当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: Correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity.

Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: Correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity.

Abstract：

:Regulatory molecules produced by stromal cells are often membrane bound until cleaved by matrix metalloproteinases (MMPs); cleavage can either activate or inactivate regulatory functions. We report here that marrow stromal cells induce the expression of MMP-9 in monocytes. Induction was contact independent and could be reproduced with recombinant MCP-1/CCL2, whereas IL-6, M-CSF, G-CSF, GM-CSF, IL-8/CXCL8, SDF-1/CXCL12, and MGSA/CXCL1 did not have this effect. Stroma-induced levels of MMP-9 in the monocyte population from healthy donors were relatively consistent, whereas induced levels varied significantly (P < .001) in the CD14+ population from 27 patients with myelodysplastic syndrome (MDS). In patients with a clonal chromosomal marker, the level of inducible MMP-9 expression in the monocyte population was inversely correlated with the percentage of marker-positive cells (n = 11, P = .01), suggesting that the ability to induce MMP-9 may be compromised in clonally derived monocytes. The inducible levels of MMP-9 were also inversely correlated with marrow cellularity observed in biopsies from MDS patients (P < .001). We conclude that monocytes can express MMP-9 in response to stromal factors and that this response may be significantly decreased in MDS-derived monocytes.

journal_name

Blood

journal_title

Blood

authors

Iwata M,Pillai M,Ramakrishnan A,Hackman RC,Deeg HJ,Opdenakker G,Torok-Storb B

doi

10.1182/blood-2006-05-020289

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

85-92

issue

1

eissn

0006-4971

issn

1528-0020

pii

blood-2006-05-020289

journal_volume

109

pub_type

杂志文章

相关文献

BLOOD文献大全
  • A rapid assay for evaluation of iron-chelating agents in rats.

    abstract：:The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hep...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Pippard MJ,Johnson DK,Finch CA

    更新日期：1981-10-01 00:00:00

  • Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

    abstract：:Histone deacetylase (HDAC) inhibitors (HDACis) have demonstrated activity in hematological and solid malignancies. Vorinostat, romidepsin, belinostat, and panobinostat are Food and Drug Administration-approved for hematological malignancies and inhibit class II and/or class I HDACs, including HDAC1, 2, 3, and 6. We co...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2015-03-632984

    authors： Matthews GM,Mehdipour P,Cluse LA,Falkenberg KJ,Wang E,Roth M,Santoro F,Vidacs E,Stanley K,House CM,Rusche JR,Vakoc CR,Zuber J,Minucci S,Johnstone RW

    更新日期：2015-11-19 00:00:00

  • Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait.

    abstract：:Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of thalassemia carriage o...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-10-606491

    authors： Jones E,Pasricha SR,Allen A,Evans P,Fisher CA,Wray K,Premawardhena A,Bandara D,Perera A,Webster C,Sturges P,Olivieri NF,St Pierre T,Armitage AE,Porter JB,Weatherall DJ,Drakesmith H

    更新日期：2015-01-29 00:00:00

  • Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels.

    abstract：:The t(11;14)(q13;q32) is the most common translocation in multiple myeloma (MM), resulting in up-regulation of cyclin D1. We used a segregation fluorescence in situ hybridization (FISH) assay to detect t(11;14) breakpoints in primary MM cases and real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to qu...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-11-3837

    authors： Specht K,Haralambieva E,Bink K,Kremer M,Mandl-Weber S,Koch I,Tomer R,Hofler H,Schuuring E,Kluin PM,Fend F,Quintanilla-Martinez L

    更新日期：2004-08-15 00:00:00

  • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents.

    abstract：:Numerous studies have suggested that iron (Fe) chelators such as desferrioxamine (DFO) may be useful antitumor agents (Blatt and Stitely, Cancer Res 47:1749, 1987; Becton and Bryles, Cancer Res 48:7189, 1988). Recent work with several analogues of the lipophilic Fe chelator, pyridoxal isonicotinoyl hydrazone (PIH), in...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Richardson DR,Tran EH,Ponka P

    更新日期：1995-12-01 00:00:00

  • Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients.

    abstract：:Fifty-eight acute promyelocytic leukemia (APL) patients (11 newly diagnosed and 47 relapsed) were studied for arsenic trioxide (As2O3) treatment. Clinical complete remission (CR) was obtained in 8 of 11 (72.7%) newly diagnosed cases. However, As2O3 treatment resulted in hepatic toxicity in 7 cases including 2 deaths, ...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：

    authors： Niu C,Yan H,Yu T,Sun HP,Liu JX,Li XS,Wu W,Zhang FQ,Chen Y,Zhou L,Li JM,Zeng XY,Yang RR,Yuan MM,Ren MY,Gu FY,Cao Q,Gu BW,Su XY,Chen GQ,Xiong SM,Zhang TD,Waxman S,Wang ZY,Chen Z,Hu J,Shen ZX,Chen SJ

