NHERF-2 silences the silencers.

abstract：:The translocation t(15;17)(q22;q21) is seen exclusively in patients with acute promyelocytic leukemia (APL) and in the promyelocytic blast crisis of chronic myeloid leukemia (CML). This translocation juxta-poses the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor-alpha (RARA) gene on ...

journal_title：Blood

authors： Hiorns LR,Min T,Swansbury GJ,Zelent A,Dyer MJ,Catovsky D

更新日期：1994-05-15 00:00:00

abstract：:In this cooperative study, we explored the role of the carbohydrate moiety (CHO) of von Willebrand factor (vWF) in supporting platelet adhesion. Because of previous discrepant results, all purification steps and CHO modifications by various enzymes were critically evaluated. Under our conditions, CHO-modified vWF prep...

journal_title：Blood

authors： Federici AB,De Romeuf C,De Groot PG,Samor B,Lombardi R,D'Alessio P,Mazurier C,Mannucci PM,Sixma JJ

更新日期：1988-04-01 00:00:00

abstract：:Antiplatelet factor 4 (PF4) antibodies have an important role in the most frequent drug-induced immune disorder, heparin-induced thrombocytopenia (HIT). In this issue of Blood, Sachais and coworkers propose a new feature that may explain why only some anti-PF4 antibodies are pathogenic.(1) In addition to epitope speci...

journal_title：Blood

authors： Greinacher A,Krauel K,Jensch I

更新日期：2012-08-02 00:00:00

abstract：:Ribosomal protein S19 (RPS19) is frequently mutated in Diamond-Blackfan anemia (DBA), a rare congenital hypoplastic anemia. Recent studies have shown that RPS19 expression decreases during terminal erythroid differentiation. Currently no information is available on the subcellular localization of normal RPS19 and the ...

journal_title：Blood

authors： Da Costa L,Tchernia G,Gascard P,Lo A,Meerpohl J,Niemeyer C,Chasis JA,Fixler J,Mohandas N

更新日期：2003-06-15 00:00:00

abstract：:Unfractionated heparin (UFH) is a widely used anticoagulant that has long been known to potentiate platelet responses to subthreshold doses of platelet agonists. UFH has been reported to bind and induce modest conformational changes in the major platelet integrin, αIIbβ3, and induce minor changes in platelet morpholog...

journal_title：Blood

authors： Gao C,Boylan B,Fang J,Wilcox DA,Newman DK,Newman PJ

更新日期：2011-05-05 00:00:00

abstract：:The effective activation of factor X by factor IXa requires the co-factor activity of activated factor VIII (FVIII). Factor Xa formation is also dependent on the presence of negatively charged phospholipid. A phospholipid binding domain of FVIII has been reported to be present on the FVIII light chain. Recent observat...

journal_title：Blood

authors： Foster PA,Fulcher CA,Houghten RA,Zimmerman TS

更新日期：1990-05-15 00:00:00

abstract：:We investigated whether the stem cell that reconstitutes total erythropoiesis of a WBB6F1-W/Wv mouse differentiates into lymphoid lineage. The electrophoretic pattern of hemoglobin was used as a marker of the reconstitution; 3-phosphoglycerate kinase (PGK), an X chromosome-linked enzyme was used as a tool for estimati...

journal_title：Blood

authors： Nakano T,Waki N,Asai H,Kitamura Y

更新日期：1989-04-01 00:00:00

abstract：:Marginal zone B-cell lymphoma (MZL) is a recently individualized lymphoma that encompasses mucosa-associated lymphoid tissue (MALT) lymphoma, splenic lymphoma with or without villous lymphocytes, and nodal lymphoma with or without monocytoid B-cells. If the clinical description and outcome of MALT lymphoma is well kno...

journal_title：Blood

authors： Berger F,Felman P,Thieblemont C,Pradier T,Baseggio L,Bryon PA,Salles G,Callet-Bauchu E,Coiffier B

更新日期：2000-03-15 00:00:00

abstract：:We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1 (HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 pr...

journal_title：Blood

authors： Gibbons J,Cory JM,Hewlett IK,Epstein JS,Eyster ME

更新日期：1990-11-15 00:00:00

abstract：:We investigated the potential role of an immune reaction in mediating the dominant engraftment of 1 cord blood unit in 14 patients who received a double-unit cord blood transplantation (CBT). In 10 patients, dominant engraftment of a single donor unit emerged by day 28 after CBT. In 9 of these 10 patients, a significa...

