Activity of transgene-produced B-domain-deleted factor VIII in human plasma following AAV5 gene therapy.

abstract：:Keratinocyte growth factor (KGF) is important in tissue repair and wound healing and its administration can abrogate chemical- and radiation-induced tissue damage in rodents. We investigated KGF as a therapeutic agent for the prevention of graft-versus-host disease (GVHD)-induced tissue damage, morbidity, and mortalit...

journal_title：Blood

authors： Panoskaltsis-Mortari A,Lacey DL,Vallera DA,Blazar BR

更新日期：1998-11-15 00:00:00

abstract：:A 14-year-old boy with hemoglobin SC disease and alpha-thalassemia-2 experienced five episodes of acute splenic sequestration crisis (ASSC), while two of his siblings with identical globin genotypes (SC and -alpha/alpha alpha) had no such experience. To determine if an additional red blood cell (RBC) defect was respon...

journal_title：Blood

authors： Warkentin TE,Barr RD,Ali MA,Mohandas N

更新日期：1990-01-01 00:00:00

abstract：:Most anticancer chemotherapies are immunosuppressive and induce nonimmunogenic tumor cell death. Bortezomib, a specific inhibitor of 26S proteasome, has shown clinical activity in several human tumors, including myeloma. Here we show that the uptake of human myeloma cells by dendritic cells (DCs) after tumor cell deat...

journal_title：Blood

authors： Spisek R,Charalambous A,Mazumder A,Vesole DH,Jagannath S,Dhodapkar MV

更新日期：2007-06-01 00:00:00

abstract：:Erdheim-Chester disease (ECD) pathophysiology remains largely unknown. Its treatment is not codified and usually disappointing. Interferon (IFN)-α therapy lacks efficacy for some life-threatening manifestations and has a poor tolerance profile. Because interleukin (IL)-1Ra synthesis is naturally induced after stimulat...

journal_title：Blood

authors： Aouba A,Georgin-Lavialle S,Pagnoux C,Martin Silva N,Renand A,Galateau-Salle F,Le Toquin S,Bensadoun H,Larousserie F,Silvera S,Provost N,Candon S,Seror R,de Menthon M,Hermine O,Guillevin L,Bienvenu B

更新日期：2010-11-18 00:00:00

abstract：:In a study of the relationship between thrombocytopenia and increased vascular fragility, changes in the endothelium of capillaries and postcapillary venules of the tongue were examined by electron microscopy. Adult male albino rabbits (4 kg) were maintained thrombocytopenic (platelets less than 20,000/cu mm) up to 24...

journal_title：Blood

authors： Kitchens CS,Weiss L

更新日期：1975-10-01 00:00:00

abstract：:Posttranscriptional modification of histones by methylation plays an important role in regulating Ag-driven T-cell responses. We have recently drawn correlations between allogeneic T-cell responses and the histone methyltransferase Ezh2, which catalyzes histone H3 lysine 27 trimethylation. The functional relevance of ...

journal_title：Blood

authors： He S,Xie F,Liu Y,Tong Q,Mochizuki K,Lapinski PE,Mani RS,Reddy P,Mochizuki I,Chinnaiyan AM,Mineishi S,King PD,Zhang Y

更新日期：2013-12-12 00:00:00

abstract：:Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholester...

journal_title：Blood

authors： Krigel R,Liebes LF,Pelle E,Silber R

更新日期：1982-07-01 00:00:00

abstract：:Notch is a major factor mediating interaction between hematopoietic progenitor cells (HPCs) and bone marrow stroma (BMS). However its contribution to dendritic cell (DC) differentiation is controversial. We found that main Notch ligands Delta-1 and Jagged-1 had the opposite effect on DC differentiation. Delta-1 promot...

journal_title：Blood

authors： Cheng P,Nefedova Y,Corzo CA,Gabrilovich DI

更新日期：2007-01-15 00:00:00

abstract：:Cholesterol, in addition to providing rigidity to the fluid membrane, plays a critical role in receptor function, endocytosis, recycling, and signal transduction. In the present study, we examined the effect of membrane cholesterol on functional expression of tissue factor (TF), a cellular receptor for clotting factor...

journal_title：Blood

authors： Mandal SK,Iakhiaev A,Pendurthi UR,Rao LV

更新日期：2005-01-01 00:00:00

abstract：:The mechanisms by which transforming growth factor beta (TGF-beta) exerts a negative effect on cell-cycle entry in primary human hematopoietic stem/progenitor cells were examined at the molecular and cellular levels. After treatment of primary human CD34+ progenitors with TGF-beta there was a decrease in the levels of...

