Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study.

abstract：:We show that lentiviral delivery of human gamma-globin gene under beta-globin regulatory control elements in hematopoietic stem cells (HSCs) results in sufficient postnatal fetal hemoglobin (HbF) expression to correct sickle cell anemia (SCA) in the Berkeley "humanized" sickle mouse. Upon de-escalating the amount of t...

journal_title：Blood

authors： Perumbeti A,Higashimoto T,Urbinati F,Franco R,Meiselman HJ,Witte D,Malik P

更新日期：2009-08-06 00:00:00

abstract：:The ex vivo expansion of hematopoietic progenitors is a promising approach for accelerating the engraftment of recipients, particularly when cord blood (CB) is used as a source of hematopoietic graft. With the aim of defining the in vivo repopulating properties of ex vivo-expanded CB cells, purified CD34(+) cells were...

journal_title：Blood

authors： Guenechea G,Segovia JC,Albella B,Lamana M,Ramírez M,Regidor C,Fernández MN,Bueren JA

更新日期：1999-02-01 00:00:00

abstract：:Recombinant human interleukin-6 (IL-6) has previously been shown to increase platelet counts in normal and sublethally irradiated mice, dogs, and primates. To assess its tolerance and efficacy in clinical use, we performed a randomized phase Ib study in patients with ovarian carcinoma. IL-6 was administered during an ...

journal_title：Blood

authors： D'Hondt V,Humblet Y,Guillaume T,Baatout S,Chatelain C,Berlière M,Longueville J,Feyens AM,de Greve J,Van Oosterom A

更新日期：1995-05-01 00:00:00

abstract：:A randomized study was performed in 54 thrombocytopenic patients with acute leukemia. Alloimmunization of recipients of random multiple-donor platelet concentrates (MD group) was compared to that of patients receiving random single-donor platelets (SD group). In the SD patients, formation of alloantibodies (mostly ant...

journal_title：Blood

authors： Gmür J,von Felten A,Osterwalder B,Honegger H,Hörmann A,Sauter C,Deubelbeiss K,Berchtold W,Metaxas M,Scali G,Frick PG

更新日期：1983-08-01 00:00:00

abstract：:AALL07P2 evaluated whether substitution of Erwinia asparaginase 25000 IU/m(2) for 6 doses given intramuscularly Monday/Wednesday/Friday (M/W/F) to children and young adults with acute lymphoblastic leukemia and clinical allergy to pegaspargase would provide a 48-hour nadir serum asparaginase activity (NSAA) ≥ 0.10 IU/...

journal_title：Blood

authors： Salzer WL,Asselin B,Supko JG,Devidas M,Kaiser NA,Plourde P,Winick NJ,Reaman GH,Raetz E,Carroll WL,Hunger SP

更新日期：2013-07-25 00:00:00

abstract：:A 64-yr-old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. In contrast, only type B G-6-PD was observed in peripheral bl...

journal_title：Blood

authors： Wiggans RG,Jacobson RJ,Fialkow PJ,Woolley PV 3rd,Macdonald JS,Schein PS

更新日期：1978-10-01 00:00:00

abstract：:Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) in eliminating differentiated chronic myeloid leukemia (CML) cells, recent evidence suggests that leukemic stem and progenitor cells (LSPCs) persist long term, which may be partly attributable to cytokine-mediated resistance. We evaluated the express...

journal_title：Blood

authors： Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK

更新日期：2014-02-20 00:00:00

abstract：:Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and its human homologue GOS19.1/LD78 are members of the C-C chemokine/intercrine family of secreted proteins. They have proinflammatory properties and also inhibit cell cycle progression of hematopoietic stem cells. Characterization of MIP-1 alpha receptor(s) has b...

journal_title：Blood

authors： Avalos BR,Bartynski KJ,Elder PJ,Kotur MS,Burton WG,Wilkie NM

更新日期：1994-09-15 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency with microthrombocytopenia, eczema, recurrent infections, autoimmune disorders, and malignancies that are life-threatening in the majority of patients. In this long-term, retrospective, multicenter study, we analyzed events that occurred in 96 WAS pati...

journal_title：Blood

authors： Ozsahin H,Cavazzana-Calvo M,Notarangelo LD,Schulz A,Thrasher AJ,Mazzolari E,Slatter MA,Le Deist F,Blanche S,Veys P,Fasth A,Bredius R,Sedlacek P,Wulffraat N,Ortega J,Heilmann C,O'Meara A,Wachowiak J,Kalwak K,Matthes-

更新日期：2008-01-01 00:00:00

abstract：:We sequentially studied bone marrow (BM) samples of 25 patients in complete remission of an acute lymphoblastic leukemia (ALL) using a simplified polymerase chain reaction (PCR) strategy (direct use of the PCR product as a clonogenic probe recognizing rearranged Ig heavy chain sequences) as a first approach. BM aspira...

journal_title：Blood

authors： Nizet Y,Van Daele S,Lewalle P,Vaerman JL,Philippe M,Vermylen C,Cornu G,Ferrant A,Michaux JL,Martiat P

