Remission of HHV-8 and HIV-associated multicentric Castleman disease with ganciclovir treatment.

abstract：:Interleukin-2 (IL-2) and IL-15 exert similar biological actions, which largely reflect the fact that their receptors share common beta and gamma subunits; in contrast, distinct subunits are required for high-affinity binding of either cytokine to a heterotrimeric receptor complex. Human neutrophils are known to expres...

journal_title：Blood

authors： McDonald PP,Russo MP,Ferrini S,Cassatella MA

更新日期：1998-12-15 00:00:00

abstract：:Bone marrow suppression is an adverse effect associated with many antibiotics, especially when administered for prolonged treatment courses. Recent advances in our understanding of steady-state hematopoiesis have allowed us to explore the effects of antibiotics on hematopoietic progenitors in detail using a murine mod...

journal_title：Blood

authors： Josefsdottir KS,Baldridge MT,Kadmon CS,King KY

更新日期：2017-02-09 00:00:00

abstract：:In previous experimental animal studies it has been demonstrated that antibody depletion is not followed by increased antibody synthesis. To assess whether these results are conferrable to antibody-depleted humans, we measured free light chains (flcs) as markers of current antibody synthesis in 8 patients treated with...

journal_title：Blood

authors： Goldammer A,Derfler K,Herkner K,Bradwell AR,Hörl WH,Haas M

更新日期：2002-07-01 00:00:00

abstract：:Rh(o)(D) immune globulin intravenous (anti-D IGIV) was licensed by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP). Anti-D IGIV induces extravascular hemolysis, an expected adverse reaction that is consistent with the presumed mechanism of...

journal_title：Blood

authors： Gaines AR

更新日期：2000-04-15 00:00:00

abstract：:We analyzed the effect of aspirin, salicylate, and other nonsteroidal antiinflammatory drugs (NSAIDs) on the viability of B-chronic lymphocytic leukemia (B-CLL) cells. Aspirin induced a decrease in cell viability in a dose- and time-dependent manner. The mean IC50 for cells from 5 patients was 5.9 +/- 1.13 mmol/L (ran...

journal_title：Blood

authors： Bellosillo B,Piqué M,Barragán M,Castaño E,Villamor N,Colomer D,Montserrat E,Pons G,Gil J

更新日期：1998-08-15 00:00:00

abstract：:Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe anticoagulation therapy development. Prostate cancer-mediated procoagulant activity was reduced in plasma in the absence of factor XII or its substrate of the int...

journal_title：Blood

authors： Nickel KF,Ronquist G,Langer F,Labberton L,Fuchs TA,Bokemeyer C,Sauter G,Graefen M,Mackman N,Stavrou EX,Ronquist G,Renné T

更新日期：2015-09-10 00:00:00

abstract：:The reported outcome of hematopoietic stem cell transplantation (HSCT) from HLA-mismatched family members has been inconsistent. The object of this study was to evaluate the true impact of HLA-mismatch by using recent data from a homogenous population, excluding HSCT procedures that used graft manipulations, and by co...

journal_title：Blood

authors： Kanda Y,Chiba S,Hirai H,Sakamaki H,Iseki T,Kodera Y,Karasuno T,Okamoto S,Hirabayashi N,Iwato K,Maruta A,Fujimori Y,Furukawa T,Mineishi S,Matsuo K,Hamajima N,Imamura M

更新日期：2003-08-15 00:00:00

abstract：:The plasma membrane calcium pump (PMCA) is the only active Ca2+ transporter in human red blood cells (RBCs). Previous measurements of maximal Ca2+ extrusion rates (Vmax) reported only mean values in the RBC population. Despite early evidence for differences in Ca2+ extrusion capacity among RBCs, the precise Vmax distr...