    更新日期：1999-11-15 00:00:00

  • Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

    abstract：:We recently identified aberrant cytoplasmic expression of nucleophosmin (NPM) as the immunohistochemical marker of a large subgroup of acute myeloid leukemia (AML) (about one-third of adult AML) that is characterized by normal karyotype and mutations occurring at the exon-12 of the NPM gene. In this paper, we have elu...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-11-4745

    authors： Falini B,Bolli N,Shan J,Martelli MP,Liso A,Pucciarini A,Bigerna B,Pasqualucci L,Mannucci R,Rosati R,Gorello P,Diverio D,Roti G,Tiacci E,Cazzaniga G,Biondi A,Schnittger S,Haferlach T,Hiddemann W,Martelli MF,Gu W,

    更新日期：2006-06-01 00:00:00

  • Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

    abstract：:To address the mechanism by which the human globin genes are activated during erythropoiesis, we have used a tiled microarray to analyze the pattern of transcription factor binding and associated histone modifications across the telomeric region of human chromosome 16 in primary erythroid and nonerythroid cells. This ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-06-097964

    authors： De Gobbi M,Anguita E,Hughes J,Sloane-Stanley JA,Sharpe JA,Koch CM,Dunham I,Gibbons RJ,Wood WG,Higgs DR

    更新日期：2007-12-15 00:00:00

  • Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia.

    abstract：:The promyelocytic leukemia (PML) tumor suppressor of acute promyelocytic leukemia (APL) is essential for a number of proapoptotic and growth-suppressive pathways as well as for the activity of differentiating agents such as retinoic acid (RA). In human APL, the dose of PML is reduced to heterozygosity given that one a...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-07-2200

    authors： Gurrieri C,Nafa K,Merghoub T,Bernardi R,Capodieci P,Biondi A,Nimer S,Douer D,Cordon-Cardo C,Gallagher R,Pandolfi PP

    更新日期：2004-03-15 00:00:00

  • Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector.

    abstract：:Gene therapy for hemophilia A requires efficient delivery of the factor VIII gene and sustained protein expression at circulating levels of at least 1% to 2% of normal. Adeno-associated viral type 2 (AAV2) vectors have a number of advantages over other viral vectors, including an excellent safety profile and persisten...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-01-0292

    authors： Scallan CD,Lillicrap D,Jiang H,Qian X,Patarroyo-White SL,Parker AE,Liu T,Vargas J,Nagy D,Powell SK,Wright JF,Turner PV,Tinlin SJ,Webster SE,McClelland A,Couto LB

    更新日期：2003-09-15 00:00:00

  • Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies.

    abstract：:We aimed to determine the prognostic impact of monosomal karyotype (MK) in acute myeloid leukemia (AML) in the context of the current World Health Organization (WHO) classification and to evaluate the outcome of MK(+) patients after allogeneic HSCT. Of 1058 patients with abnormal cytogenetics, 319 (30%) were MK MK(+)....

    journal_title：Blood

    pub_type： 杂志文章,多中心研究

    doi：10.1182/blood-2011-07-367508

    authors： Kayser S,Zucknick M,Döhner K,Krauter J,Köhne CH,Horst HA,Held G,von Lilienfeld-Toal M,Wilhelm S,Rummel M,Germing U,Götze K,Nachbaur D,Schlegelberger B,Göhring G,Späth D,Morlok C,Teleanu V,Ganser A,Döhner H,Schlenk

    更新日期：2012-01-12 00:00:00

  • In vitro analysis of the homing properties of human lymphocytes: developmental regulation of functional receptors for high endothelial venules.

    abstract：:Circulating lymphocytes leave the blood by binding to specialized high endothelial cells lining postcapillary venules in lymphoid organs or sites of chronic inflammations, migrating through the vessel wall into the surrounding tissue. The capacity of lymphocytes to recognize and bind to high endothelial venules (HEVs)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Jalkanen ST,Butcher EC

    更新日期：1985-09-01 00:00:00

  • Granulocyte modulation of endotoxin-stimulated colony-stimulating activity (CSA) production.

