Human neutrophils release the Leu-8 lymph node homing receptor during cell activation.

abstract：:The human pluripotent UT-7 cell line is growth factor-dependent for proliferation and differentiation. We have previously shown that (1) granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Epo) induce a myeloid and erythroid pattern of differentiation, respectively; (2) GM-CSF acts predominan...

journal_title：Blood

authors： Hermine O,Dubart A,Porteux F,Mayeux P,Titeux M,Dumenil D,Vainchenker W

更新日期：1996-03-01 00:00:00

abstract：:The promising activity of BET protein inhibitors (BETi's) is compromised by adaptive or innate resistance in acute myeloid leukemia (AML). Here, modeling of BETi-persister/resistance (BETi-P/R) in human postmyeloproliferative neoplasm (post-MPN) secondary AML (sAML) cells demonstrated accessible and active chromatin i...

journal_title：Blood

authors： Saenz DT,Fiskus W,Mill CP,Perera D,Manshouri T,Lara BH,Karkhanis V,Sharma S,Horrigan SK,Bose P,Kadia TM,Masarova L,DiNardo CD,Borthakur G,Khoury JD,Takahashi K,Bhaskara S,Lin CY,Green MR,Coarfa C,Crews CM,Versto

更新日期：2020-04-09 00:00:00

abstract：:The abl oncogene is translocated from chromosome 9 to 22 in the creation of the Philadelphia (Ph1) chromosome. This article describes new translocation breakpoints identified in two patients with chronic myelogenous leukemia using Southern blotting and cloned human DNA probes from chromosome 9. The translocation break...

journal_title：Blood

authors： Leibowitz D,Schaefer-Rego K,Popenoe DW,Mears JG,Bank A

更新日期：1985-07-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a frequent complication in cancer patients and represents an important cause of morbidity and mortality. Especially in patients who have a poor life expectancy, preventing death from pulmonary embolism is the mainstay of treatment. Critically ill patients should promptly be administered...

journal_title：Blood

authors： Prandoni P

更新日期：2005-12-15 00:00:00

abstract：:Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The molecular basis for the selective elimination of mitochondria from mature red blood cells remains controversial. Recent evidence...

journal_title：Blood

authors： Kundu M,Lindsten T,Yang CY,Wu J,Zhao F,Zhang J,Selak MA,Ney PA,Thompson CB

更新日期：2008-08-15 00:00:00

abstract：:The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fcgamma receptor-mediated effects of IVIg, although well elucidated in certain pathologies, cannot entirely account for its proven benefit in several autoimmune disorders me...

journal_title：Blood

authors： Ephrem A,Chamat S,Miquel C,Fisson S,Mouthon L,Caligiuri G,Delignat S,Elluru S,Bayry J,Lacroix-Desmazes S,Cohen JL,Salomon BL,Kazatchkine MD,Kaveri SV,Misra N

更新日期：2008-01-15 00:00:00

abstract：:Low-density lipoprotein (LDL) receptor (LDLR) and LDLR-related protein (LRP) are members of the LDLR family of endocytic receptors. LRP recognizes a wide spectrum of structurally and functionally unrelated ligands, including coagulation factor VIII (FVIII). In contrast, the ligand specificity of LDLR is restricted to ...

journal_title：Blood

authors： Bovenschen N,Mertens K,Hu L,Havekes LM,van Vlijmen BJ

更新日期：2005-08-01 00:00:00

abstract：:Serum cobalamin (vitamin B12) and unsaturated B12 binding capacity (UBBC) have been measured in 24 cases of hypereosinophilia: 16 were cases of hypereosinophilic syndrome (HES) and 8 of secondary eosinophilia. The two groups were similar with respect to absolute eosinophil counts. Serum cobalamin and UBBC were found t...

journal_title：Blood

authors： Zittoun J,Farcet JP,Marquet J,Sultan C,Zittoun R

更新日期：1984-04-01 00:00:00

abstract：:The IFN-inducible immunity-related p47 GTPase Irgm1 has been linked to Crohn disease as well as susceptibility to tuberculosis. Previously we demonstrated that HSC quiescence and function are aberrant in mice lacking Irgm1. To investigate the molecular basis for these defects, we conducted microarray expression profil...

journal_title：Blood

authors： King KY,Baldridge MT,Weksberg DC,Chambers SM,Lukov GL,Wu S,Boles NC,Jung SY,Qin J,Liu D,Songyang Z,Eissa NT,Taylor GA,Goodell MA

