miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response.

abstract：:Krüppel-like factor 5 (Klf5) encodes a zinc-finger transcription factor and has been reported to be a direct target of C/EBPα, a master transcription factor critical for formation of granulocyte-macrophage progenitors (GMP) and leukemic GMP. Using an in vivo hematopoietic-specific gene ablation model, we demonstrate t...

journal_title：Blood

authors： Shahrin NH,Diakiw S,Dent LA,Brown AL,D'Andrea RJ

更新日期：2016-07-07 00:00:00

abstract：:Outcome in multiple myeloma is highly variable and a better understanding of the factors that influence disease biology is essential to understand and predict behavior in individual patients. In the present study, we analyzed combined genomewide DNA methylation and gene expression data of patients treated in the Medic...

journal_title：Blood

authors： Kaiser MF,Johnson DC,Wu P,Walker BA,Brioli A,Mirabella F,Wardell CP,Melchor L,Davies FE,Morgan GJ

更新日期：2013-07-11 00:00:00

abstract：:Memory stem T cells (TSCM) have been proposed as key determinants of immunologic memory. However, their exact contribution to a mounting immune response, as well as the mechanisms and timing of their in vivo generation, are poorly understood. We longitudinally tracked TSCM dynamics in patients undergoing haploidentica...

journal_title：Blood

authors： Cieri N,Oliveira G,Greco R,Forcato M,Taccioli C,Cianciotti B,Valtolina V,Noviello M,Vago L,Bondanza A,Lunghi F,Marktel S,Bellio L,Bordignon C,Bicciato S,Peccatori J,Ciceri F,Bonini C

更新日期：2015-04-30 00:00:00

abstract：:1-D-Amino(8-D-arginine)-vasopressin (DDAVP) infusion in three patients with type IIa von Willebrand's disease (vWD) resulted in a normalization of the factor VIII coagulant, factor VIII-related antigen, and von Willebrand factor (vWF) (ristocetin cofactor) activities and the bleeding time. The normalization of these h...

journal_title：Blood

authors： Gralnick HR,Williams SB,McKeown LP,Rick ME,Maisonneuve P,Jenneau C,Sultan Y

更新日期：1986-02-01 00:00:00

abstract：:To understand the regulatory mechanism of erythropoietin (EPO) receptor (EPOR) gene expression, the effect of EPO on the steady-state level of EPOR mRNA was examined using the human EPO-dependent cell line UT-7 as a model system. We found that the treatment of UT-7 cells with EPO resulted in a transient decrease of th...

journal_title：Blood

authors： Komatsu N,Kirito K,Kashii Y,Furukawa Y,Kikuchi J,Suwabe N,Yamamoto M,Miura Y

更新日期：1997-02-15 00:00:00

abstract：:Interphase cytogenetics by means of in situ hybridization with the chromosome 12-specific biotinylated alpha satellite DNA probe pSP 12-1 was used for the study of trisomy 12, the most common chromosomal abnormality in chronic lymphocytic leukemia. In situ hybridization was performed on methanol/acetic acid fixed cell...

journal_title：Blood

authors： Losada AP,Wessman M,Tiainen M,Hopman AH,Willard HF,Solé F,Caballín MR,Woessner S,Knuutila S

更新日期：1991-08-01 00:00:00

abstract：:Exposure to HIV-1 does not necessarily result in infection and progression toward disease, thus suggesting that the control of viral infection may be achieved. Antibodies to CCR5 have been detected in HIV-exposed but uninfected subjects (ESNs); thus, these antibodies could be involved in HIV protection. To assess whet...

journal_title：Blood

authors： Pastori C,Weiser B,Barassi C,Uberti-Foppa C,Ghezzi S,Longhi R,Calori G,Burger H,Kemal K,Poli G,Lazzarin A,Lopalco L

