Midostaurin, enasidenib, CPX-351, gemtuzumab ozogamicin, and venetoclax bring new hope to AML.

Abstract:

:In 2017, 4 drugs received US Food and Drug Administration marketing approval for acute myeloid leukemia (AML) treatment: targeted therapies for mutant FLT3 and IDH2, a liposomal cytarabine-daunorubicin formulation for therapy-related AML and AML with myelodysplasia-related changes, and resurgence of an antibody-drug conjugate designed to target CD33. Promising results also emerged for the BCL-2 inhibitor venetoclax combined with low-intensity therapy in older patients unfit for intensive chemotherapy. This quintet of new drugs is likely to reshape the therapeutic landscape of AML.

journal_name

Blood

journal_title

Blood

authors

Wei AH,Tiong IS

doi

10.1182/blood-2017-08-784066

subject

Has Abstract

pub_date

2017-12-07 00:00:00

pages

2469-2474

issue

23

eissn

0006-4971

issn

1528-0020

pii

blood-2017-08-784066

journal_volume

130

pub_type

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