更新日期：1993-09-01 00:00:00

abstract：:Asthma is associated with airway remodeling. Evidence of platelet recruitment to the lungs of asthmatics after allergen exposure suggests platelets participate in various aspects of asthma; although their importance is unknown in the context of airway remodeling, their involvement in atherosclerosis is established. St...

journal_title：Blood

authors： Pitchford SC,Riffo-Vasquez Y,Sousa A,Momi S,Gresele P,Spina D,Page CP

更新日期：2004-01-15 00:00:00

abstract：:Exposed subendothelial collagen acts as a substrate for platelet adhesion and thrombus formation after vascular injury. Synthetic collagen-derived triple-helical peptides, designated collagen-related peptide (CRP), GFOGER, and VWF-III, can specifically engage the platelet collagen receptors, glycoprotein VI and integr...

journal_title：Blood

authors： Pugh N,Simpson AM,Smethurst PA,de Groot PG,Raynal N,Farndale RW

更新日期：2010-06-17 00:00:00

abstract：:Persistent NF-κB activation is a hallmark of the malignant Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Genomic lesions, Epstein-Barr virus infection, soluble factors, and tumor-microenvironment interactions contribute to this activation. Here, in an unbiased approach to identify the cHL cel...

journal_title：Blood

authors： von Hoff L,Kärgel E,Franke V,McShane E,Schulz-Beiss KW,Patone G,Schleussner N,Kolesnichenko M,Hübner N,Daumke O,Selbach M,Akalin A,Mathas S,Scheidereit C

更新日期：2019-03-28 00:00:00

abstract：:By using a cDNA clone of the myeloperoxidase (MPO) gene, we have studied, by Northern blot analysis, the level of MPO mRNA in eight cases of acute lymphoblastic leukemia (ALL). The blast cell populations studied were characterized by morphologic, cytochemical, immunochemical, and molecular criteria. With all the metho...

journal_title：Blood

authors： Ferrari S,Mariano MT,Tagliafico E,Sarti M,Ceccherelli G,Selleri L,Merli F,Narni F,Donelli A,Torelli G

更新日期：1988-09-01 00:00:00

abstract：:Aggregation of blood platelets contributes to the arrest of bleeding at sites of vascular injury, but it can occlude atherosclerotic arteries and precipitate diseases such as myocardial infarction. The bonds that link platelets under flow conditions were identified using confocal videomicroscopy in real time. Glycopro...

journal_title：Blood

authors： Ruggeri ZM,Dent JA,Saldívar E

更新日期：1999-07-01 00:00:00

abstract：:Advances in immune assessment, including the development of T-cell receptor excision circle (TREC) assays of thymopoiesis, cytokine-flow cytometry assays of T-cell function, and higher-order phenotyping of T-cell maturation subsets have improved our understanding of T-cell homeostasis. Limited data exist using these m...

journal_title：Blood

authors： Komanduri KV,St John LS,de Lima M,McMannis J,Rosinski S,McNiece I,Bryan SG,Kaur I,Martin S,Wieder ED,Worth L,Cooper LJ,Petropoulos D,Molldrem JJ,Champlin RE,Shpall EJ

更新日期：2007-12-15 00:00:00

abstract：:The t(1;19)(q23;p13) chromosomal translocation is observed cytogenetically in 25% of children with pre-B-cell acute lymphoblastic leukemia (ALL) and is associated with an adverse treatment outcome. The t(1;19) juxtaposes the E2A gene from chromosome 19 with the PBX1 gene on chromosome 1, leading to the production of f...

journal_title：Blood

authors： Hunger SP,Galili N,Carroll AJ,Crist WM,Link MP,Cleary ML

更新日期：1991-02-15 00:00:00

abstract：:Hepatitis C virus (HCV) infection is not uncommon in cancer patients. Over the past 5 years, treatment of chronic HCV infection in patients with hematologic malignancies has evolved rapidly as safe and effective direct-acting antivirals (DAAs) have become the standard-of-care treatment. Today, chronic HCV infection sh...

journal_title：Blood

authors： Torres HA,McDonald GB

更新日期：2016-09-15 00:00:00

abstract：:The iron storage macrophage has been isolated from the marrow of Imferon-treated mice and studied in vitro by morphologic, histochemical, and functional tests and isotope labeling techniques. These macrophages on stained preparations are large, many times binucleate cells (up to 150 mu), and show Prussian blue reactiv...

journal_title：Blood

authors： Fedorko ME

更新日期：1975-03-01 00:00:00

abstract：:To investigate genetic variants that affect iron concentrations in persons not affected by overt genetic disorders of iron metabolism, a genome-wide association study was conducted in the InCHIANTI Study (N = 1206) and the Baltimore Longitudinal Study of Aging (N = 713). The top 2 single-nucleotide polymorphisms were ...

journal_title：Blood

authors： Tanaka T,Roy CN,Yao W,Matteini A,Semba RD,Arking D,Walston JD,Fried LP,Singleton A,Guralnik J,Abecasis GR,Bandinelli S,Longo DL,Ferrucci L