journal_title：Blood

authors： Lew VL,Daw N,Perdomo D,Etzion Z,Bookchin RM,Tiffert T

更新日期：2003-12-01 00:00:00

abstract：:During the course of multiple myeloma (MM), new monoclonal proteins of an isotype distinct from the original clone, referred to as secondary monoclonal gammopathy of undetermined significance (MGUS), have been described. We report on the frequency, characteristics, and outcome of secondary MGUS. Of the 1942 patients w...

journal_title：Blood

authors： Wadhera RK,Kyle RA,Larson DR,Dispenzieri A,Kumar S,Lazarus HM,Rajkumar SV

更新日期：2011-09-15 00:00:00

abstract：:Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm with variable clinical course. To predict the clinical outcome, we previously developed a CMML-specific prognostic scoring system (CPSS) based on clinical parameters and cytogenetics. In this work, we tested the hypothesis that acc...

journal_title：Blood

authors： Elena C,Gallì A,Such E,Meggendorfer M,Germing U,Rizzo E,Cervera J,Molteni E,Fasan A,Schuler E,Ambaglio I,Lopez-Pavia M,Zibellini S,Kuendgen A,Travaglino E,Sancho-Tello R,Catricalà S,Vicente AI,Haferlach T,Haferlach

更新日期：2016-09-08 00:00:00

abstract：:The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its role in normal adult hematopoiesis, a bicistronic retroviral vector encoding GATA-2 and the green fluorescent protein (GFP) was used to maintain the high levels of...

journal_title：Blood

authors： Persons DA,Allay JA,Allay ER,Ashmun RA,Orlic D,Jane SM,Cunningham JM,Nienhuis AW

更新日期：1999-01-15 00:00:00

abstract：:To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph(-) ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph(-) ALL patients using the registry data, particula...

journal_title：Blood

authors： Nishiwaki S,Inamoto Y,Sakamaki H,Kurokawa M,Iida H,Ogawa H,Fukuda T,Ozawa Y,Kobayashi N,Kasai M,Mori T,Iwato K,Yoshida T,Onizuka M,Kawa K,Morishima Y,Suzuki R,Atsuta Y,Miyamura K

更新日期：2010-11-18 00:00:00

abstract：:von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of debate. In order to study the spectrum of type 1 VWD in the United States, the Zimmerman Program enrolled 482 subjects with a...

journal_title：Blood

authors： Flood VH,Christopherson PA,Gill JC,Friedman KD,Haberichter SL,Bellissimo DB,Udani RA,Dasgupta M,Hoffmann RG,Ragni MV,Shapiro AD,Lusher JM,Lentz SR,Abshire TC,Leissinger C,Hoots WK,Manco-Johnson MJ,Gruppo RA,Boggio LN

更新日期：2016-05-19 00:00:00

abstract：:The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based evaluation of survival, the available data fully justify critical reassessment of CML management. The panel therefore reviewed treatment of CML sinc...

journal_title：Blood

authors： Baccarani M,Saglio G,Goldman J,Hochhaus A,Simonsson B,Appelbaum F,Apperley J,Cervantes F,Cortes J,Deininger M,Gratwohl A,Guilhot F,Horowitz M,Hughes T,Kantarjian H,Larson R,Niederwieser D,Silver R,Hehlmann R,Europea

更新日期：2006-09-15 00:00:00

abstract：:Rabbit polyclonal antibodies were raised against synthetic peptides corresponding to hydrophilic regions of the human Rhesus (Rh) IX cDNA-encoded polypeptide predicted to be extracellularly or intracellularly exposed in the topologic model of the Rh blood group protein. Four antibodies encompassing residues 33-45 (MPC...

journal_title：Blood

authors： Hermand P,Mouro I,Huet M,Bloy C,Suyama K,Goldstein J,Cartron JP,Bailly P

更新日期：1993-07-15 00:00:00

abstract：:Cellulose ester membranes (CEM) were coated with stromal cells from bone marrow (BM) or bone and implanted intraperitoneally (IP) in CAF1 mice for intervals of 1 to 6 months. Previous studies indicated that matrix factors [glycoproteins (GPs), proteoglycans (PGs), and glycosaminoglycans (GAGs)] were secreted by the re...

