Characterization of the mouse von Willebrand factor promoter.

abstract：:Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular hemostasis and local inflammation. Endothelial activation triggers rapid exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rolling (P-selectin) and pl...

journal_title：Blood

authors： Holthenrich A,Drexler HCA,Chehab T,Naß J,Gerke V

更新日期：2019-09-19 00:00:00

abstract：:Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical presentation in a uniquely vulnerable host, its poor response to current therapies, and its fascinating biology. Increasingly, these biological insights are pointing the way toward novel therapeutic approaches. Using represent...

journal_title：Blood

authors： Brown P,Pieters R,Biondi A

更新日期：2019-01-17 00:00:00

abstract：:A 13-yr-old Japanese female with acute lymphoblastic leukemia (ALL) that was associated with a Philadelphia chromosome (Ph1) as well as a 14q+ chromosome abnormality is reported. The cell surface phenotype of leukemic cells was determined to be non-T, non-B ALL on the basis of positive Ia-like antigen, terminal deoxyn...

journal_title：Blood

authors： Maekawa T,Sonoda Y,Taniwaki M,Misawa S,Abe T,Takino T

更新日期：1984-02-01 00:00:00

abstract：:The chemokine receptors (CCRs) CCR4 and CCR10, and the cutaneous lymphocyte antigen (CLA), have each been proposed as critical mediators of skin-specific TH lymphocyte homing in mice and humans. CLA initiates skin homing by mediating E-selectin-dependent tethering and rolling within cutaneous venules, but the specific...

journal_title：Blood

authors： Soler D,Humphreys TL,Spinola SM,Campbell JJ

更新日期：2003-03-01 00:00:00

abstract：:The POEMS syndrome is associated with elevated vascular endothelial growth factor (VEGF) levels. Several studies have compared serum VEGF levels between POEMS patients and other disease entities showing higher serum VEGF in POEMS syndrome; however, it is unknown whether serum levels are reliable and reproducible given...

journal_title：Blood

authors： D'Souza A,Hayman SR,Buadi F,Mauermann M,Lacy MQ,Gertz MA,Kyle RA,Kumar S,Greipp PR,Lust JA,Russell SJ,Zeldenrust S,Dingli D,Witzig TE,Rajkumar SV,Dispenzieri A

更新日期：2011-10-27 00:00:00

abstract：:Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymphoblastic leukemia (...

journal_title：Blood

authors： Bortin MM,D'Amaro J,Bach FH,Rimm AA,van Rood JJ

更新日期：1987-07-01 00:00:00

abstract：:Chromosomal translocations involving the platelet-derived growth factor beta receptor (PDGFbetaR) gene have been reported in some patients with chronic myelomonocytic leukemia (CMML). The resultant fusion proteins have constitutive PDGFbetaR tyrosine kinase activity, but the partner genes previously reported (tel, Hun...

journal_title：Blood

authors： Magnusson MK,Meade KE,Brown KE,Arthur DC,Krueger LA,Barrett AJ,Dunbar CE

更新日期：2001-10-15 00:00:00

abstract：:The effects of recombinant human erythropoietin (rEp) on murine hematopoietic progenitors were studied using a serum-free culture. A high concentration of rEp stimulated the formation of mixed erythroid-megakaryocyte colonies (EM colonies) and blast cell colonies, as well as erythroid colonies, erythroid bursts, and m...

journal_title：Blood

authors： Nishi N,Nakahata T,Koike K,Takagi M,Naganuma K,Akabane T

更新日期：1990-10-01 00:00:00

abstract：:The D816V mutation of c-kit has been detected in patients with mastocytosis. This mutation leads to constitutive tyrosine kinase activation of Kit. Because stem cell factor (SCF), the ligand for Kit (CD117(+)), is a chemoattractant for CD117(+) cells and one feature of mastocytosis is an abnormal collection of mast ce...

journal_title：Blood

authors： Taylor ML,Dastych J,Sehgal D,Sundstrom M,Nilsson G,Akin C,Mage RG,Metcalfe DD

更新日期：2001-08-15 00:00:00

abstract：:Adhesion to extracellular ligands through integrins regulates cell shape, migration, growth, and survival. How integrins transmit signals in the outside-to-in direction remains unknown. Whereas in resting integrins the alpha and beta subunit transmembrane domains are associated, ligand binding promotes dissociation an...

journal_title：Blood

authors： Zhu J,Carman CV,Kim M,Shimaoka M,Springer TA,Luo BH

更新日期：2007-10-01 00:00:00

abstract：:RUNX1 is crucial for the regulation of megakaryocyte specification, maturation, and thrombopoiesis. Runx1 possesses 2 promoters: the distal P1 and proximal P2 promoters. The major protein isoforms generated by P1 and P2 are RUNX1C and RUNX1B, respectively, which differ solely in their N-terminal amino acid sequences. ...

journal_title：Blood

authors： Draper JE,Sroczynska P,Leong HS,Fadlullah MZH,Miller C,Kouskoff V,Lacaud G

