Activated expression of the chemokine Mig after chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity.

abstract：:The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation. Definitive erythroid cells from mutant mice arrest at the transition from proerythroblast to basophilic erythroblast. Rema...

journal_title：Blood

authors： Yao H,Goldman DC,Nechiporuk T,Kawane S,McWeeney SK,Tyner JW,Fan G,Kerenyi MA,Orkin SH,Fleming WH,Mandel G

更新日期：2014-05-15 00:00:00

abstract：:Class A scavenger receptor (SRA), also known as CD204, has been shown to participate in the pathogenesis of atherosclerosis and the pattern recognition of pathogen infection. However, its role in adaptive immune responses has not been well defined. In this study, we report that the lack of SRA/CD204 promotes Toll-like...

journal_title：Blood

authors： Yi H,Yu X,Gao P,Wang Y,Baek SH,Chen X,Kim HL,Subjeck JR,Wang XY

更新日期：2009-06-04 00:00:00

abstract：:MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is rate-limiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote sel...

journal_title：Blood

authors： Argiropoulos B,Yung E,Xiang P,Lo CY,Kuchenbauer F,Palmqvist L,Reindl C,Heuser M,Sekulovic S,Rosten P,Muranyi A,Goh SL,Featherstone M,Humphries RK

更新日期：2010-05-20 00:00:00

abstract：:By stimulating the expression of murine IP-10 and Mig, CXC chemokines that inhibit neovascularization and cause damage to established tumor vasculature, human B cells immortalized with Epstein-Barr virus (EBV) can promote an effective antitumor response in athymic mice. In the present study, we examined the potential ...

journal_title：Blood

authors： Cherney BW,Sgadari C,Kanegane C,Wang F,Tosato G

更新日期：1998-04-01 00:00:00

abstract：:Identification of receptor activator of nuclear factor-kappaB (RANK) and RANK-ligand (RANKL) has provided new insights into the osteoclast differentiation pathway. Osteoclast precursor cells were isolated using monoclonal antibodies against c-Fms and RANK, and the effect of adherence on the in vitro differentiation an...

journal_title：Blood

authors： Miyamoto T,Arai F,Ohneda O,Takagi K,Anderson DM,Suda T

更新日期：2000-12-15 00:00:00

abstract：:The activities of four purified human growth factors: biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor (GM-CSF); recombinant erythroid-potentiating activity (EPA); natural and recombinant pluripoietin (Ppo); and natural pluripoietin alpha (Ppo alpha), were compared on the growth of hematopoi...

journal_title：Blood

authors： Strife A,Lambek C,Wisniewski D,Gulati S,Gasson JC,Golde DW,Welte K,Gabrilove JL,Clarkson B

更新日期：1987-05-01 00:00:00

abstract：:We show here that alpha2(G-Phila.) beta2(C) has an increased rate of crystal nucleation compared to alpha2 beta2(C) (HbC). We conclude from this finding that position alpha68, the mutation site of alpha2(G-Phila.) beta2 (HbG(Philadelphia)), is a contact site in the crystal of HbC. In addition, that HbS enhances HbC cr...

journal_title：Blood

authors： Lawrence C,Hirsch RE,Fataliev NA,Patel S,Fabry ME,Nagel RL

更新日期：1997-10-01 00:00:00

abstract：:LIRs are immunoglobulinlike receptors that have activating and inhibitory functions in leukocytes. Here we report the identification of the first LIR family member, LIR9, expressed as a membrane-bound receptor and as a secreted molecule. We identified 4 different forms of LIR9, 2 of which encode transmembrane molecule...

journal_title：Blood

authors： Borges L,Kubin M,Kuhlman T

更新日期：2003-02-15 00:00:00

abstract：:Seven of 21 patients with sickle cell anemia developed neurologic complications 5 to 243 days (median, 33 days) after allogeneic marrow transplantation. Among these 7 patients, indications for transplantation included either a past history of stroke (4 patients) or recurrent severe vaso-occlusive events (3 patients). ...

journal_title：Blood

authors： Walters MC,Sullivan KM,Bernaudin F,Souillet G,Vannier JP,Johnson FL,Lenarsky C,Powars D,Bunin N,Ohene-Frempong K

更新日期：1995-02-15 00:00:00

abstract：:The bcr1- and bcr3- promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR alpha) are the two major fusion proteins expressed in acute promyelocytic leukemia (APL) patients. These proteins, which are present in different lengths of PML (amino acids 1-552 and 1-394, respectively), contain most of the functional d...

journal_title：Blood

authors： Benedetti L,Levin AA,Scicchitano BM,Grignani F,Allenby G,Diverio D,Lo Coco F,Avvisati G,Ruthardt M,Adamo S,Pelicci PG,Nervi C

