Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.

abstract：:Notch and its ligands have been implicated in the regulation and differentiation of various CD4(+) T-helper cells. Regulatory T cells (T(regs)), which express the transcription factor Foxp3, suppress aberrant immune responses that are typically associated with autoimmunity or excessive inflammation. Previous studies h...

journal_title：Blood

authors： Samon JB,Champhekar A,Minter LM,Telfer JC,Miele L,Fauq A,Das P,Golde TE,Osborne BA

更新日期：2008-09-01 00:00:00

abstract：:T-cell depletion of donor marrow decreases graft-versus-host disease resulting from transplants from unrelated and human leukocyte antigen (HLA)-mismatched related donors. However, there are diverse strategies for T-cell-depleted transplantation, and it is uncertain whether any improve leukemia-free survival (LFS). To...

journal_title：Blood

authors： Champlin RE,Passweg JR,Zhang MJ,Rowlings PA,Pelz CJ,Atkinson KA,Barrett AJ,Cahn JY,Drobyski WR,Gale RP,Goldman JM,Gratwohl A,Gordon-Smith EC,Henslee-Downey PJ,Herzig RH,Klein JP,Marmont AM,O'Reilly RJ,Ringdén O,Slav

更新日期：2000-06-15 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV) is detected in approximately 80% of Merkel cell carcinomas (MCC). Yet, clonal integration and truncating mutations of the large T antigen (LTAg) of MCPyV are restricted to MCC. We tested the presence and mutations of MCPyV in highly purified leukemic cells of 70 chronic lymphocytic leu...

journal_title：Blood

authors： Pantulu ND,Pallasch CP,Kurz AK,Kassem A,Frenzel L,Sodenkamp S,Kvasnicka HM,Wendtner CM,Zur Hausen A

更新日期：2010-12-09 00:00:00

abstract：:Subclones homozygous for JAK2V617F are more common in polycythemia vera (PV) than essential thrombocythemia (ET), but their prevalence and significance remain unclear. The JAK2 mutation status of 6495 BFU-E, grown in low erythropoietin conditions, was determined in 77 patients with PV or ET. Homozygous-mutant colonies...

journal_title：Blood

authors： Godfrey AL,Chen E,Pagano F,Ortmann CA,Silber Y,Bellosillo B,Guglielmelli P,Harrison CN,Reilly JT,Stegelmann F,Bijou F,Lippert E,McMullin MF,Boiron JM,Döhner K,Vannucchi AM,Besses C,Campbell PJ,Green AR

更新日期：2012-09-27 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by antibody-mediated platelet destruction. Different mechanisms have been suggested to explain accelerated platelet clearance and impaired thrombopoiesis, but the pathophysiology of ITP has yet to be fully delineated. In this study, we tested...

journal_title：Blood

authors： Morodomi Y,Kanaji S,Won E,Ruggeri ZM,Kanaji T

更新日期：2020-06-18 00:00:00

abstract：:Microscopic intracellular detection of Epstein-Barr virus (EBV) messenger RNA in Reed-Sternberg cells of Hodgkin's disease (HD) was possible by in situ hybridization, in tissue sections prepared by a method termed modified acetone methyl benzoate xylene (ModAMeX). The ModAMeX method was initially developed for simulta...

journal_title：Blood

authors： Brousset P,Chittal S,Schlaifer D,Icart J,Payen C,Rigal-Huguet F,Voigt JJ,Delsol G

更新日期：1991-04-15 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) inhibits proteases in the blood coagulation cascade that lead to the production of thrombin, including prothrombinase (factor Xa [FXa]/FVa), the catalytic complex that directly generates thrombin. Thus, TFPI and FV are directly linked in regulating the procoagulant response. Stud...

journal_title：Blood

authors： Maroney SA,Westrick RJ,Cleuren AC,Martinez ND,Siebert AE,Zogg M,Ginsburg D,Weiler H,Mast AE

更新日期：2021-01-14 00:00:00

abstract：:Inhibition of the B-cell receptor (BCR) signaling pathway is a promising treatment strategy in multiple B-cell malignancies. However, the role of BCR blockade in diffuse large B-cell lymphoma (DLBCL) remains undefined. We recently characterized primary DLBCL subsets with distinct genetic bases for perturbed BCR/phosph...

journal_title：Blood

authors： Bojarczuk K,Wienand K,Ryan JA,Chen L,Villalobos-Ortiz M,Mandato E,Stachura J,Letai A,Lawton LN,Chapuy B,Shipp MA

更新日期：2019-01-03 00:00:00

abstract：:We have analyzed the phenotype, cytokine profile, and mitotic history (telomere length) of monoclonal T-cell expansions in 5 CD3(+) T-cell large granular lymphocyte (TLGL) leukemia patients by fluorescence activated cell sorting (FACS) and single-cell polymerase chain reaction (PCR). We confirm that the common phenoty...

