Abstract:
:Class A scavenger receptor (SRA), also known as CD204, has been shown to participate in the pathogenesis of atherosclerosis and the pattern recognition of pathogen infection. However, its role in adaptive immune responses has not been well defined. In this study, we report that the lack of SRA/CD204 promotes Toll-like receptor (TLR)4 agonist-augmented tumor-protective immunity, which is associated with enhanced activation of CD8(+) effector T cell and improved inhibition of tumor growth. Dendritic cells (DCs) deficient in SRA/CD204 display more effective immunostimulatory activities upon TLR4 engagement than those from wild-type counterparts. Silencing of SRA/CD204 by RNA interference improves the ability of DCs to prime antigen-specific CD8(+) T cells, suggesting that antigen-presenting cells, for example, DCs, play a major role in SRA/CD204-mediated immune modulation. Our findings reveal a previously unrecognized role for SRA/CD204, a non-TLR pattern recognition receptor, as a physiologic negative regulator of TLR4-mediated immune consequences, which has important clinical implications for development of TLR-targeted immunotherapeutic intervention.
journal_name
Bloodjournal_title
Bloodauthors
Yi H,Yu X,Gao P,Wang Y,Baek SH,Chen X,Kim HL,Subjeck JR,Wang XYdoi
10.1182/blood-2008-11-190033subject
Has Abstractpub_date
2009-06-04 00:00:00pages
5819-28issue
23eissn
0006-4971issn
1528-0020pii
blood-2008-11-190033journal_volume
113pub_type
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