,Bernardi F

更新日期：2000-08-15 00:00:00

abstract：:Platelets are pivotal to the process of arterial thrombosis resulting in ischemic stroke. Occlusive thrombosis is initiated by the interaction of von Willebrand factor (vWf) and platelet glycoprotein (GP) Ibalpha. Three polymorphisms have been described in GP Ibalpha (Kozak T/C polymorphism, variable number of tandem ...

journal_title：Blood

authors： Baker RI,Eikelboom J,Lofthouse E,Staples N,Afshar-Kharghan V,López JA,Shen Y,Berndt MC,Hankey G

更新日期：2001-07-01 00:00:00

abstract：:E-cadherin gene is often termed a "metastasis suppressor" gene because the E-cadherin protein can suppress tumor cell invasion and metastasis. Inactivation of the E-cadherin gene occurs in undifferentiated solid tumors by both genetic and epigenetic mechanisms; however, the role of E-cadherin in hematologic malignanci...

journal_title：Blood

authors： Melki JR,Vincent PC,Brown RD,Clark SJ

更新日期：2000-05-15 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia characterized by the presence of abnormal subpopulations of blood cells that are deficient in surface expression of glycosylphosphatidylinositol (GPI)-anchored proteins. Recent studies showed that the gene termed PIG-A, which participates in the...

journal_title：Blood

authors： Iida Y,Takeda J,Miyata T,Inoue N,Nishimura J,Kitani T,Maeda K,Kinoshita T

更新日期：1994-06-01 00:00:00

abstract：:The mechanisms by which hematopoietic progenitor cells become lineage-committed remain poorly understood. A cloned subline of the AML14 cell line (AML14.3D10) that spontaneously differentiates to eosinophilic myelocytes in the absence of cytokine stimulation was obtained by limiting dilution. This subline exhibits aug...

journal_title：Blood

authors： Paul CC,Mahrer S,Tolbert M,Elbert BL,Wong I,Ackerman SJ,Baumann MA

更新日期：1995-11-15 00:00:00

abstract：:Aberrant activation of the Wnt pathway plays a pathogenetic role in various tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). LEF1, a key mediator of Wnt signaling, has been linked to leukemic transformation, and recurrent mutations of LEF1 have been identified in pediatric T-A...

journal_title：Blood

authors： Kühnl A,Gökbuget N,Kaiser M,Schlee C,Stroux A,Burmeister T,Mochmann LH,Hoelzer D,Hofmann WK,Thiel E,Baldus CD

更新日期：2011-12-08 00:00:00

abstract：:This study includes 47 normal subjects and 25 hemophilia B patients without inhibitor(s), showing different factor IX coagulant activity and antigen levels. Genomic DNA, digested with various restriction endonucleases, was hybridized with two different factor IX probes, ie, the cDNA and the subgenomic probe for the in...

journal_title：Blood

authors： Hassan HJ,Orlando M,Leonardi A,Chelucci C,Guerriero R,Mannucci PM,Mariani G,Peschle C

更新日期：1985-02-01 00:00:00

abstract：:There has been increasing interest in the involvement of mammalian homeobox (HOX) genes in hematopoietic regulation. The HOX genes are clustered in 4 chromosomes in mice and humans. In general, 5' end HOX gene expression is predominant in hematopoietic stem cell populations, whereas 3' end HOX gene expression are prim...

journal_title：Blood

authors： Zimmermann F,Rich IN

更新日期：1997-04-15 00:00:00

abstract：:A novel thrombin inhibitor based on single-stranded (ss) deoxynucleotides with the sequence GGTTGGTGTGGTTGG (thrombin aptamer) has been recently discovered. In this study, we tested its efficacy in inhibiting clot-bound thrombin activity and platelet thrombus formation in an ex vivo whole artery angioplasty model. The...

journal_title：Blood

authors： Li WX,Kaplan AV,Grant GW,Toole JJ,Leung LL

更新日期：1994-02-01 00:00:00

abstract：:Gimap4, a member of the newly identified GTPase of the immunity-associated protein family (Gimap), is strongly induced by the pre-T-cell receptor in precursor T lymphocytes, transiently shut off in double-positive thymocytes, and reappears after TCR-mediated positive selection. Here, we show that Gimap4 remains expres...

journal_title：Blood

authors： Schnell S,Démollière C,van den Berk P,Jacobs H

更新日期：2006-07-15 00:00:00

abstract：:The interleukin (IL)-22R1 chain of the heterodimeric IL-22 receptor is not expressed on normal leukocytes, but this receptor is expressed on T cells from anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large cell lymphoma (ALCL) patients. To investigate the consequences of aberrant expression of this receptor ...

journal_title：Blood

authors： Savan R,McFarland AP,Reynolds DA,Feigenbaum L,Ramakrishnan K,Karwan M,Shirota H,Klinman DM,Dunleavy K,Pittaluga S,Anderson SK,Donnelly RP,Wilson WH,Young HA

更新日期：2011-01-13 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency with microthrombocytopenia, eczema, recurrent infections, autoimmune disorders, and malignancies that are life-threatening in the majority of patients. In this long-term, retrospective, multicenter study, we analyzed events that occurred in 96 WAS pati...

journal_title：Blood

authors： Ozsahin H,Cavazzana-Calvo M,Notarangelo LD,Schulz A,Thrasher AJ,Mazzolari E,Slatter MA,Le Deist F,Blanche S,Veys P,Fasth A,Bredius R,Sedlacek P,Wulffraat N,Ortega J,Heilmann C,O'Meara A,Wachowiak J,Kalwak K,Matthes-

更新日期：2008-01-01 00:00:00

abstract：:In Wiskott-Aldrich syndrome (WAS), immunodeficiency and autoimmunity often comanifest, yet how WAS mutations misregulate chromatin-signaling in Thelper (TH) cells favoring development of auto-inflammation over protective immunity is unclear. Previously, we identified an essential promoter-specific, coactivator role of...

journal_title：Blood

authors： Sarkar K,Sadhukhan S,Han SS,Vyas YM

更新日期：2015-10-01 00:00:00

abstract：:The ability to transfer new genetic material into human hematopoietic cells provides the foundation for characterizing the organization and developmental program of human hematopoietic stem cells. It also provides a valuable model in which to test gene transfer and long-term expression in human hematopoietic cells as ...

journal_title：Blood

authors： Dick JE,Kamel-Reid S,Murdoch B,Doedens M

更新日期：1991-08-01 00:00:00