    abstract：:Incubation of human macrophages with endotoxin resulted in significantly enhanced colony-stimulating activity (CSA) production by these cells. Preincubation of endotoxin with mature granulocytes abolished this stimulatory effect. The stimulatory effect of endotoxin on macrophage CSA production was not abolished, howev...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Mahmood T,Robinson WA

    更新日期：1978-05-01 00:00:00

  • Macrophage colony-stimulating factor (CSF-1) gene expression in human T-lymphocyte clones.

    abstract：:Macrophage colony stimulating factor (CSF-1) is one of several cytokines that control the differentiation, survival, and proliferation of monocytes and macrophages. A set of 11 human T-cell clones, chosen for their phenotypic diversity, were tested for their ability to express CSF-1 mRNA. After 5 hours of stimulation ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Hallet MM,Praloran V,Vié H,Peyrat MA,Wong G,Witek-Giannotti J,Soulillou JP,Moreau JF

    更新日期：1991-02-15 00:00:00

  • Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor-deficient mice.

    abstract：:Multiple lines of evidence indicate that thrombopoietin (TPO) substantially impacts the number of hematopoietic stem cells and progenitors of all myeloid lineages. Nevertheless, tpo knock-out mice (T(-)) display thrombocytopenia only; blood erythroid and neutrophil levels are normal despite 60% to 85% reductions in st...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v99.10.3573

    authors： Kaushansky K,Fox N,Lin NL,Liles WC

    更新日期：2002-05-15 00:00:00

  • A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase.

    abstract：:Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical m...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Weiss SJ,Turk J,Needleman P

    更新日期：1979-06-01 00:00:00

  • Long-term health-related quality of life evaluated more than 20 years after hematopoietic stem cell transplantation for thalassemia.

    abstract：:The principal aim of our study was to investigate whether patients transplanted more than 20 years ago for β-thalassemia major had a different health-related quality of life (HRQoL) compared with the general population. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Functional Assessment o...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2013-05-502658

    authors： La Nasa G,Caocci G,Efficace F,Dessì C,Vacca A,Piras E,Sanna M,Marcias M,Littera R,Carcassi C,Lucarelli G

    更新日期：2013-09-26 00:00:00

  • Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4.

    abstract：:Toll-like receptor 4 (TLR4) initiates both myeloid differentiation factor 88 (MyD88)-dependent and Toll/interleukin (IL)-1R domain-containing adapter, inducing interferon (IFN)-beta-dependent signaling, leading to production of proinflammatory mediators and type I interferon (IFN) to eliminate pathogens. However, unco...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-01-066027

    authors： Wang Y,Chen T,Han C,He D,Liu H,An H,Cai Z,Cao X

    更新日期：2007-08-01 00:00:00

  • Clinical relevance of point mutations in the cytoplasmic domain of the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia.

    abstract：:Recently, point mutations in the gene of the granulocyte colony-stimulating factor (G-CSF) receptor have been reported in two patients with severe congenital neutropenia who developed acute myeloid leukemia (AML). We investigated the frequency of these specific G-CSF receptor mutations in patients with congenital neut...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Tidow N,Pilz C,Teichmann B,Müller-Brechlin A,Germeshausen M,Kasper B,Rauprich P,Sykora KW,Welte K

    更新日期：1997-04-01 00:00:00

  • Normal cycling patterns of hematopoietic stem cell subpopulations: an assay using long-term in vivo BrdU infusion.

    abstract：:It was found in a long-term bromodeoxyuridine (BrdU) infusion study that two or more different subpopulations of bone marrow stem cells exist in mice. One of these subpopulations appears to be noncycling and forms approximately 10% of eight-day CFU-S. Another one, a subpopulation of slowly cycling bone marrow cells, i...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Pietrzyk ME,Priestley GV,Wolf NS

    更新日期：1985-12-01 00:00:00

  • Interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis and demonstration of FGF receptor expression in megakaryocytes and megakaryocytic-like cells.

    abstract：:We have investigated the interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis. Acidic FGF (aFGF) stimulated the proliferation of murine megakaryocytes and human erythroleukemia (HEL) cells in a concentration-dependent manner. The concentrations of aFGF required to elicit half-maximum and maximum eff...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bikfalvi A,Han ZC,Fuhrmann G

    更新日期：1992-10-15 00:00:00

  • Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients.

    abstract：:The extent and rapidity with which T cells are regenerated from graft-derived precursor cells directly influences the incidence of infection and the T-cell-based graft-versus-tumor effect. Measurement of T-cell receptor excision circles (TRECs) in peripheral blood is a means of quantifying recent thymic T-cell product...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-04-1405

    authors： Chen X,Barfield R,Benaim E,Leung W,Knowles J,Lawrence D,Otto M,Shurtleff SA,Neale GA,Behm FG,Turner V,Handgretinger R

