Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry.

abstract：:Although the role of systemic activation of the nuclear factor kappaB (NF-kappaB) pathway in septic coagulation has been well documented, little is known about the contribution of endothelial-specific NF-kappaB signaling in this pathologic process. Here, we used transgenic mice that conditionally overexpress a mutant ...

journal_title：Blood

authors： Song D,Ye X,Xu H,Liu SF

更新日期：2009-09-17 00:00:00

abstract：:Children with constitutional trisomy 21 (Down syndrome) have an approximately 500-fold increased risk of developing acute megakaryoblastic leukemia (AMKL), a form of acute myeloid leukemia. Unique to newborn infants with Down syndrome is a transient leukemia (TL), also referred to as transient myeloproliferative syndr...

journal_title：Blood

authors： Hitzler JK,Cheung J,Li Y,Scherer SW,Zipursky A

更新日期：2003-06-01 00:00:00

abstract：:We determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, alpha87 (F8) His --> Tyr] resides in the alpha1-globin gene. The proportion of Hb M observed is higher than that predicted for an alpha1-globin variant. Our evidence suggests that the greater-than-expected proportion of ...

journal_title：Blood

authors： Ameri A,Fairbanks VF,Yanik GA,Mahdi F,Thibodeau SN,McCormick DJ,Boxer LA,McDonagh KT

更新日期：1999-09-01 00:00:00

abstract：:The extracellular presence of endotoxin-free heat shock protein 70 (HSP70) enhances the rate and capacity of macrophage-mediated phagocytosis at 6 times the basal rate. It is protein-specific, dose- and time-dependent and involves the internalization of inert microspheres, Gram-positive and -negative bacteria and fung...

journal_title：Blood

authors： Wang R,Kovalchin JT,Muhlenkamp P,Chandawarkar RY

更新日期：2006-02-15 00:00:00

abstract：:The incidence of venous thromboembolism (VTE) in adult patients with sickle cell disease (SCD) is high. However, overlapping features between the clinical presentation of VTE and SCD complications and a low index of suspicion for thrombosis can influence patient management decisions. VTE in SCD can therefore present m...

journal_title：Blood

authors： Shet AS,Wun T

更新日期：2018-10-25 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive syndrome characterized by progressive bone marrow failure and cancer predisposition. Eight FA complementation groups have been identified. The FANCA, FANCC, FANCE, FANCF, and FANCG proteins form a nuclear complex required for the monoubiquination of the FANCD2 protein. To ...

journal_title：Blood

authors： Gordon SM,Buchwald M

更新日期：2003-07-01 00:00:00

abstract：:Extracellular histones have been shown to play an important pathogenic role in many diseases, primarily through their cytotoxicity toward nucleated cells and their ability to promote platelet activation with resultant thrombosis and thrombocytopenia. In contrast, little is known about the effect of extracellular histo...

journal_title：Blood

authors： Kordbacheh F,O'Meara CH,Coupland LA,Lelliott PM,Parish CR

更新日期：2017-12-28 00:00:00

abstract：:Previous analyses of the roles of alpha4 integrins in hematopoiesis by other groups have led to conflicting evidence. alpha4 integrin mutant cells developing in [alpha4 integrin(-/-): wt] chimeric mice are not capable of completing lymphomyeloid differentiation, whereas conditional inactivation of alpha4 integrin in a...

journal_title：Blood

authors： Gribi R,Hook L,Ure J,Medvinsky A

更新日期：2006-07-15 00:00:00

abstract：:To define the efficacy of venetoclax with extended follow-up and identify clinical or biological treatment effect modifiers, updated data for previously treated patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) enrolled in 4 early-phase trials were pooled. Rates of response, complete...

journal_title：Blood

authors： Roberts AW,Ma S,Kipps TJ,Coutre SE,Davids MS,Eichhorst B,Hallek M,Byrd JC,Humphrey K,Zhou L,Chyla B,Nielsen J,Potluri J,Kim SY,Verdugo M,Stilgenbauer S,Wierda WG,Seymour JF

更新日期：2019-07-11 00:00:00

abstract：:The Leu-8 molecule, the human homologue of the murine MEL-14 peripheral lymph node homing receptor, is expressed on neutrophils in both species and may be important in localization of cells to sites of inflammation. Most circulating human neutrophils express the Leu-8 molecule, and activation of neutrophils with phorb...

journal_title：Blood

authors： Berg M,James SP

更新日期：1990-12-01 00:00:00

abstract：:Cytokine gene-modified tumor cells have increased immunogenicity and retain the antigenic repertoire of a particular neoplasia. However, practical concerns have led to an increased interest in allogeneic gene-transduced bystander cells as a broader source of cytokines for autologous tumor cell-based vaccines. Here, we...

