Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications.

abstract：:Seventy-one patients with hematologic malignancies received bone marrow from a histocompatible sibling (n = 48) or a partially matched relative (n = 23) that had been depleted of CD5+ T cells with either an anti-CD5 mooclonal antibody (MoAb) plus complement (anti-Leu1 + C) or an anti-CD5 MoAb conjugated to ricin A cha...

journal_title：Blood

authors： Antin JH,Bierer BE,Smith BR,Ferrara J,Guinan EC,Sieff C,Golan DE,Macklis RM,Tarbell NJ,Lynch E

更新日期：1991-10-15 00:00:00

abstract：:CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been identified as hyaluronic acid (HA), a major component of the extracellular matrix (ECM). Recent studies have demonstrated that activation through CD44 leads to induction of effector function in T cells and macrophages. In the curren...

journal_title：Blood

authors： Rafi A,Nagarkatti M,Nagarkatti PS

更新日期：1997-04-15 00:00:00

abstract：:Hydroxyurea (HU), a drug effective in the treatment of sickle cell disease, is thought to indirectly promote fetal hemoglobin (Hb F) production by perturbing the maturation of erythroid precursors. The molecular mechanisms involved in HU-mediated regulation of gamma-globin expression are currently unclear. We identifi...

journal_title：Blood

authors： Tang DC,Zhu J,Liu W,Chin K,Sun J,Chen L,Hanover JA,Rodgers GP

更新日期：2005-11-01 00:00:00

abstract：:Interactions between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) mediate the earliest "rolling" of leukocytes on the lumenal surface of endothelial cells at sites of inflammation. Previously, PSGL-1 has been shown to be the primary mediator of interactions between neutrophils and P-selectin, but studies o...

journal_title：Blood

authors： Snapp KR,Ding H,Atkins K,Warnke R,Luscinskas FW,Kansas GS

更新日期：1998-01-01 00:00:00

abstract：:Successful immune reconstitution (IR) is associated with improved outcomes following pediatric cord blood transplantation (CBT). Usage and timing of anti-thymocyte globulin (ATG), introduced to the conditioning to prevent graft-versus-host disease and graft failure, negatively influences T-cell IR. We studied the rela...

journal_title：Blood

authors： Admiraal R,Lindemans CA,van Kesteren C,Bierings MB,Versluijs AB,Nierkens S,Boelens JJ

更新日期：2016-12-08 00:00:00

abstract：:To increase transgenic production of granulocyte-macrophage colony-stimulating factor (GM-CSF), we mutated the mRNA's 3'-untranslated region, AUUUA instability elements. Expression vectors containing human or murine GM-CSF cDNAs coding for wild-type (GM-AUUUA) or mutant versions with reiterated AUGUA repeats (GM-AUGUA...

journal_title：Blood

authors： Rajagopalan LE,Burkholder JK,Turner J,Culp J,Yang NS,Malter JS

更新日期：1995-10-01 00:00:00

abstract：:Over the past 2 decades considerable evidence has accumulated on the association between hepatitis C virus (HCV) and hepatitis B virus (HBV) and several hematologic malignancies, most notably B-cell non-Hodgkin lymphoma (NHL). In this review we summarize this evidence, address possible mechanisms whereby hepatitis vir...

journal_title：Blood

authors： Marcucci F,Mele A

更新日期：2011-02-10 00:00:00

abstract：:Previous studies have suggested that, in patients with AL amyloidosis treated with high-dose melphalan and autologous stem-cell transplantation (HDM/SCT), the greatest benefit is seen in those patients achieving a hematologic complete response (CR). We analyzed a series of 421 consecutive patients treated with HDM/SCT...

journal_title：Blood

authors： Cibeira MT,Sanchorawala V,Seldin DC,Quillen K,Berk JL,Dember LM,Segal A,Ruberg F,Meier-Ewert H,Andrea NT,Sloan JM,Finn KT,Doros G,Blade J,Skinner M

更新日期：2011-10-20 00:00:00

abstract：:A 37-year-old man of Guyanese origin was found to have homozygous beta-thalassemia without anemia. There were no physical stigmata of thalassemia. The hematocrit value was 41 to 45.8, the mean corpuscular volume was 61 fL, and the mean corpuscular hemoglobin was 18.9 pg. The HbF was 45% with a G gamma:A gamma ratio of...

journal_title：Blood

authors： Safaya S,Rieder RF,Dowling CE,Kazazian HH Jr,Adams JG 3rd

更新日期：1989-01-01 00:00:00

abstract：:Rh blood group antigens of the D, C/c, and E/e series are carried by at least three red cell membrane polypeptides encoded by two highly related genes, RHD and RHCE. Homozygous individuals carrying the D--, Dc-, and DCw- gene complexes are characterized by a total or partial lack of expression of the RHCE-encoded anti...

journal_title：Blood

authors： Chérif-Zahar B,Raynal V,D'Ambrosio AM,Cartron JP,Colin Y

更新日期：1994-12-15 00:00:00

abstract：:The expression of tumor-associated antigens (TAAs) might play a critical role in the control of minimal residual disease (MRD) in acute myeloid leukemia (AML), and therefore might be associated with clinical outcome in AML. In a DNA microarray analysis of 116 AML samples, we found a significant correlation between hig...

