KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma.

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated numbers of double-negative T (DNT) cells, and increased risk of lymphoma. Most cases of ALPS are associated with germline mutations of the FAS gene (type Ia), where...

journal_title：Blood

authors： Dowdell KC,Niemela JE,Price S,Davis J,Hornung RL,Oliveira JB,Puck JM,Jaffe ES,Pittaluga S,Cohen JI,Fleisher TA,Rao VK

更新日期：2010-06-24 00:00:00

abstract：:Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage colony-stimulating factor (M-CSF)-driven macrophages (Mø2s) are potent phagocytes that have the unique capacity to preferentially bind and ingest early apoptotic cells. This ma...

journal_title：Blood

authors： Xu W,Roos A,Schlagwein N,Woltman AM,Daha MR,van Kooten C

更新日期：2006-06-15 00:00:00

abstract：:We have isolated and characterized the human cardiac mast cell (CMC) and compared this novel mast cell (MC type with MC obtained from uterus, skin, and lung. Heart tissue was obtained from 14 patients with cardiomyopathy (CMP, heart transplantation). CMC were isolated by enzymatic digestion using collagenase, pronase-...

journal_title：Blood

authors： Sperr WR,Bankl HC,Mundigler G,Klappacher G,Grossschmidt K,Agis H,Simon P,Laufer P,Imhof M,Radaszkiewicz T,Glogar D,Lechner K,Valent P

更新日期：1994-12-01 00:00:00

abstract：:In healthy carriers of human cytomegalovirus (HCMV), the virus-specific memory CD8(+) T-cell population is often dominated by CD28(-) CD45RA(hi) cells that exhibit direct ex vivo cytotoxicity but whose capacity for proliferation and generation of further memory cells has been questioned. We show that when highly purif...

journal_title：Blood

authors： Waller EC,McKinney N,Hicks R,Carmichael AJ,Sissons JG,Wills MR

更新日期：2007-12-15 00:00:00

abstract：:ASXL1 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies, and its alterations are associated with poor prognosis. De novo ASXL1 mutations cause Bohring-Opitz syndrome characterized by multiple congenital malformations. We show that Asxl1 deletion in mice led to developmental abnormaliti...

journal_title：Blood

authors： Wang J,Li Z,He Y,Pan F,Chen S,Rhodes S,Nguyen L,Yuan J,Jiang L,Yang X,Weeks O,Liu Z,Zhou J,Ni H,Cai CL,Xu M,Yang FC

更新日期：2014-01-23 00:00:00

abstract：:A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a...

journal_title：Blood

authors： Drouin J,McGregor JL,Parmentier S,Izaguirre CA,Clemetson KJ

更新日期：1988-09-01 00:00:00

abstract：:Neuroserpin, a recently identified inhibitor of tissue-type plasminogen activator (tPA), is primarily localized to neurons within the central nervous system, where it is thought to regulate tPA activity. In the present study neuroserpin expression and its potential therapeutic benefits were examined in a rat model of ...

journal_title：Blood

authors： Yepes M,Sandkvist M,Wong MK,Coleman TA,Smith E,Cohan SL,Lawrence DA

更新日期：2000-07-15 00:00:00

abstract：:In this issue of Blood, Acharya and colleagues provide evidence for the role of angiogenesis in the pathophysiology of hemophilic joint disease. Is this the linchpin that unravels this important clinical condition or merely a cog in a not so stepwise process? ...

journal_title：Blood

authors： Abshire T

更新日期：2011-02-24 00:00:00

abstract：:Approximately 20% of childhood B-precursor acute lymphoblastic leukemia (ALL) has a TEL-AML1 fusion gene, often in association with deletions of the nonrearranged TEL allele. TEL-AML1 gene fusion appears to be an initiating event and usually occurs before birth, in utero. This subgroup of ALL generally presents with l...

journal_title：Blood

authors： Ford AM,Fasching K,Panzer-Grümayer ER,Koenig M,Haas OA,Greaves MF

更新日期：2001-08-01 00:00:00

abstract：:Optimal dose and timing of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy for aggressive non-Hodgkin lymphoma (NHL) is still an unresolved issue. We assessed whether dose intensifications with cyclophosphamide and doxorubicin might improve outcome in younger patients with intermediate-r...

journal_title：Blood

authors： Verdonck LF,Notenboom A,de Jong DD,MacKenzie MA,Verhoef GE,Kramer MH,Ossenkoppele GJ,Doorduijn JK,Sonneveld P,van Imhoff GW

更新日期：2007-04-01 00:00:00

abstract：:Erythropoiesis is a robust process of cellular expansion and maturation occurring in murine bone marrow and spleen. We previously determined that sublethal irradiation, unlike bleeding or hemolysis, depletes almost all marrow and splenic erythroblasts but leaves peripheral erythrocytes intact. To better understand the...

