Frontline brentuximab vedotin in combination with dacarbazine or bendamustine in patients aged ≥60 years with HL.

abstract：:The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based evaluation of survival, the available data fully justify critical reassessment of CML management. The panel therefore reviewed treatment of CML sinc...

journal_title：Blood

authors： Baccarani M,Saglio G,Goldman J,Hochhaus A,Simonsson B,Appelbaum F,Apperley J,Cervantes F,Cortes J,Deininger M,Gratwohl A,Guilhot F,Horowitz M,Hughes T,Kantarjian H,Larson R,Niederwieser D,Silver R,Hehlmann R,Europea

更新日期：2006-09-15 00:00:00

abstract：:Leukocyte extravasation involves interdependent signaling pathways underlying the complex dynamics of firm adhesion, crawling, and diapedesis. While signal transduction by agonist-bound chemokine receptors plays a central role in the above responses, it is unclear how it contributes to the sustained and concurrent nat...

journal_title：Blood

authors： Molteni R,Crespo CL,Feigelson S,Moser C,Fabbri M,Grabovsky V,Krombach F,Laudanna C,Alon R,Pardi R

更新日期：2009-07-30 00:00:00

abstract：:Previous studies have implicated activation-induced cytidine deaminase (AID) in B-cell translocations but have failed to identify any association between their chromosomal breakpoints and known AID target sequences. Analysis of 56 unclustered IgH-CCND1 translocations in mantle cell lymphoma across the ~ 344-kb bcl-1 b...

journal_title：Blood

authors： Greisman HA,Lu Z,Tsai AG,Greiner TC,Yi HS,Lieber MR

更新日期：2012-10-04 00:00:00

abstract：:Human myeloma cells freshly isolated from 40 patients with IgG multiple myeloma (MM, 10 in stage I and 30 in stage III), were cultured for 48 hours with recombinant B cell stimulatory factor 2 (rBSF-2)/interleukin-6 (IL-6), which is considered a major growth factor for myeloma cells. Uptake of 3H-thymidine by these pu...

journal_title：Blood

authors： Asaoku H,Kawano M,Iwato K,Tanabe O,Tanaka H,Hirano T,Kishimoto T,Kuramoto A

更新日期：1988-08-01 00:00:00

abstract：:The pp65(495-503) cytotoxic T-lymphocyte (CTL) epitope from cytomegalovirus (CMV) is universally recognized among CMV+ individuals who express an allele of the human leukocyte antigen A (HLA-A*0201). The relative binding affinity of the epitope to HLA-A*0201 is moderate, and its increased activity might prove benefici...

journal_title：Blood

authors： La Rosa C,Krishnan R,Markel S,Schneck JP,Houghten R,Pinilla C,Diamond DJ

更新日期：2001-03-15 00:00:00

abstract：:Red cell concentrates (RCC) are stored for 35 to 42 days in plastic containers manufactured with the liquid plasticizer di(2-ethylhexyl)phthalate (DEHP). DEHP leaches from the polyvinylchloride (PVC) plastic bag, then binds to and stabilizes the RC membrane. This study was undertaken to determine the deformability of ...

journal_title：Blood

authors： Labow RS,Card RT,Rock G

更新日期：1987-07-01 00:00:00

abstract：:Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The molecular basis for the selective elimination of mitochondria from mature red blood cells remains controversial. Recent evidence...

journal_title：Blood

authors： Kundu M,Lindsten T,Yang CY,Wu J,Zhao F,Zhang J,Selak MA,Ney PA,Thompson CB

更新日期：2008-08-15 00:00:00

abstract：:Severe congenital neutropenia as well as primary myelofibrosis are rare in infancy. Elucidation of the underlying mechanism is important because it extends our understanding of the more common adult forms of these disorders. Using homozygosity mapping followed by exome sequencing, we identified a Thr224Asn mutation in...

journal_title：Blood

authors： Stepensky P,Saada A,Cowan M,Tabib A,Fischer U,Berkun Y,Saleh H,Simanovsky N,Kogot-Levin A,Weintraub M,Ganaiem H,Shaag A,Zenvirt S,Borkhardt A,Elpeleg O,Bryant NJ,Mevorach D

更新日期：2013-06-20 00:00:00

abstract：:The replating capability of human umbilical cord blood (CB) multipotential (CFU-GEMM) progenitors was assessed in vitro as an estimate of self-renewal using erythropoietin (Epo), steel factor (SLF), and either fetal bovine serum (FBS) or CB plasma. This study found a much higher replating efficiency for CB CFU-GEMM th...

journal_title：Blood

authors： Carow CE,Hangoc G,Broxmeyer HE

更新日期：1993-02-15 00:00:00

abstract：:Approximately 30% to 40% of patients with acute leukemia receiving repeated pooled random-donor platelet transfusions develop anti-HLA alloantibodies. Over time, however, serum anti-HLA concentrations decrease in approximately 50% of these patients, despite continued exposure to platelet and/or red blood cell transfus...