journal_title：Blood

authors： Greiner J,Schmitt M,Li L,Giannopoulos K,Bosch K,Schmitt A,Dohner K,Schlenk RF,Pollack JR,Dohner H,Bullinger L

更新日期：2006-12-15 00:00:00

abstract：:Therapy for childhood acute lymphoblastic leukemia (ALL) is associated with 5-year survival rates of ∼90% even after largely eliminating cranial radiation. This meta-analysis assesses the long-term neurocognitive functioning after chemotherapy-only regimens among survivors of childhood ALL. We conducted a systematic r...

journal_title：Blood

authors： Iyer NS,Balsamo LM,Bracken MB,Kadan-Lottick NS

更新日期：2015-07-16 00:00:00

abstract：:Twenty-two molecular diagnostic laboratories from 14 countries participated in a consortium study to estimate the impact of Factor VIII gene inversions in severe hemophilia A. A total of 2,093 patients with severe hemophilia A were studied; of those, 740 (35%) had a type 1 (distal) factor VIII inversion, and 140 (7%) ...

journal_title：Blood

authors： Antonarakis SE,Rossiter JP,Young M,Horst J,de Moerloose P,Sommer SS,Ketterling RP,Kazazian HH Jr,Négrier C,Vinciguerra C,Gitschier J,Goossens M,Girodon E,Ghanem N,Plassa F,Lavergne JM,Vidaud M,Costa JM,Laurian Y,Lin

更新日期：1995-09-15 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is characterized by the continuous proliferation and abnormal circulation of malignant hematopoietic progenitors. This may be related to the unresponsiveness of CML progenitors to beta1 integrin adhesion receptor-mediated inhibition of progenitor proliferation by the marrow microenvi...

journal_title：Blood

authors： Bhatia R,Verfaillie CM

更新日期：1998-05-01 00:00:00

abstract：:Distinct human dendritic cell (DC) subsets differentially control immunity. Thus, insights into their in vivo functions are important to understand the launching and modulation of immune responses. We show that nonobese diabetic/LtSz-scid/scid (NOD/SCID) mice engrafted with human CD34+ hematopoietic progenitors develo...

journal_title：Blood

authors： Palucka AK,Gatlin J,Blanck JP,Melkus MW,Clayton S,Ueno H,Kraus ET,Cravens P,Bennett L,Padgett-Thomas A,Marches F,Islas-Ohlmayer M,Garcia JV,Banchereau J

更新日期：2003-11-01 00:00:00

abstract：:Zosuquidar, which modulates P-glycoprotein (P-gp) with minimal delay of anthracycline clearance, may reverse P-gp-mediated resistance in acute myeloid leukemia without increased toxicity. A total of 449 adults older than 60 years with acute myeloid leukemia or high-risk myelodysplastic syndrome enrolled in a randomize...

journal_title：Blood

authors： Cripe LD,Uno H,Paietta EM,Litzow MR,Ketterling RP,Bennett JM,Rowe JM,Lazarus HM,Luger S,Tallman MS

更新日期：2010-11-18 00:00:00

abstract：:Among 1153 new adult cases of peripheral/T-cell lymphoma from 1990-2002 at 22 centers in 13 countries, 136 cases (11.8%) of extranodal natural killer (NK)/T-cell lymphoma were identified (nasal 68%, extranasal 26%, aggressive/unclassifiable 6%). The disease frequency was higher in Asian than in Western countries and i...

journal_title：Blood

authors： Au WY,Weisenburger DD,Intragumtornchai T,Nakamura S,Kim WS,Sng I,Vose J,Armitage JO,Liang R,International Peripheral T-Cell Lymphoma Project.

更新日期：2009-04-23 00:00:00

abstract：:In B cells, expression of CIITA and resulting major histocompatibility complex II (MHCII) is mediated exclusively by promoter III (CIITA-PIII) activation. Recent studies have established that CIITA-PIII also participates in the expression of CIITA in activated human T cells, dendritic cells, and monocytes. In this stu...

journal_title：Blood

authors： van der Stoep N,Quinten E,Marcondes Rezende M,van den Elsen PJ

更新日期：2004-11-01 00:00:00

abstract：:Thrombospondin is a principal glycoprotein secreted by thrombin-stimulated platelets and has known affinities for fibrinogen and fibrin. We studied the distribution of thrombospondin in clots formed in situ on Formvar-coated coverslips at 37 degrees C for intervals up to 17 hours. The distributions of three other majo...

journal_title：Blood

authors： Murphy-Ullrich JE,Mosher DF

更新日期：1985-11-01 00:00:00

abstract：:Natural killer (NK) cell activity is severely impaired in untreated patients with hairy cell leukemia (HCL). In an attempt to investigate whether this impairment is related to a defect at the target cell binding and/or at the post target cell binding level, we evaluated the peripheral blood mononuclear cells (PBMC) of...