journal_title：Blood

authors： Peslak SA,Wenger J,Bemis JC,Kingsley PD,Koniski AD,McGrath KE,Palis J

更新日期：2012-09-20 00:00:00

abstract：:A large English pedigree in which heterocellular hereditary persistence of fetal hemoglobin (HPFH) segregates is described. beta-globin cluster deletions and gamma gene promoter mutations associated with HPFH have been excluded. Of particular importance in this pedigree is the absence of any cosegregating hemoglobinop...

journal_title：Blood

authors： Craig JE,Rochette J,Sampietro M,Wilkie AO,Barnetson R,Hatton CS,Demenais F,Thein SL

更新日期：1997-07-01 00:00:00

abstract：:CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), a recently described subtype of pediatric high-risk B-precursor ALL (B-ALL) which exhibits a gene expression profile similar to Ph-positive ALL and has a poo...

journal_title：Blood

authors： Maude SL,Tasian SK,Vincent T,Hall JW,Sheen C,Roberts KG,Seif AE,Barrett DM,Chen IM,Collins JR,Mullighan CG,Hunger SP,Harvey RC,Willman CL,Fridman JS,Loh ML,Grupp SA,Teachey DT

更新日期：2012-10-25 00:00:00

abstract：:Chronic granulomatous disease (CGD) can result from any of four single gene defects involving the components of the superoxide (O-2) generating phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. We show that transduction of peripheral blood CD34+ hematopoietic progenitors from a p67phox deficient C...

journal_title：Blood

authors： Weil WM,Linton GF,Whiting-Theobald N,Vowells SJ,Rafferty SP,Li F,Malech HL

更新日期：1997-03-01 00:00:00

abstract：:CD4+Foxp3+ regulatory T cells (Treg) are a subpopulation of T cells, which regulate the immune system and enhance immune tolerance after transplantation. Donor-derived Treg prevent the development of lethal acute graft-versus-host disease (GVHD) in murine models of allogeneic hematopoietic stem cell transplantation. W...

journal_title：Blood

authors： Nishikii H,Kim BS,Yokoyama Y,Chen Y,Baker J,Pierini A,Alvarez M,Mavers M,Maas-Bauer K,Pan Y,Chiba S,Negrin RS

更新日期：2016-12-15 00:00:00

abstract：:FTY720 is an immunosuppressant developed to prevent organ transplant rejection. Recent studies indicate an additional role for FTY720 in inducing cell apoptosis. We demonstrate here that FTY720 mediates toxic effects in cell lines representing different B-cell malignancies and primary B cells from patients with chroni...

journal_title：Blood

authors： Liu Q,Zhao X,Frissora F,Ma Y,Santhanam R,Jarjoura D,Lehman A,Perrotti D,Chen CS,Dalton JT,Muthusamy N,Byrd JC

更新日期：2008-01-01 00:00:00

abstract：:The PIT1/SLC20A1 protein, a well-described sodium/phosphate cotransporter and retrovirus receptor, has been identified recently as a modular of proliferation and apoptosis in vitro. The targeted deletion of the PIT1 gene in mice revealed a lethal phenotype due to severe anemia attributed to defects in liver developmen...

journal_title：Blood

authors： Forand A,Beck L,Leroy C,Rousseau A,Boitez V,Cohen I,Courtois G,Hermine O,Friedlander G

更新日期：2013-01-24 00:00:00

abstract：:It has been reported that the intracellular antiapoptotic factor myeloid cell leukemia sequence 1 (Mcl-1) is required for mast cell survival in vitro, and that genetic manipulation of Mcl-1 can be used to delete individual hematopoietic cell populations in vivo. In the present study, we report the generation of C57BL/...

journal_title：Blood

authors： Lilla JN,Chen CC,Mukai K,BenBarak MJ,Franco CB,Kalesnikoff J,Yu M,Tsai M,Piliponsky AM,Galli SJ

更新日期：2011-12-22 00:00:00

abstract：:Gene therapy for hemophilia A requires efficient delivery of the factor VIII gene and sustained protein expression at circulating levels of at least 1% to 2% of normal. Adeno-associated viral type 2 (AAV2) vectors have a number of advantages over other viral vectors, including an excellent safety profile and persisten...

journal_title：Blood

authors： Scallan CD,Lillicrap D,Jiang H,Qian X,Patarroyo-White SL,Parker AE,Liu T,Vargas J,Nagy D,Powell SK,Wright JF,Turner PV,Tinlin SJ,Webster SE,McClelland A,Couto LB

更新日期：2003-09-15 00:00:00

abstract：:The transcription of insulin-like growth factor 2 (IGF-2) is affected by genomic imprinting, a multistep process through which the parental origin of a gene influences its transcription. The maternal copy of IGF-2 is silenced in most human tissues, but in the choroid plexus and the adult liver both alleles of IGF-2 ar...

journal_title：Blood

authors： Morison IM,Eccles MR,Reeve AE

更新日期：2000-11-01 00:00:00

abstract：:The study of chemoattractant receptors on human monocytes had been limited by the lack of a radioligand suitable for use with the small numbers of cells routinely available from human donors. A new synthetic oligopeptide radioligand f[35S]met-leu-phe, with a higher specific radioactivity than was available with the tr...