journal_title：Blood

authors： Atlas E,Freedman J,Blanchette V,Kazatchkine MD,Semple JW

更新日期：1993-01-15 00:00:00

abstract：:Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated with favorable overall...

journal_title：Blood

authors： Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Del

更新日期：2012-03-08 00:00:00

abstract：:In this study, the question of whether glycoprotein Ib (GPIb) mediates both high and moderate affinity pathways of alpha-thrombin-induced platelet activation was examined. Flow cytometric studies, using a panel of monoclonal antibodies (MoAbs), showed that Serratia marcescens protease treatment removed greater than 97...

journal_title：Blood

authors： Yamamoto N,Greco NJ,Barnard MR,Tanoue K,Yamazaki H,Jamieson GA,Michelson AD

更新日期：1991-04-15 00:00:00

abstract：:The principal aim of our study was to investigate whether patients transplanted more than 20 years ago for β-thalassemia major had a different health-related quality of life (HRQoL) compared with the general population. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Functional Assessment o...

journal_title：Blood

authors： La Nasa G,Caocci G,Efficace F,Dessì C,Vacca A,Piras E,Sanna M,Marcias M,Littera R,Carcassi C,Lucarelli G

更新日期：2013-09-26 00:00:00

abstract：:The recent success of chimeric antigen receptor (CAR)-T cell therapy for treatment of hematologic malignancies supports further development of treatments for both liquid and solid tumors. However, expansion of CAR-T cell therapy is limited by the availability of surface antigens specific for the tumor while sparing no...

journal_title：Blood

authors： Akahori Y,Wang L,Yoneyama M,Seo N,Okumura S,Miyahara Y,Amaishi Y,Okamoto S,Mineno J,Ikeda H,Maki T,Fujiwara H,Akatsuka Y,Kato T,Shiku H

更新日期：2018-09-13 00:00:00

abstract：:During the early period following bone marrow transplantation before the immune system has reached full functional maturity, unprimed, nonspecific lytic systems may play a critical role as antiviral or antitumor effectors. The reconstitution of cells with this potential is of particular importance in recipients of bon...

journal_title：Blood

authors： Keever CA,Welte K,Small T,Levick J,Sullivan M,Hauch M,Evans RL,O'Reilly RJ

更新日期：1987-12-01 00:00:00

abstract：:Activation of sialic-acid-binding immunoglobulin-like lectin-G (Siglec-G) by noninfectious damage-associated molecular patterns controls innate immune responses. However, whether it also regulates T-cell-mediated adaptive immune responses is not known. Graft-versus-host reaction is a robust adaptive immune response ca...

journal_title：Blood

authors： Toubai T,Hou G,Mathewson N,Liu C,Wang Y,Oravecz-Wilson K,Cummings E,Rossi C,Evers R,Sun Y,Wu J,Choi SW,Fang D,Zheng P,Liu Y,Reddy P

更新日期：2014-05-29 00:00:00

abstract：:Arsenic trioxide (As2O3) induces clinical remission in acute promyelocytic leukemia (APL) with minimal toxicity and apoptosis in APL-derived NB4 cells at low (1 to 2 micromol/L) concentration. We examined the basis for NB4 cell sensitivity to As2O3 to identify experimental conditions that would render other malignant ...

journal_title：Blood

authors： Dai J,Weinberg RS,Waxman S,Jing Y

更新日期：1999-01-01 00:00:00

abstract：:A hamster antimouse CD3 monoclonal antibody (MoAb) opened the way to experimental studies on the suppression of allograft rejection and cytokine-related morbidity after treatment with antibodies modulating the CD3/T-cell receptor complex (CD3/TCR). Because earlier attempts to suppress graft-versus-host disease (GVHD) ...

journal_title：Blood

authors： Mysliwietz J,Thierfelder S

更新日期：1992-11-15 00:00:00

abstract：:Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are critical for first-line host defense and elicitation of adaptive immune responses. Many pathogen-associated molecular patterns activate both TLR and complement, but whether and how these 2 systems, when coactivated in vivo, interact...

journal_title：Blood

authors： Zhang X,Kimura Y,Fang C,Zhou L,Sfyroera G,Lambris JD,Wetsel RA,Miwa T,Song WC

更新日期：2007-07-01 00:00:00

abstract：:In this study human mononuclear phagocytes from the bone marrow (promonocytes and monocytes), peripheral blood monocytes, and tissue macrophages from the skin and the peritoneal cavity were studied with respect to their morphological, cytochemical, and functional characteristics, cell surface receptors, and 3H-thymidi...