journal_title：Blood

authors： Gutman JA,Turtle CJ,Manley TJ,Heimfeld S,Bernstein ID,Riddell SR,Delaney C

更新日期：2010-01-28 00:00:00

abstract：:A randomized study was performed in 54 thrombocytopenic patients with acute leukemia. Alloimmunization of recipients of random multiple-donor platelet concentrates (MD group) was compared to that of patients receiving random single-donor platelets (SD group). In the SD patients, formation of alloantibodies (mostly ant...

journal_title：Blood

authors： Gmür J,von Felten A,Osterwalder B,Honegger H,Hörmann A,Sauter C,Deubelbeiss K,Berchtold W,Metaxas M,Scali G,Frick PG

更新日期：1983-08-01 00:00:00

abstract：:New Zealand Black (NZB) autoimmune mice exhibit progressive, age-dependent reduction in bone marrow pre-B cells. To ascertain the capacity of NZB bone marrow B220- cells to generate pre-B cells in a supportive environment, B-lineage (B220+) cell-depleted and T-cell-depleted bone marrow cells from NZB mice at 1 to 3, 6...

journal_title：Blood

authors： Merchant MS,Garvy BA,Riley RL

更新日期：1995-04-01 00:00:00

abstract：:Donor lymphocyte infusion (DLI) can restore durable molecular remission in a high percentage of patients with chronic myeloid leukemia (CML) who have relapses after allogeneic stem cell transplantation, but for patients who do not respond survival is poor. Imatinib mesylate (STI571) is a specific inhibitor of BCR-ABL ...

journal_title：Blood

authors： Olavarria E,Craddock C,Dazzi F,Marin D,Marktel S,Apperley JF,Goldman JM

更新日期：2002-05-15 00:00:00

abstract：:Follicular dendritic cells (FDCs) in the lymphoid follicle (LF) are essential to the sequential processes of B-cell proliferation, selection, and differentiation. Although the importance of some cytokines in these processes has been pointed out, there is little information about the follicular localization of their re...

journal_title：Blood

authors： Yamada K,Yamakawa M,Imai Y,Tsukamoto M

更新日期：1997-12-15 00:00:00

abstract：:Immunohistochemistry (IHC) was performed on archived bone marrow (BM) with a phosphospecific anti-AKT antibody. IHC on 26 BM biopsies from patients with multiple myeloma (MM) demonstrated phospho-AKT staining of malignant plasma cells in a cell membrane-specific pattern, whereas nonmalignant hematopoietic cells did no...

journal_title：Blood

authors： Hsu J,Shi Y,Krajewski S,Renner S,Fisher M,Reed JC,Franke TF,Lichtenstein A

更新日期：2001-11-01 00:00:00

abstract：:Perioperative management of antithrombotic therapy is a situation that occurs frequently and requires consideration of the patient, the procedure, and an expanding array of anticoagulant and antiplatelet agents. Preoperative assessment must address each patient's risk for thromboembolic events balanced against the ris...

journal_title：Blood

authors： Ortel TL

更新日期：2012-12-06 00:00:00

abstract：:We studied the expression of CD5 and immunoglobulin variable gene families in a panel of monoclonal Epstein-Barr virus (EBV) transformed lines, chronic lymphocytic leukemias (CLLs) and CD5+ and CD5- B-cell lymphomas. The CD5 gene expression was in all cases identical to that of T-cell malignancies. The utilization of ...

journal_title：Blood

authors： Mayer R,Logtenberg T,Strauchen J,Dimitriu-Bona A,Mayer L,Mechanic S,Chiorazzi N,Borche L,Dighiero G,Mannheimer-Lory A

更新日期：1990-04-01 00:00:00

abstract：:Tumor cells from six patients with immunoglobulin G (IgG) multiple myeloma were analyzed for surface antigens, cytoplasmic paraprotein, morphology, and response to various culture conditions. The tumor marker was the paraprotein idiotype. Low numbers of tumor cells were found in the blood of most of the patients. In s...

journal_title：Blood

authors： King MA,Nelson DS

更新日期：1989-05-15 00:00:00

abstract：:The hematopoietically expressed homeobox gene, Hhex, is a transcription factor that is important for development of definitive hematopoietic stem cells (HSCs) and B cells, and that causes T-cell leukemia when overexpressed. Here, we have used an Hhex inducible knockout mouse model to study the role of Hhex in adult he...

journal_title：Blood

authors： Jackson JT,Nasa C,Shi W,Huntington ND,Bogue CW,Alexander WS,McCormack MP