journal_title：Blood

authors： Bigouret V,Hoffmann T,Arlettaz L,Villard J,Colonna M,Ticheli A,Gratwohl A,Samii K,Chapuis B,Rufer N,Roosnek E

更新日期：2003-04-15 00:00:00

abstract：:Using flow cytometric and RNase protection assays, this study examined the expression of chemokine receptors in nonactivated natural killer (NK) cells and compared this expression with NK cells activated with interleukin (IL)-2, which either adhered to plastic flasks (AD) or did not adhere (NA). None of the NK cell su...

journal_title：Blood

authors： Inngjerdingen M,Damaj B,Maghazachi AA

更新日期：2001-01-15 00:00:00

abstract：:The more distal enhancers of the immunoglobulin heavy-chain 3' regulatory region, hs3b and hs4, were recently demonstrated as master control elements of germline transcription and class switch recombination to most immunoglobulin constant genes. In addition, they were shown to enhance the accumulation of somatic mutat...

journal_title：Blood

authors： Morvan CL,Pinaud E,Decourt C,Cuvillier A,Cogné M

更新日期：2003-08-15 00:00:00

abstract：:Adenosine deaminase (ADA) is an enzyme in the purine catabolic pathway that has been used as an enzymatic marker of T cell lymphoblastic malignancies due to its high specific activity in thymocytes and immature T cells. We have investigated whether the level of ADA activity in lymphoid leukemic cells correlates with t...

journal_title：Blood

authors： Gan TE,Dadonna PE,Mitchell BS

更新日期：1987-05-01 00:00:00

abstract：:In severe human beta-thalassemia, the pathophysiology relates to accumulation of excess alpha-globin chains at the membrane. One hypothesis is that membrane-associated alpha-globin by virtue of it's iron or hemichromes produces oxidation of adjacent membrane proteins. The availability of a mouse model of severe beta-t...

journal_title：Blood

authors： Advani R,Rubin E,Mohandas N,Schrier SL

更新日期：1992-02-15 00:00:00

abstract：:Interleukin-8 (IL-8) belongs to a family of chemoattractant cytokines involved in chemotaxis and activation of neutrophils. As in vivo administration of IL-8 induces granulocytosis and the release of immature white blood cells into the circulation, we assessed a possible mobilizing effect of IL-8 on myeloid progenitor...

journal_title：Blood

authors： Laterveer L,Lindley IJ,Hamilton MS,Willemze R,Fibbe WE

更新日期：1995-04-15 00:00:00

abstract：:Patients aged ≥60 years with treatment-naive Hodgkin lymphoma (HL) have few treatment options and inferior survival due to treatment-related toxicities and comorbidities. This phase 2, nonrandomized, open-label study evaluated brentuximab vedotin (BV) monotherapy (results previously reported), BV plus dacarbazine (DTI...

journal_title：Blood

authors： Friedberg JW,Forero-Torres A,Bordoni RE,Cline VJM,Patel Donnelly D,Flynn PJ,Olsen G,Chen R,Fong A,Wang Y,Yasenchak CA

更新日期：2017-12-28 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-beta1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which is disulf...

journal_title：Blood

authors： Ahamed J,Burg N,Yoshinaga K,Janczak CA,Rifkin DB,Coller BS

更新日期：2008-11-01 00:00:00

abstract：:Human neutrophils exposed to chemotactic concentrations of zymosan-activated serum (ZAS) and a formylated chemotactic peptide (FMLP, 10(-7)--10(-9) M) were markedly enhanced in their ability to generate superoxide (O2-) upon stimulation with either sodium fluoride or phorbol myristate acetate (PMA). For both fluoride ...

journal_title：Blood

authors： English D,Roloff JS,Lukens JN

更新日期：1981-07-01 00:00:00

abstract：:In this issue of Blood, Bachanova et al describe how modulation of the inhibitory tumor environment may enhance natural killer (NK) cell clinical activity and produce encouraging results in the treatment of refractory acute myeloid leukemia (AML). NK cells are highly proliferative, early responders of the innate immun...

journal_title：Blood

authors： Rooney CM

更新日期：2014-06-19 00:00:00

abstract：:The serpin antithrombin III (AT III) is reported to have hemostasis-regulating and anti-inflammatory properties. To determine its ability to influence thrombin-independent leukocyte responses, the direct effects of the AT III concentrate Kybernin P and a monoclonal antibody-purified AT III on neutrophil migration were...

journal_title：Blood

authors： Dunzendorfer S,Kaneider N,Rabensteiner A,Meierhofer C,Reinisch C,Römisch J,Wiedermann CJ

更新日期：2001-02-15 00:00:00

abstract：:Tissue-type plasminogen activator (t-PA) is less active in vivo and in vitro against clots that are enriched in platelets, even at therapeutic concentrations. The release of radioactivity from 125I-fibrin-labeled clots was decreased by 47% 6 hours after the addition of t-PA 400 U/mL when formed in platelet-rich versus...