    更新日期：2005-01-15 00:00:00

  • L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling.

    abstract：:Pneumonia induced by Gram-negative bacteria is a common and serious disease associated with high morbidity and mortality. Elimination of bacterial pathogens relies on the recruitment and functions of neutrophils. The adhesion molecule L-selectin has recently been implicated in integrin activation in neutrophils (insid...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2019000685

    authors： Cappenberg A,Margraf A,Thomas K,Bardel B,McCreedy DA,Van Marck V,Mellmann A,Lowell CA,Zarbock A

    更新日期：2019-10-24 00:00:00

  • Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

    abstract：:The clinical course of chronic lymphocytic leukemia (CLL) differs significantly between patients with mutated (M-CLL) and unmutated (U-CLL) immunoglobulin (Ig) variable heavy-chain (V(H)) genes, implying a role for B-cell receptor (BCR) signaling in the pathogenesis of this disease. We have now investigated activation...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-07-2669

    authors： Petlickovski A,Laurenti L,Li X,Marietti S,Chiusolo P,Sica S,Leone G,Efremov DG

    更新日期：2005-06-15 00:00:00

  • Interleukin-15 (IL-15) induces NF-kappaB activation and IL-8 production in human neutrophils.

    abstract：:Interleukin-2 (IL-2) and IL-15 exert similar biological actions, which largely reflect the fact that their receptors share common beta and gamma subunits; in contrast, distinct subunits are required for high-affinity binding of either cytokine to a heterotrimeric receptor complex. Human neutrophils are known to expres...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： McDonald PP,Russo MP,Ferrini S,Cassatella MA

    更新日期：1998-12-15 00:00:00

  • Defective delivery of iron to the developing red cell of the Belgrade laboratory rat.

    abstract：:Erythroid cell iron and transferrin uptake and release was studied in the anemia of the Belgrade laboratory rat (gene symbol, b), an autosomal recessive trait characterized by hypochromia and hyperferrinemia. When reticulocyte-rich red cells were incubated in vitro with doubly (59Fe, 125I) labeled transferrin, b/b cel...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Edwards JA,Sullivan AL,Hoke JE

    更新日期：1980-04-01 00:00:00

  • CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53.

    abstract：:Intravenous infusion of autologous chronic lymphocytic leukemia (CLL) cells transduced with an adenovirus encoding CD40-ligand (CD154) caused rapid reductions in leukemia-cell counts and lymphnode size. We hypothesized that CD40-ligation via CD154 sensitized CLL cells to death-receptor-mediated apoptosis. We found tha...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-04-017749

    authors： Dicker F,Kater AP,Prada CE,Fukuda T,Castro JE,Sun G,Wang JY,Kipps TJ

    更新日期：2006-11-15 00:00:00

  • PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis.

    abstract：:The heterodimeric transcription factor RUNX1/PEBP2-beta (also known as AML1/CBF-beta) is essential for definitive hematopoiesis. Here, we show that interaction with PEBP2-beta leads to the phosphorylation of RUNX1, which in turn induces p300 phosphorylation. This is mediated by homeodomain interacting kinase 2 (HIPK2)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-01-134122

    authors： Wee HJ,Voon DC,Bae SC,Ito Y

    更新日期：2008-11-01 00:00:00

  • Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation.

    abstract：:Idiopathic pneumonia syndrome (IPS) is a relatively common, frequently fatal clinical entity, characterized by noninfectious acute lung inflammation following allogeneic stem cell transplantation (SCT), the mechanisms of which are unclear. In this study, we demonstrate that immune suppression with cyclosporin after SC...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-07-590232

    authors： Varelias A,Gartlan KH,Kreijveld E,Olver SD,Lor M,Kuns RD,Lineburg KE,Teal BE,Raffelt NC,Cheong M,Alexander KA,Koyama M,Markey KA,Sturgeon E,Leach J,Reddy P,Kennedy GA,Yanik GA,Blazar BR,Tey SK,Clouston AD,MacDon

    更新日期：2015-04-09 00:00:00

  • Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy.

    abstract：:Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy. We examined the expression of the flavoproteins and oxidative stress-promoting enzymes, NADPH oxidases (Nox's), in MKs because of their known role in promoting the cell cycle. Although the expression of Nox isoforms varies between cell type...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-12-195883

    authors： McCrann DJ,Eliades A,Makitalo M,Matsuno K,Ravid K

    更新日期：2009-08-06 00:00:00