In vivo removal of malaria parasites from red blood cells without their destruction in acute falciparum malaria.

abstract：:Recent evidence suggests that proteolysis plays an important role in some forms of inherited and acquired von Willebrand disease (vWD). Because calpains and one or more enzymes released from polymorphonuclear leukocytes are known to proteolyze von Willebrand factor (vWF) in vitro with resultant loss of large multimers...

journal_title：Blood

authors： Berkowitz SD,Nozaki H,Titani K,Murachi T,Plow EF,Zimmerman TS

更新日期：1988-08-01 00:00:00

abstract：:Ectopic expression of fibroblast growth factor receptor 3 (FGFR3) associated with t(4;14) has been implicated in the pathogenesis of human multiple myeloma. Some t(4;14) patients have activating mutations of FGFR3, of which a minority are K650E (thanatophoric dysplasia type II [TDII]). To investigate the role of autop...

journal_title：Blood

authors： Chen J,Williams IR,Lee BH,Duclos N,Huntly BJ,Donoghue DJ,Gilliland DG

更新日期：2005-07-01 00:00:00

abstract：:Platelet endothelial cell adhesion molecule 1 (PECAM-1) is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution. This study investigated the effect of PECAM-1 deficiency on thrombus resolution in FVB/n mice and the extent to which levels of soluble PECAM-1 (sPECAM-1)...

journal_title：Blood

authors： Kellermair J,Redwan B,Alias S,Jabkowski J,Panzenboeck A,Kellermair L,Winter MP,Weltermann A,Lang IM

更新日期：2013-11-07 00:00:00

abstract：:Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholester...

journal_title：Blood

authors： Krigel R,Liebes LF,Pelle E,Silber R

更新日期：1982-07-01 00:00:00

abstract：:Whole saliva samples collected from available people at risk in Boston for infection with human T-lymphotropic virus type III (HTLV-III/LAV), from late 1984 through early 1985, were analyzed for the presence of antibodies to viral proteins. Fourteen of 20 (70%) acquired immunodeficiency syndrome (AIDS) patients and 14...

journal_title：Blood

authors： Archibald DW,Zon L,Groopman JE,McLane MF,Essex M

更新日期：1986-03-01 00:00:00

abstract：:Cumulative evidence indicates that MYC, one of the major downstream effectors of NOTCH1, is a critical component of T-cell acute lymphoblastic leukemia (T-ALL) oncogenesis and a potential candidate for targeted therapy. However, MYC is a complex oncogene, involving both fine protein dosage and cell-context dependency,...

journal_title：Blood

authors： Bonnet M,Loosveld M,Montpellier B,Navarro JM,Quilichini B,Picard C,Di Cristofaro J,Bagnis C,Fossat C,Hernandez L,Mamessier E,Roulland S,Morgado E,Formisano-Tréziny C,Dik WA,Langerak AW,Prebet T,Vey N,Michel G,Gabert

更新日期：2011-06-16 00:00:00

abstract：:The translocation t(15;17)(q22;q21) is seen exclusively in patients with acute promyelocytic leukemia (APL) and in the promyelocytic blast crisis of chronic myeloid leukemia (CML). This translocation juxta-poses the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor-alpha (RARA) gene on ...

journal_title：Blood

authors： Hiorns LR,Min T,Swansbury GJ,Zelent A,Dyer MJ,Catovsky D

更新日期：1994-05-15 00:00:00

abstract：:In severe human beta-thalassemia, the pathophysiology relates to accumulation of excess alpha-globin chains at the membrane. One hypothesis is that membrane-associated alpha-globin by virtue of it's iron or hemichromes produces oxidation of adjacent membrane proteins. The availability of a mouse model of severe beta-t...

journal_title：Blood

authors： Advani R,Rubin E,Mohandas N,Schrier SL

更新日期：1992-02-15 00:00:00

abstract：:Cancer cells require glutamine to adapt to increased biosynthetic activity. The limiting step in intracellular glutamine catabolism involves its conversion to glutamate by glutaminase (GA). Different GA isoforms are encoded by the genes GLS1 and GLS2 in humans. Herein, we show that glutamine levels control mitochondri...

journal_title：Blood

authors： Jacque N,Ronchetti AM,Larrue C,Meunier G,Birsen R,Willems L,Saland E,Decroocq J,Maciel TT,Lambert M,Poulain L,Hospital MA,Sujobert P,Joseph L,Chapuis N,Lacombe C,Moura IC,Demo S,Sarry JE,Recher C,Mayeux P,Tambur

更新日期：2015-09-10 00:00:00

abstract：:The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hep...

journal_title：Blood

authors： Pippard MJ,Johnson DK,Finch CA

更新日期：1981-10-01 00:00:00

abstract：:The pattern of expression of several protein kinase C (PKC) isoforms (alpha, betaI, delta, epsilon, eta, and zeta) during the course of hematopoietic development was investigated using primary human CD34(+) hematopoietic cells and stable cell lines subcloned from the growth factor-dependent 32D murine hematopoietic ce...