更新日期：2017-07-20 00:00:00

abstract：:Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph-like ALL in adults. Patients with newly diagnosed B-cell ALL (B-ALL) who received frontline chemotherapy at MD Anderson Cancer Center underwent...

journal_title：Blood

authors： Jain N,Roberts KG,Jabbour E,Patel K,Eterovic AK,Chen K,Zweidler-McKay P,Lu X,Fawcett G,Wang SA,Konoplev S,Harvey RC,Chen IM,Payne-Turner D,Valentine M,Thomas D,Garcia-Manero G,Ravandi F,Cortes J,Kornblau S,O'Brien

更新日期：2017-02-02 00:00:00

abstract：:Fetal/neonatal immune responses generally are considered to be immature and weaker than that of adults. We have studied the cord-blood T cells of newborns congenitally infected with Trypanosoma cruzi, the protozoan agent of Chagas disease. Our data demonstrate a predominant activation of CD8 T cells expressing activat...

journal_title：Blood

authors： Hermann E,Truyens C,Alonso-Vega C,Even J,Rodriguez P,Berthe A,Gonzalez-Merino E,Torrico F,Carlier Y

更新日期：2002-09-15 00:00:00

abstract：:Fetal hemoglobin (HbF) is a potent genetic modifier of the severity of beta-thalassemia and sickle cell anemia. We used an in vitro culture model of human erythropoiesis in which late-stage erythroblasts are derived directly from human CD34(+) hematopoietic cells to evaluate HbF production. This system recapitulates e...

journal_title：Blood

authors： Wilber A,Tschulena U,Hargrove PW,Kim YS,Persons DA,Barbas CF 3rd,Nienhuis AW

更新日期：2010-04-15 00:00:00

abstract：:Primary infection with the human herpesvirus, Epstein-Barr virus (EBV), may result in subclinical seroconversion or may appear as infectious mononucleosis (IM), a lymphoproliferative disease of variable severity. Why primary infection manifests differently between patients is unknown, and, given the difficulties in id...

journal_title：Blood

authors： Silins SL,Sherritt MA,Silleri JM,Cross SM,Elliott SL,Bharadwaj M,Le TT,Morrison LE,Khanna R,Moss DJ,Suhrbier A,Misko IS

更新日期：2001-12-15 00:00:00

abstract：:Forty-nine patients with primary myelodysplastic syndromes (MDS) were subclassified according to French-American-British (FAB) Cooperative Group criteria. Eight patients had acquired idiopathic sideroblastic anemia (AISA), ten had chronic myelomonocytic leukemia (CMMoL), 14 had refractory anemia (RA), nine had refract...

journal_title：Blood

authors： Jacobs RH,Cornbleet MA,Vardiman JW,Larson RA,Le Beau MM,Rowley JD

更新日期：1986-06-01 00:00:00

abstract：:Although NPM1 gene mutations leading to aberrant cytoplasmic expression of nucleophosmin (NPMc(+)) are the most frequent genetic lesions in acute myeloid leukemia, there is yet no experimental model demonstrating their oncogenicity in vivo. We report the generation and characterization of a transgenic mouse model expr...

journal_title：Blood

authors： Cheng K,Sportoletti P,Ito K,Clohessy JG,Teruya-Feldstein J,Kutok JL,Pandolfi PP

更新日期：2010-04-22 00:00:00

abstract：:Relapse following remission induction chemotherapy remains a barrier to survival in approximately 20% of children suffering from acute lymphoblastic leukemia (ALL). To investigate the mechanism of relapse, 27 matched diagnosis and relapse ALL samples were analyzed for clonal populations using polymerase chain reaction...

journal_title：Blood

authors： Choi S,Henderson MJ,Kwan E,Beesley AH,Sutton R,Bahar AY,Giles J,Venn NC,Pozza LD,Baker DL,Marshall GM,Kees UR,Haber M,Norris MD

更新日期：2007-07-15 00:00:00

abstract：:FLT3-ITD+ acute myeloid leukemia (AML) accounts for ∼25% of all AML cases and is a subtype that carries a poor prognosis. microRNA-155 (miR-155) is specifically overexpressed in FLT3-ITD+ AML compared with FLT3 wild-type (FLT3-WT) AML and is critical for the growth of FLT3-ITD+ AML cells in vitro. However, miR-155's r...

journal_title：Blood

authors： Wallace JA,Kagele DA,Eiring AM,Kim CN,Hu R,Runtsch MC,Alexander M,Huffaker TB,Lee SH,Patel AB,Mosbruger TL,Voth WP,Rao DS,Miles RR,Round JL,Deininger MW,O'Connell RM

更新日期：2017-06-08 00:00:00

abstract：:We studied the impact of driver mutations of JAK2, CALR, (calreticulin gene) or MPL on clinical course, leukemic transformation, and survival of patients with primary myelofibrosis (PMF). Of the 617 subjects studied, 399 (64.7%) carried JAK2 (V617F), 140 (22.7%) had a CALR exon 9 indel, 25 (4.0%) carried an MPL (W515)...

