Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro.

abstract：:The development of erythroid colonies of fetal liver hemopoietic cell origin in adult irradiated polycythemic mice was studied. It was found that orchidectomy sharply reduced the number of erythroid colonies developed in the spleen of these polycythemic male recipients. Estrogen injection to the orchidectomized polycy...

journal_title：Blood

authors： Bleiberg I,Perah G

更新日期：1975-04-01 00:00:00

abstract：:Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we found that the A77D, V162del, and G490D mutations inhibited FPN activity, but that other disease-associated FPN variants retained full iron export capability. The peptide h...

journal_title：Blood

authors： Drakesmith H,Schimanski LM,Ormerod E,Merryweather-Clarke AT,Viprakasit V,Edwards JP,Sweetland E,Bastin JM,Cowley D,Chinthammitr Y,Robson KJ,Townsend AR

更新日期：2005-08-01 00:00:00

abstract：:During the past decade it was recognized that homeobox gene families such as the clustered Hox genes play pivotal roles both in normal and malignant hematopoiesis. More recently, similar roles have also become apparent for members of the ParaHox gene cluster, evolutionarily closely related to the Hox gene cluster. Thi...

journal_title：Blood

authors： Rawat VP,Humphries RK,Buske C

更新日期：2012-07-19 00:00:00

abstract：:Human natural killer (NK) cells express Toll-like receptor 9 (TLR9) transcript and, upon exposure to microbial CpG oligodeoxynucleotide (ODN), release cytokines and kill target cells. Here we show that NK cell treatment with CpG ODN results in down-modulation of KIR3DL2 inhibitory receptor from the cell surface and in...

journal_title：Blood

authors： Sivori S,Falco M,Carlomagno S,Romeo E,Soldani C,Bensussan A,Viola A,Moretta L,Moretta A

更新日期：2010-09-09 00:00:00

abstract：:Pure red cell aplasia (PRCA) is a rare complication in patients with chronic lymphocytic leukemia (CLL). It is characterized by reticulocytopenia and by an absence of red cell precursors in the bone marrow. Unlike autoimmune hemolytic anemia, which is characterized by an increased number of reticulocytes, positive Coo...

journal_title：Blood

authors： Ghazal H

更新日期：2002-02-01 00:00:00

abstract：:Cellular interleukin 6 (IL-6) is an important growth factor for Kaposi sarcoma- associated herpesvirus (KSHV)-associated neoplasms, which include human immunodeficiency virus (HIV)-related and -unrelated cases of Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Increased ...

journal_title：Blood

authors： An J,Lichtenstein AK,Brent G,Rettig MB

更新日期：2002-01-15 00:00:00

abstract：:Although sickle cell disease (SCD) has a variable clinical course, many patients develop end-organ complications that are associated with significant morbidity and early mortality. Myeloablative allogeneic HSCT (allo-HSCT) is curative but has been historically performed only in children younger than 16 years of age. M...

journal_title：Blood

authors： Hsieh MM,Fitzhugh CD,Tisdale JF

更新日期：2011-08-04 00:00:00

abstract：:Targeted irradiation of the bone marrow with radiolabeled monoclonal antibodies (radioimmunotherapy) represents a novel therapeutic approach with both myeloablative and antileukemic potential. In an open-label, single-center pilot study, 30 pediatric and adolescent patients undergoing hematopoietic cell transplantatio...

journal_title：Blood

authors： Schulz AS,Glatting G,Hoenig M,Schuetz C,Gatz SA,Grewendorf S,Sparber-Sauer M,Muche R,Blumstein N,Kropshofer G,Suttorp M,Bunjes D,Debatin KM,Reske SN,Friedrich W

更新日期：2011-04-28 00:00:00

abstract：:The t(8;21) RUNX1-ETO translocation is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). In RUNX1-ETO(+) patient samples, differing classes of activating c-KIT receptor tyrosine kinase mutations have been observed. The most common (12%-48%) involves mutations, such as D816V, which occ...

journal_title：Blood

authors： Nick HJ,Kim HG,Chang CW,Harris KW,Reddy V,Klug CA

更新日期：2012-02-09 00:00:00

abstract：:Complete interleukin-12/interleukin-23 receptor beta1 (IL-12Rbeta1) deficiency is the most frequent known genetic etiology of the syndrome of Mendelian susceptibility to mycobacterial disease. The patients described to date lack IL-12Rbeta1 at the surface of their natural killer (NK) and T cells due to IL12RB1 mutatio...

journal_title：Blood

authors： Fieschi C,Bosticardo M,de Beaucoudrey L,Boisson-Dupuis S,Feinberg J,Santos OF,Bustamante J,Levy J,Candotti F,Casanova JL

更新日期：2004-10-01 00:00:00

abstract：:Hematopoietic transplantation is the preferred treatment for many patients with hematologic malignancies. Some patients may develop invasive fungal diseases (IFDs) during initial chemotherapy, which need to be considered when assessing patients for transplantation and treatment posttransplantation. Given the associate...

