Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice.

abstract：:Drug-dependent antibodies (DDAbs) that cause acute thrombocytopenia upon drug exposure are nonreactive in the absence of the drug but bind tightly to a platelet membrane glycoprotein, usually α(IIb)/β3 integrin (GPIIb/IIIa) when the drug is present. How a drug promotes binding of antibody to its target is unknown and ...

journal_title：Blood

authors： Bougie DW,Peterson J,Rasmussen M,Aster RH

更新日期：2015-10-29 00:00:00

abstract：:Recent population-based studies demonstrate an increased fracture risk with monoclonal gammopathy of undetermined significance (MGUS). The etiology of this increased risk remains unclear, however, because areal bone mineral density (aBMD) measurements by dual-energy x-ray absorptiometry cannot assess bone microstructu...

journal_title：Blood

authors： Ng AC,Khosla S,Charatcharoenwitthaya N,Kumar SK,Achenbach SJ,Holets MF,McCready LK,Melton LJ 3rd,Kyle RA,Rajkumar SV,Drake MT

更新日期：2011-12-15 00:00:00

abstract：:Arsenic trioxide (As₂O₃) is a highly effective treatment for patients with refractory/relapsed acute promyelocytic leukemia (APL), but resistance to As₂O₃ has recently been seen. In the present study, we report the findings that 2 of 15 patients with refractory/relapsed APL treated with As₂O₃ were clinically As₂O₃ res...

journal_title：Blood

authors： Goto E,Tomita A,Hayakawa F,Atsumi A,Kiyoi H,Naoe T

更新日期：2011-08-11 00:00:00

abstract：:Lymphocyte kinetic studies employing 51-chromium-labeled autologous lymphocytes were performed in nine normal volunteers in order to determine the effects of hydrocortisone administration on the recirculating versus the nonrecirculating intravascular lymphocyte pools. Following infusion of labeled cells, the recircula...

journal_title：Blood

authors： Fauci AS,Dale DC

更新日期：1975-08-01 00:00:00

abstract：:Recently G alpha 16, a new guanosine triphosphate (GTP) binding protein alpha subunit has been described to be specifically expressed in human hematopoietic cells. Expression of G alpha 16 was observed in human cell lines of myelomonocytic and T-lymphocytic origin, but not in human B-cell lines Raji and IM9. We studie...

journal_title：Blood

authors： Mapara MY,Bommert K,Bargou RC,Leng C,Beck C,Ludwig WD,Gierschik P,Dörken B

更新日期：1995-04-01 00:00:00

abstract：:In eighty-three patients with confirmed deep vein thrombosis, the fibrinolytic system was studied before and after a 10-minute venous occlusion. Blood was collected at least 3 months after the last acute episode, and PAI-1 antigen and activity, as well as tissue-type plasminogen activator (t-PA) antigen, urokinase-typ...

journal_title：Blood

authors： Nguyen G,Horellou MH,Kruithof EK,Conard J,Samama MM

更新日期：1988-08-01 00:00:00

abstract：:Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. Defective HJV reduces hepcidin up-regulation both in humans and in Hjv-deficient mice. To investigate the JH pathogenesis and the fun...

journal_title：Blood

authors： Silvestri L,Pagani A,Fazi C,Gerardi G,Levi S,Arosio P,Camaschella C

更新日期：2007-05-15 00:00:00

abstract：:T cell-depleted haploidentical hematopoietic stem cell transplantation (haploHSCT) is an option to treat children with very high-risk acute lymphoblastic leukemia (ALL) lacking an HLA-identical donor. We analyzed 127 children with ALL who underwent haploHSCT in first (n = 22), second (n = 48), or third (n = 32), compl...

journal_title：Blood

authors： Klingebiel T,Cornish J,Labopin M,Locatelli F,Darbyshire P,Handgretinger R,Balduzzi A,Owoc-Lempach J,Fagioli F,Or R,Peters C,Aversa F,Polge E,Dini G,Rocha V,Pediatric Diseases and Acute Leukemia Working Parties of the Europe

更新日期：2010-04-29 00:00:00

abstract：:A noninferiority study was performed comparing low-dose and standard-dose prophylactic platelet transfusions. A double-blind randomized controlled trial (RCT) was performed in 6 sites in 3 countries. Thrombocytopenic adults requiring prophylactic platelet transfusion were randomly allocated to standard-dose (300-600 x...

journal_title：Blood

authors： Heddle NM,Cook RJ,Tinmouth A,Kouroukis CT,Hervig T,Klapper E,Brandwein JM,Szczepiorkowski ZM,AuBuchon JP,Barty RL,Lee KA,SToP Study Investigators of the BEST Collaborative.

