Abstract:
:GVHD is still one of the major complications after allogeneic stem cell transplantation. Whereas murine data have clearly shown the beneficial effects of regulatory T cells (Tregs) on the prevention of GVHD, data from the human system are rare. Here, we present a comparative dynamic analysis of CD4(+)CD25(hi)CD127(lo/-) Tregs from patients with and without GVHD analyzing the whole genome profile over the first 6 months after stem cell transplantation, representing the most sensitive time window for tolerance induction. The Treg transcriptome showed a high stability. However, the comparison of Treg transcriptomes from patients with and without GVHD uncovered regulated gene transcripts highly relevant for Treg cell function. The confirmative protein analyses demonstrated a significantly higher expression of granzyme A, CXCR3, and CCR5 in Tregs of immune tolerant patients. These results point to a reduced suppressive function of Tregs from GVHD patients with diminished migration capacity to the target organs.
journal_name
Bloodjournal_title
Bloodauthors
Ukena SN,Velaga S,Geffers R,Grosse J,Baron U,Buchholz S,Stadler M,Bruder D,Ganser A,Franzke Adoi
10.1182/blood-2011-05-352708subject
Has Abstractpub_date
2011-09-29 00:00:00pages
e82-92issue
13eissn
0006-4971issn
1528-0020pii
blood-2011-05-352708journal_volume
118pub_type
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