Defective delivery of iron to the developing red cell of the Belgrade laboratory rat.

abstract：:The combination of imatinib with chemotherapy has been recently reported as very promising in patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). During 2004 and 2005, 45 patients with newly diagnosed Ph+ ALL were treated in the Group for Research on Adult Acute Lymphoblastic Leuke...

journal_title：Blood

authors： de Labarthe A,Rousselot P,Huguet-Rigal F,Delabesse E,Witz F,Maury S,Réa D,Cayuela JM,Vekemans MC,Reman O,Buzyn A,Pigneux A,Escoffre M,Chalandon Y,MacIntyre E,Lhéritier V,Vernant JP,Thomas X,Ifrah N,Dombret H,Group

更新日期：2007-02-15 00:00:00

abstract：:Adherent cell layers and their associated extracellular matrices form when human marrow is incubated in cultures containing hydrocortisone and horse serum. These stromal layers contain cells positive for alkaline phosphatase; secrete collagens types I and III and fibronectin, bind the anti-actin monoclonal antibodies ...

journal_title：Blood

authors： Liesveld JL,Abboud CN,Duerst RE,Ryan DH,Brennan JK,Lichtman MA

更新日期：1989-05-15 00:00:00

abstract：:Notch signaling pathway regulates many different events of embryonic and adult development; among them, Notch plays an essential role in the onset of hematopoietic stem cells and influences multiple maturation steps of developing lymphoid and myeloid cells. Deregulation of Notch signaling determines several human diso...

journal_title：Blood

authors： Nwabo Kamdje AH,Krampera M

更新日期：2011-12-15 00:00:00

abstract：:Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self-renews, proliferates, and differentiates to give rise to a myeloproliferative disease. Although tyrosine kinase inhibitors (TKIs) that target...

journal_title：Blood

authors： Holyoake TL,Vetrie D

更新日期：2017-03-23 00:00:00

abstract：:Infusions of large numbers (> 10(8)/kg) of donor leukocytes can induce remissions in patients with chronic myeloid leukemia (CML) who relapse after marrow transplantation. We wanted to determine if substantially lower numbers of donor leukocytes could induce remissions and, if so, whether this would reduce the 90% inc...

journal_title：Blood

authors： Mackinnon S,Papadopoulos EB,Carabasi MH,Reich L,Collins NH,Boulad F,Castro-Malaspina H,Childs BH,Gillio AP,Kernan NA

更新日期：1995-08-15 00:00:00

abstract：:In order to determine if mutant hemoglobins can be identified by relatively simple methods, a Working Group of the ICSH Expert Panel on Abnormal Hemoglobins and Thalassemia analyzed 17 hemolysates containing 14 different mutant hemoglobins by four electrophoretic methods: (1) cellulose acetate in alkaline buffers, (2)...

journal_title：Blood

authors：

更新日期：1978-11-01 00:00:00

abstract：:The stage of progenitor maturation and factors that determine the fate and clonal acquisition of human natural killer (NK) cell receptors during development are unknown. To study human NK cell receptor ontogeny, umbilical cord blood CD34(+)/Lin(-)/CD38(-) cells were cultured with a murine fetal liver line (AFT024) and...

journal_title：Blood

authors： Miller JS,McCullar V

更新日期：2001-08-01 00:00:00

abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...

journal_title：Blood

authors： Chen Y,Schlegel PG,Tran N,Thompson D,Zehnder JL,Chao NJ

更新日期：1997-02-15 00:00:00

abstract：:The Aalpha-fibrinogen Thr312Ala polymorphism, which occurs in a region involved in factor XIII (FXIII)-dependent cross-linking processes, is associated with poststroke mortality in subjects with atrial fibrillation, suggesting an influence either on intraatrial clot formation or embolization. We have determined the as...

journal_title：Blood

authors： Carter AM,Catto AJ,Kohler HP,Ariëns RA,Stickland MH,Grant PJ

更新日期：2000-08-01 00:00:00

abstract：:T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MT...

journal_title：Blood

authors： Madani A,Choukroun V,Soulier J,Cacheux V,Claisse JF,Valensi F,Daliphard S,Cazin B,Levy V,Leblond V,Daniel MT,Sigaux F,Stern MH

更新日期：1996-03-01 00:00:00

abstract：:The Y chromosome encodes male-specific minor histocompatibility (H-Y) antigens that stimulate T- and B-lymphocyte responses after sex-mismatched allogeneic hematopoietic cell transplantation (HCT). A CD8(+) cytotoxic T lymphocyte (CTL) clone that recognizes a novel HLA-B*2705-restricted H-Y antigen encoded by the DDX3...

journal_title：Blood

authors： Rosinski KV,Fujii N,Mito JK,Koo KK,Xuereb SM,Sala-Torra O,Gibbs JS,Radich JP,Akatsuka Y,Van den Eynde BJ,Riddell SR,Warren EH

