Genetic evidence for an additional factor required for erythropoietin-induced signal transduction.

abstract：:Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-...

journal_title：Blood

authors： Dhédin N,Huynh A,Maury S,Tabrizi R,Beldjord K,Asnafi V,Thomas X,Chevallier P,Nguyen S,Coiteux V,Bourhis JH,Hichri Y,Escoffre-Barbe M,Reman O,Graux C,Chalandon Y,Blaise D,Schanz U,Lhéritier V,Cahn JY,Dombret H,If

更新日期：2015-04-16 00:00:00

abstract：:Stimulated neutrophils show ionic fluxes that may function as "transducers" between stimuli and effector functions. Using fluorescent probes, patterns of membrane-associated calcium (chlortetracycline, CTC) and membrane potential (3-3'-dipentyloxacarbocyanine, di-O-C5 (3)) in single living human neutrophils were obser...

journal_title：Blood

authors： Sullivan GW,Donowitz GR,Sullivan JA,Mandell GL

更新日期：1984-12-01 00:00:00

abstract：:Cytofluorimetric detection of the multidrug resistance (MDR)-associated membrane protein (P-170) was performed at the time of diagnosis in 158 patients with acute myeloid leukemia using the C219 monoclonal antibody (MoAb). In 108 of these cases the JSB1 MoAb was also tested. An improved histogram subtraction analysis,...

journal_title：Blood

authors： Del Poeta G,Stasi R,Aronica G,Venditti A,Cox MC,Bruno A,Buccisano F,Masi M,Tribalto M,Amadori S,Papa G

更新日期：1996-03-01 00:00:00

abstract：:The balanced manifestation of effector functions and the generation of long-living memory cells is a hallmark of efficient CD8(+) T-cell response. Accumulating data pinpoint CD4(+) CD25(high) regulatory T (Treg) cells as a key factor for the inefficiency of CD8(+) T-cell responses in viral persistence. Little is known...

journal_title：Blood

authors： Nikolova M,Lelievre JD,Carriere M,Bensussan A,Lévy Y

更新日期：2009-05-07 00:00:00

abstract：:People with hemophilia were formerly at very high risk of infection with hepatitis C virus (HCV). Approximately 20% of HCV-infected patients spontaneously clear the virus. To identify correlates of spontaneous clearance of HCV, we studied a cohort of HCV-infected hemophilic subjects without human immunodeficiency viru...

journal_title：Blood

authors： Zhang M,Rosenberg PS,Brown DL,Preiss L,Konkle BA,Eyster ME,Goedert JJ,Second Multicenter Hemophilia Cohort Study.

更新日期：2006-02-01 00:00:00

abstract：:Congenital erythropoietic porphyria (CEP) is an autosomal recessive disorder of heme synthesis characterized by reduced activity of uroporphyrinogen III synthase and the accumulation of nonphysiologic isomer I porphyrin metabolites, resulting in ineffective erythropoiesis and devastating skin photosensitivity. Managem...

journal_title：Blood

authors： Egan DN,Yang Z,Phillips J,Abkowitz JL

更新日期：2015-07-09 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an increased number of double-negative T cells (DNTs). Treatment options for patients with ALPS are limited. Rapamycin has been sh...

journal_title：Blood

authors： Teachey DT,Obzut DA,Axsom K,Choi JK,Goldsmith KC,Hall J,Hulitt J,Manno CS,Maris JM,Rhodin N,Sullivan KE,Brown VI,Grupp SA

更新日期：2006-09-15 00:00:00

abstract：:Human platelets are anucleate blood cells that retain cytoplasmic mRNA and maintain functionally intact protein translational capabilities. We have adapted complementary techniques of microarray and serial analysis of gene expression (SAGE) for genetic profiling of highly purified human blood platelets. Microarray ana...

journal_title：Blood

authors： Gnatenko DV,Dunn JJ,McCorkle SR,Weissmann D,Perrotta PL,Bahou WF

更新日期：2003-03-15 00:00:00

abstract：:Localized tumors composed of immature cells of the myelogenous series have been recognized for many years as an uncommon manifestation of granulocytic leukemia. The histologic diagnosis of chloroma (granulocytic sarcoma) may be extremely difficult when the myeloblastic cells are poorly differentiated and the tumor lac...

journal_title：Blood

authors： McCarty KS Jr,Wortman J,Daly J,Rundles RW,Hanker JS

更新日期：1980-07-01 00:00:00

abstract：:Large granular lymphocyte (LGL) leukemia results from clonal expansion of CD3+ cytotoxic T lymphocytes or CD3- natural killer (NK) cells. Chronic antigen stimulation is postulated to promote long-term survival of LGL leukemia cells through constitutive activation of multiple survival pathways, resulting in global dysr...

