Hepcidin and iron regulation, 10 years later.


:Under evolutionary pressure to counter the toxicity of iron and to maintain adequate iron supply for hemoglobin synthesis and essential metabolic functions, humans and other vertebrates have effective mechanisms to conserve iron and to regulate its concentration, storage, and distribution in tissues. The iron-regulatory hormone hepcidin, first described 10 years ago, and its receptor and iron channel ferroportin control the dietary absorption, storage, and tissue distribution of iron. Hepcidin causes ferroportin internalization and degradation, thereby decreasing iron transfer into blood plasma from the duodenum, from macrophages involved in recycling senescent erythrocytes, and from iron-storing hepatocytes. Hepcidin is feedback regulated by iron concentrations in plasma and the liver and by erythropoietic demand for iron. Genetic malfunctions affecting the hepcidin-ferroportin axis are a main cause of iron overload disorders but can also cause iron-restricted anemias. Modulation of hepcidin and ferroportin expression during infection and inflammation couples iron metabolism to host defense and decreases iron availability to invading pathogens. This response also restricts the iron supply to erythropoietic precursors and may cause or contribute to the anemia associated with infections and inflammatory disorders.






Ganz T




Has Abstract


2011-04-28 00:00:00
















  • Telomere length correlates with histopathogenesis according to the germinal center in mature B-cell lymphoproliferative disorders.

    abstract::In this study we investigated telomere restriction fragment (TRF) length in a panel of mature B-cell lymphoproliferative disorders (MBCLDs) and correlated this parameter with histology and histopathogenesis in relation to the germinal center (GC). We assessed 123 MBCLD samples containing 80% or more tumor cells. TRF l...


    pub_type: 杂志文章


    authors: Ladetto M,Compagno M,Ricca I,Pagano M,Rocci A,Astolfi M,Drandi D,di Celle PF,Dell'Aquila M,Mantoan B,Vallet S,Pagliano G,De Marco F,Francese R,Santo L,Cuttica A,Marinone C,Boccadoro M,Tarella C

    更新日期:2004-06-15 00:00:00

  • Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance.

    abstract::Although receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) signaling has been shown to prolong the survival of mature dendritic cells (DCs), the association of RANKL pathway with Fas-mediated apoptosis is obscure. Here, we found that bone marrow-derived DCs (BMDCs) from the Fas-deficient strain MRL/lpr m...


    pub_type: 杂志文章


    authors: Izawa T,Ishimaru N,Moriyama K,Kohashi M,Arakaki R,Hayashi Y

    更新日期:2007-07-01 00:00:00

  • Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT Trial.

    abstract::We report a transfusion trial of platelets photochemically treated for pathogen inactivation using the synthetic psoralen amotosalen HCl. Patients with thrombocytopenia were randomly assigned to receive either photochemically treated (PCT) or conventional (control) platelets for up to 28 days. The primary end point wa...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: McCullough J,Vesole DH,Benjamin RJ,Slichter SJ,Pineda A,Snyder E,Stadtmauer EA,Lopez-Plaza I,Coutre S,Strauss RG,Goodnough LT,Fridey JL,Raife T,Cable R,Murphy S,Howard F 4th,Davis K,Lin JS,Metzel P,Corash L,Koutso

    更新日期:2004-09-01 00:00:00

  • The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function.

    abstract::Four patients with lymphoproliferative disease of granular lymphocytes (LDGL) coexpressing CD3 and the natural killer (NK)-related "p58" receptor for HLA-C alleles were studied. These CD3+p58+ LDGLs have been detected among a series of 44 CD3+ LDGLs analyzed. Two patients with LDGL (GI and BA) expressed only the p58 m...


    pub_type: 杂志文章


    authors: Cambiaggi A,Orengo AM,Meazza R,Sforzini S,Tazzari PL,Lauria F,Raspadori D,Zambello R,Semenzato G,Moretta L,Ferrini S

    更新日期:1996-03-15 00:00:00

  • The multifaceted role of fibrinogen in tissue injury and inflammation.

    abstract::The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity. Perturbations in either system can prompt primary pathological end points of hemorrhage or thrombosis with vessel occlusion. However, fibrin(ogen) and proteases controlling its deposition and clearance, including (pro)thro...


    pub_type: 杂志文章,评审


    authors: Luyendyk JP,Schoenecker JG,Flick MJ

    更新日期:2019-02-07 00:00:00

  • Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production.