journal_title：Blood

authors： Kunitada S,FitzGerald GA,Fitzgerald DJ

更新日期：1992-03-15 00:00:00

abstract：:Lipids extracted with chloroform-methanol from red blood cell membranes of 7 PNH and 13 control subjects were used for the preparation of liposomes, which were then examined with the reactive lysis test. PNH liposomes lysed to a higher extent than control liposomes as indicated by the higher dilution of the limiting c...

journal_title：Blood

authors： Tedesco F,Kahane I,Zanella A,Giovanetti AM,Sirchia G

更新日期：1981-05-01 00:00:00

abstract：:Reconstitution of cellular immunity by 3 months after hematopoietic stem cell transplantation (HSCT) is a critical determinant of the long-term success of the transplantation. We analyzed the factors affecting recovery of cytomegalovirus (CMV)-specific CD4+ and CD8+ function at 3 months after HSCT by univariate and mu...

journal_title：Blood

authors： Hakki M,Riddell SR,Storek J,Carter RA,Stevens-Ayers T,Sudour P,White K,Corey L,Boeckh M

更新日期：2003-10-15 00:00:00

abstract：:Although the binding of endothelial cell protein C receptor (EPCR) to its ligands is well characterized at the biochemical level, it remains unclear how EPCR interaction with its ligands at the cell surface impacts its cellular trafficking. We characterized the cellular localization and trafficking of EPCR in endothel...

journal_title：Blood

authors： Nayak RC,Sen P,Ghosh S,Gopalakrishnan R,Esmon CT,Pendurthi UR,Rao LV

更新日期：2009-08-27 00:00:00

abstract：:Evidence has been provided recently that shows that high concentrations of cytokines can fulfill functions previously attributed to stromal cells, such as promote the survival of, and led to a net increase in human primitive progenitors initiating long-term cultures in vitro (LTC-IC) or engrafting NOD-SCID (nonobese d...

journal_title：Blood

authors： Bennaceur-Griscelli A,Tourino C,Izac B,Vainchenker W,Coulombel L

更新日期：1999-07-15 00:00:00

abstract：:Genetic analysis of hemochromatosis has led to the discovery of a number of genes whose mutations disrupt iron homeostasis and lead to iron overload. The introduction of molecular tests into clinical practice has provided a tool for early diagnosis of these conditions. It has become clear that hemochromatosis includes...

journal_title：Blood

authors： Camaschella C

更新日期：2005-12-01 00:00:00

abstract：:Mammalian TOR (mTOR) regulates cell growth, proliferation, and migration. Because mTOR knock-outs are embryonic lethal, we generated a viable hypomorphic mouse by neo-insertion that partially disrupts mTOR transcription and creates a potential physiologic model of mTORC1/TORC2 inhibition. Homozygous knock-in mice exhi...

journal_title：Blood

authors： Zhang S,Readinger JA,DuBois W,Janka-Junttila M,Robinson R,Pruitt M,Bliskovsky V,Wu JZ,Sakakibara K,Patel J,Parent CA,Tessarollo L,Schwartzberg PL,Mock BA

更新日期：2011-01-27 00:00:00

abstract：:During the course of multiple myeloma (MM), new monoclonal proteins of an isotype distinct from the original clone, referred to as secondary monoclonal gammopathy of undetermined significance (MGUS), have been described. We report on the frequency, characteristics, and outcome of secondary MGUS. Of the 1942 patients w...

journal_title：Blood

authors： Wadhera RK,Kyle RA,Larson DR,Dispenzieri A,Kumar S,Lazarus HM,Rajkumar SV

更新日期：2011-09-15 00:00:00

abstract：:The presence and physiologic role of cyclic GMP-dependent protein kinase (G-kinase) in human neutrophils was investigated by Western blot analysis and immunocytochemistry. Small quantities of G-kinase were found in the cytoskeletal-enriched fraction of neutrophil lysates as detected by Western blots using a polyclonal...

journal_title：Blood

authors： Pryzwansky KB,Wyatt TA,Nichols H,Lincoln TM

更新日期：1990-08-01 00:00:00

abstract：:Cytotoxic T lymphocytes kill target cells via the polarized secretion of cytotoxic granules at the immune synapse. The lytic granules are initially recruited around the polarized microtubule-organizing center. In a dynein-dependent transport process, the granules move along microtubules toward the microtubule-organizi...

journal_title：Blood

authors： Kurowska M,Goudin N,Nehme NT,Court M,Garin J,Fischer A,de Saint Basile G,Ménasché G

更新日期：2012-04-26 00:00:00

abstract：:In this issue of Blood, Tebas et al report antiviral effects in a clinical trial of multiple infusions of lentiviral vector–modified autologous CD4T lymphocytes in 17 HIV-infected patients aviremic on antiretroviral therapy (ART). ...

journal_title：Blood

authors： Jacobson JM

更新日期：2013-02-28 00:00:00