Nonimmunoglobulin (non-Ig)/BCL6 gene fusion in diffuse large B-cell lymphoma results in worse prognosis than Ig/BCL6.

abstract：:Reticulocytes release small membrane vesicles termed exosomes during their maturation into erythrocytes. It has been suggested that reticulocytes remodel the plasma membrane of the immature red cell during erythropoiesis by specifically eliminating various proteins. We report here that exosome release is associated wi...

journal_title：Blood

authors： Blanc L,Barres C,Bette-Bobillo P,Vidal M

更新日期：2007-11-01 00:00:00

abstract：:Previously, it was believed that megakaryocytopoiesis was regulated by two types of humoral factors: megakaryocyte colony-stimulating factor (MK-CSF), which acts on progenitors inducing their proliferation, and thrombopoietin (TPO), a megakaryocyte(s) (MK) maturational factor that induces platelet formation. The recen...

journal_title：Blood

authors： Debili N,Wendling F,Katz A,Guichard J,Breton-Gorius J,Hunt P,Vainchenker W

更新日期：1995-10-01 00:00:00

abstract：:To test the in vivo cooperativity between interleukin-3 (IL-3) and erythropoietin (Epo) in stimulating erythropoiesis and hemoglobin F (HbF) production in primates, we administered recombinant human IL-3 and recombinant human Epo to baboons and macaques. The effect of these treatments was assessed by serial bone marro...

journal_title：Blood

authors： Umemura T,al-Khatti A,Donahue RE,Papayannopoulou T,Stamatoyannopoulos G

更新日期：1989-10-01 00:00:00

abstract：:Chronic lymphocytic leukemia is characterized by relapse after treatment and chemotherapy resistance. Similarly, in other malignancies leukemia cells accumulate mutations during growth, forming heterogeneous cell populations that are subject to Darwinian selection and may respond differentially to treatment. There is ...

journal_title：Blood

authors： Schuh A,Becq J,Humphray S,Alexa A,Burns A,Clifford R,Feller SM,Grocock R,Henderson S,Khrebtukova I,Kingsbury Z,Luo S,McBride D,Murray L,Menju T,Timbs A,Ross M,Taylor J,Bentley D

更新日期：2012-11-15 00:00:00

abstract：:Lipoprotein (a) [Lp(a)] has been associated with both anti-fibrinolytic and atherogenic effects. However, no direct link currently exists between this atherogenic lipoprotein and intravascular coagulation. The current study examined the binding and functional effects of Lp(a), its lipoprotein constituents, apoliprotei...

journal_title：Blood

authors： Caplice NM,Panetta C,Peterson TE,Kleppe LS,Mueske CS,Kostner GM,Broze GJ Jr,Simari RD

更新日期：2001-11-15 00:00:00

abstract：:Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. For personalized advice and follow-up regimens for patients, information is needed on how the radiotherapy-related risk is affected by other breast cancer risk factors. Genome-wide ...

journal_title：Blood

authors： Ma YP,van Leeuwen FE,Cooke R,Broeks A,Enciso-Mora V,Olver B,Lloyd A,Broderick P,Russell NS,Janus C,Ashworth A,Houlston RS,Swerdlow AJ

更新日期：2012-01-26 00:00:00

abstract：:Transplantation with 2-5 × 10(6) mobilized CD34(+)cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a proportion of patients/donors fail to mobilize sufficient cells. BM disease, prior treatment, and a...

journal_title：Blood

authors： To LB,Levesque JP,Herbert KE

更新日期：2011-10-27 00:00:00

abstract：:The biochemical signaling mechanisms involved in transducing the effects of interferon-gamma (IFN-gamma) on human leukemia-derived HL-60 cell differentiation are not completely understood. Recent studies established the existence of a sphingomyelin (SM) cycle that operates in response to the action of IFN-gamma on HL-...

journal_title：Blood

authors： Visnjić D,Batinić D,Banfić H

更新日期：1997-01-01 00:00:00

abstract：:Neuropilin-1 (Npn-1) is a receptor shared by class 3 semaphorins and heparin-binding forms of vascular endothelial growth factor (VEGF), protein families that regulate endothelial and neuronal-cell function. Ligand interaction with Npn-1 dictates the choice of signal transducer; plexins transduce semaphorin signals, a...

journal_title：Blood

authors： Narazaki M,Tosato G

更新日期：2006-05-15 00:00:00

abstract：:Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) in eliminating differentiated chronic myeloid leukemia (CML) cells, recent evidence suggests that leukemic stem and progenitor cells (LSPCs) persist long term, which may be partly attributable to cytokine-mediated resistance. We evaluated the express...

