当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Perturbed hematopoiesis in mice lacking ATMIN.

Perturbed hematopoiesis in mice lacking ATMIN.

Abstract：

:The ataxia telangiectasia mutated (ATM)-interacting protein ATMIN mediates noncanonical ATM signaling in response to oxidative and replicative stress conditions. Like ATM, ATMIN can function as a tumor suppressor in the hematopoietic system: deletion of Atmin under the control of CD19-Cre results in B-cell lymphomas in aging mice. ATM signaling is essential for lymphopoiesis and hematopoietic stem cell (HSC) function; however, little is known about the role of ATMIN in hematopoiesis. We thus sought to investigate whether the absence of ATMIN would affect primitive hematopoietic cells in an ATM-dependent or -independent manner. Apart from its role in B-cell development, we show that ATMIN has an ATM-independent function in the common myeloid progenitors (CMPs) by deletion of Atmin in the entire hematopoietic system using Vav-Cre. Despite the lack of lymphoma formation, ATMIN-deficient mice developed chronic leukopenia as a result of high levels of apoptosis in B cells and CMPs and induced a compensatory mechanism in which HSCs displayed enhanced cycling. Consequently, ATMIN-deficient HSCs showed impaired regeneration ability with the induction of the DNA oxidative stress response, especially when aged. ATMIN, therefore, has multiple roles in different cell types, and its absence results in perturbed hematopoiesis, especially during stress conditions and aging.

journal_name

Blood

journal_title

Blood

authors

Anjos-Afonso F,Loizou JI,Bradburn A,Kanu N,Purewal S,Da Costa C,Bonnet D,Behrens A

doi

10.1182/blood-2015-09-672980

subject

Has Abstract

pub_date

2016-10-20 00:00:00

pages

2017-2021

issue

16

eissn

0006-4971

issn

1528-0020

pii

blood-2015-09-672980

journal_volume

128

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination.

    abstract：:The recent success of chimeric antigen receptor (CAR)-T cell therapy for treatment of hematologic malignancies supports further development of treatments for both liquid and solid tumors. However, expansion of CAR-T cell therapy is limited by the availability of surface antigens specific for the tumor while sparing no...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2017-08-802926

    authors： Akahori Y,Wang L,Yoneyama M,Seo N,Okumura S,Miyahara Y,Amaishi Y,Okamoto S,Mineno J,Ikeda H,Maki T,Fujiwara H,Akatsuka Y,Kato T,Shiku H

    更新日期：2018-09-13 00:00:00

  • Th1 and Th2 T-helper cells exert opposite regulatory effects on procoagulant activity and tissue factor production by human monocytes.

    abstract：:The role of T-cell subsets in the induction of tissue factor (TF) production by human monocytes in vitro was investigated. Mitogen stimulation enabled both unfractionated T cells and their CD4+ or CD8+ subsets to promote procoagulant activity (PCA). After mitogen or antigen activation, all seven T-cell clones with Th1...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Del Prete G,De Carli M,Lammel RM,D'Elios MM,Daniel KC,Giusti B,Abbate R,Romagnani S

    更新日期：1995-07-01 00:00:00

  • The effect of serum on monocyte tissue factor generation.

    abstract：:Human monocytes generate the procoagulant tissue factor (MTF) following exposure to a variety of immune stimuli in vitro. The generation of MTF is modified by T cells, lymphokines, and immunoregulatory lipoproteins, and recent studies have shown that MTF can be activated in an immune-specific manner following exposure...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Edwards RL,Perla D

    更新日期：1984-09-01 00:00:00

  • Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B.

    abstract：:Inflammation and thrombosis are increasingly recognized as interrelated biologic processes. Endothelial cell expression of thrombomodulin (TM), a key component of the anticoagulant protein C pathway, is potently inhibited by inflammatory cytokines. Because the mechanism underlying this effect is largely unknown, we in...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-03-0928

    authors： Sohn RH,Deming CB,Johns DC,Champion HC,Bian C,Gardner K,Rade JJ

    更新日期：2005-05-15 00:00:00

  • Ferritin iron absorption in man.

    abstract：:The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects wit...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Layrisse M,Martínez-Torres C,Renzy M,Leets I

    更新日期：1975-05-01 00:00:00

  • Asymptomatic hemochromatosis subjects: genotypic and phenotypic profiles.

