Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha/CCL20 in human B cells.

abstract：:The Lunenburg Lymphoma Biomarker Consortium (LLBC) evaluated the prognostic value of IHC biomarkers in a large series of patients with diffuse large B-cell lymphoma (DLBCL). Clinical data and tumor samples were retrieved from 12 studies from Europe and North America, with patients treated before or after the rituximab...

journal_title：Blood

authors： Salles G,de Jong D,Xie W,Rosenwald A,Chhanabhai M,Gaulard P,Klapper W,Calaminici M,Sander B,Thorns C,Campo E,Molina T,Lee A,Pfreundschuh M,Horning S,Lister A,Sehn LH,Raemaekers J,Hagenbeek A,Gascoyne RD,Weller E

更新日期：2011-06-30 00:00:00

abstract：:Graft-versus-host disease (GVHD) remains one of the major complications after allogeneic bone marrow transplantation (allo-BMT). Sirtuin-1 (Sirt-1) plays a crucial role in various biological processes including cellular senescence, metabolism, and inflammatory responses. Sirt-1 deacetylation regulates different transc...

journal_title：Blood

authors： Daenthanasanmak A,Iamsawat S,Chakraborty P,Nguyen HD,Bastian D,Liu C,Mehrotra S,Yu XZ

更新日期：2019-01-17 00:00:00

abstract：:There has been increasing interest in the involvement of mammalian homeobox (HOX) genes in hematopoietic regulation. The HOX genes are clustered in 4 chromosomes in mice and humans. In general, 5' end HOX gene expression is predominant in hematopoietic stem cell populations, whereas 3' end HOX gene expression are prim...

journal_title：Blood

authors： Zimmermann F,Rich IN

更新日期：1997-04-15 00:00:00

abstract：:Polycythemia vera (PV) treatment with interferon α (IFNα) is frequently limited by dose-related toxicity. PV CD34(+) cells are characterized by overexpression of Bcl-xL, which can be antagonized by ABT-737 leading to apoptosis. We explored the effects of ABT-737 and IFNα on PV hematopoiesis. Both IFNα and ABT-737 alon...

journal_title：Blood

authors： Lu M,Wang J,Li Y,Berenzon D,Wang X,Mascarenhas J,Xu M,Hoffman R

更新日期：2010-11-18 00:00:00

abstract：:In this issue of Blood, Jodele and colleagues report that defective complement regulation contributes to the development of thrombotic microangiopathy (TMA) after hematopoietic stem cell transplantation (HSCT) with important implications for diagnosis and management of this severe clinical complication. ...

journal_title：Blood

authors： Ricklin D,Cines DB

更新日期：2013-09-19 00:00:00

abstract：:Recent studies have shown that soluble factors elaborated by human T lymphocytes enhance erythroid burst formation by human peripheral blood null cells. This study demonstrates that media conditioned by a long-term T lymphocyte line augmented the growth of erythroid colonies in vitro in the presence of erythropoietin ...

journal_title：Blood

authors： Hamburger AW

更新日期：1980-10-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a severe renal disease that is associated with defective complement regulation caused by multiple factors. We previously described the deficiency of factor H-related proteins CFHR1 and CFHR3 as predisposing factor for aHUS. Here we identify in an extended cohort of 147 aHUS...

journal_title：Blood

authors： Józsi M,Licht C,Strobel S,Zipfel SL,Richter H,Heinen S,Zipfel PF,Skerka C

更新日期：2008-02-01 00:00:00

abstract：:Thrombophilia screening is controversial. In a retrospective family cohort, where probands had thrombosis and a thrombophilic defect, 2479 relatives were tested for thrombophilia. In antithrombin-, protein C-, and protein S-deficient relatives, annual incidences of venous thrombosis were 1.77% (95% CI, 1.14-2.60), 1.5...

journal_title：Blood

authors： Lijfering WM,Brouwer JL,Veeger NJ,Bank I,Coppens M,Middeldorp S,Hamulyák K,Prins MH,Büller HR,van der Meer J

