Abstract:
:Acute graft-versus-host disease (aGVHD) impairs thymus-dependent T-cell regeneration in recipients of allogeneic bone marrow transplants through yet to be defined mechanisms. Here, we demonstrate in mice that MHC-mismatched donor T cells home into the thymus of unconditioned recipients. There, activated donor T cells secrete IFN-gamma, which in turn stimulates the programmed cell death of thymic epithelial cells (TECs). Because TECs themselves are competent and sufficient to prime naive allospecific T cells and to elicit their effector function, the elimination of host-type professional antigen-presenting cells (APCs) does not prevent donor T-cell activation and TEC apoptosis, thus precluding normal thymopoiesis in transplant recipients. Hence, strategies that protect TECs may be necessary to improve immune reconstitution following allogeneic bone marrow transplantation.
journal_name
Bloodjournal_title
Bloodauthors
Hauri-Hohl MM,Keller MP,Gill J,Hafen K,Pachlatko E,Boulay T,Peter A,Holländer GA,Krenger Wdoi
10.1182/blood-2006-07-034157subject
Has Abstractpub_date
2007-05-01 00:00:00pages
4080-8issue
9eissn
0006-4971issn
1528-0020pii
blood-2006-07-034157journal_volume
109pub_type
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