    abstract：:Screening for hereditary hemochromatosis (HHC) by means of transferrin saturation (TS) levels has been advocated and will identify many patients who are asymptomatic. The purposes of this study were (1) to determine HFE genotypes among asymptomatic HHC patients and correlate this profile with the degree of iron overlo...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Sham RL,Raubertas RF,Braggins C,Cappuccio J,Gallagher M,Phatak PD

    更新日期：2000-12-01 00:00:00

  • Direct correlation between the load of Epstein-Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease.

    abstract：:The Epstein-Barr virus (EBV) is known to cause posttransplant lymphoproliferative disease (PTLD) in immunosuppressed transplant patients. The results of this pilot study showed that all EBV- patients pretransplant experienced primary EBV infection within the first 3 months after transplant surgery. Virtually all of th...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Savoie A,Perpête C,Carpentier L,Joncas J,Alfieri C

    更新日期：1994-05-01 00:00:00

  • Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition.

    abstract：:C-abl oncogene 1, nonreceptor tyrosine kinase (ABL1) kinase inhibitors such as imatinib mesylate (imatinib) are effective in managing chronic myeloid leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), suggesting that kinase-independent pathways support LSC survival. Given that the bone marrow (BM)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2013-07-511907

    authors： Ng KP,Manjeri A,Lee KL,Huang W,Tan SY,Chuah CT,Poellinger L,Ong ST

    更新日期：2014-05-22 00:00:00

  • Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.

    abstract：:CTLA-4 inhibits T-cell activation and protects against the development of autoimmunity. We and others previously showed that the coreceptor can induce T-cell motility and shorten dwell times with dendritic cells (DCs). However, it has been unclear whether this property of CTLA-4 affects both conventional T cells (Tcon...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2012-04-421420

    authors： Lu Y,Schneider H,Rudd CE

    更新日期：2012-11-29 00:00:00

  • Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study.

    abstract：:Acute graft-versus-host disease (GVHD) is the primary limitation of allogeneic hematopoietic cell transplantation, and once it develops, there are no reliable diagnostic tests to predict treatment outcomes. We hypothesized that 6 previously validated diagnostic biomarkers of GVHD (IL-2 receptor-α; tumor necrosis facto...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2012-01-403063

    authors： Levine JE,Logan BR,Wu J,Alousi AM,Bolaños-Meade J,Ferrara JL,Ho VT,Weisdorf DJ,Paczesny S

    更新日期：2012-04-19 00:00:00

  • Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation.

    abstract：:Class A scavenger receptor (SRA), also known as CD204, has been shown to participate in the pathogenesis of atherosclerosis and the pattern recognition of pathogen infection. However, its role in adaptive immune responses has not been well defined. In this study, we report that the lack of SRA/CD204 promotes Toll-like...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-11-190033

    authors： Yi H,Yu X,Gao P,Wang Y,Baek SH,Chen X,Kim HL,Subjeck JR,Wang XY

    更新日期：2009-06-04 00:00:00

  • SETD1A protects HSCs from activation-induced functional decline in vivo.

    abstract：:The regenerative capacity of hematopoietic stem cells (HSCs) is limited by the accumulation of DNA damage. Conditional mutagenesis of the histone 3 lysine 4 (H3K4) methyltransferase, Setd1a, revealed that it is required for the expression of DNA damage recognition and repair pathways in HSCs. Specific deletion of Setd...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2017-09-806844

    authors： Arndt K,Kranz A,Fohgrub J,Jolly A,Bledau AS,Di Virgilio M,Lesche M,Dahl A,Höfer T,Stewart AF,Waskow C

    更新日期：2018-03-22 00:00:00

  • Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry.

    abstract：:Some Ki-1 lymphomas carry a specific chromosomal translocation, t(2;5)(p23;q35). We have recently found a novel hyperphosphorylated 80-kD protein tyrosine kinase, p80, in a human Ki-1 lymphoma with this translocation. Subsequent cDNA cloning showed that p80 is a fusion protein of two different genes on chromosome 2p23...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Shiota M,Fujimoto J,Takenaga M,Satoh H,Ichinohasama R,Abe M,Nakano M,Yamamoto T,Mori S

    更新日期：1994-12-01 00:00:00

  • Incidence of therapy-related myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine: long-term follow-up of US Intergroup Study E2997.

    abstract：:Chemotherapy-related myeloid neoplasia (t-MN) is a significant late toxicity concern after cancer therapy. In the randomized intergroup phase 3 E2997 trial, initial therapy of chronic lymphocytic leukemia with fludarabine plus cyclophosphamide (FC) compared with fludarabine alone yielded higher complete and overall re...