journal_title：Blood

authors： Yang J,LeBlanc FR,Dighe SA,Hamele CE,Olson TL,Feith DJ,Loughran TP Jr

更新日期：2018-06-21 00:00:00

abstract：:The VLA-4 integrin (CD49d/CD29), initially discovered on lymphoid cells, is actually known to be highly expressed on T cells, B cells, monocytes, and derived cell lines. Unlike other VLA integrins, mainly involved in cell-matrix adhesive interactions, VLA-4 has also been implicated in several cellular interactions. Ba...

journal_title：Blood

authors： Zhang ZH,Vekemans S,Aly MS,Jaspers M,Marynen P,Cassiman JJ

更新日期：1991-11-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) that is resistant to therapy is a highly lethal complication of marrow transplantation. Inflammatory cytokines such as interleukin-1 (IL-1) may be critical mediators of this process. If so, specific inhibition of IL-1 activity with recombinant human IL-1 receptor antagonist (IL-1...

journal_title：Blood

authors： Antin JH,Weinstein HJ,Guinan EC,McCarthy P,Bierer BE,Gilliland DG,Parsons SK,Ballen KK,Rimm IJ,Falzarano G

更新日期：1994-08-15 00:00:00

abstract：:Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. ADAMTS13 inhibits the ...

journal_title：Blood

authors： Zhu J,Muia J,Gupta G,Westfield LA,Vanhoorelbeke K,Tolia NH,Sadler JE

更新日期：2019-04-25 00:00:00

abstract：:Severe congenital neutropenia as well as primary myelofibrosis are rare in infancy. Elucidation of the underlying mechanism is important because it extends our understanding of the more common adult forms of these disorders. Using homozygosity mapping followed by exome sequencing, we identified a Thr224Asn mutation in...

journal_title：Blood

authors： Stepensky P,Saada A,Cowan M,Tabib A,Fischer U,Berkun Y,Saleh H,Simanovsky N,Kogot-Levin A,Weintraub M,Ganaiem H,Shaag A,Zenvirt S,Borkhardt A,Elpeleg O,Bryant NJ,Mevorach D

更新日期：2013-06-20 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is a highly proliferative neoplasm that frequently carries the t(2;5)(p23;q35) and aberrantly expresses nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). Previously, NPM-ALK had been shown to activate the phosphatidylinositol 3 kinase (PI3K)/Akt pathway. As the cyclin-dependent ...

journal_title：Blood

authors： Rassidakis GZ,Feretzaki M,Atwell C,Grammatikakis I,Lin Q,Lai R,Claret FX,Medeiros LJ,Amin HM

更新日期：2005-01-15 00:00:00

abstract：:The malignant Reed-Sternberg cell of Hodgkin disease is an aberrant B cell that persists in an immunolgically mediated inflammatory infiltrate. Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the usual apoptotic fate of defective immune cells through an unknown mechanism. A likely candid...

journal_title：Blood

authors： Annunziata CM,Safiran YJ,Irving SG,Kasid UN,Cossman J

更新日期：2000-10-15 00:00:00

abstract：:Macrophages are reservoirs of HIV-1 infection, proposed to transmit virus to CD4(+) T cells, the primary target of the virus. Here we report that human monocyte-derived macrophages (MDMs) rapidly spread HIV-1 to autologous CD4(+) T cells resulting in productive infection. Transmission takes place across transient adhe...

journal_title：Blood

authors： Groot F,Welsch S,Sattentau QJ

更新日期：2008-05-01 00:00:00

abstract：:Allelic loss at nonrandom chromosomal sites is thought to mark the position of tumor suppressor genes involved in the pathogenesis and progression of human malignancies. Solid tumors in particular have been found to harbor multiple genetic changes resulting in loss of function mutations. Tumor suppressor genes have al...

journal_title：Blood

authors： Bullrich F,Veronese ML,Kitada S,Jurlander J,Caligiuri MA,Reed JC,Croce CM

更新日期：1996-10-15 00:00:00

abstract：:The development of peroxidase (PO) reaction in the nuclear envelope (NE) and endoplasmic reticulum (ER) of monocytes differentiating in vitro and its relationship with arachidonic acid metabolism were studied. The PO, as visualized by the diaminobenzidine (DAB) technique, appeared in the NE and ER of the majority of m...

journal_title：Blood

authors： Deimann W,Seitz M,Gemsa D,Fahimi HD

更新日期：1984-08-01 00:00:00

abstract：:In addition to its importance in transfusion, Kell protein is a member of the M13 family of zinc endopeptidases and functions as an endothelin-3-converting enzyme. To obtain information on the structure of Kell protein we built a model based on the crystal structure of the ectodomain of neutral endopeptidase 24.11 (NE...

journal_title：Blood

authors： Lee S,Debnath AK,Redman CM

更新日期：2003-10-15 00:00:00

abstract：:Human fibrinogen 1 is homodimeric with respect to its gamma chains (gammaA-gammaA'), whereas fibrinogen 2 molecules each contain one gammaA (gammaA1-411V) and one gamma' chain, which differ by containing a unique C-terminal sequence from gamma'408 to 427L that binds thrombin and factor XIII. We investigated the struct...