journal_title：Blood

authors： Knospe WH,Husseini SG,Fried W

更新日期：1989-07-01 00:00:00

abstract：:The mechanism leading to the formation of antiphospholipid antibodies (aPL) is still unknown. Because an in vitro study suggested that aPL may derive from pro-oxidant conditions, we sought a relationship between aPL and isoprostanes, indices of lipid peroxidation in vivo. Thirty patients with systemic lupus erythemato...

journal_title：Blood

authors： Iuliano L,Praticò D,Ferro D,Pittoni V,Valesini G,Lawson J,FitzGerald GA,Violi F

更新日期：1997-11-15 00:00:00

abstract：:The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of phenotypic analysis, complementarity-determining region 3 (CDR3) spectratyping during a T-in...

journal_title：Blood

authors： Weller S,Braun MC,Tan BK,Rosenwald A,Cordier C,Conley ME,Plebani A,Kumararatne DS,Bonnet D,Tournilhac O,Tchernia G,Steiniger B,Staudt LM,Casanova JL,Reynaud CA,Weill JC

更新日期：2004-12-01 00:00:00

abstract：:We assessed primary cutaneous large B-cell lymphoma, leg type (PCLBCL, leg type; n = 13), and primary cutaneous follicle center lymphoma (PCFCL; n = 19) for somatic hypermutation (SHM) of BCL6, and aberrant SHM of MYC, RhoH/TTF, and PAX5. We demonstrate SHM of BCL6 in 8 PCLBCLs (62%), leg type, and 7 PCFCL patients (3...

journal_title：Blood

authors： Dijkman R,Tensen CP,Buettner M,Niedobitek G,Willemze R,Vermeer MH

更新日期：2006-06-15 00:00:00

abstract：:Shear-induced platelet aggregation (SIPA) involves the sequential interaction of von Willebrand factor (VWF) with both glycoprotein Ib (GPIb) and alphaIIbbeta3 receptors. Type 2B recombinant VWF (2B-rVWF), characterized by an increased affinity for GPIb, induces strong SIPA at a high shear rate (4000 s-1). Despite the...

journal_title：Blood

authors： Mekrache M,Bachelot-Loza C,Ajzenberg N,Saci A,Legendre P,Baruch D

更新日期：2003-06-01 00:00:00

abstract：:The hematopoietically expressed homeobox gene, Hhex, is a transcription factor that is important for development of definitive hematopoietic stem cells (HSCs) and B cells, and that causes T-cell leukemia when overexpressed. Here, we have used an Hhex inducible knockout mouse model to study the role of Hhex in adult he...

journal_title：Blood

authors： Jackson JT,Nasa C,Shi W,Huntington ND,Bogue CW,Alexander WS,McCormack MP

更新日期：2015-01-29 00:00:00

abstract：:Interleukin-1 beta (IL-1 beta) converting enzyme (ICE) is a cysteine protease that specifically cleaves precursor IL-1 beta to its biologically active form. Recent studies have also implicated ICE in the induction of apoptosis in vertebrate cells. Because IL-1 plays a major role in acute myelogenous leukemia (AML) bla...

journal_title：Blood

authors： Estrov Z,Black RA,Sleath PR,Harris D,Van Q,LaPushin R,Estey EH,Talpaz M

更新日期：1995-12-15 00:00:00

abstract：:Stem cell factor (SCF) is expressed as an integral membrane growth factor that may be differentially processed to produce predominantly soluble (S) (SCF(248)) or membrane-associated (MA) (SCF(220)) protein. A critical role for membrane presentation of SCF in the hematopoietic microenvironment (HM) has been suggested f...