更新日期：2008-05-01 00:00:00

abstract：:Antiphospholipid antibodies including anticardiolipin antibodies, lupus anticoagulants, and anti-beta(2) glycoprotein-1-specific antibodies may identify patients at elevated risk of first or recurrent venous or arterial thromboembolism. Traditionally, published case series supplemented by anecdotal experience have for...

journal_title：Blood

authors： Garcia DA,Khamashta MA,Crowther MA

更新日期：2007-11-01 00:00:00

abstract：:Surface receptors specific for either the C4b (CR1) or C3d (CR2) component of complement were examined on the neoplastic cells from 30 cases of non-Hodgkin's lymphoma of B-cell origin and on cells derived from 9 normal lymphoid tissues. Lymphocyte suspensions from non-neoplastic peripheral blood, tonsils, and lymph no...

journal_title：Blood

authors： Cossman J,Jaffe ES

更新日期：1981-07-01 00:00:00

abstract：:Telomere erosion may be counteracted by telomerase. Here we explored telomere length (TL) and telomerase activity (TA) in primary cutaneous T-cell lymphoma (CTCL) by using quantitative polymerase chain reaction and interphase quantitative fluorescence in situ hybridization assays. Samples from patients with Sézary syn...

journal_title：Blood

authors： Chevret E,Andrique L,Prochazkova-Carlotti M,Ferrer J,Cappellen D,Laharanne E,Idrissi Y,Boettiger A,Sahraoui W,Ruiz F,Pham-Ledard A,Vergier B,Belloc F,Dubus P,Beylot-Barry M,Merlio JP

更新日期：2014-03-20 00:00:00

abstract：:Exposed subendothelial collagen acts as a substrate for platelet adhesion and thrombus formation after vascular injury. Synthetic collagen-derived triple-helical peptides, designated collagen-related peptide (CRP), GFOGER, and VWF-III, can specifically engage the platelet collagen receptors, glycoprotein VI and integr...

journal_title：Blood

authors： Pugh N,Simpson AM,Smethurst PA,de Groot PG,Raynal N,Farndale RW

更新日期：2010-06-17 00:00:00

abstract：:Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been invaluable for identification of new molecular targets. Because of low sample sizes and hetero...

journal_title：Blood

authors： Baaten CCFMJ,Meacham S,de Witt SM,Feijge MAH,Adams DJ,Akkerman JN,Cosemans JMEM,Grassi L,Jupe S,Kostadima M,Mattheij NJA,Prins MH,Ramirez-Solis R,Soehnlein O,Swieringa F,Weber C,White JK,Ouwehand WH,Heemskerk JWM

更新日期：2018-12-13 00:00:00

abstract：:We describe the cloning and characterization of Siglec-H, a novel murine CD33-related siglec-like molecule with 2 immunoglobulin domains. Unlike other CD33-related siglecs, Siglec-H lacks tyrosine-based signaling motifs in its cytoplasmic tail. Although Siglec-H has the typical structural features required for sialic ...

journal_title：Blood

authors： Zhang J,Raper A,Sugita N,Hingorani R,Salio M,Palmowski MJ,Cerundolo V,Crocker PR

更新日期：2006-05-01 00:00:00

abstract：:We have designed two subfamilies of lipophilic iron (III) chelators previously termed reversed siderophores (RSFs). The agents display physicochemical properties that favor extraction of iron beyond membrane barriers of Plasmodium falciparum-infected red blood cells. We studied the in vitro antimalarial potency of RSF...

journal_title：Blood

authors： Lytton SD,Mester B,Dayan I,Glickstein H,Libman J,Shanzer A,Cabantchik ZI

更新日期：1993-01-01 00:00:00

abstract：:One hundred thirty-eight patients with hairy cell leukemia were randomized to receive either a dose of 2.0 megaunits (MU)/m2 or a 10-fold lower dose of 0.2 MU/m2 of a highly purified natural alpha-interferon, administered daily for 28 days followed by a three times a week schedule. Ninety-seven of these patients had p...

journal_title：Blood

authors： Smalley RV,Anderson SA,Tuttle RL,Connors J,Thurmond LM,Huang A,Castle K,Magers C,Whisnant JK

更新日期：1991-12-15 00:00:00

abstract：:Interaction of platelets with collagen under conditions of blood flow is a multi-step process with tethering via glycoprotein IbIXV (GPIbIXV) over von Willebrand factor, adhesion by direct interaction with the integrin GPIaIIa, and signaling via GPVI. GPVI can be specifically agonized by cross-linked collagen-related ...

journal_title：Blood

authors： Joutsi-Korhonen L,Smethurst PA,Rankin A,Gray E,IJsseldijk M,Onley CM,Watkins NA,Williamson LM,Goodall AH,de Groot PG,Farndale RW,Ouwehand WH