更新日期：2006-06-15 00:00:00

abstract：:The histone deacetylase inhibitors (HDA-CIs) butyrate and trichostatin A activate gamma-globin expression via a p38 mitogen-activating protein kinase (MAPK)-dependent mechanism. We hypothesized that down-stream effectors of p38 MAPK, namely activating transcription factor-2 (ATF-2) and cyclic AMP response element (CRE...

journal_title：Blood

authors： Sangerman J,Lee MS,Yao X,Oteng E,Hsiao CH,Li W,Zein S,Ofori-Acquah SF,Pace BS

更新日期：2006-11-15 00:00:00

abstract：:Tissue inhibitor of metalloproteinases-1 (TIMP-1), the major physiological matrix metalloproteinase inhibitor and a potent antimetastatic factor, also stimulates the growth of erythroid progenitors (erythroid-potentiating activity). We analyzed the relationship between the growth factor activity and protease inhibitio...

journal_title：Blood

authors： Chesler L,Golde DW,Bersch N,Johnson MD

更新日期：1995-12-15 00:00:00

abstract：:Retrovirus-mediated gene transfer into long-lived human pluripotent hematopoietic stem cells (HSCs) is a widely sought but elusive goal. A major problem is the quiescent nature of most HSCs, with the perceived requirement for ex vivo prestimulation in cytokines to induce stem cell cycling and allow stable gene integra...

journal_title：Blood

authors： Rebel VI,Tanaka M,Lee JS,Hartnett S,Pulsipher M,Nathan DG,Mulligan RC,Sieff CA

更新日期：1999-04-01 00:00:00

abstract：:P-selectin glycoprotein ligand-1 (PSGL-1) serves as the leukocyte ligand for P-selectin, and many of the structural features of its ectodomain required for interactions with P-selectin have been uncovered. In contrast, the function of the highly conserved PSGL-1 cytoplasmic domain has not been explored. Stable transfe...

journal_title：Blood

authors： Snapp KR,Heitzig CE,Kansas GS

更新日期：2002-06-15 00:00:00

abstract：:Rabbit platelets were aggregated by adenosine diphosphate (ADP), allowed to deaggregate and then separated into density subpopulations by centrifugation through discontinuous Stractan density gradients. Although ADP causes little or no release of the contents of the amine storage granules of rabbit platelets, ADP caus...

journal_title：Blood

authors： Packham MA,Perry DW,Kinlough-Rathbone RL,Rand ML,Guccione MA,Evans RM,Mustard JF

更新日期：1985-03-01 00:00:00

abstract：:Various n-formylated peptides function as receptor-specific chemoattractants for both granulocytes and monocytes. Because these agents are important tools in the study of leukocyte function in vitro, we chose to examine their effects on leukocyte procoagulant activity. The synthetic chemotactic peptide N-formyl-methio...

journal_title：Blood

authors： Janco RL,Morris PJ

更新日期：1985-03-01 00:00:00

abstract：:The presence of lysosomal enzymes in human platelets is well documented; the identity of the "lysosome," however, has been the subject of some disagreement. In order to determine the time of appearance and subcellular localization of two lysosomal enzymes in megakaryocytes (MK) and platelets, we examined normal human ...

journal_title：Blood

authors： Bentfeld-Barker ME,Bainton DF

更新日期：1982-03-01 00:00:00

abstract：:Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (e.g., p53 and nucleophosmin) whose function is altered in cancer because of increased expression and overactive transport. Blocking CRM1-mediated nuclear export of such proteins is a novel therap...

journal_title：Blood

authors： Ranganathan P,Yu X,Na C,Santhanam R,Shacham S,Kauffman M,Walker A,Klisovic R,Blum W,Caligiuri M,Croce CM,Marcucci G,Garzon R

更新日期：2012-08-30 00:00:00

abstract：:Graft-versus-host disease (GVHD) is the main complication of allogeneic stem cell transplantation. However, diagnosis of GVHD and evaluation of response to immunosuppressive treatment is sometimes difficult. Since apoptosis is the histopathologic hallmark in GVHD, we investigated whether active GVHD-induced target org...