journal_title：Blood

authors： Kapur R,Cooper R,Xiao X,Weiss MJ,Donovan P,Williams DA

更新日期：1999-09-15 00:00:00

abstract：:Proinflammatory cytokines such as TNFα are elevated in patients with myeloproliferative neoplasms (MPN), but their contribution to disease pathogenesis is unknown. Here we reveal a central role for TNFα in promoting clonal dominance of JAK2(V617F) expressing cells in MPN. We show that JAK2(V617F) kinase regulates TNFα...

journal_title：Blood

authors： Fleischman AG,Aichberger KJ,Luty SB,Bumm TG,Petersen CL,Doratotaj S,Vasudevan KB,LaTocha DH,Yang F,Press RD,Loriaux MM,Pahl HL,Silver RT,Agarwal A,O'Hare T,Druker BJ,Bagby GC,Deininger MW

更新日期：2011-12-08 00:00:00

abstract：:Different forms of interleukin-15 (IL-15) have been identified and shown to elicit different transduction pathways whose impact on hematopoiesis is poorly understood. We demonstrated herein that hematopoietic CD34+ cells constitutively produced endogenous secreted IL-15 (ES-IL-15) that activated different transcriptio...

journal_title：Blood

authors： Giron-Michel J,Caignard A,Fogli M,Brouty-Boyé D,Briard D,van Dijk M,Meazza R,Ferrini S,Lebousse-Kerdilès C,Clay D,Bompais H,Chouaib S,Péault B,Azzarone B

更新日期：2003-07-01 00:00:00

abstract：:Chronic lymphocytic leukemia of B-cell origin (B-CLL) is generally thought to arise by neoplastic transformation of B lymphocytes, which express CD5 and have features of an early stage of B-cell differentiation. To study isotype-switched B-CLL as a potentially more differentiated variant, we performed genetic and func...

journal_title：Blood

authors： Friedman DF,Moore JS,Erikson J,Manz J,Goldman J,Nowell PC,Silberstein LE

更新日期：1992-11-01 00:00:00

abstract：:In lymphatic tissues, chronic lymphocytic leukemia (CLL) cells are interspersed with CD68(+) nurselike cells (NLCs), T cells, and other stromal cells that constitute the leukemia microenvironment. However, the mechanism regulating colocalization of CLL and these accessory cells are largely unknown. To dissect the mole...

journal_title：Blood

authors： Burger JA,Quiroga MP,Hartmann E,Bürkle A,Wierda WG,Keating MJ,Rosenwald A

更新日期：2009-03-26 00:00:00

abstract：:Studies have demonstrated that common polymorphisms in Th1 and Th2 cytokine genes can alter gene expression, modulate the balance between Th1/Th2 responsiveness, and influence susceptibility for autoimmune disorders, infectious diseases, and cancer. We analyzed one or more single nucleotide polymorphisms (SNPs) in 20 ...

journal_title：Blood

authors： Lan Q,Zheng T,Rothman N,Zhang Y,Wang SS,Shen M,Berndt SI,Zahm SH,Holford TR,Leaderer B,Yeager M,Welch R,Boyle P,Zhang B,Zou K,Zhu Y,Chanock S

更新日期：2006-05-15 00:00:00

abstract：:To investigate underlying mechanisms of thrombocytopenia in myelodysplastic syndrome (MDS), radiolabeled platelet studies were performed in 30 MDS patients with platelet counts less than 100 x 10(9)/L. Furthermore, plasma thrombopoietin and glycocalicin index (a parameter of platelet or megakaryocyte destruction) were...

journal_title：Blood

authors： Houwerzijl EJ,Blom NR,van der Want JJ,Louwes H,Esselink MT,Smit JW,Vellenga E,de Wolf JT

更新日期：2005-05-01 00:00:00

abstract：:The CD28 family of receptors (CD28, cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4], inducible costimulator [ICOS], program death-1 [PD-1], and B- and T-lymphocyte attenuator [BTLA]) plays a critical role in controlling the adaptive arm of the immune response. While considerable information is available regarding...

journal_title：Blood

authors： Riley JL,June CH

更新日期：2005-01-01 00:00:00