Abstract:
:The development of erythroid colonies of fetal liver hemopoietic cell origin in adult irradiated polycythemic mice was studied. It was found that orchidectomy sharply reduced the number of erythroid colonies developed in the spleen of these polycythemic male recipients. Estrogen injection to the orchidectomized polycythemic recipient did not further decrease the number of erythroid colonies developed. It is concluded that the development of erythroid colonies of fetal liver origin in polycythemic male recipients is maintained mainly by testicular testosterone. The complete suppression of these colonies in female recipients does not seem to be a result of inhibition by estrogen.
journal_name
Bloodjournal_title
Bloodauthors
Bleiberg I,Perah Gsubject
Has Abstractpub_date
1975-04-01 00:00:00pages
511-5issue
4eissn
0006-4971issn
1528-0020journal_volume
45pub_type
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