Human fetuses are able to mount an adultlike CD8 T-cell response.

abstract：:During an 8-year period, 3,638 children from institutions of the Pediatric Oncology Group (POG) were diagnosed with acute lymphoblastic leukemia (ALL). Fifty-seven patients had Philadelphia chromosome-positive (Ph1) ALL. Blast cells obtained at diagnosis from 13 of these 57 cases (23%) were also found to have partial ...

journal_title：Blood

authors： Russo C,Carroll A,Kohler S,Borowitz M,Amylon M,Homans A,Kedar A,Shuster J,Land V,Crist W

更新日期：1991-03-01 00:00:00

abstract：:Histone deacetylases (HDACs) are epigenetic erasers of lysine-acetyl marks. Inhibition of HDACs using small molecule inhibitors (HDACi) is a potential strategy in the treatment of various diseases and is approved for treating hematological malignancies. Harnessing the therapeutic potential of HDACi requires knowledge ...

journal_title：Blood

authors： Heideman MR,Wilting RH,Yanover E,Velds A,de Jong J,Kerkhoven RM,Jacobs H,Wessels LF,Dannenberg JH

更新日期：2013-03-14 00:00:00

abstract：:The extent and rapidity with which T cells are regenerated from graft-derived precursor cells directly influences the incidence of infection and the T-cell-based graft-versus-tumor effect. Measurement of T-cell receptor excision circles (TRECs) in peripheral blood is a means of quantifying recent thymic T-cell product...

journal_title：Blood

authors： Chen X,Barfield R,Benaim E,Leung W,Knowles J,Lawrence D,Otto M,Shurtleff SA,Neale GA,Behm FG,Turner V,Handgretinger R

更新日期：2005-01-15 00:00:00

abstract：:The past 40 years have witnessed major advances in defining the cytogenetic aberrations, mutational landscape, epigenetic profiles, and expression changes underlying hematological malignancies. Although it has become apparent that acute myeloid leukemia (AML) is highly heterogeneous at the molecular level, the standar...

journal_title：Blood

authors： Grimwade D,Freeman SD

更新日期：2014-11-27 00:00:00

abstract：:We previously found that the myeloid cell surface glycoprotein CD13 (gp150) is identical to aminopeptidase N (EC 3.4.11.2), a widely distributed membrane-bound, zinc-dependent metalloprotease with an extracellular enzymatic domain that cleaves N-terminal amino acid residues from oligopeptides (J Clin Invest 83:1299, 1...

journal_title：Blood

authors： Ashmun RA,Look AT

更新日期：1990-01-15 00:00:00

abstract：:Immune thrombocytopenia (ITP) is a bleeding disorder in which antibodies and/or T cells lead to enhanced peripheral platelet destruction and reduced bone marrow platelet production. Several reports have observed that ITP is associated with a peripheral deficiency of tolerance-inducing CD4+CD25+FoxP3+ T regulatory cell...

journal_title：Blood

authors： Aslam R,Hu Y,Gebremeskel S,Segel GB,Speck ER,Guo L,Kim M,Ni H,Freedman J,Semple JW

更新日期：2012-09-06 00:00:00

abstract：:Men1 is a tumor suppressor gene mutated in endocrine neoplasms. Besides its endocrine role, the Men1 gene product menin interacts with the mixed lineage leukemia (MLL) protein, a histone H3 lysine 4 methyltransferase. Although menin and MLL fusion proteins cooperate to activate Homeobox (Hox) gene expression during tr...

journal_title：Blood

authors： Maillard I,Chen YX,Friedman A,Yang Y,Tubbs AT,Shestova O,Pear WS,Hua X

更新日期：2009-02-19 00:00:00

abstract：:In this issue of Blood, Roach and colleagues show that individuals with prior superficial venous thrombosis are at increased risk of developing venous thromboembolism when exposed to acquired clinical risk factors. ...

journal_title：Blood

authors： Bates SM

更新日期：2013-12-19 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a typically aggressive myeloid neoplasm of childhood that is clinically characterized by overproduction of monocytic cells that can infiltrate organs, including the spleen, liver, gastrointestinal tract, and lung. JMML is categorized as an overlap myelodysplastic syndrome/mye...

journal_title：Blood

authors： Chang TY,Dvorak CC,Loh ML

更新日期：2014-10-16 00:00:00

abstract：:BR3, which is expressed on all mature B cells, is a specific receptor for the B-cell survival and maturation factor BAFF (B-cell-activating factor belonging to the tumor necrosis factor [TNF] family). In order to investigate the consequences of targeting BR3 in murine models and to assess the potential of BR3 antibodi...

journal_title：Blood

authors： Lee CV,Hymowitz SG,Wallweber HJ,Gordon NC,Billeci KL,Tsai SP,Compaan DM,Yin J,Gong Q,Kelley RF,DeForge LE,Martin F,Starovasnik MA,Fuh G