journal_title：Blood

authors： Rumi E,Pietra D,Pascutto C,Guglielmelli P,Martínez-Trillos A,Casetti I,Colomer D,Pieri L,Pratcorona M,Rotunno G,Sant'Antonio E,Bellini M,Cavalloni C,Mannarelli C,Milanesi C,Boveri E,Ferretti V,Astori C,Rosti V,Cerva

更新日期：2014-08-14 00:00:00

abstract：:T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MT...

journal_title：Blood

authors： Madani A,Choukroun V,Soulier J,Cacheux V,Claisse JF,Valensi F,Daliphard S,Cazin B,Levy V,Leblond V,Daniel MT,Sigaux F,Stern MH

更新日期：1996-03-01 00:00:00

abstract：:The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In T- and pre-B-cell lymphoma, KLF4 was found to act as tumor suppressor. We found the KLF4 promoter methylated in B-cell lymphoma cell lines and in primary cases of B-cell lymphomas, namely, follicular lymph...

journal_title：Blood

authors： Guan H,Xie L,Leithäuser F,Flossbach L,Möller P,Wirth T,Ushmorov A

更新日期：2010-09-02 00:00:00

abstract：:The majority of patients with Hodgkin lymphoma (HL) are cured with initial therapy. However, high-dose therapy with autologous hematopoietic cell transplant (AHCT) allows for the cure of an additional portion of patients with relapsed or primary refractory disease. Positron emission tomography-negative complete remiss...

journal_title：Blood

authors： Shah GL,Moskowitz CH

更新日期：2018-04-12 00:00:00

abstract：:ASXL1 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies, and its alterations are associated with poor prognosis. De novo ASXL1 mutations cause Bohring-Opitz syndrome characterized by multiple congenital malformations. We show that Asxl1 deletion in mice led to developmental abnormaliti...

journal_title：Blood

authors： Wang J,Li Z,He Y,Pan F,Chen S,Rhodes S,Nguyen L,Yuan J,Jiang L,Yang X,Weeks O,Liu Z,Zhou J,Ni H,Cai CL,Xu M,Yang FC

更新日期：2014-01-23 00:00:00

abstract：:Protein vaccines for T-cell immunity are not being prioritized because of poor immunogenicity. To overcome this hurdle, proteins are being targeted to maturing dendritic cells (DCs) within monoclonal antibodies (mAbs) to DC receptors. To extend the concept to humans, we immunized human immunoglobulin-expressing mice w...

journal_title：Blood

authors： Cheong C,Choi JH,Vitale L,He LZ,Trumpfheller C,Bozzacco L,Do Y,Nchinda G,Park SH,Dandamudi DB,Shrestha E,Pack M,Lee HW,Keler T,Steinman RM,Park CG

更新日期：2010-11-11 00:00:00

abstract：:High efficiency retroviral-mediated gene transfer to rhesus CD4+ peripheral blood lymphocytes (PBL) was accomplished using an optimized transduction protocol using a gibbon ape leukemia virus (GaLV) envelope-containing packaging cell line PG13. Engineered CD4+ PBL were administered to three nonmyeloablated animals in ...

journal_title：Blood

authors： Bunnell BA,Metzger M,Byrne E,Morgan RA,Donahue RE

更新日期：1997-03-15 00:00:00

abstract：:Accumulating evidence has designated B cells as central players in the pathogenesis of immune diseases. In the late 1990s, anti-CD20 monoclonal antibodies were developed for the treatment of B-cell non-Hodgkin lymphomas, offering the opportunity to efficiently deplete the B-cell compartment for therapeutic immunointer...

journal_title：Blood

authors： Thaunat O,Morelon E,Defrance T

更新日期：2010-07-29 00:00:00

abstract：:Eighty-three patients with circulating anticoagulants were studied at The New York Hospital. The lupus-type anticoagulant, an inhibitor of the prothrombin activator complex, was demonstrated in 58 patients. The inhibitor was identified using the blood and tissue thromboplastin inhibition tests. Inhibition by the lupus...

journal_title：Blood

authors： Schleider MA,Nachman RL,Jaffe EA,Coleman M

更新日期：1976-10-01 00:00:00

abstract：:The thrombolytic efficacy of recombinant unglycosylated full length single chain urokinase-type plasminogen activator (rscu-PA, saruplase), applied either as single intravenous bolus or as a continuous infusion over 60 minutes, was studied in 5 randomized blinded groups of 5 dogs with combined copper coil induced coro...

journal_title：Blood

authors： Rapold HJ,Wu ZM,Stassen T,Van de Werf F,Collen D

更新日期：1990-10-15 00:00:00

abstract：:Red blood cells deliver O(2) from the lungs to every cell in the human body. Reduced tissue oxygenation triggers increased production of erythropoietin by hypoxia-inducible factor 1 (HIF-1), which is a transcriptional activator composed of an O(2)-regulated alpha subunit and a constitutively expressed beta subunit. Hy...

journal_title：Blood

authors： Semenza GL

更新日期：2009-09-03 00:00:00