    journal_title：Blood

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1182/blood-2011-03-342485

    authors： Smith MR,Neuberg D,Flinn IW,Grever MR,Lazarus HM,Rowe JM,Dewald G,Bennett JM,Paietta EM,Byrd JC,Hussein MA,Appelbaum FR,Larson RA,Litzow MR,Tallman MS

    更新日期：2011-09-29 00:00:00

  • Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: long-term follow-up of a randomized trial.

    abstract：:In a previous multicenter phase III trial comparing peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT) from HLA-matched related donors, we found no statistically significant difference in the cumulative incidence of clinical extensive chronic graft-versus-host disease (GVHD) in the...

    journal_title：Blood

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1182/blood-2002-01-0011

    authors： Flowers ME,Parker PM,Johnston LJ,Matos AV,Storer B,Bensinger WI,Storb R,Appelbaum FR,Forman SJ,Blume KG,Martin PJ

    更新日期：2002-07-15 00:00:00

  • Detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin hypervariable region specific oligonucleotide probes.

    abstract：:To develop a sensitive and specific assay for minimal residual disease in acute lymphoblastic leukemia (ALL), we exploited the enormous diversity of genomic sequences created by immune receptor gene rearrangements. To isolate clone-specific sequences, we first synthesized oligonucleotides that match conserved variable...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Jonsson OG,Kitchens RL,Scott FC,Smith RG

    更新日期：1990-11-15 00:00:00

  • Long-term health-related quality of life evaluated more than 20 years after hematopoietic stem cell transplantation for thalassemia.

    abstract：:The principal aim of our study was to investigate whether patients transplanted more than 20 years ago for β-thalassemia major had a different health-related quality of life (HRQoL) compared with the general population. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Functional Assessment o...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2013-05-502658

    authors： La Nasa G,Caocci G,Efficace F,Dessì C,Vacca A,Piras E,Sanna M,Marcias M,Littera R,Carcassi C,Lucarelli G

    更新日期：2013-09-26 00:00:00

  • Clonal evolution in atypical chronic granulocytic leukemia: a non-Philadelphia translocation.

    abstract：:Hemopoietic cells in chronic granulocytic leukemia (CGL) frequently contain a chromosome translocation involving chromosome 22 and another autosome, usually number 9. The translocated chromosome 22 is known as the Philadelphia (Ph) chromosome. The appearance of a second Ph chromosome is the most common cytogenetic abn...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bagby GC Jr,Kaiser-McCaw B,Hecht F,Koler RD,Linman JW

    更新日期：1978-06-01 00:00:00

  • A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.

    abstract：:The Duffy blood group system is of clinical and biological significance. Antibodies to Duffy antigens are responsible for some cases of transfusion incompatibility and newborn hemolytic disease. The Duffy protein is a receptor for the Plasmodium vivax erythrocyte-binding protein and is also a receptor for various chem...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Parasol N,Reid M,Rios M,Castilho L,Harari I,Kosower NS

    更新日期：1998-10-01 00:00:00

  • ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration.

    abstract：:Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering, intercellular adhesion molecule-1 (ICAM-1)-dependent firm adhesion, and platelet/endothelial cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration. An important unanswered question is whether ICAM-1-activated signal...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-12-397430

    authors： Liu G,Place AT,Chen Z,Brovkovych VM,Vogel SM,Muller WA,Skidgel RA,Malik AB,Minshall RD

    更新日期：2012-08-30 00:00:00

  • Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model.

    abstract：:Transfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the United States and United Kingdom. Although leukoagglutinating antibodies have been frequently shown to be associated with the syndrome, the mechanism by which th...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-04-1744

    authors： Sachs UJ,Hattar K,Weissmann N,Bohle RM,Weiss T,Sibelius U,Bux J

    更新日期：2006-02-01 00:00:00

  • Growth factors and cytokines upregulate gelatinase expression in bone marrow CD34(+) cells and their transmigration through reconstituted basement membrane.

    abstract：:The mechanism(s) underlying the release of stem/progenitor cells from bone marrow into the circulation is poorly understood. We hypothesized that matrix metalloproteinases (MMPs), especially gelatinases, which are believed to participate in the proteolysis of basement membranes and in the migration of leukocytes, may ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Janowska-Wieczorek A,Marquez LA,Nabholtz JM,Cabuhat ML,Montaño J,Chang H,Rozmus J,Russell JA,Edwards DR,Turner AR