更新日期：2003-06-01 00:00:00

abstract：:All-trans-retinoic acid (ATRA) downregulates the expression of two cellular procoagulants, tissue factor (TF) and cancer procoagulant (CP), in human promyelocytic leukemia cells. To evaluate whether or not changes of the procoagulant activities (PCAs) may share mechanisms with the ATRA-induced cyto-differentiation pro...

journal_title：Blood

authors： Falanga A,Consonni R,Marchetti M,Locatelli G,Garattini E,Passerini CG,Gordon SG,Barbui T

更新日期：1998-07-01 00:00:00

abstract：:Erythropoiesis is a robust process of cellular expansion and maturation occurring in murine bone marrow and spleen. We previously determined that sublethal irradiation, unlike bleeding or hemolysis, depletes almost all marrow and splenic erythroblasts but leaves peripheral erythrocytes intact. To better understand the...

journal_title：Blood

authors： Peslak SA,Wenger J,Bemis JC,Kingsley PD,Koniski AD,McGrath KE,Palis J

更新日期：2012-09-20 00:00:00

abstract：:The 5-lipoxygenase (5-LO) pathway in human CD34(+) hematopoietic progenitor cells, which were induced to differentiate into dendritic cells (DCs) by cytokines in vitro and in DCs of lymphoid tissues in situ, was examined. Extracts prepared from HPCs contained low levels of 5-LO or 5-LO-activating protein. Granulocyte-...

journal_title：Blood

authors： Spanbroek R,Hildner M,Steinhilber D,Fusenig N,Yoneda K,Rådmark O,Samuelsson B,Habenicht AJ

更新日期：2000-12-01 00:00:00

abstract：:CD30 is a promising target for antibody-based immunotherapy of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma. To overcome the limitations from currently available murine anti-CD30 monoclonal antibodies (mAbs), a new fully human anti-CD30 antibody was generated. Binding properties were evaluated by recombina...

journal_title：Blood

authors： Borchmann P,Treml JF,Hansen H,Gottstein C,Schnell R,Staak O,Zhang HF,Davis T,Keler T,Diehl V,Graziano RF,Engert A

更新日期：2003-11-15 00:00:00

abstract：:Concentrations of plasma fibrinopeptide A (FPA) were measured by radioimmunoassay in 50 patients with venous thromboembolism or disseminated intravascular coagulation or both. A consistent discrepancy was observed in values obtained with two anti-FPA antisera. Analysis of extracts from plasma of these patients by high...

journal_title：Blood

authors： Leeksma OC,Meijer-Huizinga F,Stoepman-van Dalen EA,van Ginkel CJ,van Aken WG,van Mourik JA

更新日期：1986-05-01 00:00:00

abstract：:Electron microscopic (EM) studies were performed to clarify the interactions of membrane proteins in the red blood cell membrane structure in situ of a homozygous patient with total deficiency of protein 4.1 who carried a point mutation of the downstream translation initiation codon (AUG --> AGG) of the protein 4.1 ge...

journal_title：Blood

authors： Yawata A,Kanzaki A,Gilsanz F,Delaunay J,Yawata Y

更新日期：1997-09-15 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive syndrome featuring diverse symptoms including progressive bone marrow failure and early occurrence of acute myeloid leukemia. Nine genetic subtypes have been described for FA (A, B, C, D1, D2, E, F, G, and L), all of which have been connected to distinct disease genes, exc...

journal_title：Blood

authors： Levitus M,Rooimans MA,Steltenpool J,Cool NF,Oostra AB,Mathew CG,Hoatlin ME,Waisfisz Q,Arwert F,de Winter JP,Joenje H

更新日期：2004-04-01 00:00:00

abstract：:Using quantitative fluorescence in situ hybridization and flow cytometry, the telomere length of telomere repeat sequences after stem cell transplantation (SCT) were measured. The study included the telomeres of peripheral blood monocytes that should reflect the length of telomeres in stem cells and the telomeres of T...

journal_title：Blood

authors： Rufer N,Brümmendorf TH,Chapuis B,Helg C,Lansdorp PM,Roosnek E

更新日期：2001-01-15 00:00:00

abstract：:The number of cells transplanted and their capacity to induce graft-versus-host reactivity (GvHR) are two factors that are suspected to influence the engraftment of allogeneic bone marrow. We have investigated their impact on graft rejection rates in busulfan-treated LEW rats. In a series of experiments, we varied (1)...

journal_title：Blood

authors： Uharek L,Gassmann W,Glass B,Steinmann J,Loeffler H,Mueller-Ruchholtz W

更新日期：1992-03-15 00:00:00

abstract：:High-dose melphalan followed by stem cell transplantation (HDM-SCT) has become the treatment of choice for patients with immunoglobulin light chain amyloidosis (AL). Unfortunately, treatment mortality can be excessive in certain subpopulations. We have noted that patients who gained more than 2% body weight during mob...

journal_title：Blood

authors： Leung N,Leung TR,Cha SS,Dispenzieri A,Lacy MQ,Gertz MA

更新日期：2005-11-15 00:00:00