Abstract：
:Preliminary reports have suggested that survivors of childhood cancer and aplastic anemia who are infected with the hepatitis C virus (HCV) have a low risk for progression to significant liver disease. Among our surviving patients who were transfused between 1961 and March 1992, 77 (6.6% of surviving patients tested thus far) have evidence of HCV infection, whereas 4 surviving patients who were transfused after March 1992 are HCV-infected. One patient chronically infected with HCV died of liver failure, and 2 patients died of hepatocellular carcinoma. To characterize the risk for these and other complications, 65 patients are enrolled in a longitudinal study of HCV infection, of whom 58 (89.2%) had circulating HCV RNA at the time of protocol enrollment, with genotypes 1A and 1B most commonly isolated. Most enrolled patients have few or no symptoms, carry out normal activities, and have normal liver function. To date, 35 patients have undergone liver biopsy for abnormal liver function since the diagnosis of primary malignancy; central pathology review shows 28 (80%) have chronic active hepatitis, 25 (71%) have fibrosis, and 3 (9%) have cirrhosis. These preliminary data suggest that though most survivors of childhood cancer who are infected with HCV are clinically well, some are at risk for clinically significant liver disease. Identification of other HCV-infected patients and prospective monitoring of this cohort are ongoing to determine the risk for, and to identify factors associated with the progression of, liver disease.
journal_name
Bloodjournal_title
Bloodauthors
Strickland DK,Riely CA,Patrick CC,Jones-Wallace D,Boyett JM,Waters B,Fleckenstein JF,Dean PJ,Davila R,Caver TE,Hudson MMsubject
Has Abstractpub_date
2000-05-15 00:00:00pages
3065-70issue
10eissn
0006-4971issn
1528-0020journal_volume
95pub_type
杂志文章相关文献
BLOOD文献大全abstract：:Humans and grey collie dogs with cyclic neutropenia are known to suffer from an increased rate of bacterial infection. Because of the previously described microanatomic abnormalities of lysosome formation found in the polymorphonuclear leukocytes (PMNs) of dogs with canine cyclic neutropenia, studies of these cells we...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1975-12-01 00:00:00
abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-02-15 00:00:00
abstract：:The blood platelet is the only human cell known to have a circumferential band of microtubules. However, the mechanisms involved in assembly of the multi-looped coil, its interaction with the cell membrane to support discoid shape, and constriction into tight rings around centrally concentrated organelles in activated...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：:T-cell homing to secondary lymphoid tissues generally depends on chemokine-induced firm adhesion in high endothelial venules (HEVs) and is primarily mediated through the CC chemokine receptor 7 (CCR7) on lymphocytes. The CCR7 ligand designated CCL21 is considered the most important trigger because it appears constitut...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-11-4353
更新日期：2005-07-15 00:00:00
abstract：:C-abl oncogene 1, nonreceptor tyrosine kinase (ABL1) kinase inhibitors such as imatinib mesylate (imatinib) are effective in managing chronic myeloid leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), suggesting that kinase-independent pathways support LSC survival. Given that the bone marrow (BM)...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2013-07-511907
更新日期：2014-05-22 00:00:00
abstract：:To further evaluate the role of sialic acid in the dysfibrinogenemia associated with liver disease, we studied the effect of removal of excess sialic acid residues from the fibrinogen of five patients with liver disease on the thrombin time and fibrin monomer aggregation. Patient fibrinogens containing 1.4-3.4 residue...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1983-06-01 00:00:00
abstract：:We investigated the correlation between the detection of clonal rearrangement of the T-cell antigen receptor gene (TCRR) in lymph node tissue with histopathologic lymph node classification in 33 patients with mycosis fungoides with and without the Sezary Syndrome. We analyzed DNA extracted from lymph nodes that were h...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1992-06-15 00:00:00
abstract：:Little is known about the ontogeny of naturally occurring CD4(+)CD25(+) regulatory/suppressor T cells that play a major role in maintaining self-tolerance in mice and humans. In rodents, thymectomy on day 3 of life leads to multiple organ-specific autoimmune diseases that can be prevented by adoptive transfer of regul...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-10-4051
更新日期：2005-06-15 00:00:00
abstract：:Epithelial mesenchymal transitions are a remarkable example of cellular plasticity. These transitions are the hallmark of embryo development, are pivotal in cancer progression, and seem to occur infrequently in adult organisms. The reduced incidence of transitions in the adult could result from restrictive functions o...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2003-08-2807
更新日期：2004-04-15 00:00:00
abstract：:An attractive hypothesis is that in utero exposure of hematopoietic cells to oncogenic agents can induce molecular changes leading to overt acute lymphoblastic leukemia (ALL) in infants and perhaps older children as well. Although supported by studies of identical infant twins with concordant leukemia, and of nontwine...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
abstract：:Monitoring unfractionated heparin (UFH) is crucial to prevent over- or under-anticoagulation. However, the optimal parameters for monitoring UFH in children are not well established. The study objectives were to investigate (1) the relationship between UFH dose and its anticoagulant effect as assessed by anti-Xa, acti...