更新日期：2006-11-01 00:00:00

abstract：:Sixty-five patients with hairy cell leukemia underwent splenectomy; 27 had a complete remission as defined by a return in WBC, RBC, and platelet counts to a defined level, and 38 had a partial remission with a return of only one or two of these parameters to the defined level. The 5-yr actuarial survival for all patie...

journal_title：Blood

authors： Golomb HM,Vardiman JW

更新日期：1983-02-01 00:00:00

abstract：:The transcription factor c-Maf is extensively involved in the pathophysiology of multiple myeloma (MM), a fatal malignancy of plasma cells. In the present study, affinity chromatography and mass spectrometry were used to identify c-Maf ubiquitination-associated proteins, from which the E3 ligase HERC4 was found to int...

journal_title：Blood

authors： Zhang Z,Tong J,Tang X,Juan J,Cao B,Hurren R,Chen G,Taylor P,Xu X,Shi CX,Du J,Hou J,Wang G,Wu D,Stewart AK,Schimmer AD,Moran MF,Mao X

更新日期：2016-03-31 00:00:00

abstract：:The CD11a/CD18 (leukocyte function-associated antigen 1 [LFA-1]) integrin mediates critical leukocyte adhesive interactions during immune and inflammatory responses. The CD11a promoter directs CD11a/CD18 integrin expression, and its activity in lymphoid cells depends on a functional RUNX1/AML-1-binding site (AML-110) ...

journal_title：Blood

authors： Puig-Kröger A,Sanchez-Elsner T,Ruiz N,Andreu EJ,Prosper F,Jensen UB,Gil J,Erickson P,Drabkin H,Groner Y,Corbi AL

更新日期：2003-11-01 00:00:00

abstract：:The inclusion of exon 16 in the mature protein 4.1R messenger RNA (mRNA) is a critical event in red blood cell membrane biogenesis. It occurs during late erythroid development and results in inclusion of the 10-kd domain needed for stabilization of the spectrin/actin lattice. In this study, an experimental model was e...

journal_title：Blood

authors： Deguillien M,Huang SC,Morinière M,Dreumont N,Benz EJ Jr,Baklouti F

更新日期：2001-12-15 00:00:00

abstract：:CD44, a cell surface glycoprotein, is involved in lymphocyte trafficking from the blood to lymphatic tissues, and is of importance in dissemination of lymphoma. A variant form of CD44 that has additional amino acids in the common protein backbone (CD44v6) also seems to play a role in the metastatic dissemination of ma...

journal_title：Blood

authors： Ristamäki R,Joensuu H,Salmi M,Jalkanen S

更新日期：1994-07-01 00:00:00

abstract：:B12 deficiency is the leading cause of megaloblastic anemia, and although more common in the elderly, can occur at any age. Clinical disease caused by B12 deficiency usually connotes severe deficiency, resulting from a failure of the gastric or ileal phase of physiological B12 absorption, best exemplified by the autoi...

journal_title：Blood

authors： Green R

更新日期：2017-05-11 00:00:00

abstract：:Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of thalassemia carriage o...

journal_title：Blood

authors： Jones E,Pasricha SR,Allen A,Evans P,Fisher CA,Wray K,Premawardhena A,Bandara D,Perera A,Webster C,Sturges P,Olivieri NF,St Pierre T,Armitage AE,Porter JB,Weatherall DJ,Drakesmith H

更新日期：2015-01-29 00:00:00

abstract：:Hypoxia is a strong stimulus for the transcription of a set of genes, including erythropoietin and vascular endothelial growth factor. Here we report on the cloning, functional significance, and expression of a complementary DNA (cDNA) that is involved in hypoxia-mediated expression of these 2 genes. The full-length c...

journal_title：Blood

authors： Gupta M,Mungai PT,Goldwasser E

更新日期：2000-07-15 00:00:00

abstract：:Binding of platelets to fibrinogen via integrin alphaIIbbeta3 stimulates cytoskeletal reorganization and spreading. These responses depend on tyrosine phosphorylation of multiple proteins by Src family members and Syk. Among Src substrates in platelets is adhesion- and degranulation-promoting adapter protein (ADAP), a...

journal_title：Blood

authors： Kasirer-Friede A,Ruggeri ZM,Shattil SJ

更新日期：2010-03-18 00:00:00

abstract：:Fibrin is a hallmark of immune-mediated tissue lesions. The presence of fibrin in such lesions implies both the formation of fibrin via coagulation and the accompanying restriction of fibrinolysis, allowing fibrin to persist. Previous work has shown that human monocytes exposed to an inflammatory stimulus such as lipo...

journal_title：Blood

authors： Schwartz BS,Bradshaw JD

更新日期：1989-10-01 00:00:00

abstract：:We investigated 17 patients (12 males and 5 females, ages 2 to 57 years old) with posttransfusion non-A, non-B hepatitis to determine relationships between clinical courses and hepatitis C virus (HCV) markers. The patients were grouped according to time course of abnormal serum alanine aminotransferase (ALT) levels in...