journal_title：Blood

authors： Benyunes MC,Snyderman R

更新日期：1984-03-01 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) remains a major complication following allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is dependent on assessment in preclinical murine models of cGVHD. Rho-associated kinase 2 (ROCK2) recently was shown to be implicated in regulation of inter...

journal_title：Blood

authors： Flynn R,Paz K,Du J,Reichenbach DK,Taylor PA,Panoskaltsis-Mortari A,Vulic A,Luznik L,MacDonald KK,Hill GR,Nyuydzefe MS,Weiss JM,Chen W,Trzeciak A,Serody JS,Aguilar EG,Murphy WJ,Maillard I,Munn D,Koreth J,Cutler CS

更新日期：2016-04-28 00:00:00

abstract：:The Duffy blood group system is of clinical and biological significance. Antibodies to Duffy antigens are responsible for some cases of transfusion incompatibility and newborn hemolytic disease. The Duffy protein is a receptor for the Plasmodium vivax erythrocyte-binding protein and is also a receptor for various chem...

journal_title：Blood

authors： Parasol N,Reid M,Rios M,Castilho L,Harari I,Kosower NS

更新日期：1998-10-01 00:00:00

abstract：:Successful immune reconstitution (IR) is associated with improved outcomes following pediatric cord blood transplantation (CBT). Usage and timing of anti-thymocyte globulin (ATG), introduced to the conditioning to prevent graft-versus-host disease and graft failure, negatively influences T-cell IR. We studied the rela...

journal_title：Blood

authors： Admiraal R,Lindemans CA,van Kesteren C,Bierings MB,Versluijs AB,Nierkens S,Boelens JJ

更新日期：2016-12-08 00:00:00

abstract：:MRP8 and MRP14 are two S100-like calcium-binding proteins of unknown function, associated with numbers of human inflammatory disorders. Both molecules have been described as L1 complex, cystic fibrosis antigen, or p8 and p14. We report here the cloning of mouse MRP8 and MRP14 and their pattern of expression during hem...

journal_title：Blood

authors： Lagasse E,Weissman IL

更新日期：1992-04-15 00:00:00

abstract：:Aggregation of high-affinity receptors for immunoglobulin E (Fc epsilon RI) on the surface of mast cells results in degranulation, a response that is potentiated by binding of stem cell factor (SCF) to its receptor Kit. We observed that one of the major initial signaling events associated with Fc epsilon RI-mediated a...

journal_title：Blood

authors： Tkaczyk C,Horejsi V,Iwaki S,Draber P,Samelson LE,Satterthwaite AB,Nahm DH,Metcalfe DD,Gilfillan AM

更新日期：2004-07-01 00:00:00

abstract：:Unfractionated heparin (UFH) is a widely used anticoagulant that has long been known to potentiate platelet responses to subthreshold doses of platelet agonists. UFH has been reported to bind and induce modest conformational changes in the major platelet integrin, αIIbβ3, and induce minor changes in platelet morpholog...

journal_title：Blood

authors： Gao C,Boylan B,Fang J,Wilcox DA,Newman DK,Newman PJ

更新日期：2011-05-05 00:00:00

abstract：:The International Peripheral T-Cell Lymphoma Project is a collaborative effort designed to gain better understanding of peripheral T-cell and natural killer (NK)/T-cell lymphomas (PTCLs). A total of 22 institutions in North America, Europe, and Asia submitted clinical and pathologic information on PTCLs diagnosed and ...

journal_title：Blood

authors： Savage KJ,Harris NL,Vose JM,Ullrich F,Jaffe ES,Connors JM,Rimsza L,Pileri SA,Chhanabhai M,Gascoyne RD,Armitage JO,Weisenburger DD,International Peripheral T-Cell Lymphoma Project.

更新日期：2008-06-15 00:00:00

abstract：:Hypotransferrinemic (Trf(hpx/hpx)) mice have a severe deficiency in serum transferrin (Trf) as the result of a spontaneous mutation linked to the murine Trf locus. They are born alive, but before weaning, die from severe anemia if they are not treated with exogenous Trf or red blood cell transfusions. We have determin...

journal_title：Blood

authors： Trenor CC 3rd,Campagna DR,Sellers VM,Andrews NC,Fleming MD

更新日期：2000-08-01 00:00:00

abstract：:Mixed-lineage leukemia (MLL)-AF4 fusion arises prenatally in high-risk infant acute pro-B-lymphoblastic leukemia (pro-B-ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hematoendothelial specification but was insufficient for transformation, suggesting that additional oncogenic insults seem required for MLL...

journal_title：Blood

authors： Bueno C,Ayllón V,Montes R,Navarro-Montero O,Ramos-Mejia V,Real PJ,Romero-Moya D,Araúzo-Bravo MJ,Menendez P

更新日期：2013-05-09 00:00:00