journal_title：Blood

authors： van Furth R,Raeburn JA,van Zwet TL

更新日期：1979-08-01 00:00:00

abstract：:Although preclinical work with rapalogs suggests potential in treatment of multiple myeloma (MM), they have been less successful clinically. These drugs allostearically inhibit the mammalian target of rapamycin kinase primarily curtailing activity of the target of rapamycin complex (TORC)1. To assess if the mammalian ...

journal_title：Blood

authors： Hoang B,Frost P,Shi Y,Belanger E,Benavides A,Pezeshkpour G,Cappia S,Guglielmelli T,Gera J,Lichtenstein A

更新日期：2010-11-25 00:00:00

abstract：:Follicular dendritic cells (FDCs) in the lymphoid follicle (LF) are essential to the sequential processes of B-cell proliferation, selection, and differentiation. Although the importance of some cytokines in these processes has been pointed out, there is little information about the follicular localization of their re...

journal_title：Blood

authors： Yamada K,Yamakawa M,Imai Y,Tsukamoto M

更新日期：1997-12-15 00:00:00

abstract：:Ectopic expression of the erythropoietin receptor (EpoR) in the interleukin-3 (IL-3)-dependent cell line Ba/F3 results in growth and partial erythroid differentiation in Epo. In contrast, introduction and activation of the interleukin-5 receptor (IL-5R) or of the granulocyte-macrophage colony-stimulating factor recept...

journal_title：Blood

authors： Pless M,Norga K,Carroll M,Heim MH,D'Andrea AD,Mathey-Prevot B

更新日期：1997-05-01 00:00:00

abstract：:To investigate the heterogeneous cellular structure of human acute myeloid leukemia (AML), subpopulations of cells were distinguished by two combined criteria: proliferation and differentiation. Purified blast cells were fractionated from blood or bone marrow of patients with newly diagnosed AML and colonies and clust...

journal_title：Blood

authors： Wouters R,Löwenberg B

更新日期：1984-03-01 00:00:00

abstract：:We have analyzed the reactivation of fetal hemoglobin (HbF) synthesis under rigorous in vitro conditions, ie, in mature erythroblasts generated by erythroid burst-forming units (BFU-E) stringently purified from normal adult peripheral blood and grown in fetal calf serum(FCS)-free semisolid or liquid phase culture. In ...

journal_title：Blood

authors： Peschle C,Gabbianelli M,Testa U,Pelosi E,Barberi T,Fossati C,Valtieri M,Leone L

更新日期：1993-01-15 00:00:00

abstract：:A 9-yr-old female presented with a Wilm's tumor and a coagulopathy consistent with von Willebrand's disease. Factor VIII procoagulant activity (VIII C), factor VIII related antigen (VIIIR:Ag), and von Willebrand factor activity (VIII:vWf) were decreased. There was no evidence for a circulating inhibitor of the factor ...

journal_title：Blood

authors： Scott JP,Montgomery RR,Tubergen DG,Hays T

更新日期：1981-10-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a neutrophil chemotactic and activating cytokine that is produced in response to several stimuli. Because monocytic cells are important producers of IL-8, we investigated whether interferon-gamma (IFN-gamma), a potent inducer of activation and differentiation of mononuclear phagocytes, affected...

journal_title：Blood

authors： Bosco MC,Gusella GL,Espinoza-Delgado I,Longo DL,Varesio L

更新日期：1994-01-15 00:00:00

abstract：:In a prospective multicenter study, 368 acute lymphoblastic leukemia (ALL) patients aged 15 to 65 years were treated with an intensified induction and reinduction regimen; 272 (73.9%) achieved complete remission (CR). The median remission duration (MRD) is 24.3 months, and the probability of being in continuous CR (CC...

journal_title：Blood

authors： Hoelzer D,Thiel E,Löffler H,Büchner T,Ganser A,Heil G,Koch P,Freund M,Diedrich H,Rühl H

更新日期：1988-01-01 00:00:00

abstract：:Malignant transformation by oncogenes requires additional genetic/epigenetic changes to overcome enhanced susceptibility to apoptosis. In the present study, we report that Bif-1 (Sh3glb1), a gene encoding a membrane curvature–driving endophilin protein, is a haploinsufficient tumor suppressor that plays a key role in ...

journal_title：Blood

authors： Takahashi Y,Hori T,Cooper TK,Liao J,Desai N,Serfass JM,Young MM,Park S,Izu Y,Wang HG

更新日期：2013-02-28 00:00:00

abstract：:Acquisition of mature T cell function and the T cell antigen receptor repertoire occur in the thymus. In an effort to delineate the cascade of events leading to T cell maturation, we analyzed a series of clonal human precursor T cell neoplasms representing early, middle, and late stages of intrathymic differentiation....

journal_title：Blood

authors： Pittaluga S,Uppenkamp M,Cossman J

更新日期：1987-04-01 00:00:00