journal_title：Blood

authors： Puerta-Alcalde P,Champlin RE,Kontoyiannis DP

更新日期：2020-12-10 00:00:00

abstract：:To further investigate the erythroid nature of the two human erythroleukemia cell lines, K562 and HEL-60, and to define the ontogeny of pyruvate kinase (PK) isozymes (R, M2) in developing human erythroid cells, we have studied the isozymic alterations, if any, during differentiation of these cell lines in vitro and no...

journal_title：Blood

authors： Max-Audit I,Testa U,Kechemir D,Titeux M,Vainchenker W,Rosa R

更新日期：1984-10-01 00:00:00

abstract：:We investigated the molecular genetic and biosynthetic basis of Bernard-Soulier syndrome in a severely affected white woman. Flow cytometric analysis showed a severe deficiency of glycoprotein (GP) Ib, GP IX, and GP V on the surface of her platelets. Similarly, GP Ib alpha was undetectable by immunoblot analysis of pl...

journal_title：Blood

authors： Afshar-Kharghan V,López JA

更新日期：1997-10-01 00:00:00

abstract：:It is known from nutritional studies that vitamin A is an important factor for normal hematopoiesis, though it has been difficult to define its precise role. The vitamin A-deficient (VAD) quail embryo provides an effective ligand "knockout" model for investigating the function of retinoids during development. The VAD ...

journal_title：Blood

authors： Ghatpande S,Ghatpande A,Sher J,Zile MH,Evans T

更新日期：2002-04-01 00:00:00

abstract：:Purified recombinant human heavy-chain (acidic) ferritin (rHF) was assessed in vivo in mice for effects on the proliferation (percentage of cells in S-phase) and absolute numbers of granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and multipotential (CFU-GEMM) progenitor cells in the femur and spleen and on the nuc...

journal_title：Blood

authors： Broxmeyer HE,Williams DE,Geissler K,Hangoc G,Cooper S,Bicknell DC,Levi S,Arosio P

更新日期：1989-01-01 00:00:00

abstract：:We have previously shown that intravenously injected peripheral blood (PB) or bone marrow (BM) cells from newly diagnosed chronic myeloid leukemia (CML) patients can engraft the BM of sublethally irradiated severe combined immunodeficient (SCID) mice. We now report engraftment results for chronic phase CML cells in no...

journal_title：Blood

authors： Wang JC,Lapidot T,Cashman JD,Doedens M,Addy L,Sutherland DR,Nayar R,Laraya P,Minden M,Keating A,Eaves AC,Eaves CJ,Dick JE

更新日期：1998-04-01 00:00:00

abstract：:We have investigated the interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis. Acidic FGF (aFGF) stimulated the proliferation of murine megakaryocytes and human erythroleukemia (HEL) cells in a concentration-dependent manner. The concentrations of aFGF required to elicit half-maximum and maximum eff...

journal_title：Blood

authors： Bikfalvi A,Han ZC,Fuhrmann G

更新日期：1992-10-15 00:00:00

abstract：:Posttranscriptional mechanisms are now widely acknowledged to play a central role in orchestrating gene-regulatory networks in hematopoietic cell growth, differentiation, and tumorigenesis. Although much attention has focused on microRNAs as regulators of mRNA stability/translation, recent data have highlighted the ro...

journal_title：Blood

authors： Baou M,Norton JD,Murphy JJ

更新日期：2011-11-24 00:00:00

abstract：:Bcl-2 protein expression has been associated with poor prognosis in patients with noncutaneous diffuse large B-cell lymphomas. In primary cutaneous large B-cell lymphomas, the location on the leg, the round-cell morphology defined as the predominance of centroblasts and immunoblasts over large centrocytes, and multipl...

journal_title：Blood

authors： Grange F,Petrella T,Beylot-Barry M,Joly P,D'Incan M,Delaunay M,Machet L,Avril MF,Dalac S,Bernard P,Carlotti A,Esteve E,Vergier B,Dechelotte P,Cassagnau E,Courville P,Saiag P,Laroche L,Bagot M,Wechsler J

更新日期：2004-05-15 00:00:00

abstract：:The CD14-dependent and -independent dendritic cell (DC) pathways are instituted simultaneously when CD34(+) progenitor cells are treated with granulocyte-macrophage colony-stimulating factor (GM-CSF)/tumor necrosis factor (TNF) +/- stem cell factor (SCF) (GTS). If TNF activity is neutralized within 48 hours of cytokin...

journal_title：Blood

authors： Santiago-Schwarz F,McCarthy M,Tucci J,Carsons SE

更新日期：1998-08-01 00:00:00

abstract：:Asthma is associated with airway remodeling. Evidence of platelet recruitment to the lungs of asthmatics after allergen exposure suggests platelets participate in various aspects of asthma; although their importance is unknown in the context of airway remodeling, their involvement in atherosclerosis is established. St...

