Further characterization of the circulating cell in chronic lymphocytic leukemia.

abstract：:Acute myeloid leukemia (AML) is driven by niche-derived and cell-autonomous stimuli. Although many cell-autonomous disease drivers are known, niche-dependent signaling in the context of the genetic disease heterogeneity has been difficult to investigate. Here, we analyzed the role of Bruton tyrosine kinase (BTK) in AM...

journal_title：Blood

authors： Oellerich T,Mohr S,Corso J,Beck J,Döbele C,Braun H,Cremer A,Münch S,Wicht J,Oellerich MF,Bug G,Bohnenberger H,Perske C,Schütz E,Urlaub H,Serve H

更新日期：2015-03-19 00:00:00

abstract：:Protein vaccines for T-cell immunity are not being prioritized because of poor immunogenicity. To overcome this hurdle, proteins are being targeted to maturing dendritic cells (DCs) within monoclonal antibodies (mAbs) to DC receptors. To extend the concept to humans, we immunized human immunoglobulin-expressing mice w...

journal_title：Blood

authors： Cheong C,Choi JH,Vitale L,He LZ,Trumpfheller C,Bozzacco L,Do Y,Nchinda G,Park SH,Dandamudi DB,Shrestha E,Pack M,Lee HW,Keler T,Steinman RM,Park CG

更新日期：2010-11-11 00:00:00

abstract：:We evaluated phagocytic and lytic activities of peripheral blood monocytes (PBMo) from patients with thalassemia major (ThP) using C pseudotropicalis as the target. PBMo from ThP showed decreased lytic activity (P less than .001), whereas the phagocytic activity did not differ from that of the controls. Significant in...

journal_title：Blood

authors： Ballart IJ,Estevez ME,Sen L,Diez RA,Giuntoli J,de Miani SA,Peñalver J

更新日期：1986-01-01 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive, B-cell, non-Hodgkin lymphoma (NHL) categorized into endemic, sporadic and immunodeficiency-associated subtypes. BL has distinct pathologic and clinical features, characterized by rapidly progressive tumors with high rates of extranodal involvement. Next generation sequenci...

journal_title：Blood

authors： Crombie JL,LaCasce AS

更新日期：2020-11-10 00:00:00

abstract：:The PI3K/AKT signaling is activated in various hematologic malignancies. We evaluated the effect of a novel, pan-AKT kinase inhibitor, GSK690693, on the proliferation of 112 cell lines representing different hematologic neoplasia. Fifty-five percent of all cell lines tested were sensitive to AKT inhibitor (EC(50)<1 mi...

journal_title：Blood

authors： Levy DS,Kahana JA,Kumar R

更新日期：2009-02-19 00:00:00

abstract：:Neuroserpin, a recently identified inhibitor of tissue-type plasminogen activator (tPA), is primarily localized to neurons within the central nervous system, where it is thought to regulate tPA activity. In the present study neuroserpin expression and its potential therapeutic benefits were examined in a rat model of ...

journal_title：Blood

authors： Yepes M,Sandkvist M,Wong MK,Coleman TA,Smith E,Cohan SL,Lawrence DA

更新日期：2000-07-15 00:00:00

abstract：:A new unstable hemoglobin with high oxygen affinity, Hb Toyoake: beta 142 (H20) Ala replaced by Pro, was found in Japanese male with a normal blood hemoglobin level, shortened red cell survival, and increased plasma erythropoietin. Hemoglobin studies showed heat and isopropanol instability, and an increased tendency t...

journal_title：Blood

authors： Hirano M,Ohba Y,Imai K,Ino T,Morishita Y,Matsui T,Shimizu S,Sumi H,Yamamoto K,Miyaji T

更新日期：1981-04-01 00:00:00

abstract：:Insulin-like growth factor 1 (IGF-1) enhances thymopoiesis but given the broad distribution of IGF-1 receptors (IGF-1Rs), its mechanism of action has remained unclear. To identify points of thymic regulation by IGF-1, we examined its effects on T-cell precursors, thymocytes, and thymic epithelial cells (TECs) in norma...

journal_title：Blood

authors： Chu YW,Schmitz S,Choudhury B,Telford W,Kapoor V,Garfield S,Howe D,Gress RE

更新日期：2008-10-01 00:00:00

abstract：:We describe the membrane localization of a new platelet-specific alloantigen, designated Naka, that is involved in refractoriness to HLA-matched platelet transfusions. By indirect immunoprecipitation, anti-Naka antibody precipitated a single, radiolabeled platelet membrane protein with a molecular weight (mol wt) of 9...

journal_title：Blood

authors： Tomiyama Y,Take H,Ikeda H,Mitani T,Furubayashi T,Mizutani H,Yamamoto N,Tandon NN,Sekiguchi S,Jamieson GA

更新日期：1990-02-01 00:00:00

abstract：:Dosing of enzyme replacement therapy (ERT) for Gaucher disease type 1 is still a subject of debate and varies from 15 to 130 U/kg/mo, making a huge economic difference of 70,000 US dollars to 380,000 US dollars(euro55,000-300,000) per patient per year. To investigate whether this difference in dosing ultimately transl...