更新日期：2009-05-21 00:00:00

abstract：:Three cases of T-lymphoblastic lymphomas (T-LL) expressing the T cell antigen receptor gamma delta (TCR gamma delta) are reported. All of them were CD3+/beta F1-/TCR delta 1+. Moreover, neoplastic cells reacted with the delta TCS1 monoclonal antibody (MoAb) which binds to the non-disulfide-linked form of the TCR gamma...

journal_title：Blood

authors： Falini B,Flenghi L,Fagioli M,Martelli MF,Pileri S,Grignani F,Beltrami A,Novero D,Pelicci PG

更新日期：1989-11-15 00:00:00

abstract：:Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, uni...

journal_title：Blood

authors： Kim YH,Willemze R,Pimpinelli N,Whittaker S,Olsen EA,Ranki A,Dummer R,Hoppe RT,ISCL and the EORTC.

更新日期：2007-07-15 00:00:00

abstract：:Although a large body of data on mobilization have yielded valuable clues, the mechanism(s) dictating egress of stem/progenitor cells during baseline hematopoiesis and after their mobilization are poorly understood. We have previously provided functional in vivo evidence that cytoadhesion molecules, specifically the b...

journal_title：Blood

authors： Papayannopoulou T,Priestley GV,Nakamoto B

更新日期：1998-04-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal hyperinflammatory syndrome characterized by fever, hepatosplenomegaly, cytopenia, and in some cases hemophagocytosis. Here, we describe the mutation analysis, clinical presentation, and functional analysis of natural killer (NK) cells in patients with mutation...

journal_title：Blood

authors： Meeths M,Entesarian M,Al-Herz W,Chiang SC,Wood SM,Al-Ateeqi W,Almazan F,Boelens JJ,Hasle H,Ifversen M,Lund B,van den Berg JM,Gustafsson B,Hjelmqvist H,Nordenskjöld M,Bryceson YT,Henter JI

更新日期：2010-10-14 00:00:00

abstract：:Autosomal recessive STAT1 deficiency is associated with impaired cellular responses to interferons and susceptibility to intracellular bacterial and viral infections. We report here a new form of partial STAT1 deficiency in 2 siblings presenting mycobacterial and viral diseases. Both carried a homozygous missense muta...

journal_title：Blood

authors： Kong XF,Ciancanelli M,Al-Hajjar S,Alsina L,Zumwalt T,Bustamante J,Feinberg J,Audry M,Prando C,Bryant V,Kreins A,Bogunovic D,Halwani R,Zhang XX,Abel L,Chaussabel D,Al-Muhsen S,Casanova JL,Boisson-Dupuis S

更新日期：2010-12-23 00:00:00

abstract：:Despite potential clinical importance, target cells for mother-to-child transmission of HIV-1 have not yet been identified. Cord blood-derived CD4(+) T cells are largely naive and do not express CCR5, the mandatory coreceptor for transmitted HIV-1 R5 strains in infants. In the present study, we demonstrate that in the...

journal_title：Blood

authors： Bunders MJ,van der Loos CM,Klarenbeek PL,van Hamme JL,Boer K,Wilde JC,de Vries N,van Lier RA,Kootstra N,Pals ST,Kuijpers TW

更新日期：2012-11-22 00:00:00

abstract：:Myeloablative conditioning results in thymic epithelial cell (TEC) injury, slow T-cell reconstitution, and a high risk of opportunistic infections. Keratinocyte growth factor (KGF) stimulates TEC proliferation and, when given preconditioning, reduces TEC injury. Thymocytes and TECs express androgen receptors, and expo...

journal_title：Blood

authors： Kelly RM,Highfill SL,Panoskaltsis-Mortari A,Taylor PA,Boyd RL,Holländer GA,Blazar BR