    abstract::Nitric oxide (NO) is a potent radical produced by nitric oxide synthase (NOS) and has pleiotrophic activities in health and disease. As mast cells (MCs) play a central role in both homeostasis and pathology, we investigated NOS expression and NO production in human MC populations. Endothelial NOS (eNOS) was ubiquitous...


    pub_type: 杂志文章


    authors: Gilchrist M,McCauley SD,Befus AD

    更新日期:2004-07-15 00:00:00

  • Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction.

    abstract::BCL3 encodes a protein with close homology to IkappaB proteins and interacts with p50 NF-kappaB homodimers. However, the regulation and transcriptional activity of BCL3 remain ill-defined. We observed here that interleukin-9 (IL-9) and IL-4, but not IL-2 or IL-3, transcriptionally upregulated BCL3 expression in T cell...


    pub_type: 杂志文章


    authors: Richard M,Louahed J,Demoulin JB,Renauld JC

    更新日期:1999-06-15 00:00:00

  • Identification of BCR/ABL-negative primitive hematopoietic progenitor cells within chronic myeloid leukemia marrow.

    abstract::Chronic myeloid leukemia (CML) is a malignant disorder of the hematopoietic stem cell. It has been shown that normal stem cells coexist with malignant stem cells in the bone marrow of patients with chronic-phase CML. To characterize the primitive hematopoietic progenitor cells within CML marrow, CD34+DR- and CD34+DR+ ...


    pub_type: 杂志文章


    authors: Leemhuis T,Leibowitz D,Cox G,Silver R,Srour EF,Tricot G,Hoffman R

    更新日期:1993-02-01 00:00:00

  • CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation.

    abstract::Acute graft-versus-host disease (aGVHD) remains a serious complication following allogeneic stem-cell transplantation (SCT), and is mediated by infiltration of alloreactive donor T cells into recipient tissue. Chemokines and their receptors play a central role in controlling the recruitment of T cells into discrete ti...


    pub_type: 杂志文章


    authors: Piper KP,Horlock C,Curnow SJ,Arrazi J,Nicholls S,Mahendra P,Craddock C,Moss PA

    更新日期:2007-12-01 00:00:00

  • Cell surface expression of c-kit receptors by childhood acute myeloid leukemia blasts is not of prognostic value: a report from the Childrens Cancer Group.

    abstract::The prognostic significance of c-kit receptor expression on leukemic blast cells was determined in 122 children with acute myeloid leukemia (AML) entered onto Childrens Cancer Group protocol 213. Clinical and laboratory characteristics as well as outcome were analyzed according to the percentage of blast cells express...


    pub_type: 杂志文章,多中心研究


    authors: Smith FO,Broudy VC,Zsebo KM,Lampkin BC,Buckley CV,Buckley JD,Opie T,Woods WG,Hammond GD,Bernstein ID

    更新日期:1994-08-01 00:00:00

  • Antibodies to human T-lymphotropic virus type III (HTLV-III) in saliva of acquired immunodeficiency syndrome (AIDS) patients and in persons at risk for AIDS.

    abstract::Whole saliva samples collected from available people at risk in Boston for infection with human T-lymphotropic virus type III (HTLV-III/LAV), from late 1984 through early 1985, were analyzed for the presence of antibodies to viral proteins. Fourteen of 20 (70%) acquired immunodeficiency syndrome (AIDS) patients and 14...


    pub_type: 杂志文章


    authors: Archibald DW,Zon L,Groopman JE,McLane MF,Essex M

    更新日期:1986-03-01 00:00:00

  • Shear-dependent changes in the three-dimensional structure of human von Willebrand factor.

    abstract::The three-dimensional tertiary structure of human von Willebrand Factor (vWF) on a hydrophobic surface under aqueous conditions and different shear stress regimes was studied by atomic force microscopy (AFM). vWF was imaged by AFM at molecular level resolution under negligible shear stress, under a local applied shear...


    pub_type: 杂志文章


    authors: Siedlecki CA,Lestini BJ,Kottke-Marchant KK,Eppell SJ,Wilson DL,Marchant RE

    更新日期:1996-10-15 00:00:00

  • STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival.

    abstract::The combined blockade of the IL-6R/STAT3 and the MAPK signaling pathways has been shown to inhibit bone marrow microenvironment (BMM)-mediated survival of multiple myeloma (MM) cells. Here, we identify the molecular chaperones heat shock proteins (Hsp) 90alpha and beta as target genes of both pathways. The siRNA-media...


    pub_type: 杂志文章


    authors: Chatterjee M,Jain S,Stühmer T,Andrulis M,Ungethüm U,Kuban RJ,Lorentz H,Bommert K,Topp M,Krämer D,Müller-Hermelink HK,Einsele H,Greiner A,Bargou RC