    更新日期：1999-05-15 00:00:00

  • Persistent macrocytosis assessed by erythrocyte subpopulation analysis following erythrocyte regeneration in cats.

    abstract：:Serial erythrocyte volume distribution curves were used to characterize changes in erythrocyte subpopulations following the induction of Heinz body hemolytic anemia in cats. Macrocytes produced in response to hemolysis were observed after loss of reticulum. After recovery from hemolysis, a gradual reduction in mean ce...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Weiser MG,Kociba GJ

    更新日期：1982-08-01 00:00:00

  • Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia.

    abstract：:In a patient with nonspherocytic hemolytic anemia, a hexokinase deficiency was detected in the red cells (residual activity about 25% of normal) and in blood platelets (20%-35% of normal activity). Although the total hexokinase activity in lymphocytes was normal, the amount of hexokinase type I was decreased to about ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Rijksen G,Akkerman JW,van den Wall Bake AW,Hofstede DP,Staal GE

    更新日期：1983-01-01 00:00:00

  • Fetal liver cells produce both fetal and adult erythrocytes in semiallogeneic radiation chimeras: possible influence of adult environment.

    abstract：:Two kinds of erythrocytes are released in the blood of irradiated adult hybrid mice grafted with parental fetal liver cells: fetal antigen-bearing erythrocytes (Ft+ cells) and adult-type Ft- erythrocytes. Both are of parental origin, as determined by immune lysis using histocompatibility alloantigens. The latter cells...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Mouchiroud G,Blanchet JP

    更新日期：1981-03-01 00:00:00

  • Results of a phase 2 trial of an oral CXCR4 antagonist, mavorixafor, for treatment of WHIM syndrome.

    abstract：:Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mavorixafor from a phase 2 open-label dose-escalatio...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2020007197

    authors： Dale DC,Firkin F,Bolyard AA,Kelley M,Makaryan V,Gorelick KJ,Ebrahim T,Garg V,Tang W,Jiang H,Skerlj R,Beaussant Cohen S

    更新日期：2020-12-24 00:00:00

  • The tetraspanin superfamily member CD151 regulates outside-in integrin alphaIIbbeta3 signaling and platelet function.

    abstract：:The tetraspanin family member CD151 forms complexes with integrins and regulates cell adhesion and migration. While CD151 is highly expressed in megakaryocytes and to a lesser extent in platelets, its physiologic role in platelets is unclear. In this study, we investigate the physical and functional importance of CD15...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-12-4430

    authors： Lau LM,Wee JL,Wright MD,Moseley GW,Hogarth PM,Ashman LK,Jackson DE

    更新日期：2004-10-15 00:00:00

  • SRF is required for neutrophil migration in response to inflammation.

    abstract：:Serum response factor (SRF) is a ubiquitously expressed transcription factor and master regulator of the actin cytoskeleton. We have previously shown that SRF is essential for megakaryocyte maturation and platelet formation and function. Here we elucidate the role of SRF in neutrophils, the primary defense against inf...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2013-06-507582

    authors： Taylor A,Tang W,Bruscia EM,Zhang PX,Lin A,Gaines P,Wu D,Halene S

    更新日期：2014-05-08 00:00:00

  • Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets.

    abstract：:Hematopoietic fate maps in the developing mouse embryo remain imprecise. Definitive, adult-type hematopoiesis first appears in the fetal liver, then progresses to the spleen and bone marrow. Clonogenic common lymphoid progenitors and clonogenic common myeloid progenitors (CMPs) in adult mouse bone marrow that give ris...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v98.3.627

    authors： Traver D,Miyamoto T,Christensen J,Iwasaki-Arai J,Akashi K,Weissman IL

    更新日期：2001-08-01 00:00:00

  • Identification of normal human peripheral blood monocytes and liver as sites of synthesis of coagulation factor XIII a-chain.

    abstract：:Factor XIII is the fibrin-stabilizing factor that covalently cross-links fibrin monomers to form a highly organized, stable fibrin clot. The plasma form of factor XIII is a heterodimer, a2b2, consisting of two a-chains and two b-chains; the intracellular form, such as in platelets and placenta, is a dimer, a2, consist...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Weisberg LJ,Shiu DT,Conkling PR,Shuman MA

    更新日期：1987-08-01 00:00:00