Hodgkin disease: pharmacologic intervention of the CD40-NF kappa B pathway by a protease inhibitor.

abstract：:Naive and memory CD8(+) T cells can undergo programmed activation and expansion in response to a short T-cell receptor stimulus, but the extent to which in vitro programming can qualitatively substitute for an in vivo antigen stimulation remains unknown. We show that self-/tumor-reactive effector memory CD8(+) T cells...

journal_title：Blood

authors： Klebanoff CA,Yu Z,Hwang LN,Palmer DC,Gattinoni L,Restifo NP

更新日期：2009-08-27 00:00:00

abstract：:It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries. As these countries go through an epidemiologic transition, with a reduction in childhood and infant mortality due to ...

journal_title：Blood

authors： Weatherall DJ

更新日期：2010-06-03 00:00:00

abstract：:Andexanet alfa, a reversing agent for anticoagulants that inhibit factor Xa, has recently been licensed in the United States. We discuss the impact of this licensure on current practice and review in detail the problems of a neglected and growing clinical area: reversing the anticoagulation effect of factor Xa inhibit...

journal_title：Blood

authors： Hunt BJ,Neal MD,Stensballe J

更新日期：2018-12-06 00:00:00

abstract：:Human transferrin receptor-2 (TFR-2) is a protein highly homologous to TFR-1/CD71 and is endowed with the ability to bind transferrin (TF) with low affinity. High levels of TFR-2 mRNA were found in the liver and in erythroid precursors. Mutations affecting the TFR-2 gene led to hemochromatosis type 3, a form of inheri...

journal_title：Blood

authors： Deaglio S,Capobianco A,Calì A,Bellora F,Alberti F,Righi L,Sapino A,Camaschella C,Malavasi F

更新日期：2002-11-15 00:00:00

abstract：:B-lymphoid kinase (Blk) is exclusively expressed in B cells and thymocytes. Interestingly, transgenic expression of a constitutively active form of Blk in the T-cell lineage of mice results in the development of T-lymphoid lymphomas. Here, we demonstrate nuclear factor-kappa B (NF-kappaB)-mediated ectopic expression o...

journal_title：Blood

authors： Krejsgaard T,Vetter-Kauczok CS,Woetmann A,Kneitz H,Eriksen KW,Lovato P,Zhang Q,Wasik MA,Geisler C,Ralfkiaer E,Becker JC,Ødum N

更新日期：2009-06-04 00:00:00

abstract：:Stem cell factor (SCF) is expressed as an integral membrane growth factor that may be differentially processed to produce predominantly soluble (S) (SCF(248)) or membrane-associated (MA) (SCF(220)) protein. A critical role for membrane presentation of SCF in the hematopoietic microenvironment (HM) has been suggested f...

journal_title：Blood

authors： Kapur R,Cooper R,Xiao X,Weiss MJ,Donovan P,Williams DA

更新日期：1999-09-15 00:00:00

abstract：:Recently various genetic defects in immunity mediated by interferon gamma (IFN-gamma) have been described, including mutations in the IFN-gamma receptor 1 (IFN-gammaR1) and receptor 2 (IFN-gammaR2), signal transducer and activator of transcription 1 (STAT 1), and interleukin 12 receptor beta 1 (IL-12Rbeta1), and IL-12...

journal_title：Blood

authors： Höflich C,Sabat R,Rosseau S,Temmesfeld B,Slevogt H,Döcke WD,Grütz G,Meisel C,Halle E,Göbel UB,Volk HD,Suttorp N

更新日期：2004-01-15 00:00:00

abstract：:Leukemia relapse is a major cause of treatment failure for patients with acute leukemia given allogeneic bone marrow transplantation (BMT). This study evaluated whether a reduction of the dosage of cyclosporine-A (Cs-A) used for graft versus host disease (GVHD) prophylaxis could reduce relapse rate (RR) in children wi...

journal_title：Blood

authors： Locatelli F,Zecca M,Rondelli R,Bonetti F,Dini G,Prete A,Messina C,Uderzo C,Ripaldi M,Porta F,Giorgiani G,Giraldi E,Pession A

更新日期：2000-03-01 00:00:00

abstract：:Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroid cells not only co...

journal_title：Blood

authors： Zhang DL,Ghosh MC,Ollivierre H,Li Y,Rouault TA

更新日期：2018-11-08 00:00:00

abstract：:Immunosuppression resulting in impaired Epstein-Barr virus (EBV)-specific T-cell immunity is involved in the pathogenesis of EBV-positive post-transplantation lymphoproliferative disorder (EBV(+) PTLD). Restoration of EBV-specific T-cell immunity by adoptive immunotherapy can induce remission. EBV-nuclear antigen-1 (E...

journal_title：Blood

authors： Jones K,Nourse JP,Morrison L,Nguyen-Van D,Moss DJ,Burrows SR,Gandhi MK

更新日期：2010-09-30 00:00:00

abstract：:T-cell receptor (TCR) beta-chain proteins appear early (approximately 15th week of gestation) during human thymic ontogenesis. These beta-chain proteins, which appear before terminal deoxynucleotidyl transferase (TdT), could be an expression of a fully rearranged (V-D-J), incompletely rearranged (D-J), or germline TCR...

