EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.

abstract：:The transcription factor c-Maf is extensively involved in the pathophysiology of multiple myeloma (MM), a fatal malignancy of plasma cells. In the present study, affinity chromatography and mass spectrometry were used to identify c-Maf ubiquitination-associated proteins, from which the E3 ligase HERC4 was found to int...

journal_title：Blood

authors： Zhang Z,Tong J,Tang X,Juan J,Cao B,Hurren R,Chen G,Taylor P,Xu X,Shi CX,Du J,Hou J,Wang G,Wu D,Stewart AK,Schimmer AD,Moran MF,Mao X

更新日期：2016-03-31 00:00:00

abstract：:Murine myeloid cells can be transformed in vitro by infection with recombinant retroviruses carrying activated myb genes. While these myb-transformed hematopoietic cells (MTHCs) can proliferate continuously in culture, they exhibit several characteristics of progenitor cells of the granulocyte-macrophage (GM) lineage,...

journal_title：Blood

authors： Macmillan EM,Gonda TJ

更新日期：1994-01-01 00:00:00

abstract：:It has been suggested that neutrophil tissue repopulation following bone marrow transplantation (BMT) serves as an earlier and more relevant marker of susceptibility to infection than circulating neutrophil counts. In a previous study using an oral rinse protocol, we found that oral neutrophil recovery always preceded...

journal_title：Blood

authors： Cheretakis C,Leung R,Sun CX,Dror Y,Glogauer M

更新日期：2006-10-15 00:00:00

abstract：:Cell-cell contact-dependent mechanisms that modulate proliferation and/or differentiation in the context of hematopoiesis include mechanisms characteristic of the interactions between members of the Notch family of signal transduction molecules and their ligands. Whereas Notch family members and their ligands clearly ...

journal_title：Blood

authors： Zhou L,Li LW,Yan Q,Petryniak B,Man Y,Su C,Shim J,Chervin S,Lowe JB

更新日期：2008-07-15 00:00:00

abstract：:A 7-yr-old girl with self-limited pulmonary aspergillosis was found to have a defect in granulocyte superoxide production. Her cells produced superoxide at 3% of control rates in response to phorbol myristate acetate (PMA) and opsonized zymosan. Lag times for O-2 production were normal with PMA, opsonized zymosan, and...

journal_title：Blood

authors： Shurin SB,Cohen HJ,Whitin JC,Newburger PE

更新日期：1983-09-01 00:00:00

abstract：:Choosing Wisely® is a medical stewardship and quality improvement initiative led by the American Board of Internal Medicine Foundation in collaboration with leading medical societies in the United States. The ASH is an active participant in the Choosing Wisely® project. Using an iterative process and an evidence-based...

journal_title：Blood

authors： Hicks LK,Bering H,Carson KR,Kleinerman J,Kukreti V,Ma A,Mueller BU,O'Brien SH,Pasquini M,Sarode R,Solberg L Jr,Haynes AE,Crowther MA

更新日期：2013-12-05 00:00:00

abstract：:IL-25, a member of the IL-17 cytokine family, is known to enhance Th2-like responses associated with increased serum levels of IgE, IgG1, IgA, blood eosinophilia, and eosinophilic infiltrates in various tissues. However, IL-25 also abrogates inflammatory responses driven by Th17 cells. However, the cell types that res...

journal_title：Blood

authors： Caruso R,Stolfi C,Sarra M,Rizzo A,Fantini MC,Pallone F,MacDonald TT,Monteleone G

更新日期：2009-04-09 00:00:00

abstract：:Plasma fibronectin (Fn) induces phagocytosis of C3b-opsonized sheep erythrocytes (EC3b) by human peripheral blood monocytes. However, Fn does not induce erythrophagocytosis of EC3b by human polymorphonuclear leukocytes (PMN), unless the PMN have been exposed to C5a or N-formyl-methionyl-leucyl-phenylalanine. Because o...