journal_title：Blood

authors： de Fost M,Hollak CE,Groener JE,Aerts JM,Maas M,Poll LW,Wiersma MG,Häussinger D,Brett S,Brill N,vom Dahl S

更新日期：2006-08-01 00:00:00

abstract：:Deficiency of folate or vitamin B(12) (cobalamin) causes megaloblastic anemia, a disease characterized by pancytopenia due to the excessive apoptosis of hematopoietic progenitor cells. Clinical and experimental studies of megaloblastic anemia have demonstrated an impairment of DNA synthesis and repair in hematopoietic...

journal_title：Blood

authors： Koury MJ,Price JO,Hicks GG

更新日期：2000-11-01 00:00:00

abstract：:Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and its human homologue GOS19.1/LD78 are members of the C-C chemokine/intercrine family of secreted proteins. They have proinflammatory properties and also inhibit cell cycle progression of hematopoietic stem cells. Characterization of MIP-1 alpha receptor(s) has b...

journal_title：Blood

authors： Avalos BR,Bartynski KJ,Elder PJ,Kotur MS,Burton WG,Wilkie NM

更新日期：1994-09-15 00:00:00

abstract：:Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. ADAMTS13 inhibits the ...

journal_title：Blood

authors： Zhu J,Muia J,Gupta G,Westfield LA,Vanhoorelbeke K,Tolia NH,Sadler JE

更新日期：2019-04-25 00:00:00

abstract：:To examine the role of the fibrinogen gamma chain in the assembly and secretion of this multichain protein, we synthesized a series of fibrinogen variants with truncated gamma chains, terminating between residues gamma379 and the C-terminus, gamma411. The variant fibrinogens were synthesized from altered gamma-chain c...

journal_title：Blood

authors： Okumura N,Terasawa F,Tanaka H,Hirota M,Ota H,Kitano K,Kiyosawa K,Lord ST

更新日期：2002-05-15 00:00:00

abstract：:D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D'D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides to form ultralong VWF concatemers. D'D3 forms the binding site fo...

journal_title：Blood

authors： Dong X,Leksa NC,Chhabra ES,Arndt JW,Lu Q,Knockenhauer KE,Peters RT,Springer TA

更新日期：2019-04-04 00:00:00

abstract：:The effects of colony-stimulating factor 1 (CSF-1), the primary regulator of mononuclear phagocyte production, are thought to be mediated by the CSF-1 receptor (CSF-1R), encoded by the c-fms proto-oncogene. To investigate the in vivo specificity of CSF-1 for the CSF-1R, the mouse Csf1r gene was inactivated. The phenot...

journal_title：Blood

authors： Dai XM,Ryan GR,Hapel AJ,Dominguez MG,Russell RG,Kapp S,Sylvestre V,Stanley ER

更新日期：2002-01-01 00:00:00

abstract：:Sickle red cell (SS RBC) adhesion is believed to contribute to the process of vaso-occlusion in sickle cell disease (SCD). We previously found that the LW RBC adhesion receptor can be activated by epinephrine to mediate SS RBC adhesion to endothelial alphavbeta3 integrin. To determine the contribution of LW activation...

journal_title：Blood

authors： Zennadi R,Moeller BJ,Whalen EJ,Batchvarova M,Xu K,Shan S,Delahunty M,Dewhirst MW,Telen MJ

更新日期：2007-10-01 00:00:00

abstract：:B19 parvovirus is the etiologic agent of fifth disease and transient aplastic crisis. In natural infections, B19 antigen and DNA have been detected in sera early in the course of aplastic crisis and only rarely in fifth disease. We have found B19 DNA in circulating cells of infected patients by DNA dot blot with a vir...

journal_title：Blood

authors： Kurtzman GJ,Gascon P,Caras M,Cohen B,Young NS

更新日期：1988-05-01 00:00:00

abstract：:Monocytes regulate host defenses, inflammation, and tissue homeostasis. The transcription factor interferon regulatory factor-8 (IRF8) stimulates monocyte/macrophage differentiation, yet genome-wide understanding of the differentiation program initiated by IRF8 is lacking. By combining chromatin immunoprecipitation se...

journal_title：Blood

authors： Kurotaki D,Osato N,Nishiyama A,Yamamoto M,Ban T,Sato H,Nakabayashi J,Umehara M,Miyake N,Matsumoto N,Nakazawa M,Ozato K,Tamura T

更新日期：2013-03-07 00:00:00

abstract：:Cellular oncogenes have been localized at the breakpoints of characteristic chromosomal rearrangements occurring in certain hematologic malignancies. This has been reported to result in aberrant expression of the involved oncogenes. Over 90% of chronic myelogenous leukemia (CML) is characterized by a reciprocal transl...

journal_title：Blood

authors： Romero P,Blick M,Talpaz M,Murphy E,Hester J,Gutterman J

更新日期：1986-03-01 00:00:00

abstract：:Classical 5q- syndrome is an acquired macrocytic anemia of the elderly. Similar to Diamond Blackfan anemia (DBA), an inherited red cell aplasia, the bone marrow is characterized by a paucity of erythroid precursors. RPS14 deletions in combination with other deletions in the region have been implicated as causative of ...