更新日期：2011-08-11 00:00:00

abstract：:A1, a bcl-2 family member, has been identified as a hematopoietic-specific, early inducible gene. In this study it is shown that stable transfection of A1 into an interleukin-3 (IL-3)-dependent myeloid precursor cell line, 32D c13, leads to a retardation of IL-3 withdrawal-induced cell death similar to that observed w...

journal_title：Blood

authors： Lin EY,Orlofsky A,Wang HG,Reed JC,Prystowsky MB

更新日期：1996-02-01 00:00:00

abstract：:c-Myc (Myc hereafter) is found to be deregulated and/or amplified in most acute myeloid leukemias (AMLs). Almost all AML cells are dependent upon Myc for their proliferation and survival. Thus, Myc has been proposed as a critical anti-AML target. Myc has Max-mediated transactivational and Myc-interacting zinc finger p...

journal_title：Blood

authors： Zhang L,Li J,Xu H,Shao X,Fu L,Hou Y,Hao C,Li W,Joshi K,Wei W,Xu Y,Zhang F,Dai S,Breslin P,Zhang J,Zhang J

更新日期：2020-04-02 00:00:00

abstract：:We describe a patient with the so-called "prolymphocytic variant" form of hairy cell leukemia (HCL) resistant to treatment with interferon-alpha (IFN-alpha). Analysis of immunoglobulin (Ig) and T-cell receptor-beta (TCR beta) gene rearrangements from serial peripheral blood mononuclear cell specimens (MNCs) confirmed ...

journal_title：Blood

authors： Giardina SL,Young HA,Faltynek CR,Jaffe ES,Clark JW,Steis RG,Urba WJ,Mathieson BJ,Gralnick H,Lawrence J

更新日期：1988-11-01 00:00:00

abstract：:Although molecular biologic techniques can now detect minimal numbers of residual cancer cells in patients in complete clinical remission, the clinical significance of minimal residual disease has never been conclusively established. If the detection of minimal residual disease predicts which patients will relapse, th...

journal_title：Blood

authors： Gribben JG,Neuberg D,Freedman AS,Gimmi CD,Pesek KW,Barber M,Saporito L,Woo SD,Coral F,Spector N

更新日期：1993-06-15 00:00:00

abstract：:To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide upon silencing. Ribosomal pro...

journal_title：Blood

authors： Zhu YX,Yin H,Bruins LA,Shi CX,Jedlowski P,Aziz M,Sereduk C,Kortuem KM,Schmidt JE,Champion M,Braggio E,Keith Stewart A

更新日期：2015-01-15 00:00:00

abstract：:Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymphoblastic leukemia (...

journal_title：Blood

authors： Bortin MM,D'Amaro J,Bach FH,Rimm AA,van Rood JJ

更新日期：1987-07-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) with thrombosis is a serious complication of heparin use. HIT sera can generate platelet-derived microparticles, which are produced in a heparin-dependent manner and are hypothesized to be important initial pathological participants because they promote vascular occlusion. To dat...

journal_title：Blood

authors： Hughes M,Hayward CP,Warkentin TE,Horsewood P,Chorneyko KA,Kelton JG

更新日期：2000-07-01 00:00:00

abstract：:Hyperresponsiveness to growth factors underlies a wide variety of human diseases,including hemangiomas, the most common tumor of childhood. Hemangiomas have been found to be clonal neoplasms of endothelial cells, with somatic mutations in unknown genes likely to be responsible for their development. ...

journal_title：Blood

authors： Arbiser JL

更新日期：2012-05-17 00:00:00

abstract：:The more distal enhancers of the immunoglobulin heavy-chain 3' regulatory region, hs3b and hs4, were recently demonstrated as master control elements of germline transcription and class switch recombination to most immunoglobulin constant genes. In addition, they were shown to enhance the accumulation of somatic mutat...

journal_title：Blood

authors： Morvan CL,Pinaud E,Decourt C,Cuvillier A,Cogné M

更新日期：2003-08-15 00:00:00

abstract：:Important predictors of adverse outcomes of thrombosis in children, including postthrombotic syndrome (PTS), have recently been identified. Given this knowledge and the encouraging preliminary pediatric experience with systemic thrombolysis, we sought to retrospectively analyze our institutional experience with a thro...

journal_title：Blood

authors： Goldenberg NA,Durham JD,Knapp-Clevenger R,Manco-Johnson MJ

更新日期：2007-07-01 00:00:00

abstract：:Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making sickle cell disease one of the most common monogenetic diseases worldwide. Because ...

