Clinical relevance of decreased free protein S levels: results from a retrospective family cohort study involving 1143 relatives.


:Conflicting data have been reported on the risk for venous thrombosis in subjects with low free protein S levels. We performed a post-hoc analysis in a single-center retrospective thrombophilic family cohort, to define the optimal free protein S level that can identify subjects at risk for venous thrombosis. Relatives (1143) were analyzed. Relatives with venous thrombosis (mean age 39 years) had lower free protein S levels than relatives without venous thrombosis (P < .001), which was most pronounced in the lowest quartile. Only relatives with free protein S levels less than the 5th percentile (< 41 IU/dL) or less than the 2.5th percentile (< 33 IU/dL) were at higher risk of first venous thrombosis compared with the upper quartile (> 91 IU/dL); annual incidence 1.20% (95% confidence interval [CI], 0.72-1.87) and 1.81% (95% CI, 1.01-2.99), respectively; adjusted hazard ratios 5.6, (95% CI, 2.7-11.5) and 11.3 (95% CI, 5.4-23.6). Recurrence rates were 12.12% (95 CI, 5.23-23.88) and 12.73% (95% CI, 5.12-26.22) per year; adjusted hazard ratios were 3.0 (95% CI, 1.03-8.5) and 3.4 (95% CI, 1.1-10.3). In conclusion, free protein S level can identify young subjects at risk for venous thrombosis in thrombophilic families, although the cutoff level lies far below the normal range in healthy volunteers.






Lijfering WM,Mulder R,ten Kate MK,Veeger NJ,Mulder AB,van der Meer J




Has Abstract


2009-02-05 00:00:00
















  • A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.

    abstract::To develop safer and more effective vectors for gene therapy of X-linked severe combined immunodeficiency (SCID-X1), we have evaluated new self-inactivating lentiviral vectors based on the HIV virus. The CL20i4-hgamma(c)-Revgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by t...


    pub_type: 杂志文章


    authors: Zhou S,Mody D,DeRavin SS,Hauer J,Lu T,Ma Z,Hacein-Bey Abina S,Gray JT,Greene MR,Cavazzana-Calvo M,Malech HL,Sorrentino BP

    更新日期:2010-08-12 00:00:00

  • Interleukin-4 suppresses plasminogen activator inhibitor-2 formation in stimulated human monocytes.

    abstract::Using a specific enzyme-linked immunosorbent assay, plasminogen activator inhibitor-2 (PAI-2) was quantitated in cultures of human monocytes. Lipopolysaccharide (LPS) increased both extracellular and cell-associated PAI-2 levels, as well as PAI-2 mRNA measured by Northern analysis. Both the lymphokine, interleukin-4 (...


    pub_type: 杂志文章


    authors: Hamilton JA,Whitty GA,Last K,Royston AK,Hart PH,Burgess DR

    更新日期:1992-07-01 00:00:00

  • Quantitation of ferritin iron in plasma, an explanation for non-transferrin iron.

    abstract::In 33 patients with thalassemia and idiopathic hemochromatosis, plasma ferritin protein levels ranged from 36 to 5,850 micrograms/L. The iron content of this ferritin as determined by immunoprecipitation ranged from undetectable amounts to 507 micrograms/L. The mean iron content of ferritin protein in those and other ...


    pub_type: 杂志文章


    authors: Pootrakul P,Josephson B,Huebers HA,Finch CA

    更新日期:1988-04-01 00:00:00

  • The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages.

    abstract::CCR5 is a receptor for several beta chemokines and the entry coreceptor used by macrophage-tropic (R5) strains of HIV-1. In addition to supporting viral entry, CCR5 ligation by the HIV-1 envelope glycoprotein 120 (gp120) can activate intracellular signals in macrophages and trigger inflammatory mediator release. Using...


    pub_type: 杂志文章


    authors: Tomkowicz B,Lee C,Ravyn V,Cheung R,Ptasznik A,Collman RG

    更新日期:2006-08-15 00:00:00

  • CD34+ marrow cells, devoid of T and B lymphocytes, reconstitute stable lymphopoiesis and myelopoiesis in lethally irradiated allogeneic baboons.

    abstract::CD34+ cells devoid of detectable mature and immature T and B lymphocytes, expressing the CD2, CD10, and CD20 antigens, were isolated from marrows of three pairs of sex-mismatched, mixed lymphocyte culture (MLC) nonreactive, sibling baboons. Reciprocal transplants were performed between members of each pair, using the ...


    pub_type: 杂志文章


    authors: Andrews RG,Bryant EM,Bartelmez SH,Muirhead DY,Knitter GH,Bensinger W,Strong DM,Bernstein ID

    更新日期:1992-10-01 00:00:00

  • A site involving the "hybrid" and PSI homology domains of GPIIIa (beta 3-integrin subunit) is a common target for antibodies associated with quinine-induced immune thrombocytopenia.