journal_title：Blood

authors： Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK

更新日期：2014-02-20 00:00:00

abstract：:The VLA-4 integrin (CD49d/CD29), initially discovered on lymphoid cells, is actually known to be highly expressed on T cells, B cells, monocytes, and derived cell lines. Unlike other VLA integrins, mainly involved in cell-matrix adhesive interactions, VLA-4 has also been implicated in several cellular interactions. Ba...

journal_title：Blood

authors： Zhang ZH,Vekemans S,Aly MS,Jaspers M,Marynen P,Cassiman JJ

更新日期：1991-11-01 00:00:00

abstract：:In the majority of Philadelphia (Ph)-positive chronic myeloid leukemia (CML) patients, the c-abl gene is fused to the bcr gene, resulting in the transcription of an 8.5 kb chimeric bcr-abl mRNA, which is translated into a p210bcr-abl fusion protein. In about 50% of the Ph-positive acute lymphoid leukemias (ALL), the b...

journal_title：Blood

authors： Selleri L,von Lindern M,Hermans A,Meijer D,Torelli G,Grosveld G

更新日期：1990-03-01 00:00:00

abstract：:Six patients with relapsed hairy cell leukemia after splenectomy were treated with high-dose methotrexate and leucovorin rescue. Five patients had objective responses as determined by improved blood counts. In two of them, the response has continued for more than 14 and 44 months, respectively. Intensive treatment wit...

journal_title：Blood

authors： Joosten P,Hagenbeek A,Löwenberg B,Sizoo W

更新日期：1985-07-01 00:00:00

abstract：:Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA). To investigate whether certain HLA class II genes are associated with susceptibility to such CyA-dependent AA, we determined the HLA class II alleles of 59 AA patients treated with CyA. Among 26 patie...

journal_title：Blood

authors： Nakao S,Takamatsu H,Chuhjo T,Ueda M,Shiobara S,Matsuda T,Kaneshige T,Mizoguchi H

更新日期：1994-12-15 00:00:00

abstract：:Although allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for patients with Fanconi anemia (FA), published series mostly refer to single-center experience with limited numbers of patients. We analyzed results in 795 patients with FA who underwent first HSCT between May 1972...

journal_title：Blood

authors： Peffault de Latour R,Porcher R,Dalle JH,Aljurf M,Korthof ET,Svahn J,Willemze R,Barrenetxea C,Mialou V,Soulier J,Ayas M,Oneto R,Bacigalupo A,Marsh JC,Peters C,Socie G,Dufour C,FA Committee of the Severe Aplastic Anemia W

更新日期：2013-12-19 00:00:00

abstract：:Pruritus is a common symptom in patients with Philadelphia chromosome-negative myeloproliferative disorders (MPDs). The pathophysiology of MPD-associated pruritus is unclear. We have demonstrated that MPD mast cells (MCs) are involved by the malignant process. In the present study, we explored the hypothesis that MCs ...

journal_title：Blood

authors： Ishii T,Wang J,Zhang W,Mascarenhas J,Hoffman R,Dai Y,Wisch N,Xu M

更新日期：2009-06-04 00:00:00

abstract：:Human myeloma cells freshly isolated from 40 patients with IgG multiple myeloma (MM, 10 in stage I and 30 in stage III), were cultured for 48 hours with recombinant B cell stimulatory factor 2 (rBSF-2)/interleukin-6 (IL-6), which is considered a major growth factor for myeloma cells. Uptake of 3H-thymidine by these pu...

journal_title：Blood

authors： Asaoku H,Kawano M,Iwato K,Tanabe O,Tanaka H,Hirano T,Kishimoto T,Kuramoto A

更新日期：1988-08-01 00:00:00

abstract：:An 81-year-old woman, who presented with sudden episodes of spontaneous bleeding, was found to have a specific inhibitor of factor XIII. Her fibrin clots had approximately 70% gamma-gamma and no alpha polymer formation, under conditions where normal fibrin was fully cross-linked; the patient's clots were soluble in ur...

journal_title：Blood

authors： Fukue H,Anderson K,McPhedran P,Clyne L,McDonagh J

更新日期：1992-01-01 00:00:00

abstract：:Although it is recognized that red cells lose membrane during storage, estimation of the osmotic fragility of erythrocytes has not previously proven to be a useful measurement of the storage lesion. Erythrocytes from blood stored in CPD-A2 were found to have a markedly increased osmotic fragility. A major portion of t...