更新日期：2008-06-15 00:00:00

abstract：:Skewed X-chromosome inactivation in peripheral blood granulocytes becomes more frequent with increasing age, affecting up to half of those over 75 years old. To investigate the mechanisms underlying this phenomenon, X-inactivation profiles in 33 monozygotic and 22 dizygotic elderly twin pairs were studied. Differentia...

journal_title：Blood

authors： Vickers MA,McLeod E,Spector TD,Wilson IJ

更新日期：2001-03-01 00:00:00

abstract：:The association of fibroblast growth factor receptor 3 (FGFR3) expression with t(4;14) multiple myeloma (MM) and the demonstration of the transforming potential of this receptor tyrosine kinase (RTK) make it a particularly attractive target for drug development. We report here a novel and highly specific anti-FGFR3-ne...

journal_title：Blood

authors： Trudel S,Stewart AK,Rom E,Wei E,Li ZH,Kotzer S,Chumakov I,Singer Y,Chang H,Liang SB,Yayon A

更新日期：2006-05-15 00:00:00

abstract：:The CD11a/CD18 (leukocyte function-associated antigen 1 [LFA-1]) integrin mediates critical leukocyte adhesive interactions during immune and inflammatory responses. The CD11a promoter directs CD11a/CD18 integrin expression, and its activity in lymphoid cells depends on a functional RUNX1/AML-1-binding site (AML-110) ...

journal_title：Blood

authors： Puig-Kröger A,Sanchez-Elsner T,Ruiz N,Andreu EJ,Prosper F,Jensen UB,Gil J,Erickson P,Drabkin H,Groner Y,Corbi AL

更新日期：2003-11-01 00:00:00

abstract：:We have studied the impact of B-cell receptor (BCR) or CD40 ligation on the in vitro chemotactic response of tonsillar B cells to 4 chemokines: stromal cell-derived factor (SDF)-1alpha, macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and B-cell-attracting chemokine (BCA)-1. In the tonsil, SDF-1 and MIP-3alpha...

journal_title：Blood

authors： Casamayor-Pallejà M,Mondière P,Verschelde C,Bella C,Defrance T

更新日期：2002-03-15 00:00:00

abstract：:Fibrillar collagens are among the most potent activators of platelets and play an important role in the initiation of thrombosis. The glycoprotein VI (GPVI)/FcRgamma-chain complex is a central collagen receptor and inhibitors of GPVI produce a major defect in arterial thrombogenesis. In this study we have examined art...

journal_title：Blood

authors： Mangin P,Yap CL,Nonne C,Sturgeon SA,Goncalves I,Yuan Y,Schoenwaelder SM,Wright CE,Lanza F,Jackson SP

更新日期：2006-06-01 00:00:00

abstract：:Cutaneous involvement is seen in ~ 50% of adult T-cell leukemia/lymphoma (ATLL) patients. We investigated the association between skin eruption type and prognosis in 119 ATLL patients. ATLL eruptions were categorized into patch (6.7%), plaque (26.9%), multipapular (19.3%), nodulotumoral (38.7%), erythrodermic (4.2%), ...

journal_title：Blood

authors： Sawada Y,Hino R,Hama K,Ohmori S,Fueki H,Yamada S,Fukamachi S,Tajiri M,Kubo R,Yoshioka M,Nakashima D,Sugita K,Yoshiki R,Shimauchi T,Mori T,Izu K,Kobayashi M,Nakamura M,Tokura Y

更新日期：2011-04-14 00:00:00

abstract：:Monocytes regulate host defenses, inflammation, and tissue homeostasis. The transcription factor interferon regulatory factor-8 (IRF8) stimulates monocyte/macrophage differentiation, yet genome-wide understanding of the differentiation program initiated by IRF8 is lacking. By combining chromatin immunoprecipitation se...

journal_title：Blood

authors： Kurotaki D,Osato N,Nishiyama A,Yamamoto M,Ban T,Sato H,Nakabayashi J,Umehara M,Miyake N,Matsumoto N,Nakazawa M,Ozato K,Tamura T