    abstract::Drug-dependent antibodies (DDAbs) can cause the precipitous destruction of platelets if a patient is exposed to the drug for which the antibodies are specific. The molecular character of the epitopes recognized is poorly understood, and the mechanism by which drugs promote tight binding of these antibodies to platelet...


    pub_type: 杂志文章


    authors: Peterson JA,Nyree CE,Newman PJ,Aster RH

    更新日期:2003-02-01 00:00:00

  • Myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission prolongs progression-free survival in follicular lymphoma: results of a prospective, randomized trial of the German Low-Grade Lymphoma Study Group.

    abstract::Conventional chemotherapy has failed to substantially prolong survival for patients with advanced follicular lymphoma. To improve outcomes, the German Low-Grade Lymphoma Study Group (GLSG) initiated a randomized trial to compare the effect of potentially curative myeloablative radiochemotherapy followed by autologous ...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Lenz G,Dreyling M,Schiegnitz E,Forstpointner R,Wandt H,Freund M,Hess G,Truemper L,Diehl V,Kropff M,Kneba M,Schmitz N,Metzner B,Pfirrmann M,Unterhalt M,Hiddemann W,German Low-Grade Lymphoma Study Group.

    更新日期:2004-11-01 00:00:00

  • Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa.

    abstract::Because free factor VIIa is inactivated only very slowly by a plasma concentration of antithrombin III (AT III) even in the presence of heparin, it has been assumed that AT III plays no significant role in regulating the initiation of tissue factor-dependent blood coagulation. However, in the present study, we present...


    pub_type: 杂志文章


    authors: Rao LV,Rapaport SI,Hoang AD

    更新日期:1993-05-15 00:00:00

  • Rabbit reticulocyte coated vesicles carrying the transferrin-transferrin receptor complex: I. Purification and partial characterization.

    abstract::Coated vesicles bearing the transferrin-transferrin receptor complex were isolated from rabbit reticulocytes by freeze-thaw cell lysis, followed by differential centrifugation with pelleting of vesicles at 100,000 g. Electronmicroscopy demonstrated the vesicles to have the characteristic morphology of coated vesicles,...


    pub_type: 杂志文章


    authors: Choe HR,Moseley ST,Glass J,Nunez MT

    更新日期:1987-10-01 00:00:00

  • Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium.

    abstract::The chemokines platelet factor 4 (PF4) and RANTES (regulated on activation normal T cell expressed and secreted) are secreted by activated platelets and influence multiple cell types and biologic processes. For instance, PF4 inhibits progenitor cell proliferation and angiogenesis, while platelet-derived RANTES is invo...


    pub_type: 杂志文章


    authors: von Hundelshausen P,Koenen RR,Sack M,Mause SF,Adriaens W,Proudfoot AE,Hackeng TM,Weber C

    更新日期:2005-02-01 00:00:00

  • Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway.

    abstract::The endogenous presentation of the majority of viral epitopes through MHC class I pathway is strictly dependent on the transporter associated with antigen processing (TAP) complex, which transfers the peptide products of proteasomal degradation into the endoplasmic reticulum. A small number of epitopes can be presente...


    pub_type: 杂志文章


    authors: Tey SK,Khanna R

    更新日期:2012-08-02 00:00:00

  • Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors.

    abstract::Merkel cell polyomavirus (MCPyV), a DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukemia. MCPyV sequences have also been detected in various normal tissues in tumor-affected patients. Immunologic studies have detected MCPyV antibodies in as many as 80% of healthy...


    pub_type: 杂志文章


    authors: Pancaldi C,Corazzari V,Maniero S,Mazzoni E,Comar M,Martini F,Tognon M

    更新日期:2011-06-30 00:00:00

  • Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly human leukocyte antigen-disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishin

    abstract::The purpose of this study was to compare transplantation outcomes in patients with hematologic malignancies who received marrow grafts from either phenotypically matched unrelated, one-antigen-mismatched unrelated, or highly human leukocyte antigen (HLA)-disparate family donors. Between 1993 and 2000, 139 patients und...


    pub_type: 杂志文章


    authors: Drobyski WR,Klein J,Flomenberg N,Pietryga D,Vesole DH,Margolis DA,Keever-Taylor CA

    更新日期:2002-02-01 00:00:00

  • Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas.

    abstract::The incidence of follicular lymphoma (FL) in industrialized countries has been increasing since the 1950s. Polymorphisms in genes encoding key enzymes controlling folate-methionine metabolism, including methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS or MTR), serine hydroxymethyltransferase (SHMT)...


    pub_type: 杂志文章


    authors: Niclot S,Pruvot Q,Besson C,Savoy D,Macintyre E,Salles G,Brousse N,Varet B,Landais P,Taupin P,Junien C,Baudry-Bluteau D

