Abstract:
:The VLA-4 integrin (CD49d/CD29), initially discovered on lymphoid cells, is actually known to be highly expressed on T cells, B cells, monocytes, and derived cell lines. Unlike other VLA integrins, mainly involved in cell-matrix adhesive interactions, VLA-4 has also been implicated in several cellular interactions. Based on the published alpha 4 cDNA sequence, a 1,142-bp alpha 4 cDNA fragment was amplified using the polymerase chain reaction. This fragment was used to isolate three overlapping genomic clones from a phage library. By Southern analysis with the cDNA probe, and using the polymerase chain reaction on DNA isolated from a panel of human/mouse somatic cell hybrids, the alpha 4 gene was mapped to chromosome 2. Fluorescence in situ hybridization confirmed this assignment and allowed a more precise mapping to chromosome 2q31-32.
journal_name
Bloodjournal_title
Bloodauthors
Zhang ZH,Vekemans S,Aly MS,Jaspers M,Marynen P,Cassiman JJsubject
Has Abstractpub_date
1991-11-01 00:00:00pages
2396-9issue
9eissn
0006-4971issn
1528-0020journal_volume
78pub_type
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