journal_title：Blood

authors： Dao MA,Hwa J,Nolta JA

更新日期：2002-01-15 00:00:00

abstract：:To examine the relationship between dietary iron exposure through the consumption of traditional beer and the presence of iron overload in black Africans not related by birth, we studied 28 husband and wife pairs from a rural Zimbabwean community. Lifetime traditional beer consumption was estimated by questioning subj...

journal_title：Blood

authors： Moyo VM,Gangaidzo IT,Gomo ZA,Khumalo H,Saungweme T,Kiire CF,Rouault T,Gordeuk VR

更新日期：1997-03-15 00:00:00

abstract：:Adenosine diphosphate (ADP)-ribosyl-transferases (ARTs) transfer ADP-ribose from nicotinamide adenine dinucleotide (NAD) onto target proteins. T cells express ART2.2, a toxin-related, glycosylphosphatidylinositol (GPI)-anchored ecto-enzyme. After the release of NAD from cells, ART2.2 ADP-ribosylates the P2X7 purinocep...

journal_title：Blood

authors： Bannas P,Adriouch S,Kahl S,Braasch F,Haag F,Koch-Nolte F

更新日期：2005-05-01 00:00:00

abstract：:We have recently demonstrated that IgD(hi) B cells can occupy an extravascular perisinusoidal niche in the bone marrow in addition to the well-established follicular niche in conventional secondary lymphoid organs. The spleen has long been considered to be the site at which newly formed B lymphocytes mature into IgD(h...

journal_title：Blood

authors： Cariappa A,Chase C,Liu H,Russell P,Pillai S

更新日期：2007-03-15 00:00:00

abstract：:The CD11b/CD18 leukocyte integrin molecule mediates diverse neutrophil adherence-related functions, including cell:cell and cell:extracellular matrix attachments. To study the individual role of this leukocyte integrin in cell adherence in hematopoietic cells, we expressed the CD11b/CD18 complex on the surface of K562...

journal_title：Blood

authors： Hickstein DD,Grunvald E,Shumaker G,Baker DM,Back AL,Embree LJ,Yee E,Gollahon KA

更新日期：1993-10-15 00:00:00

abstract：:Preliminary reports have suggested that survivors of childhood cancer and aplastic anemia who are infected with the hepatitis C virus (HCV) have a low risk for progression to significant liver disease. Among our surviving patients who were transfused between 1961 and March 1992, 77 (6.6% of surviving patients tested t...

journal_title：Blood

authors： Strickland DK,Riely CA,Patrick CC,Jones-Wallace D,Boyett JM,Waters B,Fleckenstein JF,Dean PJ,Davila R,Caver TE,Hudson MM

更新日期：2000-05-15 00:00:00

abstract：:To elucidate the biochemical basis of megaloblastic hematopoiesis, the cellular content and metabolism of deoxyribonucleoside triphosphates (dNTPs) were investigated using the bone marrow cells from nine patients with untreated vitamin B12 deficiency and one with folic acid deficiency. The marked imbalance among four ...

journal_title：Blood

authors： Iwata N,Omine M,Yamauchi H,Maekawa T

更新日期：1982-10-01 00:00:00

abstract：:The influence of intestinal bacterial decontamination on the occurrence of grades II to IV acute graft-versus-host disease (GVHD) was retrospectively analyzed in 194 predominantly adult patients treated by genotypically identical sibling marrow transplantation under conditions of strict protective isolation and intest...

journal_title：Blood

authors： Beelen DW,Haralambie E,Brandt H,Linzenmeier G,Müller KD,Quabeck K,Sayer HG,Graeven U,Mahmoud HK,Schaefer UW

更新日期：1992-11-15 00:00:00

abstract：:Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, uni...

journal_title：Blood

authors： Kim YH,Willemze R,Pimpinelli N,Whittaker S,Olsen EA,Ranki A,Dummer R,Hoppe RT,ISCL and the EORTC.

更新日期：2007-07-15 00:00:00

abstract：:Despite many studies on the pathophysiology of antiphospholipid antibodies (aPL), the mechanism by which aPL causes thrombosis has not been established. We have tried to elucidate the paradox between the prolongation of the clotting time of phospholipid-dependent coagulation tests in vitro and the occurrence of thromb...

journal_title：Blood

authors： Oosting JD,Derksen RH,Bobbink IW,Hackeng TM,Bouma BN,de Groot PG

更新日期：1993-05-15 00:00:00

abstract：:Enforced BCL-2 gene expression in leukemic cell lines suppresses apoptosis and confers resistance to anticancer drugs, but the clinical significance of increased BCL-2 protein levels in acute lymphoblastic leukemia (ALL) is unknown. Among 52 children with newly diagnosed ALL, BCL-2 expression in leukemic lymphoblasts ...

