Abstract：
:To investigate the natural history of stage A chronic lymphocytic leukemia (CLL) we reviewed 84 such patients. Among 74 cases evaluable for disease progression, 22 (29.6%) progressed to more advanced clinical stages (9 to stage B, 13 to stage C); the actuarial estimation of such an event at 4 years was 30% (95% CI: 26.3% to 33.6%). Despite a linear trend toward an increasing risk (r = .92), the hazard function analysis showed a constant pattern of progression, suggesting a lack of correlation of such an event with time (r = .04). Furthermore, disease progression when analyzed as a time-dependent variable had a clear-cut impact on survival (P less than .001). With the aim of identifying a subgroup of patients with low probability of disease progression and death, we applied to our set of patients four different proposals for subclassifying stage A. All methods were similar in terms of sample size, 5-year survival rate, and disease progression risk, suggesting that the choice between different proposals is somewhat arbitrary. Whatever the criteria are for defining "smoldering" CLL, such patients (accounting in the present study for 20.5% of overall series and 46.7% of stage A patients) should not be treated until progression occurs.
journal_name
Bloodjournal_title
Bloodauthors
Molica Ssubject
Has Abstractpub_date
1991-08-15 00:00:00pages
895-9issue
4eissn
0006-4971issn
1528-0020journal_volume
78pub_type
杂志文章相关文献
BLOOD文献大全abstract：:Interleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15. They belong to a cytokine family that uses the common gamma chain for signaling but also have their private high-affinity receptors. Since it is well known that IL-4 modulates differentiation and activation of dendritic cells (DCs), ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2003-03-0669
更新日期：2003-12-01 00:00:00
abstract：:We have cloned, expressed, and partially purified a naturally occurring, truncated, soluble form of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit to investigate its biochemical and biologic properties. The soluble receptor species lacks the transmembrane and cytoplasmic dom...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1995-03-15 00:00:00
abstract：:A novel gene, jumonji was identified by a mouse gene trap strategy. The jumonji gene encodes a protein containing a putative DNA binding domain. The mice homozygous for jumonji gene with a BALB/cA genetic background show hypoplasia of the fetal liver and embryonic lethality, suggesting impaired hematopoiesis. In the p...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:We retrospectively analyzed outcomes among 567 patients with hematologic malignancies who had hematopoietic cell transplantation from human leukocyte antigen-identical sibling donors between 2001 and 2007 for a correlation between statin use and risk of graft-versus-host disease (GVHD). Compared with allografts where ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2009-08-240358
更新日期：2010-02-11 00:00:00
abstract：:The regulation of CCR6 (chemokine receptor 6) expression during B-cell ontogeny and antigen-driven B-cell differentiation was analyzed. None of the CD34(+)Lin(-) hematopoietic stem cell progenitors or the CD34(+)CD19(+) (pro-B) or the CD19(+)CD10(+) (pre-B/immature B cells) B-cell progenitors expressed CCR6. CCR6 is a...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：2000-10-01 00:00:00
abstract：:A genetic mutation in mice (W/Wv) causes an autosomal recessive disease characterized by hypoplastic anemia which lasts throughout life. Double-dominant W/Wv anemic mice were sublethally irradiated to facilitate repopulation of marrow with transplanted cells and were injected intravenously with suspensions of 5-10 mil...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1977-10-01 00:00:00
abstract：:Optimal conditions necessary for the cytochemical demonstration of megakaryocyte (Mk) and platelet acid phosphatase (AP) were determined. Methanol, a constituent of fixatives commonly used in AP cytochemistry, was found to inhibit MkAP, and the degree of inhibition varied with Mk maturity. Immature Mk contained predom...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
abstract：:To elucidate the pathways by which nitric oxide (NO) influences macrophage iron metabolism, the uptake, release, and intracellular distribution of iron in the murine macrophage cell line J774 has been investigated, together with transferrin receptor (TfR) expression and iron-regulatory protein (IRP1 and IRP2) activity...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:Although much of the function of von Willebrand factor (VWF) has been revealed, detailed insight into the molecular structure that enables VWF to orchestrate hemostatic processes, in particular factor VIII (FVIII) binding and stabilization in plasma, is lacking. Here, we present the high-resolution solution structure ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2013-07-517086
更新日期：2014-06-26 00:00:00
abstract：:A technique has been developed for handling human bone marrow cells intended for the examination of DNA repair synthesis. DNA-repair synthesis, induced by melphalan and nitrogen mustard, was measured as the incorporation of 3H-thymidine, registered by autoradiography as unscheduled DNA synthesis (UDS). Comparison of v...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1979-12-01 00:00:00
abstract：:The NADPH:O2 oxidoreductase catalyzing the respiratory burst in activated phagocytes from healthy individuals is not operative in phagocytes from patients with chronic granulomatous disease (CGD). In a microscopic slide test using the dye nitroblue tetrazolium (NBT), carriers of X-linked CGD can be recognized by a mos...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:The intercellular crosstalk between hematological malignancies and the tumor microenvironment is mediated by cell-to-cell interactions and soluble factors. One component of the secretome that is gaining increasing attention is the extracellular vesicles and, in particular, the exosomes. Apart from the role as vectors ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2016-05-715961
更新日期：2016-12-08 00:00:00
abstract：:Chronic graft-versus-host disease (GVHD) requires long-term immunosuppressive therapy after hematopoietic cell transplantation. We retrospectively analyzed a cohort of 751 patients with chronic GVHD to identify characteristics associated with the duration of immunosuppressive treatment. Among the 274 patients who disc...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-01-0200