journal_title：Blood

authors： Beutler E,Kuhl W,West C

更新日期：1982-06-01 00:00:00

abstract：:During this time of transition in the federal government and the National Institutes of Health, I write to assure the Blood community of the National Heart, Lung, and Blood Institute's (NHLBI) commitment to new and established investigators as outlined in the NHLBI Strategic Plan. This perspective discusses the NHLBI ...

journal_title：Blood

authors： Nabel EG

更新日期：2009-03-26 00:00:00

abstract：:Several primary murine and human B lymphomas and cell lines were found to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a member of the mitogen-activated protein (MAP) kinase family. Proliferation of murine B lymphomas CH31, CH12.Lx, BKS-2, and WEHI-231 and the human B lymp...

journal_title：Blood

authors： Gururajan M,Chui R,Karuppannan AK,Ke J,Jennings CD,Bondada S

更新日期：2005-08-15 00:00:00

abstract：:Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholester...

journal_title：Blood

authors： Krigel R,Liebes LF,Pelle E,Silber R

更新日期：1982-07-01 00:00:00

abstract：:The calcium, sodium, and magnesium permeability of erythrocytes from blood stored at 4 degrees C in various anticoagulant media has been studied and compared to that of fresh erythrocytes. Passive influx of CA2+ was measured at 37 degrees C in cells pretreated to abolish Ca2+ pumping and was up to fivefold greater for...

journal_title：Blood

authors： Wiley JS,McCulloch KE,Bowden DS

更新日期：1982-07-01 00:00:00

abstract：:Stem cell proliferation induced by potent cytokines usually leads to a loss of primitive potential through differentiation. In this study, the ability of cytokines and murine MS5 stromal cells to independently regulate the proliferation and long-term culture-initiating cell (LTC-IC) activity of primitive CD34(+)CD38(l...

journal_title：Blood

authors： Bennaceur-Griscelli A,Pondarré C,Schiavon V,Vainchenker W,Coulombel L

更新日期：2001-01-15 00:00:00

abstract：:Follicular lymphoma (FL) grades 1 and 2 are regarded as a distinct disease entity, whereas data suggest that FL grade 3 might be an inhomogeneous tumor category. To define the biologic spectrum of FL, 89 follicular lymphomas were studied for their cytologic composition, antigen expression, mitotic and proliferation in...

journal_title：Blood

authors： Ott G,Katzenberger T,Lohr A,Kindelberger S,Rüdiger T,Wilhelm M,Kalla J,Rosenwald A,Müller JG,Ott MM,Müller-Hermelink HK

更新日期：2002-05-15 00:00:00

abstract：:This study demonstrates that when platelets are stimulated by thrombin in the presence of low concentrations of purified human fibrinogen (10 to 20 micrograms/mL, final concentration) binding of released platelet von Willebrand factor (plt-vWF) to the platelet membrane is enhanced. This effect appears to be mediated b...

journal_title：Blood

authors： Parker RI,Gralnick HR

更新日期：1987-11-01 00:00:00

abstract：:Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called proplatelets, into bone marrow sinusoids. Proplatelet formation requires a profound reorganization of the MK actin and tubulin cytoskelet...

journal_title：Blood

authors： Pleines I,Dütting S,Cherpokova D,Eckly A,Meyer I,Morowski M,Krohne G,Schulze H,Gachet C,Debili N,Brakebusch C,Nieswandt B

更新日期：2013-10-31 00:00:00

abstract：:Mixed-lineage leukemia (MLL)-AF4 fusion arises prenatally in high-risk infant acute pro-B-lymphoblastic leukemia (pro-B-ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hematoendothelial specification but was insufficient for transformation, suggesting that additional oncogenic insults seem required for MLL...

journal_title：Blood

authors： Bueno C,Ayllón V,Montes R,Navarro-Montero O,Ramos-Mejia V,Real PJ,Romero-Moya D,Araúzo-Bravo MJ,Menendez P

更新日期：2013-05-09 00:00:00

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:The effects of recombinant human erythropoietin (rEp) on murine hematopoietic progenitors were studied using a serum-free culture. A high concentration of rEp stimulated the formation of mixed erythroid-megakaryocyte colonies (EM colonies) and blast cell colonies, as well as erythroid colonies, erythroid bursts, and m...

journal_title：Blood

authors： Nishi N,Nakahata T,Koike K,Takagi M,Naganuma K,Akabane T

更新日期：1990-10-01 00:00:00