Shiga-like toxin purges human lymphoma from bone marrow of severe combined immunodeficient mice.

abstract：:Inactivation of the tumor suppressor p53 is essential for unrestrained growth of cancers. However, only 11% of hematological malignancies have mutant p53. Mechanisms that cause wild-type p53 dysfunction and promote leukemia are inadequately deciphered. The stem cell protein Asrij/OCIAD1 is misexpressed in several huma...

journal_title：Blood

authors： Sinha S,Dwivedi TR,Yengkhom R,Bheemsetty VA,Abe T,Kiyonari H,VijayRaghavan K,Inamdar MS

更新日期：2019-05-30 00:00:00

abstract：:Migration to lymph nodes and secretion of cytokines are critical functions of mature dendritic cells (DCs); however, these 2 functions are not necessarily linked. This is the first report showing that quantitative differences in identical signaling pathways determine DC migration and cytokine secretion. Using differen...

journal_title：Blood

authors： Luft T,Maraskovsky E,Schnurr M,Knebel K,Kirsch M,Görner M,Skoda R,Ho AD,Nawroth P,Bierhaus A

更新日期：2004-08-15 00:00:00

abstract：:Chemoresistance is a major problem in the treatment of patients with multiple myeloma (MM). Because of the central role of the nuclear transcription factors nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) in chemoresistance, cell survival, and proliferation, we investig...

journal_title：Blood

authors： Bharti AC,Shishodia S,Reuben JM,Weber D,Alexanian R,Raj-Vadhan S,Estrov Z,Talpaz M,Aggarwal BB

更新日期：2004-04-15 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) is etiologically linked to Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease. Vascular endothelial growth factor-A (VEGF-A) is one of the essential factors required in KSHV pathogenesis, mainly due to its abil...

journal_title：Blood

authors： Akula SM,Ford PW,Whitman AG,Hamden KE,Bryan BA,Cook PP,McCubrey JA

更新日期：2005-06-01 00:00:00

abstract：:HIV-1-associated thrombocytopenia (HIV-1-ITP) is a common complication of HIV-1 infection, frequently caused by increased peripheral platelet destruction mediated by antiplatelet antibodies (Abs) and/or platelet-bound immune complexes. Little is known about the specificity of the antiplatelet Abs at a molecular level....

journal_title：Blood

authors： Koefoed K,Ditzel HJ

更新日期：2004-12-15 00:00:00

abstract：:The initiation of primary hemostasis is mediated by interaction of the platelet glycoprotein Ib (GPIb) surface receptor and its arterial subendothelial von Willebrand factor (vWF) ligand. The intracellular signaling immediately following GPIb receptor occupancy connecting the adhesive event to platelet activation and ...

journal_title：Blood

authors： Calverley DC,Kavanagh TJ,Roth GJ

更新日期：1998-02-15 00:00:00

abstract：:We analyzed factors having an impact on response to treatment and survival in 78 consecutive patients with chronic myeloid leukemia (CML) in blastic transformation (BT) referred to the Hammersmith Hospital from January 1995 to December 2000. BT was defined as the presence of at least 30% blasts in blood or marrow or e...

journal_title：Blood

authors： Wadhwa J,Szydlo RM,Apperley JF,Chase A,Bua M,Marin D,Olavarria E,Kanfer E,Goldman JM

更新日期：2002-04-01 00:00:00

abstract：:Chronic graft-v-host disease (chronic GVHD) is a frequent cause of late morbidity and death after bone marrow transplantation (BMT). The actuarial survival after onset of chronic GVHD in 85 patients was 42% (95%Cl = 29%, 54%) at 10 years. Baseline characteristics present at the onset of chronic GVHD (before therapy) i...

journal_title：Blood

authors： Wingard JR,Piantadosi S,Vogelsang GB,Farmer ER,Jabs DA,Levin LS,Beschorner WE,Cahill RA,Miller DF,Harrison D

更新日期：1989-09-01 00:00:00

abstract：:Because interleukin-10 (IL-10) is a potent differentiation factor of human B cells into mature plasma cells, we investigated its effect on human malignant plasma cells. IL-10 did not induce any differentiation and increase in Ig synthesis in four human IL-6-dependent malignant plasma cell lines. However, it stimulated...

journal_title：Blood

authors： Lu ZY,Zhang XG,Rodriguez C,Wijdenes J,Gu ZJ,Morel-Fournier B,Harousseau JL,Bataille R,Rossi JF,Klein B

更新日期：1995-05-01 00:00:00

abstract：:Deletion of TP53 gene, under routine assessment by fluorescence in situ hybridization analysis, connects with the worst prognosis in chronic lymphocytic leukemia (CLL). The presence of isolated TP53 mutation (without deletion) is associated with reduced survival in CLL patients. It is unclear how these abnormalities a...