journal_title：Blood

authors： Coustan-Smith E,Kitanaka A,Pui CH,McNinch L,Evans WE,Raimondi SC,Behm FG,Aricò M,Campana D

更新日期：1996-02-01 00:00:00

abstract：:The mi locus of mice encodes a member of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). Cultured mast cells of mi/mi genotype (mi/mi CMCs) did not normally respond to stem cell factor (SCF), a ligand for the c-kit receptor tyrosine kinase. The poor...

journal_title：Blood

authors： Tsujimura T,Morii E,Nozaki M,Hashimoto K,Moriyama Y,Takebayashi K,Kondo T,Kanakura Y,Kitamura Y

更新日期：1996-08-15 00:00:00

abstract：:We describe a novel localization of C7 as a membrane-bound molecule on endothelial cells (ECs). Data obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), Western blot analysis, Northern blot analysis, and mass spectrometry revealed that membrane-associated C7 (mC7) was indistinguishable fr...

journal_title：Blood

authors： Bossi F,Rizzi L,Bulla R,Debeus A,Tripodo C,Picotti P,Betto E,Macor P,Pucillo C,Würzner R,Tedesco F

更新日期：2009-04-09 00:00:00

abstract：:In order to determine if mutant hemoglobins can be identified by relatively simple methods, a Working Group of the ICSH Expert Panel on Abnormal Hemoglobins and Thalassemia analyzed 17 hemolysates containing 14 different mutant hemoglobins by four electrophoretic methods: (1) cellulose acetate in alkaline buffers, (2)...

journal_title：Blood

authors：

更新日期：1978-11-01 00:00:00

abstract：:Soluble thrombomodulin plasma concentrations are elevated in steroid-resistant graft-versus-host disease (GVHD), implying endothelial hypofunctioning for thrombomodulin-dependent generation of activated protein C's (APC) anticoagulant, anti-inflammatory, and antiapoptotic functions. Recombinant thrombomodulin or APC a...

journal_title：Blood

authors： Sinha RK,Flynn R,Zaiken M,Paz K,Gavin AL,Nemazee D,Fernández JA,Xu X,Griffin JH,Blazar BR

更新日期：2019-08-29 00:00:00

abstract：:A new human leukemia cell line, KT-1, was established from a patient in the blastic crisis phase of chronic myelogenous leukemia (CML). This cell line had a positive reaction for intracytoplasmic myeloperoxidase and two Philadelphia chromosomes (Ph1) [t(9;22)(q34;q11)] and lacked normal copies of chromosomes 9 and 22....

journal_title：Blood

authors： Yanagisawa K,Yamauchi H,Kaneko M,Kohno H,Hasegawa H,Fujita S

更新日期：1998-01-15 00:00:00

abstract：:In this issue of Blood, Navarrete et al report that upfront immunization of follicular B-cell lymphoma patients with bacterially produced Fab fragments induces immune responses; however, the influence on patient outcome is not yet known. ...

journal_title：Blood

authors： Bogen B

更新日期：2011-02-03 00:00:00

abstract：:To directly determine whether the mechanism of activation of human plasminogen (HPg) by staphylokinase (Sak) required formation of an active complex of Sak and HPg, recombinant (r) variants of HPg were examined that allowed dissection of the steps involved in this activation. The rate of activation of wild-type (wt) r...

journal_title：Blood

authors： Grella DK,Castellino FJ

更新日期：1997-03-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering, intercellular adhesion molecule-1 (ICAM-1)-dependent firm adhesion, and platelet/endothelial cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration. An important unanswered question is whether ICAM-1-activated signal...

journal_title：Blood

authors： Liu G,Place AT,Chen Z,Brovkovych VM,Vogel SM,Muller WA,Skidgel RA,Malik AB,Minshall RD

更新日期：2012-08-30 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are widespread in adult organisms and may be involved in tissue maintenance and repair as well as in the regulation of hematopoiesis and immunologic responses. Thus, it is important to discover the factors controlling MSC renewal and differentiation. Here we report that adult MSCs express...

journal_title：Blood

authors： Pevsner-Fischer M,Morad V,Cohen-Sfady M,Rousso-Noori L,Zanin-Zhorov A,Cohen S,Cohen IR,Zipori D

更新日期：2007-02-15 00:00:00

abstract：:The putative chemokine receptor BLR1 has been identified as the first G-protein-coupled receptor involved in B-cell migration and in microenvironmental homing to B-cell follicles and to germinal centers. In healthy individuals, expression of BLR1 is restricted to all mature recirculating B cells and to a subpopulation...

journal_title：Blood

authors： Förster R,Schweigard G,Johann S,Emrich T,Kremmer E,Nerl C,Lipp M

更新日期：1997-07-15 00:00:00