Abstract:
:We evaluated phagocytic and lytic activities of peripheral blood monocytes (PBMo) from patients with thalassemia major (ThP) using C pseudotropicalis as the target. PBMo from ThP showed decreased lytic activity (P less than .001), whereas the phagocytic activity did not differ from that of the controls. Significant inverse correlations were found between lytic activity of PBMo and age of patients (r2 = .47; P less than .01) and also between lytic activity and serum ferritin levels (r2 = .65; P less than .001). No association was found between lytic activity and other variables (blood transfusion regimens, therapy with desferrioxamine, liver damage, and the presence of sHBAg). Splenectomy showed no positive effect on PBMo functions from ThP. Our results suggest that PBMo from ThP have an intracellular defect in their microbicidal mechanisms associated with iron overload. This cell dysfunction could be responsible, at least in part, for the increased susceptibility to infections reported in ThP.
journal_name
Bloodjournal_title
Bloodauthors
Ballart IJ,Estevez ME,Sen L,Diez RA,Giuntoli J,de Miani SA,Peñalver Jsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
105-9issue
1eissn
0006-4971issn
1528-0020journal_volume
67pub_type
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