journal_title：Blood

authors： Pitchford SC,Riffo-Vasquez Y,Sousa A,Momi S,Gresele P,Spina D,Page CP

更新日期：2004-01-15 00:00:00

abstract：:The first hematopoietic and endothelial progenitors are derived from a common embryonic precursor termed the hemangioblast. The genetic cascades that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are largely unknown. In general, much of embryonic development is coordinately r...

journal_title：Blood

authors： Guo Y,Chan R,Ramsey H,Li W,Xie X,Shelley WC,Martinez-Barbera JP,Bort B,Zaret K,Yoder M,Hromas R

更新日期：2003-10-01 00:00:00

abstract：:Malignant cells are capable of influencing the microenvironment in a manner that facilitates tumor cell survival. Bidirectional crosstalk between chronic lymphocytic leukemic (CLL) cells and marrow-derived mesenchymal stromal cells (MSCs) activates both cell types. In this study, we observed that the conditioned mediu...

journal_title：Blood

authors： Ding W,Knox TR,Tschumper RC,Wu W,Schwager SM,Boysen JC,Jelinek DF,Kay NE

更新日期：2010-10-21 00:00:00

abstract：:Families with 3 different syndromes characterized by autosomal dominant inheritance of low platelet count and giant platelets were studied. Fechtner syndrome is an autosomal-dominant variant of Alport syndrome manifested by nephritis, sensorineural hearing loss, and cataract formation in addition to macrothrombocytope...

journal_title：Blood

authors： Toren A,Rozenfeld-Granot G,Rocca B,Epstein CJ,Amariglio N,Laghi F,Landolfi R,Brok-Simoni F,Carlsson LE,Rechavi G,Greinacher A

更新日期：2000-11-15 00:00:00

abstract：:We studied the impact of driver mutations of JAK2, CALR, (calreticulin gene) or MPL on clinical course, leukemic transformation, and survival of patients with primary myelofibrosis (PMF). Of the 617 subjects studied, 399 (64.7%) carried JAK2 (V617F), 140 (22.7%) had a CALR exon 9 indel, 25 (4.0%) carried an MPL (W515)...

journal_title：Blood

authors： Rumi E,Pietra D,Pascutto C,Guglielmelli P,Martínez-Trillos A,Casetti I,Colomer D,Pieri L,Pratcorona M,Rotunno G,Sant'Antonio E,Bellini M,Cavalloni C,Mannarelli C,Milanesi C,Boveri E,Ferretti V,Astori C,Rosti V,Cerva

更新日期：2014-08-14 00:00:00

abstract：:The erythroid Krüppel-like factor (EKLF) is a key regulatory protein in globin gene expression. This zinc finger transcription factor is required for expression of the adult beta globin gene, and it has been suggested that it plays an important role in the developmental switch from fetal gamma to adult beta globin gen...

journal_title：Blood

authors： Anderson KP,Crable SC,Lingrel JB

更新日期：2000-03-01 00:00:00

abstract：:In severe human beta-thalassemia, the pathophysiology relates to accumulation of excess alpha-globin chains at the membrane. One hypothesis is that membrane-associated alpha-globin by virtue of it's iron or hemichromes produces oxidation of adjacent membrane proteins. The availability of a mouse model of severe beta-t...

journal_title：Blood

authors： Advani R,Rubin E,Mohandas N,Schrier SL

更新日期：1992-02-15 00:00:00

abstract：:We demonstrated that Flk-1(+) cells derived from mouse embryonic stem (ES) cells can differentiate into both endothelial cells (ECs) and mural cells (MCs) to suffice as vascular progenitor cells (VPCs). In the present study, we investigated the importance of the stage of ES cell differentiation on effective participat...

journal_title：Blood

authors： Yurugi-Kobayashi T,Itoh H,Yamashita J,Yamahara K,Hirai H,Kobayashi T,Ogawa M,Nishikawa S,Nishikawa S,Nakao K

更新日期：2003-04-01 00:00:00

abstract：:Murine autoreactive anti-Smith (Sm) B cells are negatively regulated by anergy and developmental arrest, but are also positively selected into the marginal zone (MZ) and B-1 B-cell populations. Despite positive selection, anti-Sm production occurs only in autoimmune-prone mice. To investigate autoreactive B-cell activ...

journal_title：Blood

authors： Qian Y,Conway KL,Lu X,Seitz HM,Matsushima GK,Clarke SH

更新日期：2006-08-01 00:00:00

abstract：:Although infants with acute lymphoblastic leukemia (ALL) and a germline MLL gene have a better prognosis than comparable infants with a rearranged MLL gene, their optimal therapy is controversial. In 2 consecutive studies, conducted between 1996 and 2002, we treated 22 cases of infant ALL with germline MLL using chemo...

journal_title：Blood

authors： Nagayama J,Tomizawa D,Koh K,Nagatoshi Y,Hotta N,Kishimoto T,Takahashi Y,Kuno T,Sugita K,Sato T,Kato K,Ogawa A,Nakahata T,Mizutani S,Horibe K,Ishii E,Japan Infant Leukemia Study Group.

更新日期：2006-06-15 00:00:00