journal_title：Blood

authors： Malcikova J,Smardova J,Rocnova L,Tichy B,Kuglik P,Vranova V,Cejkova S,Svitakova M,Skuhrova Francova H,Brychtova Y,Doubek M,Brejcha M,Klabusay M,Mayer J,Pospisilova S,Trbusek M

更新日期：2009-12-17 00:00:00

abstract：:Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from macrophages. Mutations affecting hepcidin regulators or the hepcidin gene itself cause hemochromatosis, a common genetic disorder. Hepcidin is produced mainly b...

journal_title：Blood

authors： Zumerle S,Mathieu JR,Delga S,Heinis M,Viatte L,Vaulont S,Peyssonnaux C

更新日期：2014-06-05 00:00:00

abstract：:The regulatory function of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) on granulocyte production in vivo was evaluated in an autologous bone marrow transplantation model using rhesus monkeys. Monkeys were exposed to 9.0 Gy total body irradiation and then transplanted with 5.0 x 10(7) ...

journal_title：Blood

authors： Monroy RL,Skelly RR,MacVittie TJ,Davis TA,Sauber JJ,Clark SC,Donahue RE

更新日期：1987-11-01 00:00:00

abstract：:Dickkopf-1 (DKK1), a soluble inhibitor of Wnt signaling secreted by multiple myeloma (MM) cells contributes to osteolytic bone disease by inhibiting the differentiation of osteoblasts. In this study, we tested the effect of anti-DKK1 therapy on bone metabolism and tumor growth in a SCID-rab system. SCID-rab mice were ...

journal_title：Blood

authors： Yaccoby S,Ling W,Zhan F,Walker R,Barlogie B,Shaughnessy JD Jr

更新日期：2007-03-01 00:00:00

abstract：:LIRs are immunoglobulinlike receptors that have activating and inhibitory functions in leukocytes. Here we report the identification of the first LIR family member, LIR9, expressed as a membrane-bound receptor and as a secreted molecule. We identified 4 different forms of LIR9, 2 of which encode transmembrane molecule...

journal_title：Blood

authors： Borges L,Kubin M,Kuhlman T

更新日期：2003-02-15 00:00:00

abstract：:Nijmegen breakage syndrome 1 (NBS1) is a component of the MRE11 complex, which is a sensor of DNA double-strand breaks and plays a crucial role in the DNA damage response. Because activated macrophages produce large amounts of reactive oxygen species (ROS) that can cause DNA lesions, we examined the role of NBS1 in ma...

journal_title：Blood

authors： Pereira-Lopes S,Tur J,Calatayud-Subias JA,Lloberas J,Stracker TH,Celada A

更新日期：2015-11-26 00:00:00

abstract：:To know the role and initiation mechanism of the interaction of glycoprotein (GP) Ib with surface-immobilized von Willebrand factor (vWF), we examined the effect of shear stress levels on platelet binding to vWF-coated plates using a cone-and-plate type viscometer capable of loading various levels of shear stress. The...

journal_title：Blood

authors： Tsuji S,Sugimoto M,Kuwahara M,Nishio K,Takahashi Y,Fujimura Y,Ikeda Y,Yoshioka A

更新日期：1996-11-15 00:00:00

abstract：:Immune thrombocytopenias are usually associated with normal or increased numbers of megakaryocytes in the marrow. Therefore, the mechanism(s) responsible for the destruction of circulating platelets may not affect megakaryocytes in the same way. One of the possibilities which could account for the differential effect ...

journal_title：Blood

authors： Stahl CP,Zucker-Franklin D,McDonald TP

更新日期：1986-02-01 00:00:00

abstract：:The Graffi murine leukemia virus induces a large spectrum of leukemias in mice and thus provides a good model to compare the transcriptome of all types of leukemias. We analyzed the gene expression profiles of both T and B leukemias induced by the virus with DNA microarrays. Given that we considered that a 4-fold chan...

journal_title：Blood

authors： Charfi C,Voisin V,Levros LC Jr,Edouard E,Rassart E

更新日期：2011-02-10 00:00:00

abstract：:The glycoprotein (GP) IIb-IIIa complex was isolated from human platelet membranes by immunoaffinity chromatography using a monoclonal antibody specific for GP IIb-IIIa. GP IIb and IIIa were further separated in the presence of sodium dodecyl sulfate (SDS) by gel filtration high-performance liquid chromatography (HPLC)...

journal_title：Blood

authors： Hiraiwa A,Matsukage A,Shiku H,Takahashi T,Naito K,Yamada K

更新日期：1987-02-01 00:00:00

abstract：:Granulocytic colonies grown in culture from marrow and peripheral blood from five patients with Ph1-positive CML and heterozygous at the G-6-PD locus were analyzed for G-6-PD in order to identify CFU-C that do not arise from the CML clone. The patients had both B and A enzymes in normal tissues, but their CML clones t...

