CD40 activation does not protect chronic lymphocytic leukemia B cells from apoptosis induced by cytotoxic T lymphocytes.

abstract：:The c-myc oncoprotein accelerates programmed cell death (apoptosis) after growth factor deprivation or pharmacological insult in many cell lines. We have shown that max, the obligate c-myc heterodimeric partner protein, also promotes apoptosis after serum withdrawal in NIH3T3 fibroblasts or cytokine deprivation in int...

journal_title：Blood

authors： Nesbit CE,Fan S,Zhang H,Prochownik EV

更新日期：1998-08-01 00:00:00

abstract：:P-selectin expression has been shown in Helicobacter pylori-infected persons, an infection that has been clinically associated with platelet-related diseases, such as idiopathic thrombocytopenic purpura. However, the role of P-selectin expression during H pylori infection remains unclear. In this study, we hypothesize...

journal_title：Blood

authors： Yeh JJ,Tsai S,Wu DC,Wu JY,Liu TC,Chen A

更新日期：2010-05-27 00:00:00

abstract：:CD4(+)CD25(+)FOXP3(+) regulatory T cells (CD4(+) Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-...

journal_title：Blood

authors： Wei S,Kryczek I,Zou W

更新日期：2006-07-15 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) regulates hematopoietic stem/progenitor cell (HSPC) activity. However, the receptor(s) responsible for PGE(2) signaling remains unclear. Here, we identified EP4 as a receptor activated by PGE(2) to regulate HSPCs. Knockdown of Ep4 in HSPCs reduced long-term reconstitution capacity, whereas ...

journal_title：Blood

authors： Ikushima YM,Arai F,Hosokawa K,Toyama H,Takubo K,Furuyashiki T,Narumiya S,Suda T

更新日期：2013-03-14 00:00:00

abstract：:Pluripotent hematopoietic stem cells have been studied extensively, but the events that occur during their differentiation remain largely uncharted. To develop a system that allows the differentiation of cultured multipotent progenitors by time-lapse fluorescence microscopy, myelomonocytic cells were labeled with gree...

journal_title：Blood

authors： Faust N,Varas F,Kelly LM,Heck S,Graf T

更新日期：2000-07-15 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a typically aggressive myeloid neoplasm of childhood that is clinically characterized by overproduction of monocytic cells that can infiltrate organs, including the spleen, liver, gastrointestinal tract, and lung. JMML is categorized as an overlap myelodysplastic syndrome/mye...

journal_title：Blood

authors： Chang TY,Dvorak CC,Loh ML

更新日期：2014-10-16 00:00:00

abstract：:Exposure to HIV-1 does not necessarily result in infection and progression toward disease, thus suggesting that the control of viral infection may be achieved. Antibodies to CCR5 have been detected in HIV-exposed but uninfected subjects (ESNs); thus, these antibodies could be involved in HIV protection. To assess whet...

journal_title：Blood

authors： Pastori C,Weiser B,Barassi C,Uberti-Foppa C,Ghezzi S,Longhi R,Calori G,Burger H,Kemal K,Poli G,Lazzarin A,Lopalco L

更新日期：2006-06-15 00:00:00

abstract：:We report in this paper that a novel small molecule, JTZ-132, induced growth and differentiation of megakaryocytic progenitor cells and improved thrombocytopenia in myelosuppressed mice. JTZ-132 stimulated proliferation of UT-7/TPO cells, a cell line highly sensitive to thrombopoietin (TPO), and exhibited full efficac...

journal_title：Blood

authors： Inagaki K,Oda T,Naka Y,Shinkai H,Komatsu N,Iwamura H

更新日期：2004-07-01 00:00:00

abstract：:The family of core-binding factors includes the DNA-binding subunits Runx1-3 and their common non-DNA-binding partner CBFbeta. We examined the collective role of core-binding factors in hematopoiesis with a hypomorphic Cbfb allelic series. Reducing CBFbeta levels by 3- or 6-fold caused abnormalities in bone developmen...

journal_title：Blood

authors： Talebian L,Li Z,Guo Y,Gaudet J,Speck ME,Sugiyama D,Kaur P,Pear WS,Maillard I,Speck NA

更新日期：2007-01-01 00:00:00

abstract：:Antibody-mediated pure red cell aplasia is a rare but serious event resulting from the induction of neutralizing erythropoietin (Epo)-specific antibodies provoked by treatment with recombinant Epo. Because of the crucial role of CD4 T cells in humoral response, we have quantified the number of Epo-specific CD4 T cells...

journal_title：Blood

authors： Delluc S,Ravot G,Maillere B

更新日期：2010-11-25 00:00:00

abstract：:We have investigated the role of the Rho and Rac family small guanine triphosphate (GTP) exchange factors (RhoGEFs), Vav1 and Vav2, in the activation of platelets by the immunoreceptor tyrosine-based activation motif (ITAM)-coupled collagen receptor GPVI and by the G protein-coupled receptor agonist thrombin. The glyc...