更新日期：2013-03-07 00:00:00

abstract：:Severe congenital neutropenia as well as primary myelofibrosis are rare in infancy. Elucidation of the underlying mechanism is important because it extends our understanding of the more common adult forms of these disorders. Using homozygosity mapping followed by exome sequencing, we identified a Thr224Asn mutation in...

journal_title：Blood

authors： Stepensky P,Saada A,Cowan M,Tabib A,Fischer U,Berkun Y,Saleh H,Simanovsky N,Kogot-Levin A,Weintraub M,Ganaiem H,Shaag A,Zenvirt S,Borkhardt A,Elpeleg O,Bryant NJ,Mevorach D

更新日期：2013-06-20 00:00:00

abstract：:Thrombopoietin (TPO), the major growth factor for cells of the megakaryocytic lineage, is removed from circulation by binding to c-mpl receptors present on platelets and megakaryocytes. We studied patients with acute lymphoblastic leukemia (ALL) or acute myeloblastic leukemia (AML) and used TPO-induced c-fos protein u...

journal_title：Blood

authors： Corazza F,Hermans C,D'Hondt S,Ferster A,Kentos A,Benoît Y,Sariban E

更新日期：2006-03-15 00:00:00

abstract：:Protein vaccines for T-cell immunity are not being prioritized because of poor immunogenicity. To overcome this hurdle, proteins are being targeted to maturing dendritic cells (DCs) within monoclonal antibodies (mAbs) to DC receptors. To extend the concept to humans, we immunized human immunoglobulin-expressing mice w...

journal_title：Blood

authors： Cheong C,Choi JH,Vitale L,He LZ,Trumpfheller C,Bozzacco L,Do Y,Nchinda G,Park SH,Dandamudi DB,Shrestha E,Pack M,Lee HW,Keler T,Steinman RM,Park CG

更新日期：2010-11-11 00:00:00

abstract：:Large granular lymphocytes (LGL) are defined as nonadherent mononuclear cells with cytoplasmic azurophilic granules, avid receptors for the Fc portion of IgG, and cytotoxic functions (NK or ADCC activities). In the present study, the granules of LGL isolated from human peripheral blood have been analyzed by enzyme cyt...

journal_title：Blood

authors： Grossi CE,Cadoni A,Zicca A,Leprini A,Ferrarini M

更新日期：1982-02-01 00:00:00

abstract：:Erythroid (red blood) cells are the first cell type to be specified in the postimplantation mammalian embryo and serve highly specialized, essential functions throughout gestation and postnatal life. The existence of 2 developmentally and morphologically distinct erythroid lineages, primitive (embryonic) and definitiv...

journal_title：Blood

authors： Baron MH,Isern J,Fraser ST

更新日期：2012-05-24 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) family of cytokines regulates vascular development and inflammatory responses. We have recently shown that exposure of human umbilical vein endothelial cells (HUVECs) to hypoxia (1% O(2)) increases gene expression and bioactivation of TGF-beta2 and induces its downstream ...

journal_title：Blood

authors： Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA

更新日期：2003-03-15 00:00:00

abstract：:Immunosuppressive therapy can produce hematologic improvement in a large proportion of patients with severe aplastic anemia. Antithymocyte globulin (ATG) is the current treatment of choice for patients who do not have histocompatible sibling donors or who are otherwise inegligible for allogeneic bone marrow transplant...

journal_title：Blood

authors： Rosenfeld SJ,Kimball J,Vining D,Young NS

更新日期：1995-06-01 00:00:00

abstract：:We compared the effects of phorbol 12-myristate 13-acetate (PMA) and thrombin with those of nonlytic concentrations of reactive oxygen species (ROS) generated by hypoxanthine (HX)-xanthine oxidase (XO) on the adhesion properties of human umbilical cord vein endothelial cells (HUVEC) to resting polymorphonuclear neutro...

journal_title：Blood

authors： Sellak H,Franzini E,Hakim J,Pasquier C

更新日期：1994-05-01 00:00:00