journal_title：Blood

authors： Bonati A,Zanelli P,Ferrari S,Plebani A,Starcich B,Savi M,Neri TM

更新日期：1992-03-15 00:00:00

abstract：:Fanconi anemia (FA) is a hereditary disorder caused by mutations in any 1 of 22 FA genes. The disease is characterized by hypersensitivity to interstrand crosslink (ICL) inducers such as mitomycin C (MMC). In addition to promoting ICL repair, FA proteins such as RAD51, BRCA2, or FANCD2 protect stalled replication fork...

journal_title：Blood

authors： Okamoto Y,Abe M,Mu A,Tempaku Y,Rogers CB,Mochizuki AL,Katsuki Y,Kanemaki MT,Takaori-Kondo A,Sobeck AT,Bielinsky AK,Takata M

更新日期：2020-07-31 00:00:00

abstract：:The response of human myeloid leukemia cells to treatment with 1-beta-arabinofuranosylcytosine (ara-C) includes the induction of apoptosis. Ara-C induced apoptosis is associated with proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and protein kinase C (PKC) delta. However, the signals involved in this respo...

journal_title：Blood

authors： Datta R,Banach D,Kojima H,Talanian RV,Alnemri ES,Wong WW,Kufe DW

更新日期：1996-09-15 00:00:00

abstract：:Phospholipase A(2) type IVA (IVAPLA(2)) is a cytosolic enzyme that on activation selectively releases arachidonic acid (AA) from cell membrane phospholipids. Both AA and lysophospholipid, products of the enzymic reaction, can function as signal transducers in cellular interactions. The enzyme is present in most cells,...

journal_title：Blood

authors： Macdonald DJ,Boyle RM,Glen AC,Horrobin DF

更新日期：2004-05-01 00:00:00

abstract：:This phase 2 study evaluated the efficacy and safety of the oral farnesyltransferase inhibitor tipifarnib in adults with refractory or relapsed acute myeloid leukemia (AML). Patients (n=252) received tipifarnib 600 mg twice a day for 21 days in 28-day cycles. Median age was 62 years; 99 (39%) patients were 65 years or...

journal_title：Blood

authors： Harousseau JL,Lancet JE,Reiffers J,Lowenberg B,Thomas X,Huguet F,Fenaux P,Zhang S,Rackoff W,De Porre P,Stone R,Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group.

更新日期：2007-06-15 00:00:00

abstract：:A 42-yr-old woman with systemic lupus erythematosus without bleeding diathesis developed a prolonged activated partial thromboplastin time that was not corrected by normal plasma. An inhibitor that acted rapidly and inactivated 0.5 U/ml plasma thromboplastin antecedent (PTA, factor XI) at a 1:200 plasma dilution was d...

journal_title：Blood

authors： Poon MC,Saito H,Koopman WJ

更新日期：1984-06-01 00:00:00

abstract：:Interleukin-3 (IL-3) has been shown to be a promising agent in the stimulation of bone marrow regeneration following myeloablative therapy. The biologic half-life of this agent is very short (5 to 15 minutes), which limits the effectiveness of low-dose therapy. Here we show that the biologic effects of low-dose IL-3 i...

journal_title：Blood

authors： Jones AT,Ziltener HJ

更新日期：1993-08-15 00:00:00

abstract：:Wilms' tumor 1 (WT1) is constantly expressed in leukemic cells of acute leukemia and myelodysplastic syndrome (MDS). A T-cell receptor (TCR) that specifically reacts with WT1 peptide in the context of HLA-A*24:02 has been identified. We conducted a first-in-human trial of TCR-gene transduced T-cell (TCR-T-cell) transf...

journal_title：Blood

authors： Tawara I,Kageyama S,Miyahara Y,Fujiwara H,Nishida T,Akatsuka Y,Ikeda H,Tanimoto K,Terakura S,Murata M,Inaguma Y,Masuya M,Inoue N,Kidokoro T,Okamoto S,Tomura D,Chono H,Nukaya I,Mineno J,Naoe T,Emi N,Yasukawa M,

更新日期：2017-11-02 00:00:00

abstract：:Laminin is a heterotrimeric glycoprotein that plays a central role in promoting neutrophil chemotaxis, motility, and attachment to basement membrane. Rabbit peritoneal exudate neutrophils stain positively for laminin, which is presumed to be of exogenous origin and bound to laminin receptors on the cell surface. We ex...

journal_title：Blood

authors： Tweardy DJ,Sasaki M,Cardamone JJ Jr,McCoy JP Jr,Bonidie MJ,Signorella AP

更新日期：1990-10-01 00:00:00

abstract：:Telomere length has been linked to disease stage and degree of (pan-)cytopenia in patients with bone marrow failure syndromes. The aim of the current study was to analyze the impact of replicative stress on telomere length in residual glycosylphosphatidylinositol-positive (GPI+) versus GPI- hematopoiesis in patients w...

