IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo.

abstract：:Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe anticoagulation therapy development. Prostate cancer-mediated procoagulant activity was reduced in plasma in the absence of factor XII or its substrate of the int...

journal_title：Blood

authors： Nickel KF,Ronquist G,Langer F,Labberton L,Fuchs TA,Bokemeyer C,Sauter G,Graefen M,Mackman N,Stavrou EX,Ronquist G,Renné T

更新日期：2015-09-10 00:00:00

abstract：:The inherited skeletal dysplasia osteogenesis imperfecta (OI) results in multiple fractures and is currently treated empirically. We transplanted human first-trimester fetal blood mesenchymal stem cells (MSCs) into homozygous oim mice in utero. This resulted in a two-thirds reduction in long bone fractures (P < .01), ...

journal_title：Blood

authors： Guillot PV,Abass O,Bassett JH,Shefelbine SJ,Bou-Gharios G,Chan J,Kurata H,Williams GR,Polak J,Fisk NM

更新日期：2008-02-01 00:00:00

abstract：:Bleeding problems are associated with defects in platelet alpha-granules, yet little is known about how these granules are formed and released. Mutations affecting VPS33B, a novel Sec1/Munc18 protein, have recently been linked to arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome. We have characterized ...

journal_title：Blood

authors： Lo B,Li L,Gissen P,Christensen H,McKiernan PJ,Ye C,Abdelhaleem M,Hayes JA,Williams MD,Chitayat D,Kahr WH

更新日期：2005-12-15 00:00:00

abstract：:D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D'D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides to form ultralong VWF concatemers. D'D3 forms the binding site fo...

journal_title：Blood

authors： Dong X,Leksa NC,Chhabra ES,Arndt JW,Lu Q,Knockenhauer KE,Peters RT,Springer TA

更新日期：2019-04-04 00:00:00

abstract：:Although molecular biologic techniques can now detect minimal numbers of residual cancer cells in patients in complete clinical remission, the clinical significance of minimal residual disease has never been conclusively established. If the detection of minimal residual disease predicts which patients will relapse, th...

journal_title：Blood

authors： Gribben JG,Neuberg D,Freedman AS,Gimmi CD,Pesek KW,Barber M,Saporito L,Woo SD,Coral F,Spector N

更新日期：1993-06-15 00:00:00

abstract：:Notch signaling pathway regulates many different events of embryonic and adult development; among them, Notch plays an essential role in the onset of hematopoietic stem cells and influences multiple maturation steps of developing lymphoid and myeloid cells. Deregulation of Notch signaling determines several human diso...

journal_title：Blood

authors： Nwabo Kamdje AH,Krampera M

更新日期：2011-12-15 00:00:00

abstract：:Immunohistochemistry (IHC) was performed on archived bone marrow (BM) with a phosphospecific anti-AKT antibody. IHC on 26 BM biopsies from patients with multiple myeloma (MM) demonstrated phospho-AKT staining of malignant plasma cells in a cell membrane-specific pattern, whereas nonmalignant hematopoietic cells did no...

journal_title：Blood

authors： Hsu J,Shi Y,Krajewski S,Renner S,Fisher M,Reed JC,Franke TF,Lichtenstein A

更新日期：2001-11-01 00:00:00

abstract：:The IFN-inducible immunity-related p47 GTPase Irgm1 has been linked to Crohn disease as well as susceptibility to tuberculosis. Previously we demonstrated that HSC quiescence and function are aberrant in mice lacking Irgm1. To investigate the molecular basis for these defects, we conducted microarray expression profil...

journal_title：Blood

authors： King KY,Baldridge MT,Weksberg DC,Chambers SM,Lukov GL,Wu S,Boles NC,Jung SY,Qin J,Liu D,Songyang Z,Eissa NT,Taylor GA,Goodell MA

更新日期：2011-08-11 00:00:00

abstract：:TLRs expressed on dendritic cells (DCs) differentially activate DCs when activated alone or in combination, inducing distinct cytokines and costimulatory molecules that influence T-cell responses. Defining the requirements of DCs to program T cells during priming to become memory rather than effector cells could enhan...

journal_title：Blood

authors： Pufnock JS,Cigal M,Rolczynski LS,Andersen-Nissen E,Wolfl M,McElrath MJ,Greenberg PD

更新日期：2011-06-16 00:00:00

abstract：:Although preclinical work with rapalogs suggests potential in treatment of multiple myeloma (MM), they have been less successful clinically. These drugs allostearically inhibit the mammalian target of rapamycin kinase primarily curtailing activity of the target of rapamycin complex (TORC)1. To assess if the mammalian ...

journal_title：Blood

authors： Hoang B,Frost P,Shi Y,Belanger E,Benavides A,Pezeshkpour G,Cappia S,Guglielmelli T,Gera J,Lichtenstein A

更新日期：2010-11-25 00:00:00

abstract：:Myelodysplastic and leukemic stem cell clones that evolve in children and adults with Fanconi anemia universally bear complex cytogenetic abnormalities. The abnormalities are generally recurring deletions or chromosomal loss and involve precisely the same chromosomes with the same frequency as has been described in ma...