journal_title：Blood
pub_type： 杂志文章,随机对照试验
doi：10.1182/blood-2015-06-651661
更新日期：2015-10-29 00:00:00
abstract：:Human K562 erythroleukemia cells were transfected with human band 3 (anion exchanger 1 [AE1]) cDNA, using the pBabe retroviral vector. Stable K562 clones expressing band 3 were isolated by flow cytometry, and surface expression was quantified by immunoblotting. The function of band 3 expressed at the cell surface was ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:The induction of tumor cell differentiation represents an attractive strategy for the treatment of a wide range of malignancies. Differentiation of HL-60 promyelocytic leukemia cells towards neutrophils or monocytes has been shown to induce apoptotic cell death, which is inhibited by bcl-2 over-expression. However, th...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:Human polymorphonuclear leukocytes adhesion to endothelial cells during the early stage of inflammation leads to cell surface externalization of Annexin A1 (AnxA1), an effector of endogenous anti-inflammation. The antiadhesive properties of AnxA1 become operative to finely tune polymorphonuclear leukocytes transmigrat...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-02-270520
更新日期：2010-11-18 00:00:00
abstract：:Hand mirror cells are a morphological configuration that are seen in immunologically stimulated lymphocytes and can be induced by antigen--antibody complexes. Therefore, the bone marrow and peripheral blood plasma of two patients with acute lymphoblastic leukemia--hand mirror variant were evaluated for the presence of...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:A novel gene, jumonji was identified by a mouse gene trap strategy. The jumonji gene encodes a protein containing a putative DNA binding domain. The mice homozygous for jumonji gene with a BALB/cA genetic background show hypoplasia of the fetal liver and embryonic lethality, suggesting impaired hematopoiesis. In the p...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:A novel deletion in the human beta-globin gene cluster associated with increased levels of fetal hemoglobin (HbF) in adult life was molecularly characterized in a member of a family of Eastern European descent. The phenotype of the deletion, documented in five members of the family, shows mild hypochromia and microcyt...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1994-06-15 00:00:00
abstract：:We performed a randomized trial to compare the safety and efficacy of itraconazole with fluconazole in preventing fungal infections in patients undergoing allogeneic stem cell transplantation (SCT). Itraconazole (intravenous 200 mg daily, or oral solution 2.5 mg/kg 3 times daily) and fluconazole (intravenous or oral, ...
journal_title：Blood
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1182/blood-2003-07-2512
更新日期：2004-02-15 00:00:00
abstract：:Posttransplantation lymphoproliferative disease (PTLD) associated with Epstein-Barr virus (EBV) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation. PTLD is efficiently prevented by adoptive transfer of EBV-specific T cells from the donor. To make EBV-specific T cells available ...
journal_title：Blood
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1182/blood-2009-08-236356
更新日期：2010-04-08 00:00:00
abstract：:T-cell alloreactivity directed against non-self-HLA molecules has been assumed to be less peptide specific than conventional T-cell reactivity. A large variation in degree of peptide specificity has previously been reported, including single peptide specificity, polyspecificity, and peptide degeneracy. Peptide polyspe...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-05-354787
更新日期：2011-12-22 00:00:00
abstract：:Graft-versus-host disease (GVHD) is a systemic inflammatory response due to the recognition of major histocompatibility complex disparity between donor and recipient after hematopoietic stem cell transplantation (HSCT). T-cell activation is critical to the induction of GVHD, and data from our group and others have sho...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2013-09-526020
更新日期：2014-03-06 00:00:00
abstract：:We investigated the in vivo effects of erythropoietin (EPO) on granulopoiesis and, conversely, the effect of granulocyte colony-stimulating factor (G-CSF) treatment on erythropoiesis. Recombinant human EPO at four different doses in combination with recombinant human G-CSF also at four different doses was simultaneous...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1994-12-15 00:00:00
abstract：:Hematopoietic stem and progenitor cells were previously found to express Toll-like receptors (TLRs), suggesting that bacterial/viral products may influence blood cell formation. We now show that common lymphoid progenitors (CLPs) from mice with active HSV-1 infection are biased to dendritic cell (DC) differentiation, ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2008-04-151506
更新日期：2008-11-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are multipotent progenitor cells that have emerged as a promising tool for clinical application. Further clinical interest has been raised by the observation that MSCs are immunoprivileged and, more important, display immunosuppressive capacities. These properties may be of therapeutic va...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2005-11-011650
更新日期：2006-09-15 00:00:00
abstract：:Arsenic trioxide, as a single agent, has proven efficacy in inducing molecular remission in patients with acute promyelocytic leukemia (APL). There is limited long-term outcome data with single-agent As2O3 in the management of newly diagnosed cases of APL. Between January 1998 to December 2004, 72 newly diagnosed case...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：10.1182/blood-2005-08-3532
更新日期：2006-04-01 00:00:00
abstract：:Different biologic features have been associated with a more or less aggressive clinical course in chronic lymphocytic leukemia (CLL). In the present study, 20 patients with highly stable CLL observed at a single institution over a period of 10 to 23 years and who never required treatment were extensively characterize...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-12-3639
更新日期：2003-08-01 00:00:00
abstract：:Interactions between vascular endothelial cells and blood platelets have been investigated using a model microcirculation consisting of microcarrier beads colonized with human umbilical vein endothelial cells (HUVECs) and perfused with washed platelet suspensions. To simulate the effects of endothelial desquamation an...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:The CD28 family of receptors (CD28, cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4], inducible costimulator [ICOS], program death-1 [PD-1], and B- and T-lymphocyte attenuator [BTLA]) plays a critical role in controlling the adaptive arm of the immune response. While considerable information is available regarding...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2004-04-1596
更新日期：2005-01-01 00:00:00
abstract：:In lymphatic tissues, chronic lymphocytic leukemia (CLL) cells are interspersed with CD68(+) nurselike cells (NLCs), T cells, and other stromal cells that constitute the leukemia microenvironment. However, the mechanism regulating colocalization of CLL and these accessory cells are largely unknown. To dissect the mole...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2008-07-170415
更新日期：2009-03-26 00:00:00
abstract：:MicroRNAs (miRNAs) have emerged as important regulators of the immune system. However, despite this prominence, our understanding of the function of miRNAs in the early hematopoietic stages is incomplete. In this study, we found that miR-139-5p negatively regulated the proliferation of hematopoietic stem cells and pro...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2016-02-702464
更新日期：2016-10-27 00:00:00