    更新日期:2006-07-01 00:00:00

  • SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signaling.

    abstract::Aggregation of the high-affinity IgE receptor induces the tyrosine phosphorylation of subunits of the receptor and the subsequent association with the receptor of the cytosolic protein tyrosine kinase Syk. The current experiments examined the functional importance of membrane association of Syk and the role of the SH2...


    pub_type: 杂志文章


    authors: Sada K,Zhang J,Siraganian RP

    更新日期:2001-03-01 00:00:00

  • Synergistic inhibition of platelet activation by plasmin and prostaglandin I2.

    abstract::Endothelial cell prostacyclin (PGI2) inhibits platelet activation by raising platelet cyclic AMP. Previously, platelet activation was also shown to be blocked by plasmin formed by endothelium-derived tissue plasminogen activator (TPA). We have now studied interactions between PGI2 and plasmin in the control of platele...


    pub_type: 杂志文章


    authors: Schafer AI,Zavoico GB,Loscalzo J,Maas AK

    更新日期:1987-05-01 00:00:00

  • Cellular response to hypoxia involves signaling via Smad proteins.

    abstract::The transforming growth factor-beta (TGF-beta) family of cytokines regulates vascular development and inflammatory responses. We have recently shown that exposure of human umbilical vein endothelial cells (HUVECs) to hypoxia (1% O(2)) increases gene expression and bioactivation of TGF-beta2 and induces its downstream ...


    pub_type: 杂志文章


    authors: Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA

    更新日期:2003-03-15 00:00:00

  • Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients.

    abstract::Whereas the chimeric type I anti-CD20 Ab rituximab has improved outcomes for patients with B-cell malignancies significantly, many patients with non-Hodgkin lymphoma (NHL) remain incurable. Obinutuzumab (GA101) is a glycoengineered, humanized anti-CD20 type II Ab that has demonstrated superior activity against type I ...


    pub_type: 杂志文章,多中心研究


    authors: Salles G,Morschhauser F,Lamy T,Milpied N,Thieblemont C,Tilly H,Bieska G,Asikanius E,Carlile D,Birkett J,Pisa P,Cartron G

    更新日期:2012-05-31 00:00:00

  • Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials.

    abstract::While investigating 2592 patients enrolled in multicenter myeloma trials, we found light chain-only (LCO) patients had worse median survival times (1.9 years) than patients with IgA and IgG paraproteins (2.3 and 2.5 years, respectively) (P < .001). However, IgA and IgG patients with levels of LC excretion similar to t...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Drayson M,Begum G,Basu S,Makkuni S,Dunn J,Barth N,Child JA

    更新日期:2006-09-15 00:00:00

  • Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment.

    abstract::The exact mechanisms underlying the role of oxidative stress in the pathogenesis and the prothrombotic or proinflammatory status of antiphospholipid syndrome (APS) remain unknown. Here, we investigate the role of oxidative stress and mitochondrial dysfunction in the proatherothrombotic status of APS patients induced b...


    pub_type: 杂志文章


    authors: Perez-Sanchez C,Ruiz-Limon P,Aguirre MA,Bertolaccini ML,Khamashta MA,Rodriguez-Ariza A,Segui P,Collantes-Estevez E,Barbarroja N,Khraiwesh H,Gonzalez-Reyes JA,Villalba JM,Velasco F,Cuadrado MJ,Lopez-Pedrera C

    更新日期:2012-06-14 00:00:00

  • Prolonged expression of c-fos suppresses cell cycle entry of dormant hematopoietic stem cells.

    abstract::The proto-oncogene c-fos was transiently upregulated in primitive hematopoietic stem (Lin-Sca-1(+)) cells stimulated with stem cell factor, interleukin-3 (IL-3), and IL-6. To investigate a role of the c-fos in hematopoietic stem cells, we used bone marrow (BM) cells from transgenic mice carrying the c-fos gene under t...


    pub_type: 杂志文章


    authors: Okada S,Fukuda T,Inada K,Tokuhisa T

    更新日期:1999-02-01 00:00:00

  • Circulating peripheral blood plasma cells as a prognostic indicator in patients with primary systemic amyloidosis.

    abstract::This study examined the prognostic value of circulating peripheral blood plasma cells (PBPCs) in patients with primary systemic amyloidosis (AL). A sensitive slide-based immunofluorescence technique was used to assess 147 patients for circulating PBPCs. Circulating monoclonal plasma cells were quantified as a percenta...


    pub_type: 杂志文章


    authors: Pardanani A,Witzig TE,Schroeder G,McElroy EA,Fonseca R,Dispenzieri A,Lacy MQ,Lust JA,Kyle RA,Greipp PR,Gertz MA,Rajkumar SV

    更新日期:2003-02-01 00:00:00

  • Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells.