更新日期：2004-12-01 00:00:00
abstract：:During an 8-year period, 28 young adults (median age 27 years) and 30 children (median age 10 years) with severe aplastic anemia have received allogeneic bone marrow transplantation (BMT) from major histocompatibility locimatched sibling donors after preparation with cyclophosphamide and total lymphoid irradiation (TL...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：:We have re-evaluated the previously reported ability of TLCK-thrombin (N alpha-tosyl-L-lysine chloromethyl ketone-treated alpha-thrombin) and PPACK-thrombin (D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone-treated alpha-thrombin) to inhibit alpha-thrombin-induced platelet activation (Harmon JT, Jamieson GA: J B...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1990-05-15 00:00:00
abstract：:The stages of human natural killer (NK) cell differentiation are not well established. Culturing CD34(+) progenitors with interleukin 7 (IL-7), IL-15, stem cell factor (SCF), FLT-3L, and murine fetal liver cell line (EL08.1D2), we identified 2 nonoverlapping subsets of differentiating CD56(+) cells based on CD117 and ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2006-04-020198
更新日期：2006-12-01 00:00:00
abstract：:The complex of the serine protease factor IX (FIX) and its cofactor, factor VIII (FVIII), is crucial for propagation of the intrinsic coagulation cascade. Absence of either factor leads to hemophilia, a disabling disorder marked by excessive hemorrhage after minor trauma. FVIII is the more commonly affected protein, e...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-05-353672
更新日期：2012-01-12 00:00:00
abstract：:A cytologic and cytogenetic study of 10 cases of acute myeloblastic leukemia with maturation and t(8;21) translocation is reported. Despite a certain polymorphic appearance, the characteristic cytologic picture, consisting essentially of large myeloblasts with an abundant cytoplasma containing a large Auer rod, allowe...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Cryoprecipitate has been demonstrated to correct the bleeding abnormality of patients with some congenital (storage pool disease) and acquired (uremia) platelet abnormalities, but the reason for this effect is unknown. We found significant platelet contamination in plasma harvested to prepare fresh frozen plasma and c...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:Natural killer (NK) cells are large granular lymphocytes (LGLs) that contain distinct lysosomal granules. The present study was undertaken to determine if these lysosomes contain glycosaminoglycans (GAGs) similar to those previously described in myeloid cells. Mononuclear cells from human blood were stained with HNK-1...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:We assessed the effects of the c-kit ligand, stem cell factor (SCF), in the jejunal mucosal mast cell hyperplasia that occurs during infection with the intestinal nematodes, Nippostrongylus brasiliensis or Trichinella spiralis in rats. Compared with vehicle-treated rats, rats treated with SCF (25 micrograms/kg/d, intr...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2015-07-533588
更新日期：2015-11-26 00:00:00
abstract：:We prospectively evaluated 169 patients with a number of screening studies performed between 71 to 121 days after allogeneic marrow transplantation to detect the development of chronic graft-versus-host disease (GVHD). Group 1 patients (n = 78) were asymptomatic and had normal physical examinations at the time of scre...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:B7-H2, which is expressed constitutively on B cells and binds the inducible costimulator (ICOS) on antigen-activated T cells, is a member of the B7 family of costimulatory ligands. We have inactivated B7-H2 in the mouse. B7-H2-/- mice generate normal populations of B and T cells in their various lymphoid organs but ha...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-08-2416
更新日期：2003-08-15 00:00:00
abstract：:The vitelline artery is a temporary structure that undergoes extensive remodeling during midgestation to eventually become the superior mesenteric artery (also called the cranial mesenteric artery, in the mouse). Here we show that, during this remodeling process, large clusters of hematopoietic progenitors emerge via ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-04-279497
更新日期：2010-11-04 00:00:00
abstract：:The mutation status and usage of specific VH genes such as V3-21 and V1-69 are potentially independent pathogenic and prognostic factors in chronic lymphocytic leukemia (CLL). To investigate the role of antigenic stimulation, we analyzed the expression of genes involved in B-cell receptor (BCR) signaling/activation, c...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2005-04-1483
更新日期：2006-03-01 00:00:00
abstract：:The ability to determine the functional capacity of putative human hematopoietic stem cell (HSC) populations requires in vivo assays in which long-term multilineage differentiation can be assessed. We hypothesized that if human fetal bone was transplanted adjacent to a fetal thymus fragment in severe combined immunode...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:In this issue of Blood, Bagnara et al describe the development of a reliable and convincing xenograft model of CLL that recapitulates aspects of the leukemic microenvironment and gives intriguing insights into disease biology. ...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2011-03-342709
更新日期：2011-05-19 00:00:00
abstract：:To evaluate internal tandem duplication (ITD) insertion sites and length as well as their clinical impact in younger adult patients with FLT3-ITD-positive acute myeloid leukemia (AML), sequencing after DNA-based amplification was performed in diagnostic samples from 241 FLT3-ITD-mutated patients. All patients were tre...
journal_title：Blood
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1182/blood-2009-03-209999
更新日期：2009-09-17 00:00:00
abstract：:Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand the role of myosin in normal platelet functions and in pathology, we generated mice with disruption of MYH9 in megakaryocytes. MYH9Delta mice displayed macrothro...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2007-03-080184
更新日期：2007-11-01 00:00:00