journal_title：Blood

authors： Luft T,Conzelmann M,Benner A,Rieger M,Hess M,Strohhaecker U,Görner M,Hegenbart U,Ho AD,Dreger P

更新日期：2007-12-15 00:00:00

abstract：:Purified human lactoferrin was assessed for its influence in vivo in untreated mice and in mice undergoing rebound myelopoiesis after sublethal dosages of Cytoxan. Fully iron-saturated lactoferrin suppressed the numbers of granulocytes and monocytes per femur, the numbers of granulocyte-macrophage progenitor cells (CF...

journal_title：Blood

authors： Gentile P,Broxmeyer HE

更新日期：1983-05-01 00:00:00

abstract：:The diagnosis of heparin-induced thrombocytopenia (HIT) requires detection of antibodies to the heparin/platelet factor 4 (PF4) complexes via enzyme-linked immunosorbent assay. Addition of excess heparin to the sample decreases the optical density by 50% or more and confirms the presence of these antibodies. One hundr...

journal_title：Blood

authors： Whitlatch NL,Kong DF,Metjian AD,Arepally GM,Ortel TL

更新日期：2010-09-09 00:00:00

abstract：:The malignant Reed-Sternberg cell of Hodgkin disease is an aberrant B cell that persists in an immunolgically mediated inflammatory infiltrate. Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the usual apoptotic fate of defective immune cells through an unknown mechanism. A likely candid...

journal_title：Blood

authors： Annunziata CM,Safiran YJ,Irving SG,Kasid UN,Cossman J

更新日期：2000-10-15 00:00:00

abstract：:During an 8-year period, 28 young adults (median age 27 years) and 30 children (median age 10 years) with severe aplastic anemia have received allogeneic bone marrow transplantation (BMT) from major histocompatibility locimatched sibling donors after preparation with cyclophosphamide and total lymphoid irradiation (TL...

journal_title：Blood

authors： McGlave PB,Haake R,Miller W,Kim T,Kersey J,Ramsay NK

更新日期：1987-11-01 00:00:00

abstract：:The metalloprotease ADAMTS13 is assumed to regulate the functional levels of von Willebrand factor (VWF) appropriate for normal hemostasis in vivo by reducing VWF multimer size, which directly represents the thrombogenic activity of this factor. Using an in vitro perfusion chamber system, we studied the mechanisms of ...

journal_title：Blood

authors： Shida Y,Nishio K,Sugimoto M,Mizuno T,Hamada M,Kato S,Matsumoto M,Okuchi K,Fujimura Y,Yoshioka A

更新日期：2008-02-01 00:00:00

abstract：:Eighty-three patients with circulating anticoagulants were studied at The New York Hospital. The lupus-type anticoagulant, an inhibitor of the prothrombin activator complex, was demonstrated in 58 patients. The inhibitor was identified using the blood and tissue thromboplastin inhibition tests. Inhibition by the lupus...

journal_title：Blood

authors： Schleider MA,Nachman RL,Jaffe EA,Coleman M

更新日期：1976-10-01 00:00:00

abstract：:Incubation of human mononuclear leukocytes (MNL) with human stroma-free hemolysate (SFH), purified adult hemoglobin Ao (HbAo), and oxidized HbAo (METHb) caused MNL to release compounds into the supernate that mediated neutrophil (polymorphonuclear leukocytes, PMN) chemotaxis and PMN adherence to human umbilical vein e...

journal_title：Blood

authors： McFaul SJ,Bowman PD,Villa VM,Gutierrez-Ibanez MJ,Johnson M,Smith D

更新日期：1994-11-01 00:00:00

abstract：:Prophylactic treatment in severe hemophilia is very effective but is limited by cost issues. The implementation of 2 different prophylactic regimens in The Netherlands and Sweden since the 1970s may be considered a natural experiment. We compared the costs and outcomes of Dutch intermediate- and Swedish high-dose prop...