journal_title：Blood

authors： Trentin L,Zambello R,Agostini C,Ambrosetti A,Chisesi T,Raimondi R,Bulian P,Pizzolo G,Semenzato G

更新日期：1990-04-01 00:00:00

abstract：:We demonstrated that Flk-1(+) cells derived from mouse embryonic stem (ES) cells can differentiate into both endothelial cells (ECs) and mural cells (MCs) to suffice as vascular progenitor cells (VPCs). In the present study, we investigated the importance of the stage of ES cell differentiation on effective participat...

journal_title：Blood

authors： Yurugi-Kobayashi T,Itoh H,Yamashita J,Yamahara K,Hirai H,Kobayashi T,Ogawa M,Nishikawa S,Nishikawa S,Nakao K

更新日期：2003-04-01 00:00:00

abstract：:We performed a randomized trial to compare the safety and efficacy of itraconazole with fluconazole in preventing fungal infections in patients undergoing allogeneic stem cell transplantation (SCT). Itraconazole (intravenous 200 mg daily, or oral solution 2.5 mg/kg 3 times daily) and fluconazole (intravenous or oral, ...

journal_title：Blood

authors： Marr KA,Leisenring W,Crippa F,Slattery JT,Corey L,Boeckh M,McDonald GB

更新日期：2004-02-15 00:00:00

abstract：:Bryostatin 1, a macrocyclic lactone isolated from the marine bryozoan Bugula neritina, has demonstrated both antineoplastic activity against the murine P388 leukemia line in vivo and stimulatory activity against mouse and human hematopoietic progenitors. We studied the effects of bryostatin 1 on the growth of human le...

journal_title：Blood

authors： Jones RJ,Sharkis SJ,Miller CB,Rowinsky EK,Burke PJ,May WS

更新日期：1990-03-15 00:00:00

abstract：:The phagocyte nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) oxidase was functionally reconstituted in monkey kidney COS-7 cells by transfection of essential subunits, gp91(phox), p22(phox), p47(phox), and p67(phox). COS-7 cells express the essential small guanosine 5'-triphosphatase, Rac1. Transge...

journal_title：Blood

authors： Price MO,McPhail LC,Lambeth JD,Han CH,Knaus UG,Dinauer MC

更新日期：2002-04-15 00:00:00

abstract：:Hematopoietic stem cells (HSCs) maintain stemness through various mechanisms that protect against stressful conditions. Heat shock proteins (HSPs) preserve cell homeostasis during stress responses through protein quality control, suggesting that HSPs may safeguard HSCs against numerous traumas. Here, we show that mort...

journal_title：Blood

authors： Tai-Nagara I,Matsuoka S,Ariga H,Suda T

更新日期：2014-01-02 00:00:00

abstract：:Thioredoxin (Trx) is a ubiquitous protein disulfide oxidoreductase with antioxidant, cytokine, and chemotactic properties. Previously, we showed that Trx, in synergy with interleukin 1 (IL-1), IL-2, IL-4, tumor necrosis factor alpha (TNF-alpha), and CD40-ligation induced S-phase entry and mitosis in normal B cells and...

journal_title：Blood

authors： Nilsson J,Söderberg O,Nilsson K,Rosén A

更新日期：2000-02-15 00:00:00

abstract：:Until recently, IgE-activated mast cells have been regarded merely as effector cells of adaptive immune responses, involved in allergic reactions and mucosal immunity to parasites. Herein, we report that murine dermal mast cells, activated by local administration of a cream containing the synthetic TLR7 ligand imiquim...

journal_title：Blood

authors： Heib V,Becker M,Warger T,Rechtsteiner G,Tertilt C,Klein M,Bopp T,Taube C,Schild H,Schmitt E,Stassen M

更新日期：2007-08-01 00:00:00

abstract：:Although phospholipid scramblase 1 (PLSCR1) was originally identified based on its capacity to promote transbilayer movement of membrane phospholipids, subsequent studies also provided evidence for its role in cell proliferation, maturation, and apoptosis. In this report, we investigate the potential role of PLSCR1 in...

journal_title：Blood

authors： Zhao KW,Li X,Zhao Q,Huang Y,Li D,Peng ZG,Shen WZ,Zhao J,Zhou Q,Chen Z,Sims PJ,Wiedmer T,Chen GQ

更新日期：2004-12-01 00:00:00

abstract：:Exposure to HIV-1 does not necessarily result in infection and progression toward disease, thus suggesting that the control of viral infection may be achieved. Antibodies to CCR5 have been detected in HIV-exposed but uninfected subjects (ESNs); thus, these antibodies could be involved in HIV protection. To assess whet...

journal_title：Blood

authors： Pastori C,Weiser B,Barassi C,Uberti-Foppa C,Ghezzi S,Longhi R,Calori G,Burger H,Kemal K,Poli G,Lazzarin A,Lopalco L

更新日期：2006-06-15 00:00:00

abstract：:A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions an...

journal_title：Blood

authors： Boukerche H,Berthier-Vergnes O,Tabone E,Doré JF,Leung LL,McGregor JL

更新日期：1989-08-01 00:00:00