更新日期：1997-08-01 00:00:00

abstract：:The interaction of thrombin with plasminogen activator inhibitor 1 (PAI-1) is shown to result in the simultaneous formation of both cleaved PAI-1 and a sodium dodecyl sulfate-stable thrombin-PAI-1 complex. The kinetics of this reaction can be described by a "suicide substrate" mechanism that includes a branched reacti...

journal_title：Blood

authors： van Meijer M,Smilde A,Tans G,Nesheim ME,Pannekoek H,Horrevoets AJ

更新日期：1997-09-01 00:00:00

abstract：:Mammalian beta-globin loci contain multiple genes that are activated at different developmental stages. Studies have suggested that the transcription of one gene in a locus can influence the expression of the other locus genes. The prevalent model to explain this transcriptional interference is that all potentially ac...

journal_title：Blood

authors： Hu X,Eszterhas S,Pallazzi N,Bouhassira EE,Fields J,Tanabe O,Gerber SA,Bulger M,Engel JD,Groudine M,Fiering S

更新日期：2007-03-01 00:00:00

abstract：:In this issue of Blood, Kassebaum et al estimate that the global anemia prevalence in 2010 was 32.9%, resulting in 68.4 million years lived with disability (YLD). The results emphasize the important contribution made by anemia to the overall global burden of disease and should help focus attention and resources toward...

journal_title：Blood

authors： Pasricha SR

更新日期：2014-01-30 00:00:00

abstract：:CD4(+) T helper 1 (Th1) cells and Th2 cells are distinguished based on the pattern of cytokines they are able to produce. Selectin ligands and chemokine receptors are differentially expressed in Th1 and Th2 cells, providing a basis for tissue-specific recruitment of helper T-cell subsets. However, the modes and mechan...

journal_title：Blood

authors： Colantonio L,Iellem A,Clissi B,Pardi R,Rogge L,Sinigaglia F,D'Ambrosio D

更新日期：1999-11-01 00:00:00

abstract：:Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not found in the...

journal_title：Blood

authors： Fang B,Zheng C,Liao L,Han Q,Sun Z,Jiang X,Zhao RC

更新日期：2005-04-01 00:00:00

abstract：:Radioiodinated L-cell-derived colony-stimulating factor (CSF) was used to characterize the binding reaction to murine bone marrow cells. The major increment in cell-associated radioactivity occurred over 24 hr incubation at 37 degrees C, but virtually no binding was observed at 4 degrees C. The reaction was saturable ...

journal_title：Blood

authors： Pigoli G,Waheed A,Shadduck RK

更新日期：1982-02-01 00:00:00

abstract：:Recent studies have identified nonredundant roles for basophils in immune responses including allergy and protective immunity. It is well known that activated basophils release granule contents such as histamine and proteases as do mast cells. However, the functional significance of basophil-derived proteases remains ...

journal_title：Blood

authors： Iki M,Tanaka K,Deki H,Fujimaki M,Sato S,Yoshikawa S,Yamanishi Y,Karasuyama H

更新日期：2016-12-22 00:00:00

abstract：:The effects of factor IX concentrate therapy on hemostasis in hemophilia patients were studied by means of the radiometric factor IXa assay, the coupled amidolytic assay for factor VIIa, and coagulant assays for factors II, IX, and X, and antithrombin III. Both activated and unactivated concentrates contained factors ...

journal_title：Blood

authors： Hultin MB

更新日期：1983-09-01 00:00:00

abstract：:Approximately 20% of children with acute lymphoblastic leukemia (ALL) relapse because of failure to eradicate the disease. Current drug efficacy studies focus on reducing leukemia cell burden. However, if drugs have limited effects on leukemia-initiating cells (LICs), then these cells may expand and eventually cause r...

journal_title：Blood

authors： Diamanti P,Cox CV,Moppett JP,Blair A

更新日期：2013-02-21 00:00:00

abstract：:Lymphocyte kinetic studies employing 51-chromium-labeled autologous lymphocytes were performed in nine normal volunteers in order to determine the effects of hydrocortisone administration on the recirculating versus the nonrecirculating intravascular lymphocyte pools. Following infusion of labeled cells, the recircula...

journal_title：Blood

authors： Fauci AS,Dale DC

更新日期：1975-08-01 00:00:00

abstract：:Serine proteinase inhibitors (serpins) play a vital regulatory role in a wide range of biological processes, and serpins from viruses have been implicated in pathogen evasion of the host defence system. For the first time, we report a functional serpin gene from nematodes that may function in this manner. This gene, n...