    abstract::CXC ligand 12 (CXCL12; also known as stromal cell-derived factor 1alpha/SDF-1alpha) chemoattracts hematopoietic stem and progenitor cells (HSCs/HPCs) and is thought to play a crucial role in the mobilization of HSCs/HPCs from the bone marrow. CD26 (dipeptidylpeptidase IV [DPPIV]) is a membrane-bound extracellular pept...


    pub_type: 杂志文章


    authors: Christopherson KW 2nd,Cooper S,Broxmeyer HE

    更新日期:2003-06-15 00:00:00

  • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma.

    abstract::Thalidomide (Thal) can overcome drug resistance in multiple myeloma (MM) but is associated with somnolence, constipation, and neuropathy. In previous in vitro studies, we have shown that the potent immunomodulatory derivative of thalidomide (IMiD) CC-5013 induces apoptosis or growth arrest even in resistant MM cell li...


    pub_type: 临床试验,杂志文章


    authors: Richardson PG,Schlossman RL,Weller E,Hideshima T,Mitsiades C,Davies F,LeBlanc R,Catley LP,Doss D,Kelly K,McKenney M,Mechlowicz J,Freeman A,Deocampo R,Rich R,Ryoo JJ,Chauhan D,Balinski K,Zeldis J,Anderson KC

    更新日期:2002-11-01 00:00:00

  • DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions.

    abstract::Age-associated clonal hematopoiesis caused by acquired mutations in myeloid cancer-associated genes is highly prevalent in the normal population. Its etiology, biological impact on hematopoiesis, and oncogenic risk is poorly defined at this time. To gain insight into this phenomenon, we analyzed a cohort of 2530 relat...


    pub_type: 杂志文章


    authors: Buscarlet M,Provost S,Zada YF,Barhdadi A,Bourgoin V,Lépine G,Mollica L,Szuber N,Dubé MP,Busque L

    更新日期:2017-08-10 00:00:00

  • Thromboprophylaxis in cancer outpatients.

    abstract::In this issue of Blood, Khorana and colleagues report a simple and practical model for the prediction of symptomatic venous thrombosis after the initiation of chemotherapy in cancer outpatients. ...


    pub_type: 评论,杂志文章


    authors: Doggen CJ

    更新日期:2008-05-15 00:00:00

  • Acute bleeding after bone marrow transplantation (BMT)- incidence and effect on survival. A quantitative analysis in 1,402 patients.

    abstract::Acute bleeding after bone marrow transplantation (BMT) was investigated in 1,402 patients receiving transplants at Johns Hopkins Hospital between January 1, 1986 and June 30, 1995. Bleeding categorization was based on daily scores of intensity used by the blood transfusion service. Moderate and severe episodes were an...


    pub_type: 杂志文章


    authors: Nevo S,Swan V,Enger C,Wojno KJ,Bitton R,Shabooti M,Fuller AK,Jones RJ,Braine HG,Vogelsang GB

    更新日期:1998-02-15 00:00:00

  • In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.

    abstract::Transforming growth factor-beta1 (TGF-beta1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-beta1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which is disulf...


    pub_type: 杂志文章


    authors: Ahamed J,Burg N,Yoshinaga K,Janczak CA,Rifkin DB,Coller BS

    更新日期:2008-11-01 00:00:00

  • Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients.

    abstract::Fifty-eight acute promyelocytic leukemia (APL) patients (11 newly diagnosed and 47 relapsed) were studied for arsenic trioxide (As2O3) treatment. Clinical complete remission (CR) was obtained in 8 of 11 (72.7%) newly diagnosed cases. However, As2O3 treatment resulted in hepatic toxicity in 7 cases including 2 deaths, ...


    pub_type: 临床试验,杂志文章


    authors: Niu C,Yan H,Yu T,Sun HP,Liu JX,Li XS,Wu W,Zhang FQ,Chen Y,Zhou L,Li JM,Zeng XY,Yang RR,Yuan MM,Ren MY,Gu FY,Cao Q,Gu BW,Su XY,Chen GQ,Xiong SM,Zhang TD,Waxman S,Wang ZY,Chen Z,Hu J,Shen ZX,Chen SJ

    更新日期:1999-11-15 00:00:00

  • A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster.

    abstract::We have identified an intergenic transcriptional activity that is located between the human HOXA1 and HOXA2 genes, shows myeloid-specific expression, and is up-regulated during granulocytic differentiation. The novel gene, termed HOTAIRM1 (HOX antisense intergenic RNA myeloid 1), is transcribed antisense to the HOXA g...


    pub_type: 杂志文章


    authors: Zhang X,Lian Z,Padden C,Gerstein MB,Rozowsky J,Snyder M,Gingeras TR,Kapranov P,Weissman SM,Newburger PE

    更新日期:2009-03-12 00:00:00