journal_title：Blood

authors： Bassini A,Zauli G,Migliaccio G,Migliaccio AR,Pascuccio M,Pierpaoli S,Guidotti L,Capitani S,Vitale M

更新日期：1999-02-15 00:00:00

abstract：:Dexamethasone (DM) is a synthetic member of the glucocorticoid (GC) class of hormones that possesses anti-inflammatory and immunosuppressant activity and is commonly used to treat chronic inflammatory disorders, severe allergies, and other disease states. Although GCs are known to mediate well-defined transcriptional ...

journal_title：Blood

authors： Ghosh MC,Baatar D,Collins G,Carter A,Indig F,Biragyn A,Taub DD

更新日期：2009-01-15 00:00:00

abstract：:Antithymocyte globulin (ATG) has recently been popularized as an effective treatment in myelodysplastic syndrome (MDS). We treated 8 anemic MDS patients (refractory anemia [RA] and refractory anemia with excess blasts [RAEB-1]) with ATG (40 mg/kg/d for 4 days) and prednisone in a phase 2 trial. The study was stopped e...

journal_title：Blood

authors： Steensma DP,Dispenzieri A,Moore SB,Schroeder G,Tefferi A

更新日期：2003-03-15 00:00:00

abstract：:We evaluated a treatment strategy targeting both lymphoma cells (by rituximab) and the microenvironment (by thalidomide) in 16 patients with relapsed/refractory mantle cell lymphoma (MCL). Rituximab was administered at 375 mg/m(2) for 4 weekly doses concomitantly with thalidomide (200 mg daily, with a dose increment t...

journal_title：Blood

authors： Kaufmann H,Raderer M,Wöhrer S,Püspök A,Bankier A,Zielinski C,Chott A,Drach J

更新日期：2004-10-15 00:00:00

abstract：:To understand the etiology of bone modulation and hypercalcemia observed in granulocytosis of a tumor-bearing animal model and to gain insight into the implication of sustained hematopoietic stimulation on the bone tissue, in vivo responses of normal mouse hematopoietic and bone tissues to long-term injections of reco...

journal_title：Blood

authors： Lee MY,Fukunaga R,Lee TJ,Lottsfeldt JL,Nagata S

更新日期：1991-05-15 00:00:00

abstract：:In this study, the question of whether glycoprotein Ib (GPIb) mediates both high and moderate affinity pathways of alpha-thrombin-induced platelet activation was examined. Flow cytometric studies, using a panel of monoclonal antibodies (MoAbs), showed that Serratia marcescens protease treatment removed greater than 97...

journal_title：Blood

authors： Yamamoto N,Greco NJ,Barnard MR,Tanoue K,Yamazaki H,Jamieson GA,Michelson AD

更新日期：1991-04-15 00:00:00

abstract：:Mutations in a recently identified gene HJV (also called HFE2, or repulsive guidance molecule C, RgmC) are the major cause of juvenile hemochromatosis (JH). The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidylinositol anchor, suggesting that it can be present in either a soluble or a cel...

journal_title：Blood

authors： Lin L,Goldberg YP,Ganz T

更新日期：2005-10-15 00:00:00

abstract：:The primitive hematopoietic stem/progenitor cells (HSPCs) during embryonic hematopoiesis are thought to be short-lived (SL) with limited self-renewal potential. The fate and consequence of these short-lived HSPCs, once reprogrammed into "long-lived" in a living animal body, remain unknown. Here we show that targeted e...

journal_title：Blood

authors： Zhou T,Wang L,Zhu KY,Dong M,Xu PF,Chen Y,Chen SJ,Chen Z,Deng M,Liu TX

更新日期：2011-10-06 00:00:00

abstract：:The introduction of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib has dramatically changed the management of chronic lymphocytic leukemia (CLL). Although responses have been durable in the majority of patients, relapses do occur, especially in the high-risk patient population. Most relapses occur as the result ...

journal_title：Blood

authors： Woyach JA

更新日期：2017-03-09 00:00:00

abstract：:The t(5;12) translocation identified in patients with chronic myelomonocytic leukemia (CMML) encodes a TEL/platelet-derived growth factor receptor beta (PDGFRbeta) fusion protein. A key hypothesis for how the TEL/PDGFRbeta fusion protein would function as an oncogene is that it represents a constitutively active versi...

journal_title：Blood

authors： Bourgeade MF,Défachelles AS,Cayre YE

更新日期：1998-05-01 00:00:00

abstract：:The combination of high levels of beta2-microglobulin (beta2-m) and chromosome 13 deletion allows identification of a high-risk subgroup of patients with de novo multiple myeloma (MM). In this population of patients, we have evaluated the impact of a murine anti-interleukin 6 (anti-IL-6) monoclonal antibody (BE-8) as ...

