Expression of the thymosin beta 4 gene during differentiation of hematopoietic cells.

abstract：:Loxosceles is the most venomous spider in Brazil, and envenomation causes dermonecrosis and complement (C)-dependent intravascular hemolysis. The authors studied the mechanism of induction of C-induced hemolysis. Purified Loxosceles toxins rendered human erythrocytes susceptible to lysis by human C but did not have an...

journal_title：Blood

authors： Tambourgi DV,Morgan BP,de Andrade RM,Magnoli FC,van Den Berg CW

更新日期：2000-01-15 00:00:00

abstract：:Lenalidomide, bortezomib, and dexamethasone (RVd) followed by autologous stem cell transplantation (ASCT) is standard frontline therapy for transplant-eligible patients with newly diagnosed multiple myeloma (NDMM). The addition of daratumumab (D) to RVd (D-RVd) in transplant-eligible NDMM patients was evaluated. Patie...

journal_title：Blood

authors： Voorhees PM,Kaufman JL,Laubach J,Sborov DW,Reeves B,Rodriguez C,Chari A,Silbermann R,Costa LJ,Anderson LD Jr,Nathwani N,Shah N,Efebera YA,Holstein SA,Costello C,Jakubowiak A,Wildes TM,Orlowski RZ,Shain KH,Cowan AJ,

更新日期：2020-08-20 00:00:00

abstract：:Natural killer (NK) cell activation is the result of a balance between positive and negative signals triggered by specific membrane receptors. We report here the activation of NK cells induced through the transmembrane glycoprotein CD43 (leukosialin, sialophorin). Engagement of CD43 by specific antibodies stimulated t...

journal_title：Blood

authors： Nieto M,Rodríguez-Fernández JL,Navarro F,Sancho D,Frade JM,Mellado M,Martínez-A C,Cabañas C,Sánchez-Madrid F

更新日期：1999-10-15 00:00:00

abstract：:Chemoresistance is a major problem in the treatment of patients with multiple myeloma (MM). Because of the central role of the nuclear transcription factors nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) in chemoresistance, cell survival, and proliferation, we investig...

journal_title：Blood

authors： Bharti AC,Shishodia S,Reuben JM,Weber D,Alexanian R,Raj-Vadhan S,Estrov Z,Talpaz M,Aggarwal BB

更新日期：2004-04-15 00:00:00

abstract：:Globally suppressed T-cell function has been described in many patients with cancer to be a major hurdle for the development of clinically efficient cancer immunotherapy. Inhibition of antitumor immune responses has been mainly linked to inhibitory factors present in cancer patients. More recently, increased frequenci...

journal_title：Blood

authors： Beyer M,Kochanek M,Darabi K,Popov A,Jensen M,Endl E,Knolle PA,Thomas RK,von Bergwelt-Baildon M,Debey S,Hallek M,Schultze JL

更新日期：2005-09-15 00:00:00

abstract：:Eleven of twenty-four patients with severe aplastic anemia given marrow grafts from HLA-identical siblings between October 1970 and March 1973 are alive with normal marrow function and continued evidence of engraftment 3-5 yr later. Ten have been leading normal lives with no immunosuppressive or other drug therapy sin...

journal_title：Blood

authors： Storb R,Thomas ED,Buckner CD,Clift RA,Fefer A,Fernando LP,Giblett ER,Johnson FL,Neiman PE

更新日期：1976-10-01 00:00:00

abstract：:Primary cutaneous lymphomas have been successfully treated with interferons (IFNs), counterbalancing the T-helper 2 (Th2)-skewing state. We undertook a phase 1, open-label, dose-escalating trial of repeated intratumoral administration of TG1042 in patients with advanced primary cutaneous T-cell lymphomas (CTCLs) and m...

journal_title：Blood

authors： Dummer R,Hassel JC,Fellenberg F,Eichmüller S,Maier T,Slos P,Acres B,Bleuzen P,Bataille V,Squiban P,Burg G,Urosevic M