journal_title：Blood

authors： Lensch MW,Tischkowitz M,Christianson TA,Reifsteck CA,Speckhart SA,Jakobs PM,O'Dwyer ME,Olson SB,Le Beau MM,Hodgson SV,Mathew CG,Larson RA,Bagby GC Jr

更新日期：2003-07-01 00:00:00

abstract：:The anemia of chronic disease (ACD) results from 3 major processes: slightly shortened red cell survival, impaired reticuloendothelial system iron mobilization, and impaired erythropoiesis. Hepcidin is an acute-phase protein with specific iron regulatory properties, which, along with the anemia seen with increased hep...

journal_title：Blood

authors： Dallalio G,Law E,Means RT Jr

更新日期：2006-04-01 00:00:00

abstract：:In diffuse large B-cell lymphoma (DLBCL), the number of circulating monocytes and neutrophils represents an independent prognostic factor. These cell subsets include monocytic and granulocytic myeloid-derived suppressor cells (M- and G-MDSCs) defined by their ability to suppress T-cell responses. MDSCs are a heterogen...

journal_title：Blood

authors： Azzaoui I,Uhel F,Rossille D,Pangault C,Dulong J,Le Priol J,Lamy T,Houot R,Le Gouill S,Cartron G,Godmer P,Bouabdallah K,Milpied N,Damaj G,Tarte K,Fest T,Roussel M

更新日期：2016-08-25 00:00:00

abstract：:The influence of the shape of the red blood cell during stomatocyte-echinocyte transformation on its deformability was studied by microsieving through pores with diameters of 2.6, 4.5, and 6.9 micron. A stomatocytic transformation was produced by chlorpromazine (0.02, 0.1, and 0.5 mmol/L) and an echinocytic transforma...

journal_title：Blood

authors： Reinhart WH,Chien S

更新日期：1986-04-01 00:00:00

abstract：:The distinct combination of homing receptors such as selectins, chemokine receptors, and integrins directs the migration of lymphocytes throughout the body. Upon activation lymphocytes irreversibly switch their set of homing receptors, now guiding them to entirely different destinations. Here we report that exposure o...

journal_title：Blood

authors： Berberich S,Förster R,Pabst O

更新日期：2007-06-01 00:00:00

abstract：:Acquired chromosomal anomalies (most commonly translocations) in lymphoma and leukemia usually result in either activation of a quiescent gene (by means of immunoglobulin or T-cell-receptor promotors) and expression of an intact protein product, or creation of a fusion gene encoding a chimeric protein. This review sum...

journal_title：Blood

authors： Falini B,Mason DY

更新日期：2002-01-15 00:00:00

abstract：:Interleukin-12 (IL-12) is a cytokine that plays a central role in the control of cell-mediated immunity. We have previously shown that transforming growth factor-beta1 (TGF-beta) inhibitory effects on human primary allogeneic cytotoxicity and proliferative responses interfere with IL-12 pathway. The present study was ...

journal_title：Blood

authors： Pardoux C,Ma X,Gobert S,Pellegrini S,Mayeux P,Gay F,Trinchieri G,Chouaib S

更新日期：1999-03-01 00:00:00

abstract：:A 14-year-old boy with hemoglobin SC disease and alpha-thalassemia-2 experienced five episodes of acute splenic sequestration crisis (ASSC), while two of his siblings with identical globin genotypes (SC and -alpha/alpha alpha) had no such experience. To determine if an additional red blood cell (RBC) defect was respon...

journal_title：Blood

authors： Warkentin TE,Barr RD,Ali MA,Mohandas N

更新日期：1990-01-01 00:00:00

abstract：:CD99 is a crucial regulator of the transmigration (diapedesis) of leukocytes through the blood vessel wall. Here, we report that CD99 acts at 2 different steps in the extravasation process. In agreement with previous antibody-blocking experiments, we found that CD99 gene inactivation caused neutrophil accumulation bet...

journal_title：Blood

authors： Goswami D,März S,Li YT,Artz A,Schäfer K,Seelige R,Pacheco-Blanco M,Jing D,Bixel MG,Araki M,Araki K,Yamamura KI,Vestweber D

更新日期：2017-03-30 00:00:00

abstract：:Although proinflammatory cytokines are key mediators of tissue damage during graft-versus-host disease (GVHD), IFNgamma has previously been attributed with both protective and pathogenic effects. We have resolved this paradox by using wild-type (wt), IFNgamma(-/-), and IFNgammaR(-/-) mice as donors or recipients in we...

journal_title：Blood

authors： Burman AC,Banovic T,Kuns RD,Clouston AD,Stanley AC,Morris ES,Rowe V,Bofinger H,Skoczylas R,Raffelt N,Fahy O,McColl SR,Engwerda CR,McDonald KP,Hill GR