journal_title：Blood

authors： Singer JW,Fialkow PJ,Steinmann L,Najfeld V,Stein SJ,Robinson WA

更新日期：1979-02-01 00:00:00

abstract：:The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter contains a consensus sequence for the polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor, which consists of alpha and beta subunits. There are at least two genes, alpha A and alpha B, encoding the alpha subunit. alpha B is th...

journal_title：Blood

authors： Takahashi A,Satake M,Yamaguchi-Iwai Y,Bae SC,Lu J,Maruyama M,Zhang YW,Oka H,Arai N,Arai K

更新日期：1995-07-15 00:00:00

abstract：:The etiopathologic basis of painful crisis in sickle cell anemia is largely unknown, and no objective criteria for its diagnosis and follow-up exist at present. We have studied 11 patients through 14 painful crises and observed a significant decrease of the densest fraction of red cells in 12 of the 14 crises as deter...

journal_title：Blood

authors： Fabry ME,Benjamin L,Lawrence C,Nagel RL

更新日期：1984-08-01 00:00:00

abstract：:Immune-mediated platelet destruction is most frequently caused by allo- or autoantibodies via Fcγ receptor-dependent phagocytosis. Disease severity can be predicted neither by antibody isotype nor by titer, indicating that other factors play a role. Here we show that the acute phase protein C-reactive protein (CRP), a...

journal_title：Blood

authors： Kapur R,Heitink-Pollé KM,Porcelijn L,Bentlage AE,Bruin MC,Visser R,Roos D,Schasfoort RB,de Haas M,van der Schoot CE,Vidarsson G

更新日期：2015-03-12 00:00:00

abstract：:Activation of human normal serum with tetanus/antitetanus immune complexes (TAT-IC) resulted in increased binding of 125I-labeled interleukin-1 beta (IL-1 beta) to serum factors, as opposed to untreated serum. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) followed by autoradiography showed label...

journal_title：Blood

authors： Borth W,Urbanski A,Prohaska R,Susanj M,Luger TA

更新日期：1990-06-15 00:00:00

abstract：:In a prospective trial in 284 children with B-lineage acute lymphoblastic leukemia (ALL), we assessed the clinical utility of real-time quantitative polymerase chain reaction analysis of antigen receptor gene rearrangements for detection of minimal residual disease (MRD) to identify children at high risk of relapse. A...

journal_title：Blood

authors： Zhou J,Goldwasser MA,Li A,Dahlberg SE,Neuberg D,Wang H,Dalton V,McBride KD,Sallan SE,Silverman LB,Gribben JG,Dana-Farber Cancer Institute ALL Consortium.

更新日期：2007-09-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) induces osteoclast formation from monocyte/macrophage lineage cells via various transcription factors, including the Mi transcription factor (Mitf). Here, we show that inhibitors of differentiation/DNA binding (Ids), helix-loop-helix (HLH) transc...

journal_title：Blood

authors： Lee J,Kim K,Kim JH,Jin HM,Choi HK,Lee SH,Kook H,Kim KK,Yokota Y,Lee SY,Choi Y,Kim N

更新日期：2006-04-01 00:00:00

abstract：:Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotrophic factor constitute the IL-6 family of cytokines and play important roles in hematopoiesis, immune response, and nervous system. The receptors for the IL-6 family of cytokines share gp130 through which signals are generated, ...

journal_title：Blood

authors： Matsuda T,Takahashi-Tezuka M,Fukada T,Okuyama Y,Fujitani Y,Tsukada S,Mano H,Hirai H,Witte ON,Hirano T

更新日期：1995-02-01 00:00:00

abstract：:To understand the etiology of bone modulation and hypercalcemia observed in granulocytosis of a tumor-bearing animal model and to gain insight into the implication of sustained hematopoietic stimulation on the bone tissue, in vivo responses of normal mouse hematopoietic and bone tissues to long-term injections of reco...

journal_title：Blood

authors： Lee MY,Fukunaga R,Lee TJ,Lottsfeldt JL,Nagata S

更新日期：1991-05-15 00:00:00

abstract：:To elucidate the biochemical basis of megaloblastic hematopoiesis, the cellular content and metabolism of deoxyribonucleoside triphosphates (dNTPs) were investigated using the bone marrow cells from nine patients with untreated vitamin B12 deficiency and one with folic acid deficiency. The marked imbalance among four ...

journal_title：Blood

authors： Iwata N,Omine M,Yamauchi H,Maekawa T

更新日期：1982-10-01 00:00:00

abstract：:The platelet collagen receptor glycoprotein (GP) VI-Fc receptor gamma-chain (FcRgamma) complex transduces signals in an immunoreceptorlike manner. We examined a role for the Triton X-100-insoluble membrane rafts in GPVI-FcRgamma complex signaling. Methyl-beta-cyclodextrin (MbetaCD)-induced disruption of the membrane r...

journal_title：Blood

authors： Ezumi Y,Kodama K,Uchiyama T,Takayama H

更新日期：2002-05-01 00:00:00