journal_title：Blood

authors： Curti A,Parenza M,Colombo MP

更新日期：2003-01-15 00:00:00

abstract：:CD4+Foxp3+ regulatory T cells (Treg) are a subpopulation of T cells, which regulate the immune system and enhance immune tolerance after transplantation. Donor-derived Treg prevent the development of lethal acute graft-versus-host disease (GVHD) in murine models of allogeneic hematopoietic stem cell transplantation. W...

journal_title：Blood

authors： Nishikii H,Kim BS,Yokoyama Y,Chen Y,Baker J,Pierini A,Alvarez M,Mavers M,Maas-Bauer K,Pan Y,Chiba S,Negrin RS

更新日期：2016-12-15 00:00:00

abstract：:In the past 5 years we have witnessed significant advances in both the diagnostic process and optimal therapy for patients with essential thrombocythemia (ET). Insights into the underlying molecular mechanisms have been accompanied by the development of new diagnostic tests and by an improved understanding of the rela...

journal_title：Blood

authors： Beer PA,Erber WN,Campbell PJ,Green AR

更新日期：2011-02-03 00:00:00

abstract：:The loss of body cell mass (bcm) in senescence and wasting is poorly understood. We now show that the plasma cystine/acid soluble thiol ratio, ie, an indicator of the redox state, is increased in old age and cancer patients and correlated with a decrease in bcm and plasma albumin. A cause/effect relationship was sugge...

journal_title：Blood

authors： Hack V,Breitkreutz R,Kinscherf R,Röhrer H,Bärtsch P,Taut F,Benner A,Dröge W

更新日期：1998-07-01 00:00:00

abstract：:It has previously been shown that human granulocyte-macrophage colony-stimulating factor (GM-CSF) can be fused to a truncated diphtheria toxin (DT) to produce a recombinant fusion toxin that kills GM-CSF receptor-bearing cells. We now report that DT388-GM-CSF induces apoptosis and inhibition of colony formation in sem...

journal_title：Blood

authors： Frankel AE,Hall PD,Burbage C,Vesely J,Willingham M,Bhalla K,Kreitman RJ

更新日期：1997-11-01 00:00:00

abstract：:Azacitidine treatment of myelodysplastic syndromes (MDSs) generally exacerbates thrombocytopenia during the first treatment cycles. A Study of Eltrombopag in Myelodysplastic Syndromes Receiving Azacitidine (SUPPORT), a phase 3, randomized, double-blind, placebo-controlled study, investigated the platelet supportive ef...

journal_title：Blood

authors： Dickinson M,Cherif H,Fenaux P,Mittelman M,Verma A,Portella MSO,Burgess P,Ramos PM,Choi J,Platzbecker U,SUPPORT study investigators.

更新日期：2018-12-20 00:00:00

abstract：:This study reassesses the occurrence of Epstein-Barr virus (EBV) diversity and coinfection versus dominance of a single viral strain within immunocompetent normal carriers. Polymerase chain reaction analysis of several different polymorphic loci of the EBV genome was performed on collections of peripheral blood mononu...

journal_title：Blood

authors： Srivastava G,Wong KY,Chiang AK,Lam KY,Tao Q

更新日期：2000-04-01 00:00:00

abstract：:The study of central nervous system (CNS) leukemia has been hampered by the lack of a suitable animal model. We report that severe combined immunodeficiency (SCID) mice invariably develop rapidly progressive fatal CNS leukemia within 3 weeks after intravenous injection of NALM-6 pre-B acute lymphoblastic leukemia (ALL...

journal_title：Blood

authors： Gunther R,Chelstrom LM,Tuel-Ahlgren L,Simon J,Myers DE,Uckun FM

更新日期：1995-05-01 00:00:00

abstract：:Four patients with lymphoproliferative disease of granular lymphocytes (LDGL) coexpressing CD3 and the natural killer (NK)-related "p58" receptor for HLA-C alleles were studied. These CD3+p58+ LDGLs have been detected among a series of 44 CD3+ LDGLs analyzed. Two patients with LDGL (GI and BA) expressed only the p58 m...

journal_title：Blood

authors： Cambiaggi A,Orengo AM,Meazza R,Sforzini S,Tazzari PL,Lauria F,Raspadori D,Zambello R,Semenzato G,Moretta L,Ferrini S

更新日期：1996-03-15 00:00:00

abstract：:The molecular basis of most beta-thalassemia syndromes has been defined, while the spectrum of mutations causing delta-thalassemia is not well characterized. In an attempt to identify such mutations, the region encompassing the delta-globin gene from three Greek Cypriot families suspected of having delta-thalassemia w...