journal_title：Blood

authors： Pecker LH,Naik RP

更新日期：2018-11-29 00:00:00

abstract：:Little is known about mechanisms involved in skin-specific homing of cutaneous T-cell lymphoma (CTCL). Chemokine/chemokine receptor interactions have been implicated in the homing of lymphoma cells to various tissue sites. We investigated tissue samples and tumor cell suspensions of patients with CD30(+) CTCL (n = 8) ...

journal_title：Blood

authors： Kleinhans M,Tun-Kyi A,Gilliet M,Kadin ME,Dummer R,Burg G,Nestle FO

更新日期：2003-02-15 00:00:00

abstract：:Fetal hemoglobin (HbF) induction can ameliorate the clinical severity of sickle cell disease and β-thalassemia. We previously reported that activation of the eukaryotic initiation factor 2α (eIF2α) stress pathway increased HbF through a posttranscriptional mechanism. In this study, we explored the underlying means by ...

journal_title：Blood

authors： Hahn CK,Lowrey CH

更新日期：2014-10-23 00:00:00

abstract：:Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signaling is involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the most common subtypes of cutaneous T-cell lymphoma. By immunohistochemistry of 4...

journal_title：Blood

authors： Kamstrup MR,Gjerdrum LM,Biskup E,Lauenborg BT,Ralfkiaer E,Woetmann A,Ødum N,Gniadecki R

更新日期：2010-10-07 00:00:00

abstract：:L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stim...

journal_title：Blood

authors： Rodriguez PC,Quiceno DG,Ochoa AC

更新日期：2007-02-15 00:00:00

abstract：:The non-Hodgkin's lymphoma (NHL) subset commonly referred to as large cell lymphoma (LCL) has historically been characterized by it's marked cytological, immunological, and clinical heterogeneity. One potential defining feature of these lymphomas, the t(2;5)(p23;q35), occurs in 25% to 30% of anaplastic LCLs and is als...

journal_title：Blood

authors： Mathew P,Sanger WG,Weisenburger DD,Valentine M,Valentine V,Pickering D,Higgins C,Hess M,Cui X,Srivastava DK,Morris SW

更新日期：1997-03-01 00:00:00

abstract：:To understand the etiology of bone modulation and hypercalcemia observed in granulocytosis of a tumor-bearing animal model and to gain insight into the implication of sustained hematopoietic stimulation on the bone tissue, in vivo responses of normal mouse hematopoietic and bone tissues to long-term injections of reco...

journal_title：Blood

authors： Lee MY,Fukunaga R,Lee TJ,Lottsfeldt JL,Nagata S

更新日期：1991-05-15 00:00:00

abstract：:Pretreatment of endothelial cells with cytokines enhances the adherence of leukocytes, a process that is mediated by surface proteins expressed on both cell types. A three-dimensional model system for the simultaneous determination of leukocyte adherence and migration was used to study the contribution of CD11/CD18, e...

journal_title：Blood

authors： Hakkert BC,Kuijpers TW,Leeuwenberg JF,van Mourik JA,Roos D

更新日期：1991-11-15 00:00:00

abstract：:The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4'-pe...

journal_title：Blood

authors： Paugh SW,Paugh BS,Rahmani M,Kapitonov D,Almenara JA,Kordula T,Milstien S,Adams JK,Zipkin RE,Grant S,Spiegel S

更新日期：2008-08-15 00:00:00

abstract：:Natural killer (NK) cells participate in host defense by surveying for and ultimately killing virally infected or malignant target cells. NK cell cytotoxicity is a tightly regulated process that proceeds stepwise from adhesion and activation to the secretion of preformed lytic granule contents onto a diseased or stres...

journal_title：Blood

authors： James AM,Hsu HT,Dongre P,Uzel G,Mace EM,Banerjee PP,Orange JS

更新日期：2013-04-04 00:00:00

abstract：:Venomous snakes produce an array of toxic compounds, including procoagulants to defend themselves and incapacitate prey. The Australian snake Pseudonaja textilis has a venom-derived prothrombin activator homologous to coagulation factors V (FV) and Xa (FXa). Here we show that the FV component (pt-FV) has unique biolog...

journal_title：Blood

authors： Bos MH,Boltz M,St Pierre L,Masci PP,de Jersey J,Lavin MF,Camire RM

更新日期：2009-07-16 00:00:00