journal_title：Blood

authors： Beier F,Balabanov S,Buckley T,Dietz K,Hartmann U,Rojewski M,Kanz L,Schrezenmeier H,Brümmendorf TH

更新日期：2005-07-15 00:00:00

abstract：:CXCL4 and CXCL4L1 are 2 closely related CXC chemokines that exhibit potent antiangiogenic activity. Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B. We further demo...

journal_title：Blood

authors： Dubrac A,Quemener C,Lacazette E,Lopez F,Zanibellato C,Wu WG,Bikfalvi A,Prats H

更新日期：2010-11-25 00:00:00

abstract：:The effect of HbA and HbF on both the aggregation and deaggregation of deoxy HbS and deoxy HbCHarlem in concentrated phosphate buffers was studied by a turbidimetric method. Although pure deoxy HbA is fully soluble in 2.4 M potassium phosphate buffer, the same concentration of deoxy HbAS was insoluble in the same buff...

journal_title：Blood

authors： Adachi K,Asakura T,Schwartz E

更新日期：1980-03-01 00:00:00

abstract：:It is known from nutritional studies that vitamin A is an important factor for normal hematopoiesis, though it has been difficult to define its precise role. The vitamin A-deficient (VAD) quail embryo provides an effective ligand "knockout" model for investigating the function of retinoids during development. The VAD ...

journal_title：Blood

authors： Ghatpande S,Ghatpande A,Sher J,Zile MH,Evans T

更新日期：2002-04-01 00:00:00

abstract：:The effect of shear force (depending on shear rate and viscosity of extracellular medium) and hematocrit of RBC suspension on RBC deformation was studied quantitatively using a cone-plate rheoscope with various kinds of cells, ie, partially hemolyzed (PH) cells, density-fractionated intact cells, and diamide-treated c...

journal_title：Blood

authors： Kon K,Maeda N,Shiga T

更新日期：1987-03-01 00:00:00

abstract：:We previously found that the myeloid cell surface glycoprotein CD13 (gp150) is identical to aminopeptidase N (EC 3.4.11.2), a widely distributed membrane-bound, zinc-dependent metalloprotease with an extracellular enzymatic domain that cleaves N-terminal amino acid residues from oligopeptides (J Clin Invest 83:1299, 1...

journal_title：Blood

authors： Ashmun RA,Look AT

更新日期：1990-01-15 00:00:00

abstract：:Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Novel therapeutic targets against preleukemic stem cells need to be identified for potentially curative strategies. We conducted parallel transcriptional...

journal_title：Blood

authors： Schinke C,Giricz O,Li W,Shastri A,Gordon S,Barreyro L,Bhagat T,Bhattacharyya S,Ramachandra N,Bartenstein M,Pellagatti A,Boultwood J,Wickrema A,Yu Y,Will B,Wei S,Steidl U,Verma A

更新日期：2015-05-14 00:00:00

abstract：:Activation of the mitogen-activated protein (MAP) kinase pathway has been associated with both cell proliferation and differentiation. Constitutively activated forms of Mek (MAP kinase/Erk kinase) and Erk (MAP kinase) have been previously shown capable of inducing differentiation or proliferation in nonhematopoietic c...

journal_title：Blood

authors： Melemed AS,Ryder JW,Vik TA

更新日期：1997-11-01 00:00:00

abstract：:Hematopoietic growth factors (HGFs) interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) individually have been shown to increase the percentage of acute myeloid leukemia (AML) blasts in S phase and enhance the cytotoxic effects of Ara-C against these blasts in culture. We compared in vit...

journal_title：Blood

authors： Bhalla K,Holladay C,Arlin Z,Grant S,Ibrado AM,Jasiok M

更新日期：1991-11-15 00:00:00

abstract：:Caloric restriction (CR) is proposed to decrease tumorigenesis through a variety of mechanisms including effects on glycolysis. However, the understanding of how CR affects the response to cancer therapy is still rudimentary. Here, using the Eµ-Myc transgenic mouse model of B-cell lymphoma, we report that by reducing ...

journal_title：Blood

authors： Meynet O,Zunino B,Happo L,Pradelli LA,Chiche J,Jacquin MA,Mondragón L,Tanti JF,Taillan B,Garnier G,Reverso-Meinietti J,Mounier N,Michiels JF,Michalak EM,Carles M,Scott CL,Ricci JE

更新日期：2013-10-03 00:00:00

abstract：:Dendritic cells (DCs) are considered critical for the induction of graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In addition to their priming function, dendritic cells have been shown to induce organ-tropism through induction of specific homing molecules on T cells. Using adoptive transfer ...

journal_title：Blood

authors： Kim TD,Terwey TH,Zakrzewski JL,Suh D,Kochman AA,Chen ME,King CG,Borsotti C,Grubin J,Smith OM,Heller G,Liu C,Murphy GF,Alpdogan O,van den Brink MR

更新日期：2008-03-01 00:00:00