更新日期：2015-01-29 00:00:00

abstract：:Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to...

journal_title：Blood

authors： Reyes M,Li S,Foraker J,Kimura E,Chamberlain JS

更新日期：2005-11-15 00:00:00

abstract：:A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a...

journal_title：Blood

authors： Drouin J,McGregor JL,Parmentier S,Izaguirre CA,Clemetson KJ

更新日期：1988-09-01 00:00:00

abstract：:Thrombopoietin (TPO, c-mpl ligand) has emerged as a major hematopoietic cytokine stimulating megakaryocyte proliferation, endomitosis, and platelet production. This study shows that a single administration of an adenovirus (Ad) vector encoding TPO (AdCMV.TPO) abrogates thrombocytopenia induced in mice by carboplatin a...

journal_title：Blood

authors： Ohwada A,Rafii S,Moore MA,Crystal RG

更新日期：1996-08-01 00:00:00

abstract：:Cell cycle checkpoints ensure orderly progression of events during cell division. A microtubule damage (MTD)-induced checkpoint has been described in G(1) phase of the cell cycle (G(1)MTC) for which little is known. The present study shows that the G(1)MTC is intact in activated T lymphocytes from mice with the p21(wa...

journal_title：Blood

authors： Mantel CR,Braun SE,Lee Y,Kim YJ,Broxmeyer HE

更新日期：2001-03-01 00:00:00

abstract：:Acquired thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by thrombotic microangiopathy leading to end-organ damage. The standard of care (SOC) treatment is therapeutic plasma exchange (TPE) alongside immunomodulation with steroids, with increasing use of rituximab +/- other immuno...

journal_title：Blood

authors： Goshua G,Sinha P,Hendrickson JE,Tormey CA,Bendapudi P,Lee AI

更新日期：2020-12-06 00:00:00

abstract：:The turnover rates of beta and gamma globin messenger RNAs and of beta and gamma globin protein synthesis in human reticulocytes have been measured. Our goal was to determine whether beta globin mRNA is significantly more stable than gamma globin mRNA during the final stages of erythroid cell maturation. Such a result...

journal_title：Blood

authors： Ross J,Sullivan TD

更新日期：1985-11-01 00:00:00

abstract：:The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In T- and pre-B-cell lymphoma, KLF4 was found to act as tumor suppressor. We found the KLF4 promoter methylated in B-cell lymphoma cell lines and in primary cases of B-cell lymphomas, namely, follicular lymph...

journal_title：Blood

authors： Guan H,Xie L,Leithäuser F,Flossbach L,Möller P,Wirth T,Ushmorov A

更新日期：2010-09-02 00:00:00

abstract：:Specific monoclonal and polyclonal antibody reagents and a double antigen indirect immunofluorescence microscopy technique were used to visualize coagulation factor V in human bone marrow. Marrow aspirates were smeared directly on glass slides, or washed and cytospun onto glass slides, or processed and plated into a p...

journal_title：Blood

authors： Nichols WL,Gastineau DA,Solberg LA Jr,Mann KG

更新日期：1985-06-01 00:00:00

abstract：:Antigenic stimulation through the B-cell antigen receptor (BCR) is considered to promote the expansion of chronic lymphocytic leukemia (CLL) B cells. The spleen tyrosine kinase (Syk), a key component of BCR signaling, can be blocked by R406, a small-molecule Syk inhibitor, that displayed activity in CLL patients in a ...

journal_title：Blood

authors： Quiroga MP,Balakrishnan K,Kurtova AV,Sivina M,Keating MJ,Wierda WG,Gandhi V,Burger JA

更新日期：2009-07-30 00:00:00

abstract：:The peripheral blood of acute myeloblastic leukemia (AML) patients often contains large numbers of two distinct cell populations, both capable of forming colonies in culture under similar conditions. The first population consists of the precursors of blast cells and has specificity for AML; the second population consi...

journal_title：Blood

authors： Minden MD,Buick RN,McCulloch EA

更新日期：1979-07-01 00:00:00

abstract：:We have shown that cytosol samples from human leukemia cells frequently contain glucocorticoid receptor fragments that have a mol wt (Mr) of approximately 52,000. In the present study we demonstrate that the Mr approximately 52,000-receptor fragments are derived from intact glucocorticoid receptors (Mr approximately 9...

journal_title：Blood

authors： Distelhorst CW,Miesfeld R

更新日期：1987-03-01 00:00:00