journal_title：Blood

authors： Moreau P,Hullin C,Garban F,Yakoub-Agha I,Benboubker L,Attal M,Marit G,Fuzibet JG,Doyen C,Voillat L,Berthou C,Ketterer N,Casassus P,Monconduit M,Michallet M,Najman A,Sotto JJ,Bataille R,Harousseau JL,Intergroupe Fran

更新日期：2006-01-01 00:00:00

abstract：:The class IA subgroup of phosphoinositide 3-kinase (PI3K) is activated downstream of antigen receptors, costimulatory molecules, and cytokine receptors on lymphocytes. Targeted deletion of individual genes for class IA regulatory subunits severely impairs the development and function of B cells but not T cells. Here w...

journal_title：Blood

authors： Deane JA,Kharas MG,Oak JS,Stiles LN,Luo J,Moore TI,Ji H,Rommel C,Cantley LC,Lane TE,Fruman DA

更新日期：2007-04-01 00:00:00

abstract：:DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and in the commitment to the lymphoid or myeloid lineages. Using purified CD34⁺ hematopoietic progenitor cells and differentiated myeloid cell populations from the same human samples, we obtained detailed methylation profiles at di...

journal_title：Blood

authors： Bocker MT,Hellwig I,Breiling A,Eckstein V,Ho AD,Lyko F

更新日期：2011-05-12 00:00:00

abstract：:We have previously reported that continuous intravenous (IV) administration of recombinant granulocyte-macrophage colony-stimulating factor (rHuGM-CSF) to humans following high-dose alkylating agent chemotherapy and autologous bone marrow support (ABMS) results in myeloid bone marrow maturation, accelerated granulocyt...

journal_title：Blood

authors： Peters WP,Stuart A,Affronti ML,Kim CS,Coleman RE

更新日期：1988-10-01 00:00:00

abstract：:miRNAs have emerged as master regulators of cancer-related events. miRNA dysregulation also occurs in Kaposi sarcoma (KS). Exploring the roles of KS-associated miRNAs should help to identify novel angiogenesis and lymphangiogenesis pathways. In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSH...

journal_title：Blood

authors： Wu YH,Hu TF,Chen YC,Tsai YN,Tsai YH,Cheng CC,Wang HW

更新日期：2011-09-08 00:00:00

abstract：:Multicentric Castleman disease (MCD) is a lymphoproliferative disorder associated with human herpesvirus 8 (HHV-8) infection among persons with human immunodeficiency virus (HIV) infection. Treatment often includes chemotherapy, and progression to non-Hodgkin lymphoma frequently occurs. MCD is characterized in part by...

journal_title：Blood

authors： Casper C,Nichols WG,Huang ML,Corey L,Wald A

更新日期：2004-03-01 00:00:00

abstract：:Caloric restriction (CR) is proposed to decrease tumorigenesis through a variety of mechanisms including effects on glycolysis. However, the understanding of how CR affects the response to cancer therapy is still rudimentary. Here, using the Eµ-Myc transgenic mouse model of B-cell lymphoma, we report that by reducing ...

journal_title：Blood

authors： Meynet O,Zunino B,Happo L,Pradelli LA,Chiche J,Jacquin MA,Mondragón L,Tanti JF,Taillan B,Garnier G,Reverso-Meinietti J,Mounier N,Michiels JF,Michalak EM,Carles M,Scott CL,Ricci JE

更新日期：2013-10-03 00:00:00

abstract：:We evaluated spleen function in 193 children with sickle cell anemia 8 to 18 months of age by (99m)Tc sulfur-colloid liver-spleen scan and correlated results with clinical and laboratory parameters, including 2 splenic biomarkers: pitted cell counts (PIT) and quantitative Howell-Jolly bodies (HJB) enumerated by flow c...

journal_title：Blood

authors： Rogers ZR,Wang WC,Luo Z,Iyer RV,Shalaby-Rana E,Dertinger SD,Shulkin BL,Miller JH,Files B,Lane PA,Thompson BW,Miller ST,Ware RE,BABY HUG.

更新日期：2011-03-03 00:00:00

abstract：:The possibility of primitive hematopoietic cell ex vivo expansion is of interest for both gene therapy and transplantation applications. The engraftment of autologous rhesus peripheral blood (PB) progenitors expanded 10 to 14 days were tracked in vivo using genetic marking. Stem cell factor (SCF)/granulocyte colony-st...

journal_title：Blood

authors： Tisdale JF,Hanazono Y,Sellers SE,Agricola BA,Metzger ME,Donahue RE,Dunbar CE

更新日期：1998-08-15 00:00:00

abstract：:Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroid cells not only co...

journal_title：Blood

authors： Zhang DL,Ghosh MC,Ollivierre H,Li Y,Rouault TA

更新日期：2018-11-08 00:00:00