journal_title：Blood

authors： Fischer K,Steen Carlsson K,Petrini P,Holmström M,Ljung R,van den Berg HM,Berntorp E

更新日期：2013-08-15 00:00:00

abstract：:Gemtuzumab ozogamicin (GO) contains an anti-CD33 antibody to facilitate uptake of a toxic calicheamicin-gamma(1) derivative. While recent in vitro data demonstrated a quantitative relationship between CD33 expression and GO cytotoxicity, previous correlative studies failed to identify a significant association between...

journal_title：Blood

authors： Walter RB,Gooley TA,van der Velden VH,Loken MR,van Dongen JJ,Flowers DA,Bernstein ID,Appelbaum FR

更新日期：2007-05-15 00:00:00

abstract：:We examined autonomous and interleukin-2 (IL-2)-responsive growth activities of leukemic cells derived from peripheral blood, as well as several clinical manifestations, including serum lactate dehydrogenase (LDH) level, of 35 patients with adult T-cell leukemia (ATL) to determine whether these properties were related...

journal_title：Blood

authors： Arima N,Hidaka S,Fujiwara H,Matsushita K,Ohtsubo H,Arimura K,Kukita T,Fukumori J,Tanaka H

更新日期：1996-04-01 00:00:00

abstract：:HS1 (hematopoietic cell-specific Lyn substrate-1) is a cytoskeletal interactor in the B-cell receptor (BCR) signaling pathway whose phosphorylation correlates with prognosis in Chronic Lymphocytic Leukemia (CLL). The differentially phosphorylated sites and the kinases that regulate HS1 activity in CLL remain poorly un...

journal_title：Blood

authors： ten Hacken E,Scielzo C,Bertilaccio MT,Scarfò L,Apollonio B,Barbaglio F,Stamatopoulos K,Ponzoni M,Ghia P,Caligaris-Cappio F

更新日期：2013-03-21 00:00:00

abstract：:Genes of the major histocompatibility complex (MHC) are associated with susceptibility to different immune and nonimmune mediated diseases. We had reported that the drug adverse reaction, clozapine-induced agranulocytosis (CA), is associated with different HLA types and HSP70 variants in Ashkenazi Jewish and non-Jewis...

journal_title：Blood

authors： Turbay D,Lieberman J,Alper CA,Delgado JC,Corzo D,Yunis JJ,Yunis EJ

更新日期：1997-06-01 00:00:00

abstract：:Fifty-eight acute promyelocytic leukemia (APL) patients (11 newly diagnosed and 47 relapsed) were studied for arsenic trioxide (As2O3) treatment. Clinical complete remission (CR) was obtained in 8 of 11 (72.7%) newly diagnosed cases. However, As2O3 treatment resulted in hepatic toxicity in 7 cases including 2 deaths, ...

journal_title：Blood

authors： Niu C,Yan H,Yu T,Sun HP,Liu JX,Li XS,Wu W,Zhang FQ,Chen Y,Zhou L,Li JM,Zeng XY,Yang RR,Yuan MM,Ren MY,Gu FY,Cao Q,Gu BW,Su XY,Chen GQ,Xiong SM,Zhang TD,Waxman S,Wang ZY,Chen Z,Hu J,Shen ZX,Chen SJ

更新日期：1999-11-15 00:00:00

abstract：:Hodgkin- and Reed-Sternberg (HRS) cells microdissected from 41 classical Hodgkin lymphomas (cHL) of 40 patients comprising 8 lymphocyte-rich (cHL-LR), 16 nodular sclerosis (cHL-NS), 15 mixed-cellularity (cHL-MC), and 2 lymphocyte-depletion (cHL-LD) subtypes were analyzed by comparative genomic hybridization for recurr...

journal_title：Blood

authors： Joos S,Menz CK,Wrobel G,Siebert R,Gesk S,Ohl S,Mechtersheimer G,Trümper L,Möller P,Lichter P,Barth TF

更新日期：2002-02-15 00:00:00