    更新日期:2007-01-15 00:00:00

  • PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis.

    abstract::The heterodimeric transcription factor RUNX1/PEBP2-beta (also known as AML1/CBF-beta) is essential for definitive hematopoiesis. Here, we show that interaction with PEBP2-beta leads to the phosphorylation of RUNX1, which in turn induces p300 phosphorylation. This is mediated by homeodomain interacting kinase 2 (HIPK2)...


    pub_type: 杂志文章


    authors: Wee HJ,Voon DC,Bae SC,Ito Y

    更新日期:2008-11-01 00:00:00

  • Survivin regulates hematopoietic progenitor cell proliferation through p21WAF1/Cip1-dependent and -independent pathways.

    abstract::The cyclin-dependent kinase inhibitor p21WAF1/Cip1 and Survivin enhance granulocyte macrophage colony-forming unit (CFU-GM) cell cycle and proliferation and have been implicated as antiapoptotic proteins. We investigated the relationships between p21 and Survivin in primary CFU-GM and c-kit+, lineage-negative (Lin-) c...


    pub_type: 杂志文章


    authors: Fukuda S,Mantel CR,Pelus LM

    更新日期:2004-01-01 00:00:00

  • PIP2-dependent regulation of Munc13-4 endocytic recycling: impact on the cytolytic secretory pathway.

    abstract::Cytotoxic lymphocytes clear infected and transformed cells by releasing the content of lytic granules at cytolytic synapses, and the ability of cytolytic effectors to kill in an iterative manner has been documented previously. Although bidirectional trafficking of cytolytic machinery components along the endosomal pat...


    pub_type: 杂志文章


    authors: Capuano C,Paolini R,Molfetta R,Frati L,Santoni A,Galandrini R

    更新日期:2012-03-08 00:00:00

  • Multiple Rh messenger RNA isoforms are produced by alternative splicing.

    abstract::Three Rh-related cDNAs have been isolated from a human bone marrow cDNA library and by polymerase chain reaction (PCR) amplification of human bone marrow and erythroblast mRNAs. They potentially encode a family of Rh protein isoforms that exhibit several unexpected structural properties as compared with the Rh polypep...


    pub_type: 杂志文章


    authors: Le Van Kim C,Chérif-Zahar B,Raynal V,Mouro I,Lopez M,Cartron JP,Colin Y

    更新日期:1992-08-15 00:00:00

  • Munc18b/STXBP2 is required for platelet secretion.

    abstract::Platelets are vital for hemostasis because they release their granule contents in response to vascular damage. Platelet exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), whose interactions are governed by regulators, eg, Sec/Munc18 proteins. These proteins chape...


    pub_type: 杂志文章


    authors: Al Hawas R,Ren Q,Ye S,Karim ZA,Filipovich AH,Whiteheart SW

    更新日期:2012-09-20 00:00:00

  • Bone microstructural changes revealed by high-resolution peripheral quantitative computed tomography imaging and elevated DKK1 and MIP-1α levels in patients with MGUS.

    abstract::Recent population-based studies demonstrate an increased fracture risk with monoclonal gammopathy of undetermined significance (MGUS). The etiology of this increased risk remains unclear, however, because areal bone mineral density (aBMD) measurements by dual-energy x-ray absorptiometry cannot assess bone microstructu...


    pub_type: 杂志文章


    authors: Ng AC,Khosla S,Charatcharoenwitthaya N,Kumar SK,Achenbach SJ,Holets MF,McCready LK,Melton LJ 3rd,Kyle RA,Rajkumar SV,Drake MT

    更新日期:2011-12-15 00:00:00

  • On the maturation order of AML cells: a distinction on the basis of self-renewal properties and immunologic phenotypes.

    abstract::To investigate the heterogeneous cellular structure of human acute myeloid leukemia (AML), subpopulations of cells were distinguished by two combined criteria: proliferation and differentiation. Purified blast cells were fractionated from blood or bone marrow of patients with newly diagnosed AML and colonies and clust...


    pub_type: 杂志文章


    authors: Wouters R,Löwenberg B

    更新日期:1984-03-01 00:00:00

  • Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.

    abstract::Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restrict...


    pub_type: 杂志文章


    authors: Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E

    更新日期:2010-07-15 00:00:00

  • 3A1 (CD7) expression precedes T beta gene rearrangements in precursor T (lymphoblastic) neoplasms.