更新日期：2004-09-15 00:00:00

abstract：:Clonal expansion of activated T cells is controlled by homeostatic mechanisms leading to cell death of a large proportion of the cells. The CD3/TcR pathway induces cell death, mostly when triggered in the absence of costimulatory signal. The unique T cell-specific chemokine of the C class, lymphotactin (Lptn), has rec...

journal_title：Blood

authors： Cerdan C,Devilard E,Xerri L,Olive D

更新日期：2001-04-15 00:00:00

abstract：:Tissue factor (TF) is expressed on nonvascular cells and cells within the vessel wall and circulates in blood associated with microparticles. Although blood-borne TF accumulates into the developing thrombus during thrombus formation, the contribution of blood-borne TF and vessel wall TF to thrombin generation in vivo ...

journal_title：Blood

authors： Chou J,Mackman N,Merrill-Skoloff G,Pedersen B,Furie BC,Furie B

更新日期：2004-11-15 00:00:00

abstract：:Postthrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT) that reduces quality of life and has important socioeconomic consequences. More than one-third of patients with DVT will develop PTS, and 5% to 10% of patients will develop severe PTS, which may manifest as venous ulceration. The p...

journal_title：Blood

authors： Kahn SR

更新日期：2009-11-19 00:00:00

abstract：:Chronic active EBV disease (CAEBV) is a lymphoproliferative disorder characterized by markedly elevated levels of antibody to EBV or EBV DNA in the blood and EBV RNA or protein in lymphocytes in tissues. We present our experience with CAEBV during the last 28 years, including the first 8 cases treated with hematopoiet...

journal_title：Blood

authors： Cohen JI,Jaffe ES,Dale JK,Pittaluga S,Heslop HE,Rooney CM,Gottschalk S,Bollard CM,Rao VK,Marques A,Burbelo PD,Turk SP,Fulton R,Wayne AS,Little RF,Cairo MS,El-Mallawany NK,Fowler D,Sportes C,Bishop MR,Wilson W,St

更新日期：2011-06-02 00:00:00

abstract：:We have previously reported that continuous intravenous (IV) administration of recombinant granulocyte-macrophage colony-stimulating factor (rHuGM-CSF) to humans following high-dose alkylating agent chemotherapy and autologous bone marrow support (ABMS) results in myeloid bone marrow maturation, accelerated granulocyt...

journal_title：Blood

authors： Peters WP,Stuart A,Affronti ML,Kim CS,Coleman RE

更新日期：1988-10-01 00:00:00

abstract：:Distinct human dendritic cell (DC) subsets differentially control immunity. Thus, insights into their in vivo functions are important to understand the launching and modulation of immune responses. We show that nonobese diabetic/LtSz-scid/scid (NOD/SCID) mice engrafted with human CD34+ hematopoietic progenitors develo...

journal_title：Blood

authors： Palucka AK,Gatlin J,Blanck JP,Melkus MW,Clayton S,Ueno H,Kraus ET,Cravens P,Bennett L,Padgett-Thomas A,Marches F,Islas-Ohlmayer M,Garcia JV,Banchereau J

更新日期：2003-11-01 00:00:00

abstract：:Hematopoiesis is a tightly regulated process resulting in the production of blood cells. Self-renewal and differentiation of hematopoietic stem cells (HSCs) are key processes in hematopoietic development. Disruption of these steps can lead to altered cell distribution and disease. To investigate the role of the nuclea...

journal_title：Blood

authors： Stein SJ,Baldwin AS

更新日期：2013-06-20 00:00:00

abstract：:A broad range of hematopoietic stem cells and progenitors reside within a fraction of umbilical cord blood (UCB) that exhibits low light scatter properties (SSC(lo)) and high expression of aldehyde dehydrogenase (ALDH(br)). Many SSC(lo) ALDH(br) cells coexpress CD34; however, other cells express either ALDH or CD34. T...