journal_title：Blood

authors： Vlachos A,Farrar JE,Atsidaftos E,Muir E,Narla A,Markello TC,Singh SA,Landowski M,Gazda HT,Blanc L,Liu JM,Ellis SR,Arceci RJ,Ebert BL,Bodine DM,Lipton JM

更新日期：2013-10-03 00:00:00

abstract：:Hydroxyurea (HU), a drug effective in the treatment of sickle cell disease, is thought to indirectly promote fetal hemoglobin (Hb F) production by perturbing the maturation of erythroid precursors. The molecular mechanisms involved in HU-mediated regulation of gamma-globin expression are currently unclear. We identifi...

journal_title：Blood

authors： Tang DC,Zhu J,Liu W,Chin K,Sun J,Chen L,Hanover JA,Rodgers GP

更新日期：2005-11-01 00:00:00

abstract：:A hybridoma-derived monoclonal antibody, produced by immunization with the Burkitt's tumor-derived B-lymphoblastoid cell line, B35M, was previously shown to detect a 68,000 dalton surface membrane protein, BL2, on the surface of peripheral blood B cells, which is absent from thymocytes, T cells, and granulocytes. In t...

journal_title：Blood

authors： Knowles DM 2nd,Tolidjian B,Marboe CC,Halper JP,Azzo W,Wang CY

更新日期：1983-07-01 00:00:00

abstract：:Peripheral blood from patients with acute myeloblastic leukemia (AML) contains cells capable of giving rise to colonies in culture when stimulated by media conditioned by leukocytes (LCM) in the presence of phytohemagglutinin (PHA). Two types of colonies are recognized with high frequency: The first grows in the prese...

journal_title：Blood

authors： Minden MD,Till JE,McCulloch EA

更新日期：1978-09-01 00:00:00

abstract：:Neutrophilic differentiation is dependent on CCAAT enhancer-binding protein α (C/EBPα), a transcription factor expressed in multiple organs including the bone marrow. Using functional genomic technologies in combination with clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 ...

journal_title：Blood

authors： Avellino R,Havermans M,Erpelinck C,Sanders MA,Hoogenboezem R,van de Werken HJ,Rombouts E,van Lom K,van Strien PM,Gebhard C,Rehli M,Pimanda J,Beck D,Erkeland S,Kuiken T,de Looper H,Gröschel S,Touw I,Bindels E,Delwel

更新日期：2016-06-16 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, or 5-HT), released from activated platelets, not only accelerates aggregation of platelets but also is known to promote mitosis, migration, and contraction of vascular smooth muscle cells (VSMCs). These effects are considered to contribute to thrombus formation and atherosclerosis. The ...

journal_title：Blood

authors： Kawano H,Tsuji H,Nishimura H,Kimura S,Yano S,Ukimura N,Kunieda Y,Yoshizumi M,Sugano T,Nakagawa K,Masuda H,Sawada S,Nakagawa M

更新日期：2001-03-15 00:00:00

abstract：:De novo presentation of acute myeloid leukemia (AML) expressing the Philadelphia (Ph) chromosomal abnormality is rare and is associated with a dismal prognosis. To date, reported cases of Ph(+) AML have expressed either the e13a2 or e14a2 BCR-ABL fusion transcripts. We report a unique case of de novo AML expressing th...

journal_title：Blood

authors： Ritchie DS,McBean M,Westerman DA,Kovalenko S,Seymour JF,Dobrovic A

更新日期：2008-03-01 00:00:00

abstract：:Neurexin I α (NRXN1α) and Dystroglycan (DAG1) are membrane receptors which serve as mutual ligands in the neuronal system. Neurexophilins (NXPHs) bind NRXN1α. NRXN1α was expressed in primitive populations in human CB (huCB) and murine BM (muBM). DAG1 is ubiquitously expressed in hematopoietic tissue; however, osteobla...

journal_title：Blood

authors： Kinzfogl J,Hangoc G,Broxmeyer HE

更新日期：2011-07-21 00:00:00

abstract：:The heterodimeric transcription factor RUNX1/PEBP2-beta (also known as AML1/CBF-beta) is essential for definitive hematopoiesis. Here, we show that interaction with PEBP2-beta leads to the phosphorylation of RUNX1, which in turn induces p300 phosphorylation. This is mediated by homeodomain interacting kinase 2 (HIPK2)...

journal_title：Blood

authors： Wee HJ,Voon DC,Bae SC,Ito Y

更新日期：2008-11-01 00:00:00

abstract：:An imbalance between cellular apoptosis and survival may be critical for the pathogenesis of lymphoma. Therefore, the gene expression pattern in lymph node preparations from patients with mantle cell lymphoma (MCL) was compared to the pattern in nonmalignant hyperplastic lymph nodes (HLs). Oligonucleotide microarray a...

journal_title：Blood

authors： Hofmann WK,de Vos S,Tsukasaki K,Wachsman W,Pinkus GS,Said JW,Koeffler HP

更新日期：2001-08-01 00:00:00