    abstract::The phenotypes of early stages of T cell maturation are reflected by precursor T (lymphoblastic) neoplasms. In the present study, a series of such neoplasms was analyzed to reveal the developmental association of the expression of stage-related cell surface markers and T cell receptor gene rearrangement. Rearrangement...


    pub_type: 杂志文章


    authors: Pittaluga S,Raffeld M,Lipford EH,Cossman J

    更新日期:1986-07-01 00:00:00

  • Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors.

    abstract::Thymus atrophy is the most common immunopathology in humans, and its occurrence is hastened by several factors that coalesce in patients receiving chemotherapy and most of all in recipients of hematopoietic cell transplantation. We have shown previously that posthematopoietic cell transplantation thymic function was i...


    pub_type: 杂志文章


    authors: Heinonen KM,Vanegas JR,Brochu S,Shan J,Vainio SJ,Perreault C

    更新日期:2011-11-10 00:00:00

  • Bim regulates the survival and suppressive capability of CD8+ FOXP3+ regulatory T cells during murine GVHD.

    abstract::CD8+ Foxp3+ T cells (Tregs) are a potent regulatory population whose functional and ontological similarities to CD4+ Fox3+ T cells have not been well delineated. Using an experimental model of graft-versus-host disease (GVHD), we observed that CD8+ Tregs were significantly less potent than CD4+ Tregs for the suppressi...


    pub_type: 杂志文章


    authors: Agle K,Vincent BG,Piper C,Belle L,Zhou V,Shlomchik W,Serody JS,Drobyski WR

    更新日期:2018-07-26 00:00:00

  • Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils.

    abstract::Neutrophil gelatinase-associated lipocalin (NGAL) is a novel 25-kD protein of human neutrophils, that is in part covalently complexed with neutrophil gelatinase. However, both NGAL and gelatinase exist mainly in forms not associated with each other. An explanation for this phenomenon might be that the unassociated pro...


    pub_type: 杂志文章


    authors: Kjeldsen L,Bainton DF,Sengeløv H,Borregaard N

    更新日期:1994-02-01 00:00:00

  • Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma.

    abstract::Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis) and direct apoptosis with crosslinking. These mechanisms may also target nonplasma cells tha...


    pub_type: 杂志文章,多中心研究


    authors: Krejcik J,Casneuf T,Nijhof IS,Verbist B,Bald J,Plesner T,Syed K,Liu K,van de Donk NW,Weiss BM,Ahmadi T,Lokhorst HM,Mutis T,Sasser AK

    更新日期:2016-07-21 00:00:00

  • Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.

    abstract::BR3, which is expressed on all mature B cells, is a specific receptor for the B-cell survival and maturation factor BAFF (B-cell-activating factor belonging to the tumor necrosis factor [TNF] family). In order to investigate the consequences of targeting BR3 in murine models and to assess the potential of BR3 antibodi...


    pub_type: 杂志文章


    authors: Lee CV,Hymowitz SG,Wallweber HJ,Gordon NC,Billeci KL,Tsai SP,Compaan DM,Yin J,Gong Q,Kelley RF,DeForge LE,Martin F,Starovasnik MA,Fuh G

    更新日期:2006-11-01 00:00:00

  • Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

    abstract::Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called proplatelets, into bone marrow sinusoids. Proplatelet formation requires a profound reorganization of the MK actin and tubulin cytoskelet...


    pub_type: 杂志文章


    authors: Pleines I,Dütting S,Cherpokova D,Eckly A,Meyer I,Morowski M,Krohne G,Schulze H,Gachet C,Debili N,Brakebusch C,Nieswandt B

    更新日期:2013-10-31 00:00:00

  • Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases.

    abstract::The signals that mediate T-cell infiltration during T-cell autoimmune diseases are poorly understood. The chemokine CCL21 (originally isolated by us and others as Exodus-2/6Ckine/SLC/TCA4) is highly potent and highly specific for stimulating T-cell migration. However, it is thought to be expressed only in secondary ly...


    pub_type: 杂志文章


    authors: Christopherson KW 2nd,Hood AF,Travers JB,Ramsey H,Hromas RA

    更新日期:2003-02-01 00:00:00

  • Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity.

    abstract::MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were associated with platelet reactivity by genome-wide profiling using platelet RNA from 19 healthy subjects. We found that human platelets expr...


    pub_type: 杂志文章


    authors: Nagalla S,Shaw C,Kong X,Kondkar AA,Edelstein LC,Ma L,Chen J,McKnight GS,López JA,Yang L,Jin Y,Bray MS,Leal SM,Dong JF,Bray PF

    更新日期:2011-05-12 00:00:00