journal_title：Blood

authors： Zang X,Yazdanbakhsh M,Jiang H,Kanost MR,Maizels RM

更新日期：1999-08-15 00:00:00

abstract：:Little is known about the molecular characteristics of alloantigens recognized by alloreactive T cells mediating hematologic stem cell graft rejection. In particular, it has never been shown that such alloantigens can be encoded by HLA-DP beta alleles. Indeed, matching for HLA-DP antigens is generally not considered t...

journal_title：Blood

authors： Fleischhauer K,Zino E,Mazzi B,Sironi E,Servida P,Zappone E,Benazzi E,Bordignon C

更新日期：2001-08-15 00:00:00

abstract：:To facilitate the investigation of the direct interaction between hematopoietic progenitors and colony-stimulating factors, we have developed a method to purify human marrow progenitor cells. Using density centrifugation, negative panning with concanavalin A coated plates, positive selection of CD34-positive cells wit...

journal_title：Blood

authors： Sato N,Sawada K,Kannonji M,Tarumi T,Sakai N,Ieko M,Sakurama S,Nakagawa S,Yasukouchi T,Krantz SB

更新日期：1991-08-15 00:00:00

abstract：:Monoclonally-derived neoplastic T-cells from a patient with cutaneous T-cell lymphoma respond to multiple human HLA-D antigens in mixed lymphocyte culture. The implications of this phenomenon relevant to normal T-cell function and to malignancy are discussed. ...

journal_title：Blood

authors： Rubenfeld MR,Edelson RL,Löfström LM,Berger CL,Warburton D

更新日期：1980-03-01 00:00:00

abstract：:A mechanism to control development of mast cells was investigated in mice. Although mast cells in the skin of normal C57BL/6 mice were still of host type 290 days after irradiation and injection of bone marrow cells from beige (Chediak-Higashi syndrome, C57BL/6 bgJ/bgJ) mice, donor-type mast cells with giant granules ...

journal_title：Blood

authors： Hatanaka K,Kitamura Y,Nishimune Y

更新日期：1979-01-01 00:00:00

abstract：:We have analyzed the phenotype, cytokine profile, and mitotic history (telomere length) of monoclonal T-cell expansions in 5 CD3(+) T-cell large granular lymphocyte (TLGL) leukemia patients by fluorescence activated cell sorting (FACS) and single-cell polymerase chain reaction (PCR). We confirm that the common phenoty...

journal_title：Blood

authors： Bigouret V,Hoffmann T,Arlettaz L,Villard J,Colonna M,Ticheli A,Gratwohl A,Samii K,Chapuis B,Rufer N,Roosnek E

更新日期：2003-04-15 00:00:00

abstract：:There have been no studies on patient outcome after allogeneic hematopoietic cell transplantation (HCT) in patients with X-linked inhibitor of apoptosis (XIAP) deficiency. To estimate the success of HCT, we conducted an international survey of transplantation outcomes. Data were reported for 19 patients. Seven patient...

journal_title：Blood

authors： Marsh RA,Rao K,Satwani P,Lehmberg K,Müller I,Li D,Kim MO,Fischer A,Latour S,Sedlacek P,Barlogis V,Hamamoto K,Kanegane H,Milanovich S,Margolis DA,Dimmock D,Casper J,Douglas DN,Amrolia PJ,Veys P,Kumar AR,Jordan MB

更新日期：2013-02-07 00:00:00

abstract：:Monocytes and T helper (T(H)) cells rapidly infiltrate inflamed tissues where monocytes differentiate into inflammatory dendritic cells (DCs) through undefined mechanisms. Our studies indicate that T(H) cells frequently interact with monocytes in inflamed skin and elicit the differentiation of specialized DC subsets c...

journal_title：Blood

authors： Alonso MN,Wong MT,Zhang AL,Winer D,Suhoski MM,Tolentino LL,Gaitan J,Davidson MG,Kung TH,Galel DM,Nadeau KC,Kim J,Utz PJ,Söderström K,Engleman EG

更新日期：2011-09-22 00:00:00

abstract：:In this issue of Blood, Usmani et al provide important information on second primary malignancies in patients treated with thalidomide and lenalidomide in the Arkansas total therapy trials. ...

journal_title：Blood

authors： Rajkumar SV

更新日期：2012-08-23 00:00:00

abstract：:We show here that a human leukemic cell line, PER-117, bearing the markers of a T-cell precursor phenotype, can be induced to express receptors for interleukin-2 (IL-2). These IL-2 receptors could be demonstrated to mediate a physiologic response to the lymphokine for which the high-affinity form of the IL-2 receptor ...

journal_title：Blood

authors： Kees UR

更新日期：1988-11-01 00:00:00