journal_title：Blood

authors： Pearce AC,Wilde JI,Doody GM,Best D,Inoue O,Vigorito E,Tybulewicz VL,Turner M,Watson SP

更新日期：2002-11-15 00:00:00

abstract：:Interactions between vascular endothelial cells and blood platelets have been investigated using a model microcirculation consisting of microcarrier beads colonized with human umbilical vein endothelial cells (HUVECs) and perfused with washed platelet suspensions. To simulate the effects of endothelial desquamation an...

journal_title：Blood

authors： Chesterman CN,Owe-Young R,Macpherson J,Krilis SA

更新日期：1986-06-01 00:00:00

abstract：:The mechanisms of CD4(+) T-cell count decline, the hallmark of HIV disease progression, and its relationship to elevated levels of immune activation are not fully understood. Massive depletion of CD4(+) T cells occurs during the course of HIV-1 infection, so that maintenance of adequate CD4(+) T-cell levels probably d...

journal_title：Blood

authors： Sauce D,Larsen M,Fastenackels S,Pauchard M,Ait-Mohand H,Schneider L,Guihot A,Boufassa F,Zaunders J,Iguertsira M,Bailey M,Gorochov G,Duvivier C,Carcelain G,Kelleher AD,Simon A,Meyer L,Costagliola D,Deeks SG,Lambotte

更新日期：2011-05-12 00:00:00

abstract：:Human hematopoietic colony-forming cells (CFC) express the CD34 antigen (CD34+) as well as differentiation antigens such as CD33 and HLA-DR. CD34+ cells that do not express these latter differentiation antigens have been shown to contain few CFC in direct culture, but generate increasing numbers of CFC when cultured o...

journal_title：Blood

authors： Litzow MR,Brashem-Stein C,Andrews RG,Bernstein ID

更新日期：1991-06-01 00:00:00

abstract：:In a previous multicenter phase III trial comparing peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT) from HLA-matched related donors, we found no statistically significant difference in the cumulative incidence of clinical extensive chronic graft-versus-host disease (GVHD) in the...

journal_title：Blood

authors： Flowers ME,Parker PM,Johnston LJ,Matos AV,Storer B,Bensinger WI,Storb R,Appelbaum FR,Forman SJ,Blume KG,Martin PJ

更新日期：2002-07-15 00:00:00

abstract：:To determine whether cytokine-induced signals generate unique responses in multipotential hemopoietic progenitor cells, the signaling domains of 3 different growth factor receptors (Mpl, granulocyte-colony-stimulating factor [G-CSF] receptor, and Flt-3) were inserted into mouse primary bone marrow cells. To circumvent...

journal_title：Blood

authors： Zeng H,Masuko M,Jin L,Neff T,Otto KG,Blau CA

更新日期：2001-07-15 00:00:00

abstract：:The transcription factor encoded by the mi locus (MITF) is a transcription factor of the basic-helix-loop-helix zipper protein family. Mice of mi/mi genotype express a normal amount of abnormal MITF, whereas mice of tg/tg genotype do not express any MITFs due to the transgene insertional mutation. The effect of normal...

journal_title：Blood

authors： Ogihara H,Morii E,Kim DK,Oboki K,Kitamura Y

更新日期：2001-02-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is a highly proliferative neoplasm that frequently carries the t(2;5)(p23;q35) and aberrantly expresses nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). Previously, NPM-ALK had been shown to activate the phosphatidylinositol 3 kinase (PI3K)/Akt pathway. As the cyclin-dependent ...

journal_title：Blood

authors： Rassidakis GZ,Feretzaki M,Atwell C,Grammatikakis I,Lin Q,Lai R,Claret FX,Medeiros LJ,Amin HM

更新日期：2005-01-15 00:00:00

abstract：:Recent studies have reported that the pharmacokinetics of high-dose busulfan in bone marrow transplantation (BMT) are age-dependent: with the usual dosage of 16 mg/kg over 4 days, systemic exposure is two to four times lower in children than in adults. Data suggested that the dose of busulfan should rather be calculat...

journal_title：Blood

authors： Vassal G,Deroussent A,Challine D,Hartmann O,Koscielny S,Valteau-Couanet D,Lemerle J,Gouyette A

更新日期：1992-05-01 00:00:00

abstract：:Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). We investigated the feasibility of intensified preemptive immunotherapy in children receiving allo-SCT for AML. Eighty-four...

journal_title：Blood

authors： Rettinger E,Willasch AM,Kreyenberg H,Borkhardt A,Holter W,Kremens B,Strahm B,Woessmann W,Mauz-Koerholz C,Gruhn B,Burdach S,Albert MH,Schlegel PG,Klingebiel T,Bader P

更新日期：2011-11-17 00:00:00

abstract：:Primary cutaneous lymphomas (PCLs) are clonal T- or B-cell neoplasms, which originate in the skin. In recent years, mast cells were described as regulators of the tumor microenvironment in different human malignancies. Here, we investigated the role of mast cells in the tumor microenvironment of PCL. We found signific...