journal_title：Blood

authors： Storms RW,Green PD,Safford KM,Niedzwiecki D,Cogle CR,Colvin OM,Chao NJ,Rice HE,Smith CA

更新日期：2005-07-01 00:00:00

abstract：:Conventional assays evaluating antitumor activity of immune effector cells have limitations that preclude their high-throughput application. We adapted the recently developed Compartment-Specific Bioluminescence Imaging (CS-BLI) technique to perform high-throughput quantification of innate antitumor activity and to sh...

journal_title：Blood

authors： McMillin DW,Delmore J,Negri JM,Vanneman M,Koyama S,Schlossman RL,Munshi NC,Laubach J,Richardson PG,Dranoff G,Anderson KC,Mitsiades CS

更新日期：2012-04-12 00:00:00

abstract：:Thrombopoietin (Tpo), the ligand for c-mpl, has been shown to be the principal regulator of megakaryocytopoiesis and platelet production. The ability of Tpo to potently stimulate the growth of committed megakaryocyte (Mk) progenitor cells has been studied in detail. Murine fetal liver cells, highly enriched in primiti...

journal_title：Blood

authors： Ramsfjell V,Borge OJ,Veiby OP,Cardier J,Murphy MJ Jr,Lyman SD,Lok S,Jacobsen SE

更新日期：1996-12-15 00:00:00

abstract：:The platelets of an infant with severe combined immune deficiency and adenosine deaminase deficiency showed markedly diminished responses to ADP-induced aggregation in vitro. This abnormality was corrected by the addition of purified adenosine deaminase in vitro. Exogenous adenosine added to platelet-rich plasma cause...

journal_title：Blood

authors： Lee CH,Evans SP,Rozenberg MC,Bagnara AS,Ziegler JB,Van der Weyden MB

更新日期：1979-03-01 00:00:00

abstract：:Ectopic expression of mutated K-ras or N-ras in the interleukin 6 (IL-6)-dependent ANBL6 multiple myeloma cell line induces cytokine-independent growth. To investigate the signaling pathways activated by oncogenic ras that may stimulate IL-6-independent growth, we compared ANBL6 cells stably transfected with mutated K...

journal_title：Blood

authors： Hu L,Shi Y,Hsu JH,Gera J,Van Ness B,Lichtenstein A

更新日期：2003-04-15 00:00:00

abstract：:The peripheral blood of acute myeloblastic leukemia (AML) patients often contains large numbers of two distinct cell populations, both capable of forming colonies in culture under similar conditions. The first population consists of the precursors of blast cells and has specificity for AML; the second population consi...

journal_title：Blood

authors： Minden MD,Buick RN,McCulloch EA

更新日期：1979-07-01 00:00:00

abstract：:Macrophages infiltrating solid tumors exhibit a tumor-supporting phenotype and are critical for tumor development. Little is known which tumor-derived signal provokes this phenotype shift and how these signals are interpreted in macrophages to support tumor growth. We used the supernatant of apoptotic cells and notice...

journal_title：Blood

authors： Herr B,Zhou J,Werno C,Menrad H,Namgaladze D,Weigert A,Dehne N,Brüne B

更新日期：2009-09-03 00:00:00

abstract：:Vascular endothelial growth factor-A is widely used in clinical trials for the treatment of cardiac ischemia. VEGF-A was recently suggested to act in a proinflammatory manner, which could aggravate adjacent atherogenesis in VEGF-A-based therapy. To assess potential bystander effects, VEGF-A was focally overexpressed i...

journal_title：Blood

authors： Lucerna M,Zernecke A,de Nooijer R,de Jager SC,Bot I,van der Lans C,Kholova I,Liehn EA,van Berkel TJ,Yla-Herttuala S,Weber C,Biessen EA

更新日期：2007-01-01 00:00:00

abstract：:Erythropoietin (EPO) and its receptor (EPOR) are required for the development of mature erythrocytes. After binding of ligand, the EPOR activates a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression. Although erythroid progenitors appear to be the princ...