journal_title：Blood

authors： Siebenlist KR,Mosesson MW,Hernandez I,Bush LA,Di Cera E,Shainoff JR,Di Orio JP,Stojanovic L

更新日期：2005-10-15 00:00:00

abstract：:Currently, there are no reliable RBC invasion assays to guide the discovery of vaccines against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America. Here we describe a protocol for an ex vivo P vivax invasion assay that can be easily deployed in laboratories located in endemic countries. Th...

journal_title：Blood

authors： Russell B,Suwanarusk R,Borlon C,Costa FT,Chu CS,Rijken MJ,Sriprawat K,Warter L,Koh EG,Malleret B,Colin Y,Bertrand O,Adams JH,D'Alessandro U,Snounou G,Nosten F,Rénia L

更新日期：2011-09-29 00:00:00

abstract：:The metalloprotease ADAMTS13 is assumed to regulate the functional levels of von Willebrand factor (VWF) appropriate for normal hemostasis in vivo by reducing VWF multimer size, which directly represents the thrombogenic activity of this factor. Using an in vitro perfusion chamber system, we studied the mechanisms of ...

journal_title：Blood

authors： Shida Y,Nishio K,Sugimoto M,Mizuno T,Hamada M,Kato S,Matsumoto M,Okuchi K,Fujimura Y,Yoshioka A

更新日期：2008-02-01 00:00:00

abstract：:In the 2005-01 trial, we have demonstrated that bortezomib-dexamethasone as induction therapy before autologous stem cell transplantation was superior to vincristine-adriamycin-dexamethasone. We conducted a post-hoc analysis to assess the prognostic impact of initial characteristics as well as response to therapy in p...

journal_title：Blood

authors： Moreau P,Attal M,Pégourié B,Planche L,Hulin C,Facon T,Stoppa AM,Fuzibet JG,Grosbois B,Doyen C,Ketterer N,Sebban C,Kolb B,Chaleteix C,Dib M,Voillat L,Fontan J,Garderet L,Jaubert J,Mathiot C,Esseltine D,Avet-Loise

更新日期：2011-03-17 00:00:00

abstract：:Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit information bidirectionally across the plasma membrane, and plays a critical role in hemostasis and thrombosis. Upon platelet activation, inside-out signaling pathways increase the affinity of αIIbβ3 for fibrinogen and other ligands...

journal_title：Blood

authors： Durrant TN,van den Bosch MT,Hers I

更新日期：2017-10-05 00:00:00

abstract：:A 14-year-old boy with hemoglobin SC disease and alpha-thalassemia-2 experienced five episodes of acute splenic sequestration crisis (ASSC), while two of his siblings with identical globin genotypes (SC and -alpha/alpha alpha) had no such experience. To determine if an additional red blood cell (RBC) defect was respon...

journal_title：Blood

authors： Warkentin TE,Barr RD,Ali MA,Mohandas N

更新日期：1990-01-01 00:00:00

abstract：:Perioperative management of antithrombotic therapy is a situation that occurs frequently and requires consideration of the patient, the procedure, and an expanding array of anticoagulant and antiplatelet agents. Preoperative assessment must address each patient's risk for thromboembolic events balanced against the ris...

journal_title：Blood

authors： Ortel TL

更新日期：2012-12-06 00:00:00

abstract：:Normal human bone marrow contains cells capable of forming colonies of hemopoietic cells in fibrin clots in diffusion chambers implanted intraperitoneally (i.p.) into irradiated mice. The present paper describes the proliferation of such colony-forming units (CFUD) in cultures in vivo. Cells harvested from diffusion c...

journal_title：Blood

authors： Jacobsen N

更新日期：1977-03-01 00:00:00

abstract：:Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2-RAD51, and RAD52-RAD51 serves as back-up. To target HRR in tumor cells, a phenomenon called "synthetic lethality" was applied, which relies on the addic...

journal_title：Blood

authors： Cramer-Morales K,Nieborowska-Skorska M,Scheibner K,Padget M,Irvine DA,Sliwinski T,Haas K,Lee J,Geng H,Roy D,Slupianek A,Rassool FV,Wasik MA,Childers W,Copland M,Müschen M,Civin CI,Skorski T

更新日期：2013-08-15 00:00:00

abstract：:Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA). To investigate whether certain HLA class II genes are associated with susceptibility to such CyA-dependent AA, we determined the HLA class II alleles of 59 AA patients treated with CyA. Among 26 patie...

journal_title：Blood

authors： Nakao S,Takamatsu H,Chuhjo T,Ueda M,Shiobara S,Matsuda T,Kaneshige T,Mizoguchi H

更新日期：1994-12-15 00:00:00