journal_title：Blood

authors： Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K

更新日期：2012-09-06 00:00:00

abstract：:Essential thrombocythemia (ET) and primary myelofibrosis (PMF) are chronic diseases characterized by clonal hematopoiesis and hyperproliferation of terminally differentiated myeloid cells. The disease is driven by somatic mutations in exon 9 of CALR or exon 10 of MPL or JAK2-V617F in >90% of the cases, whereas the rem...

journal_title：Blood

authors： Milosevic Feenstra JD,Nivarthi H,Gisslinger H,Leroy E,Rumi E,Chachoua I,Bagienski K,Kubesova B,Pietra D,Gisslinger B,Milanesi C,Jäger R,Chen D,Berg T,Schalling M,Schuster M,Bock C,Constantinescu SN,Cazzola M,Kralovi

更新日期：2016-01-21 00:00:00

abstract：:Heme biosynthesis was examined in erythroid tissue of a 4-yr-old girl with severe sideroblastic anemia since infancy, as documented by the presence of intramitochondrial deposits of iron in erythroblasts. Free red cell protoporphyrin, urinary porphyrins, and activities of erythrocyte porphobilinogen synthase, uroporph...

journal_title：Blood

authors： Buchanan GR,Bottomley SS,Nitschke R

更新日期：1980-01-01 00:00:00

abstract：:Without a prior history of hemorrhagic disease, a 62-year-old man suffered recurrent episodes of bleeding. Solubility of the patient's clot in 5 mol/L urea indicated a problem with fibrin stabilization. The transamidase activity potential of factor XIII, measured by the incorporation of radioactive putrescine into N,N...

journal_title：Blood

authors： Lorand L,Velasco PT,Murthy SN,Lefebvre P,Green D

更新日期：1999-02-01 00:00:00

abstract：:The regenerative capacity of hematopoietic stem cells (HSCs) is limited by the accumulation of DNA damage. Conditional mutagenesis of the histone 3 lysine 4 (H3K4) methyltransferase, Setd1a, revealed that it is required for the expression of DNA damage recognition and repair pathways in HSCs. Specific deletion of Setd...

journal_title：Blood

authors： Arndt K,Kranz A,Fohgrub J,Jolly A,Bledau AS,Di Virgilio M,Lesche M,Dahl A,Höfer T,Stewart AF,Waskow C

更新日期：2018-03-22 00:00:00

abstract：:Cytofluorimetric detection of the multidrug resistance (MDR)-associated membrane protein (P-170) was performed at the time of diagnosis in 158 patients with acute myeloid leukemia using the C219 monoclonal antibody (MoAb). In 108 of these cases the JSB1 MoAb was also tested. An improved histogram subtraction analysis,...

journal_title：Blood

authors： Del Poeta G,Stasi R,Aronica G,Venditti A,Cox MC,Bruno A,Buccisano F,Masi M,Tribalto M,Amadori S,Papa G

更新日期：1996-03-01 00:00:00

abstract：:It is widely accepted that the serum of healthy individuals contains natural antibodies only against those blood group A or B antigens that are not expressed on the individual's red blood cells. The mechanisms involved in tolerance to autologous blood group antigens remain unclear. In the present study, we show that I...

journal_title：Blood

authors： Spalter SH,Kaveri SV,Bonnin E,Mani JC,Cartron JP,Kazatchkine MD

更新日期：1999-06-15 00:00:00

abstract：:Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is initiated and driven by the oncogenic fusion protein BCR-ABL, a constitutively active tyrosine kinase. Despite major advances in the treatment of this highly aggressive disease with potent inhibitors of the BCR-ABL kinase such as dasatinib, pat...

journal_title：Blood

authors： Appelmann I,Rillahan CD,de Stanchina E,Carbonetti G,Chen C,Lowe SW,Sherr CJ

更新日期：2015-02-26 00:00:00

abstract：:Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that neonatal megakaryocyte (MK) progenitors are hyperproliferative and give rise to MKs smaller and of lower ploidy than adult MKs. Based on these characteristics, neonatal MKs have been consider...

journal_title：Blood

authors： Liu ZJ,Italiano J Jr,Ferrer-Marin F,Gutti R,Bailey M,Poterjoy B,Rimsza L,Sola-Visner M

更新日期：2011-04-14 00:00:00

abstract：:Erythroid progenitors (BFU-E) from adult human peripheral blood generate erythroid bursts in semisolid culture supplemented with at least two growth factors, ie, erythropoietin (Ep) and interleukin-3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF). We have analyzed the hematopoietin(s) requirement ...

journal_title：Blood

authors： Valtieri M,Gabbianelli M,Pelosi E,Bassano E,Petti S,Russo G,Testa U,Peschle C

更新日期：1989-07-01 00:00:00