journal_title：Blood

authors： Pommier CG,O'Shea J,Chused T,Takahashi T,Ochoa M,Nutman TB,Bianco C,Brown EJ

更新日期：1984-10-01 00:00:00

abstract：:Peripheral blood cells are increasingly used in place of bone marrow as a source of hematopoietic stem cells for allogeneic transplantation. The relative efficacy of these 2 approaches is unknown. This retrospective multivariate analysis compared results of 288 HLA-identical sibling blood stem cell transplantations wi...

journal_title：Blood

authors： Champlin RE,Schmitz N,Horowitz MM,Chapuis B,Chopra R,Cornelissen JJ,Gale RP,Goldman JM,Loberiza FR Jr,Hertenstein B,Klein JP,Montserrat E,Zhang MJ,Ringdén O,Tomany SC,Rowlings PA,Van Hoef ME,Gratwohl A

更新日期：2000-06-15 00:00:00

abstract：:Both SDF-1 and CXCR4 disruption are lethal to mice at the embryonic stage and cause abnormalities in B lymphopoiesis, myelopoiesis, cardiogenesis, vasculogenesis, and cerebellar development. To investigate the role of SDF-1 and CXCR4 in hematopoiesis during the adult stage, mice reconstituted with bone marrow-derived ...

journal_title：Blood

authors： Onai N,Zhang Yy,Yoneyama H,Kitamura T,Ishikawa S,Matsushima K

更新日期：2000-09-15 00:00:00

abstract：:Regulated migration of hematopoietic stem cells is fundamental for hematopoiesis. The molecular mechanisms underlying stem cell trafficking are poorly defined. Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX...

journal_title：Blood

authors： Thieme S,Gyárfás T,Richter C,Özhan G,Fu J,Alexopoulou D,Muders MH,Michalk I,Jakob C,Dahl A,Klink B,Bandola J,Bachmann M,Schröck E,Buchholz F,Stewart AF,Weidinger G,Anastassiadis K,Brenner S

更新日期：2013-03-28 00:00:00

abstract：:An immunotoxin specific for human T lymphocytes was prepared by coupling an IgG2a anti-CD3 murine monoclonal antibody (64.1) to purified ricin A chain (64.1-A). Treatment of blood mononuclear cells with this immunotoxin at a concentration of 1.7 X 10(-9) mol/L for two hours at 37 degrees C in the presence of 20 mmol/L...

journal_title：Blood

authors： Martin PJ,Hansen JA,Vitetta ES

更新日期：1985-10-01 00:00:00

abstract：:We evaluated a treatment strategy targeting both lymphoma cells (by rituximab) and the microenvironment (by thalidomide) in 16 patients with relapsed/refractory mantle cell lymphoma (MCL). Rituximab was administered at 375 mg/m(2) for 4 weekly doses concomitantly with thalidomide (200 mg daily, with a dose increment t...

journal_title：Blood

authors： Kaufmann H,Raderer M,Wöhrer S,Püspök A,Bankier A,Zielinski C,Chott A,Drach J

更新日期：2004-10-15 00:00:00

abstract：:The Gardos channel is a Ca(2+)-sensitive, intermediate conductance, potassium selective channel expressed in several tissues including erythrocytes and pancreas. In normal erythrocytes, it is involved in cell volume modification. Here, we report the identification of a dominantly inherited mutation in the Gardos chann...

journal_title：Blood

authors： Rapetti-Mauss R,Lacoste C,Picard V,Guitton C,Lombard E,Loosveld M,Nivaggioni V,Dasilva N,Salgado D,Desvignes JP,Béroud C,Viout P,Bernard M,Soriani O,Vinti H,Lacroze V,Feneant-Thibault M,Thuret I,Guizouarn H,Badens C

