Abstract:
:The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we review recent studies that highlight the heterogeneity of the stromal cells that comprise stem cell niches and the complexity of the signals that they generate. We highlight emerging data that stem cell niches in the bone marrow are not static but instead are responsive to environmental stimuli. Finally, we review recent data showing that hematopoietic niches are altered in certain hematopoietic malignancies, and we discuss how these alterations might contribute to disease pathogenesis.
journal_name
Bloodjournal_title
Bloodauthors
Calvi LM,Link DCdoi
10.1182/blood-2015-07-533588subject
Has Abstractpub_date
2015-11-26 00:00:00pages
2443-51issue
22eissn
0006-4971issn
1528-0020pii
blood-2015-07-533588journal_volume
126pub_type
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