更新日期：2007-08-01 00:00:00

abstract：:The subcellular localization of the platelet membrane receptors glycoproteins (GP) Ib and IIb/IIIa [corrected] has been studied within resting platelets by a combination of biochemical and cytochemical techniques. While both GPIb and GPIIb/IIIa are localized within the plasma membrane and surface-connected canalicular...

journal_title：Blood

authors： Cramer EM,Lu H,Caen JP,Soria C,Berndt MC,Tenza D

更新日期：1991-02-15 00:00:00

abstract：:This study assessed the incidence of cytomegalovirus (CMV) infection after transplantation of cord blood (CB) from unrelated donors and evaluated strategies for screening CB donors. Posttransplantation CMV infection, reported in 23% of 1221 CB recipients, was associated with patient pretransplantation CMV serology (P ...

journal_title：Blood

authors： Albano MS,Taylor P,Pass RF,Scaradavou A,Ciubotariu R,Carrier C,Dobrila L,Rubinstein P,Stevens CE

更新日期：2006-12-15 00:00:00

abstract：:Recent studies have shown a discrepancy between the level of tissue factor (TF) expression and the level of TF procoagulant activity on the apical and basolateral surface domains of polarized epithelial cells. The present investigation was performed to elucidate possible reasons for the discordant expression of TF and...

journal_title：Blood

authors： Hansen CB,van Deurs B,Petersen LC,Rao LV

更新日期：1999-09-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) can kill target cells by the granule/exocytosis pathway or the Fas-mediated apoptosis pathway. The sensitivity of chronic lymphocytic leukemia (CLL) B cells to CTL-mediated apoptosis before and after CD40 activation was examined. Resting or CD40-activated CLL cells were found to be equal...

journal_title：Blood

authors： Chu P,Wierda WG,Kipps TJ

更新日期：2000-06-15 00:00:00

abstract：:The interleukin-6 receptor (IL-6R)/signal transducer and activator of transcription 3 (STAT3) pathway contributes to the pathogenesis of multiple myeloma (MM) and protects MM cells from apoptosis. However, MM cells survive the IL-6R blockade if they are cocultured with bone marrow stromal cells (BMSCs), suggesting tha...

journal_title：Blood

authors： Chatterjee M,Stühmer T,Herrmann P,Bommert K,Dörken B,Bargou RC

更新日期：2004-12-01 00:00:00

abstract：:The microsomal fraction of M1 cells (an established cell line of myeloid leukemia) was capable of catalyzing acylation of sn-glycerol 3-phosphate by long-chain fatty acyl-CoA thioesters. The principal lipid product formed was identified as phosphatidic acid. Palmityl-CoA, stearyl-CoA, and oleyl-CoA were more effective...

journal_title：Blood

authors： Okuma M,Ichikawa Y,Yamashita S,Kitajima K,Numa S

更新日期：1976-03-01 00:00:00

abstract：:As tyrosine kinase inhibitors (TKIs) fail to induce long-term response in blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL), novel therapies targeting leukemia-dysregulated pathways are necessary. Exportin-1 (XPO1), also known as chromoso...

journal_title：Blood

authors： Walker CJ,Oaks JJ,Santhanam R,Neviani P,Harb JG,Ferenchak G,Ellis JJ,Landesman Y,Eisfeld AK,Gabrail NY,Smith CL,Caligiuri MA,Hokland P,Roy DC,Reid A,Milojkovic D,Goldman JM,Apperley J,Garzon R,Marcucci G,Shacham S

更新日期：2013-10-24 00:00:00

abstract：:The non-Hodgkin's lymphoma (NHL) subset commonly referred to as large cell lymphoma (LCL) has historically been characterized by it's marked cytological, immunological, and clinical heterogeneity. One potential defining feature of these lymphomas, the t(2;5)(p23;q35), occurs in 25% to 30% of anaplastic LCLs and is als...

journal_title：Blood

authors： Mathew P,Sanger WG,Weisenburger DD,Valentine M,Valentine V,Pickering D,Higgins C,Hess M,Cui X,Srivastava DK,Morris SW

更新日期：1997-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are widespread in adult organisms and may be involved in tissue maintenance and repair as well as in the regulation of hematopoiesis and immunologic responses. Thus, it is important to discover the factors controlling MSC renewal and differentiation. Here we report that adult MSCs express...

journal_title：Blood

authors： Pevsner-Fischer M,Morad V,Cohen-Sfady M,Rousso-Noori L,Zanin-Zhorov A,Cohen S,Cohen IR,Zipori D

更新日期：2007-02-15 00:00:00

abstract：:We retrospectively analyzed outcomes among 567 patients with hematologic malignancies who had hematopoietic cell transplantation from human leukocyte antigen-identical sibling donors between 2001 and 2007 for a correlation between statin use and risk of graft-versus-host disease (GVHD). Compared with allografts where ...

journal_title：Blood

authors： Rotta M,Storer BE,Storb RF,Martin PJ,Heimfeld S,Peffer A,Maloney DG,Deeg HJ,Sandmaier BM,Appelbaum FR,Mielcarek M

更新日期：2010-02-11 00:00:00