journal_title：Blood

authors： Trifillis P,Ioannou P,Schwartz E,Surrey S

更新日期：1991-12-15 00:00:00

abstract：:Multiple lines of evidence indicate that thrombopoietin (TPO) substantially impacts the number of hematopoietic stem cells and progenitors of all myeloid lineages. Nevertheless, tpo knock-out mice (T(-)) display thrombocytopenia only; blood erythroid and neutrophil levels are normal despite 60% to 85% reductions in st...

journal_title：Blood

authors： Kaushansky K,Fox N,Lin NL,Liles WC

更新日期：2002-05-15 00:00:00

abstract：:We examined the role of the T-cell antigen CD2 in the regulation of erythropoiesis by the lymphokine cascade. T-cell interleukin-2 (IL-2) receptors (p55) were induced via triggering of the antigen receptor-associated CD3 epitope. Before CD3 triggering T cells were preincubated with a CD2-blocking (Leu-5b) or isotype c...

journal_title：Blood

authors： Burdach S,Shatsky M,Wagenhorst B,Levitt L

更新日期：1988-08-01 00:00:00

abstract：:Human neutrophils possess a very short half-life because they constitutively undergo apoptosis. Cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), and other agents can rescue neutrophils from apoptosis but the molecular mechanisms involved in this rescue are undefined. Here, we show by Weste...

journal_title：Blood

authors： Moulding DA,Quayle JA,Hart CA,Edwards SW

更新日期：1998-10-01 00:00:00

abstract：:Arsenic trioxide, as a single agent, has proven efficacy in inducing molecular remission in patients with acute promyelocytic leukemia (APL). There is limited long-term outcome data with single-agent As2O3 in the management of newly diagnosed cases of APL. Between January 1998 to December 2004, 72 newly diagnosed case...

journal_title：Blood

authors： Mathews V,George B,Lakshmi KM,Viswabandya A,Bajel A,Balasubramanian P,Shaji RV,Srivastava VM,Srivastava A,Chandy M

更新日期：2006-04-01 00:00:00

abstract：:The tyrosine kinase inhibitors sorafenib and sunitinib are approved for the treatment of patients with malignant diseases. To analyze the possible use of these compounds in combination with immunotherapeutic approaches, we analyzed the effects of both inhibitors on the immunostimulatory capacity of human dendritic cel...

journal_title：Blood

authors： Hipp MM,Hilf N,Walter S,Werth D,Brauer KM,Radsak MP,Weinschenk T,Singh-Jasuja H,Brossart P

更新日期：2008-06-15 00:00:00

abstract：:Myeloma bone disease is due to interactions of myeloma cells with the bone marrow microenvironment, and is associated with pathologic fractures, neurologic symptoms and hypercalcemia. Adjacent to myeloma cells, the formation and activation of osteoclasts is increased, which results in enhanced bone resorption. The rec...

journal_title：Blood

authors： Sezer O,Heider U,Zavrski I,Kühne CA,Hofbauer LC

更新日期：2003-03-15 00:00:00

abstract：:Rabbit platelets were aggregated by adenosine diphosphate (ADP), allowed to deaggregate and then separated into density subpopulations by centrifugation through discontinuous Stractan density gradients. Although ADP causes little or no release of the contents of the amine storage granules of rabbit platelets, ADP caus...

journal_title：Blood

authors： Packham MA,Perry DW,Kinlough-Rathbone RL,Rand ML,Guccione MA,Evans RM,Mustard JF

更新日期：1985-03-01 00:00:00

abstract：:Internal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in 30% of acute myeloid leukemias (AMLs) and confers a poor prognosis. Thirteen relapsed or chemo-refractory FLT3-ITD(+) AML patients were treated with sorafenib (200-400 mg twice daily). Twelve patients showed clearance or near ...

journal_title：Blood

authors： Man CH,Fung TK,Ho C,Han HH,Chow HC,Ma AC,Choi WW,Lok S,Cheung AM,Eaves C,Kwong YL,Leung AY

更新日期：2012-05-31 00:00:00

abstract：:6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) is a novel compound that represents the prototype of a new class of synthetic retinoids with apoptogenic properties in acute promyelocytic leukemia (APL) and other types of leukemia. In this article, using SCID mice xenografted with APL-derived NB4 ...

journal_title：Blood

authors： Ponzanelli I,Giannì M,Giavazzi R,Garofalo A,Nicoletti I,Reichert U,Erba E,Rambaldi A,Terao M,Garattini E

更新日期：2000-04-15 00:00:00

abstract：:The causes of anemia and immunosuppression, major outcomes of malaria, are not well established. This study was undertaken to investigate whether erythropoietin (EP) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of infection. Groups of female Balb/c mice infected...

journal_title：Blood

authors： Silverman PH,Schooley JC,Mahlmann LJ

更新日期：1987-02-01 00:00:00