更新日期：2010-01-07 00:00:00

abstract：:Glanzmann thrombasthenia (GT) is a rare bleeding disorder resulting from mutations in either glycoprotein (GP) IIb or GPIIIa genes. The disease is relatively frequent in highly inbred populations such as Iraqi Jews. The molecular basis of GT in 6 unrelated Iraqi-Jewish patients was previously identified as an 11-bp de...

journal_title：Blood

authors： Rosenberg N,Yatuv R,Orion Y,Zivelin A,Dardik R,Peretz H,Seligsohn U

更新日期：1997-05-15 00:00:00

abstract：:A 42-yr-old woman with systemic lupus erythematosus without bleeding diathesis developed a prolonged activated partial thromboplastin time that was not corrected by normal plasma. An inhibitor that acted rapidly and inactivated 0.5 U/ml plasma thromboplastin antecedent (PTA, factor XI) at a 1:200 plasma dilution was d...

journal_title：Blood

authors： Poon MC,Saito H,Koopman WJ

更新日期：1984-06-01 00:00:00

abstract：:In patients with chronic myeloid leukemia, BCR-ABL mutations contribute to resistance to tyrosine kinase inhibitor therapy. We examined the occurrence of treatment-emergent mutations and their impact on response in patients from the ENESTnd phase 3 trial. At the 3-year data cutoff, mutations were detected in approxima...

journal_title：Blood

authors： Hochhaus A,Saglio G,Larson RA,Kim DW,Etienne G,Rosti G,De Souza C,Kurokawa M,Kalaycio ME,Hoenekopp A,Fan X,Shou Y,Kantarjian HM,Hughes TP

更新日期：2013-05-02 00:00:00

abstract：:Nonsteroidal antiinflammatory agents (NSAIA) have been shown to exert potent chemopreventive activity against colon, lung, and breast cancers. In this study, we show that at pharmacological concentrations (1 to 3 mmol/L) sodium salicylate (Na-Sal) can potently induce programmed cell death in several human myeloid leuk...

journal_title：Blood

authors： Klampfer L,Cammenga J,Wisniewski HG,Nimer SD

更新日期：1999-04-01 00:00:00

abstract：:The transcription repressor BCL-6 is known to play critical roles in B-cell lymphomagenesis, germinal center formation, and balanced Th1/Th2 differentiation. In macrophages, although BCL-6 has also been shown to regulate the expression of several chemokine genes, its function in other aspects of macrophage biology has...

journal_title：Blood

authors： Yu RY,Wang X,Pixley FJ,Yu JJ,Dent AL,Broxmeyer HE,Stanley ER,Ye BH

更新日期：2005-02-15 00:00:00

abstract：:The JAK2 V617F mutation is present in the majority of patients with a myeloproliferative neoplasm (MPN) and is sufficient to recapitulate an MPN in murine models. However, the consequences of JAK2 mutations for myeloid differentiation are poorly understood. After systematic analyses of a large cohort of JAK2-mutated M...

journal_title：Blood

authors： Anand S,Stedham F,Beer P,Gudgin E,Ortmann CA,Bench A,Erber W,Green AR,Huntly BJ

更新日期：2011-07-07 00:00:00

abstract：:A patient, CAL, with gamma heavy chain disease is presented who has had a complete remission lasting over 2 yr with combination chemotherapy consisting of pulsatile cyclophosphamide and prednisone. The patient exhibited many features of an atuoimmune process including a vasculitis, low serum complement levels, a posit...

journal_title：Blood

authors： Lyons RM,Chaplin H,Tillack TW,Majerus PW

更新日期：1975-07-01 00:00:00

abstract：:The VLA-4 integrin (CD49d/CD29), initially discovered on lymphoid cells, is actually known to be highly expressed on T cells, B cells, monocytes, and derived cell lines. Unlike other VLA integrins, mainly involved in cell-matrix adhesive interactions, VLA-4 has also been implicated in several cellular interactions. Ba...

journal_title：Blood

authors： Zhang ZH,Vekemans S,Aly MS,Jaspers M,Marynen P,Cassiman JJ

更新日期：1991-11-01 00:00:00

abstract：:Preliminary reports have suggested that survivors of childhood cancer and aplastic anemia who are infected with the hepatitis C virus (HCV) have a low risk for progression to significant liver disease. Among our surviving patients who were transfused between 1961 and March 1992, 77 (6.6% of surviving patients tested t...

journal_title：Blood

authors： Strickland DK,Riely CA,Patrick CC,Jones-Wallace D,Boyett JM,Waters B,Fleckenstein JF,Dean PJ,Davila R,Caver TE,Hudson MM

更新日期：2000-05-15 00:00:00

abstract：:In this issue of Blood, Stepensky et al provide an astute description of immunosenescence arising from deficiency in tripeptidyl peptidase II (TPPII). Senescence of T and B lymphocytes is a striking finding, which has recently come into the limelight because it can be linked to primary immunodeficiency syndromes with ...

journal_title：Blood

authors： Seidel MG

更新日期：2015-01-29 00:00:00