更新日期：2015-09-10 00:00:00

abstract：:Ischemia of the heart, brain, and limbs is a leading cause of morbidity and mortality worldwide. Treatment with tissue type plasminogen activator (tPA) can dissolve blood clots and can ameliorate the clinical outcome in ischemic diseases. But the underlying mechanism by which tPA improves ischemic tissue regeneration ...

journal_title：Blood

authors： Ohki M,Ohki Y,Ishihara M,Nishida C,Tashiro Y,Akiyama H,Komiyama H,Lund LR,Nitta A,Yamada K,Zhu Z,Ogawa H,Yagita H,Okumura K,Nakauchi H,Werb Z,Heissig B,Hattori K

更新日期：2010-05-27 00:00:00

abstract：:Anemia and vitamin D deficiency are conditions that both result in significant morbidity and increase with age. The potential relationship between them remains poorly understood, particularly in the elderly. We used the Third National Health and Nutrition Examination Survey to examine the association of vitamin D defi...

journal_title：Blood

authors： Perlstein TS,Pande R,Berliner N,Vanasse GJ

更新日期：2011-03-10 00:00:00

abstract：:Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes. We have analyzed the V(H) gene mutation status and V(H) gene usage in 119 B-CLL cases...

journal_title：Blood

authors： Tobin G,Thunberg U,Johnson A,Thörn I,Söderberg O,Hultdin M,Botling J,Enblad G,Sällström J,Sundström C,Roos G,Rosenquist R

更新日期：2002-03-15 00:00:00

abstract：:Activated ras genes are often associated with human myeloid leukemias with a monocytic differentiated phenotype. To investigate the role of the activated ras gene in leukemogenesis, a myeloid nontumorigenic cell line (FDC-P1) was infected with a selectable retroviral vector carrying the v-Ha-ras gene (H1neo). Infected...

journal_title：Blood

authors： Hibi S,Löhler J,Friel J,Stocking C,Ostertag W

更新日期：1993-04-01 00:00:00

abstract：:Congenital blood disorders are common and yet clinically challenging globin disorders. Gene therapy continues to serve as a potential therapeutic method to treat these disorders. While tremendous advances have been made in vivo, gene delivery protocols and vector prototypes still require optimization. Alternative cis-...

journal_title：Blood

authors： Staplin WR,Knezetic JA

更新日期：2003-03-01 00:00:00

abstract：:To study outcomes of adults with idiopathic thrombocytopenic purpura (ITP), we performed a follow-up study in a cohort of 152 consecutive patients who were treated according to a well-defined algorithm. Long-term outcomes were determined relative to the response 2 years after diagnosis, because most (93%) patients who...

journal_title：Blood

authors： Portielje JE,Westendorp RG,Kluin-Nelemans HC,Brand A

更新日期：2001-05-01 00:00:00

abstract：:T-cell dysfunction after human hematopoietic stem-cell transplantation (HSCT) is generally attributed to intrinsic T-cell defects. Here we show that the characteristic impaired proliferative responses to polyclonal stimulation of post-HSCT peripheral blood mononuclear cells (PB-MCs) were markedly (4-fold) improved by ...

journal_title：Blood

authors： Hainz U,Obexer P,Winkler C,Sedlmayr P,Takikawa O,Greinix H,Lawitschka A,Pötschger U,Fuchs D,Ladisch S,Heitger A

更新日期：2005-05-15 00:00:00

abstract：:Membrane markers expressed by a transplantable granulocytic leukemia induced in inbred strain 13 guinea pigs by N-nitroso-N-butylurea have been investigated by serologic and immunochemical methods. Although the leukemic myeloblasts have no detectable surface immunoglobulin or Fc receptors, they have been found to synt...

journal_title：Blood

authors： Clement LT,Hu C,Shevach EM,Green I

更新日期：1980-02-01 00:00:00

abstract：:In vitro agar culture patterns of bone marrow cells in acute myeloid leukemia may show several growth patterns, including cultures where no colonies or clusters develop, cultures with varying numbers of clusters and no colonies, or colony and cluster formation with an extremely high ratio of clusters to colonies. Twel...