journal_title：Blood

authors： Shibata M,Morishima T,Kudo T,Maki T,Maki S,Nagai Y

更新日期：1991-03-15 00:00:00

abstract：:BB-10010 is a variant of the human form of macrophage inflammatory protein-1alpha (MIP-1alpha), which has been shown in mice to block the entry of hematopoietic stem cells into S-phase and to increase their self-renewal capacity during recovery from cytotoxic damage. Its use may constitute a novel approach for protect...

journal_title：Blood

authors： Clemons MJ,Marshall E,Dürig J,Watanabe K,Howell A,Miles D,Earl H,Kiernan J,Griffiths A,Towlson K,DeTakats P,Testa NG,Dougal M,Hunter MG,Wood LM,Czaplewski LG,Millar A,Dexter TM,Lord BI

更新日期：1998-09-01 00:00:00

abstract：:Mutations in human prothrombin that generate a stable form of meizothrombin or meizothrombin(desF1) cause dysprothrombinemia in both the homozygous and heterozygous state, suggesting that meizothrombin has dominant anticoagulant effects in vivo. The enzymatic characterization of recombinant mouse meizothrombin, meizot...

journal_title：Blood

authors： Shim K,Zhu H,Westfield LA,Sadler JE

更新日期：2004-07-15 00:00:00

abstract：:Adoptive TCR transfer against rapidly mutating targets, such as HIV-1 or cancer, must counteract corresponding immune escape. Hence, we generated T cells expressing two additional receptors (TETARs) specific for HIV-1 by TCR mRNA electroporation. An HLA-A2-restricted gag-specific TCR and an HLA-B13-restricted nef-spec...

journal_title：Blood

authors： Hofmann C,Höfflin S,Hückelhoven A,Bergmann S,Harrer E,Schuler G,Dörrie J,Schaft N,Harrer T

更新日期：2011-11-10 00:00:00

abstract：:A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a...

journal_title：Blood

authors： Drouin J,McGregor JL,Parmentier S,Izaguirre CA,Clemetson KJ

更新日期：1988-09-01 00:00:00

abstract：:Transplantation of ex vivo expanded human umbilical cord blood cells (hCB) only partially enhances the hematopoietic recovery after myelosuppressive therapy. Incubation of hCB with optimal combinations of cytokines and niche cells, such as endothelial cells (ECs), could augment the efficiency of hCB expansion. We have...

journal_title：Blood

authors： Butler JM,Gars EJ,James DJ,Nolan DJ,Scandura JM,Rafii S

更新日期：2012-08-09 00:00:00

abstract：:Pim kinases are involved in B-cell development and are overexpressed in B-cell chronic lymphocytic leukemia (CLL). We hypothesized that Pim kinase inhibition would affect B-cell survival. Identified from a screen of imidazo[1,2-b]pyridazine compounds, SGI-1776 inhibits Pim-1, Pim-2, and Pim-3. Treatment of CLL cells w...

journal_title：Blood

authors： Chen LS,Redkar S,Bearss D,Wierda WG,Gandhi V

更新日期：2009-11-05 00:00:00

abstract：:Hyaluronan-binding function of the CD44 molecule has not been so far detected in myeloid cells. To study pure populations of primitive myeloid cells, we investigated the hyaluronan-binding function of the CD44 molecule from three myeloid cell lines: KG1a, KG1, and HL60. Both KG1a and KG1 cells express the CD34 antigen...

journal_title：Blood

authors： Morimoto K,Robin E,Le Bousse-Kerdiles MC,Li Y,Clay D,Jasmin C,Smadja-Joffe F

更新日期：1994-02-01 00:00:00

abstract：:Ibrutinib is highly efficacious and used at 420 mg/d for treatment of chronic lymphocytic leukemia (CLL). We previously demonstrated a decline in Bruton's tyrosine kinase (BTK) protein levels in CLL cells after 1 cycle of ibrutinib, suggesting ibrutinib dose could be lowered after the first cycle without loss of biolo...

journal_title：Blood

authors： Chen LS,Bose P,Cruz ND,Jiang Y,Wu Q,Thompson PA,Feng S,Kroll MH,Qiao W,Huang X,Jain N,Wierda WG,Keating MJ,Gandhi V

更新日期：2018-11-22 00:00:00

abstract：:Potassium tellurite (K2TeO3) was found to be a potent antisickling agent that inhibited red cell sickling at concentrations less than 10 mumol/L. The inhibitory effect depended on the incubation time, with the effect increasing with longer incubation periods. Because tellurite causes swelling of red cells, and because...

journal_title：Blood

authors： Asakura T,Shibutani Y,Reilly MP,DeMeio RH

更新日期：1984-07-01 00:00:00