journal_title：Blood

authors： Gaffen SL,Lai SY,Longmore GD,Liu KD,Goldsmith MA

更新日期：1999-07-01 00:00:00

abstract：:The production and deployment of phagocytes are central functions of the hematopoietic system. In the 1950s, radioisotopic studies demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue mac...

journal_title：Blood

authors： Dale DC,Boxer L,Liles WC

更新日期：2008-08-15 00:00:00

abstract：:In 65 patients with hemophagocytic lymphohistiocytosis (HLH), we found an as yet undescribed heterogeneity of defects in cellular cytotoxicity when assay conditions were modified by the incubation time, the presence of mitogen, or interleukin-2 (IL-2). The standard 4-hour natural killer (NK) test against K562 targets ...

journal_title：Blood

authors： Schneider EM,Lorenz I,Müller-Rosenberger M,Steinbach G,Kron M,Janka-Schaub GE

更新日期：2002-10-15 00:00:00

abstract：:Types A and B Niemann-Pick disease (NPD) result from the deficient activity of acid sphingomyelinase (ASM; E.C. 3.1.4.12) and the resultant lysosomal accumulation of sphingomyelin. Type A disease is a fatal, neurodegenerative disorder of infancy, whereas type B disease has no neurologic manifestations and is character...

journal_title：Blood

authors： Levran O,Desnick RJ,Schuchman EH

更新日期：1992-10-15 00:00:00

abstract：:Chemotherapy-related myeloid neoplasia (t-MN) is a significant late toxicity concern after cancer therapy. In the randomized intergroup phase 3 E2997 trial, initial therapy of chronic lymphocytic leukemia with fludarabine plus cyclophosphamide (FC) compared with fludarabine alone yielded higher complete and overall re...

journal_title：Blood

authors： Smith MR,Neuberg D,Flinn IW,Grever MR,Lazarus HM,Rowe JM,Dewald G,Bennett JM,Paietta EM,Byrd JC,Hussein MA,Appelbaum FR,Larson RA,Litzow MR,Tallman MS

更新日期：2011-09-29 00:00:00

abstract：:To prospectively evaluate allogeneic stem cell transplantation (allo-SCT) for myeloma as part of first-line therapy, a donor versus no-donor analysis was performed of patients treated in the HOVON-50 study, a study that was originally designed to examine thalidomide combined with intensive therapy. Two hundred sixty p...

journal_title：Blood

authors： Lokhorst HM,van der Holt B,Cornelissen JJ,Kersten MJ,van Oers M,Raymakers R,Minnema MC,Zweegman S,Janssen JJ,Zijlmans M,Bos G,Schaap N,Wittebol S,de Weerdt O,Ammerlaan R,Sonneveld P

更新日期：2012-06-28 00:00:00

abstract：:Alterations in gene expression after chemotherapy may potentially help to identify mediators that induce suppression or regeneration in bone marrow. This paper reports our observation that the expression of the chemokine monokine induced by IFN-γ (Mig) and its receptor CXCR3 was significantly activated in mice after t...

journal_title：Blood

authors： Lu H,Zhu S,Qian L,Xiang D,Zhang W,Nie A,Gao J,Wu M,Gao J,Lu B,Yu Y,Han W,Moldenhauer A

更新日期：2012-05-24 00:00:00

abstract：:We have used a combination of hematopoietic growth factors to induce in vitro granulocytic maturation. A fraction of marrow cells enriched for hematopoietic progenitor cells (CD34+, HLA-DR+) was isolated from normal human bone marrow by monoclonal antibody staining and fluorescence-activated cell sorting. Cells were c...

journal_title：Blood

authors： Berliner N,Hsing A,Graubert T,Sigurdsson F,Zain M,Bruno E,Hoffman R

更新日期：1995-02-01 00:00:00