journal_title：Blood

authors： McCarthy JH,Sullivan JR,Ungar B,Metcalf D

更新日期：1979-08-01 00:00:00

abstract：:Donor alloreactive CD4(+) T cells are important to the pathogenesis of chronic graft-versus-host disease (cGVHD), but specific subsets of CD4(+) T cells responsible for GVHD have not been defined. We hypothesized that cGVHD might be associated with a preponderance of CD4(+) effector memory cells (CCR7(-)/CD62L(low), C...

journal_title：Blood

authors： Yamashita K,Choi U,Woltz PC,Foster SF,Sneller MC,Hakim FT,Fowler DH,Bishop MR,Pavletic SZ,Tamari M,Castro K,Barrett AJ,Childs RW,Illei GG,Leitman SF,Malech HL,Horwitz ME

更新日期：2004-05-15 00:00:00

abstract：:Erythropoietin (EPO) and its receptor (EPOR) are required for the development of mature erythrocytes. After binding of ligand, the EPOR activates a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression. Although erythroid progenitors appear to be the princ...

journal_title：Blood

authors： Gaffen SL,Lai SY,Longmore GD,Liu KD,Goldsmith MA

更新日期：1999-07-01 00:00:00

abstract：:The importance of the second messengers calcium (Ca(2+)) and diacylglycerol (DAG) in platelet signal transduction was established more than 30 years ago. Whereas protein kinase C (PKC) family members were discovered as the targets of DAG, little is known about the molecular identity of the main Ca(2+) sensor(s). We he...

journal_title：Blood

authors： Stefanini L,Roden RC,Bergmeier W

更新日期：2009-09-17 00:00:00

abstract：:The tumorigenicity of most cases of ALK-positive anaplastic large-cell lymphoma (ALK+ ALCL) is driven by the oncogenic fusion protein NPM-ALK in a STAT3-dependent manner. Because it has been shown that STAT3 can be inhibited by STAT1 in some experimental models, we hypothesized that the STAT1 signaling pathway is defe...

journal_title：Blood

authors： Wu C,Molavi O,Zhang H,Gupta N,Alshareef A,Bone KM,Gopal K,Wu F,Lewis JT,Douglas DN,Kneteman NM,Lai R

更新日期：2015-07-16 00:00:00

abstract：:Graft-versus-host disease (GVHD) remains one of the major complications after allogeneic bone marrow transplantation (allo-BMT). Sirtuin-1 (Sirt-1) plays a crucial role in various biological processes including cellular senescence, metabolism, and inflammatory responses. Sirt-1 deacetylation regulates different transc...

journal_title：Blood

authors： Daenthanasanmak A,Iamsawat S,Chakraborty P,Nguyen HD,Bastian D,Liu C,Mehrotra S,Yu XZ

更新日期：2019-01-17 00:00:00

abstract：:Notch signaling has been shown to play a key role in cell fate decisions in numerous developmental systems. Using a reverse transcriptase-polymerase chain reaction (RT-PCR) assay, we reported the expression of human Notch-1 in CD34+ progenitors. In this study, we evaluated the expression of human Notch-1 and Notch-2 p...

journal_title：Blood

authors： Ohishi K,Varnum-Finney B,Flowers D,Anasetti C,Myerson D,Bernstein ID

更新日期：2000-05-01 00:00:00

abstract：:A new combination of total lymphoid irradiation and cyclophosphamide was used prior to bone marrow transplantation in an attempt to achieve decreased rejection rates and graft-versus-host disease. Nine previously transfused patients with severe aplastic anemia received marrow from an HLA-identical, MLC-compatible sibl...

journal_title：Blood

authors： Ramsay NK,Kim T,Nesbit ME,Krivit W,Coccia PF,Levitt SH,Woods WG,Kersey JH

更新日期：1980-02-01 00:00:00