更新日期：2009-02-12 00:00:00

abstract：:Children with sickle cell anemia (SCA) carry a 200-fold increased risk for cerebral infarction. Stroke can be the result of small-vessel (SV) or large-vessel (LV) disease. However, it is unknown whether these subtypes result from the same pathophysiologic processes. Complete HLA genotyping was performed on 231 eligibl...

journal_title：Blood

authors： Hoppe C,Klitz W,Noble J,Vigil L,Vichinsky E,Styles L

更新日期：2003-04-01 00:00:00

abstract：:The production of interleukin-1beta (IL-1beta), a powerful mediator of inflammation, is tightly regulated at several levels. However, in some pathologic conditions, a pharmacologic treatment is required to control the toxicity of excessive extracellular IL-1beta. Because of the heavy side effects of most therapies use...

journal_title：Blood

authors： Hamon Y,Luciani MF,Becq F,Verrier B,Rubartelli A,Chimini G

更新日期：1997-10-15 00:00:00

abstract：:Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20 spontaneous CLL regression cases incorporating phenotypic, functional, transcriptomic, and genomic studie...

journal_title：Blood

authors： Kwok M,Oldreive C,Rawstron AC,Goel A,Papatzikas G,Jones RE,Drennan S,Agathanggelou A,Sharma-Oates A,Evans P,Smith E,Dalal S,Mao J,Hollows R,Gordon N,Hamada M,Davies NJ,Parry H,Beggs AD,Munir T,Moreton P,Paneesha

更新日期：2020-02-06 00:00:00

abstract：:Because of continuous blood transfusions, thalassemia patients are subjected to peroxidative tissue injury by the secondary iron overload. In accordance, analysis of serum from 42 beta-thalassemia patients, aged 4 to 40 years, showed that the mean concentrations of conjugated diene lipid hydroperoxides (CD), lipoperox...

journal_title：Blood

authors： Livrea MA,Tesoriere L,Pintaudi AM,Calabrese A,Maggio A,Freisleben HJ,D'Arpa D,D'Anna R,Bongiorno A

更新日期：1996-11-01 00:00:00

abstract：:Gene therapy for hemophilia B aims to ameliorate bleeding risk and provide endogenous factor IX (FIX) activity/synthesis through a single treatment, eliminating the requirement for FIX concentrate. AMT-060 combines an adeno-associated virus-5 (AAV5) vector with a liver-specific promoter driving expression of a codon-o...

journal_title：Blood

authors： Miesbach W,Meijer K,Coppens M,Kampmann P,Klamroth R,Schutgens R,Tangelder M,Castaman G,Schwäble J,Bonig H,Seifried E,Cattaneo F,Meyer C,Leebeek FWG

更新日期：2018-03-01 00:00:00

abstract：:The primitive hematopoietic stem/progenitor cells (HSPCs) during embryonic hematopoiesis are thought to be short-lived (SL) with limited self-renewal potential. The fate and consequence of these short-lived HSPCs, once reprogrammed into "long-lived" in a living animal body, remain unknown. Here we show that targeted e...

journal_title：Blood

authors： Zhou T,Wang L,Zhu KY,Dong M,Xu PF,Chen Y,Chen SJ,Chen Z,Deng M,Liu TX

更新日期：2011-10-06 00:00:00

abstract：:The synthetic cytokine (Synthokine) SC-55494 is a high-affinity interleukin-3 (IL-3) receptor ligand that stimulates greater in vitro multilineage hematopoietic activity than native IL-3, while inducing no significant increase in inflammatory activity relative to native IL-3. The aim of this study was to investigate t...

journal_title：Blood

authors： Farese AM,Herodin F,McKearn JP,Baum C,Burton E,MacVittie TJ

更新日期：1996-01-15 00:00:00

abstract：:Human hematopoietic progenitor cells express L-selectin and also express PSGL-1, a ligand for all selectins. Using a shear-based adhesion assay, a hematopoietic cell L-selectin ligand (HCLL) that is expressed on the hematopoietic cell line KG1a and on normal human hematopoietic progenitors was previously identified. T...

journal_title：Blood

authors： Sackstein R,Dimitroff CJ

更新日期：2000-10-15 00:00:00

abstract：:It has been shown that histamine induces early changes on endothelial cells (EC), such as a transient expression of P-selectin and secretion and/or surface expression of early mediators (eg, prostacyclin [PG1(2)], platelet-activating factor [PAF], and leukotriene B4 [LTB4]). However, delayed effects of histamine on EC...

journal_title：Blood

authors： Jeannin P,Delneste Y,Gosset P,Molet S,Lassalle P,Hamid Q,Tsicopoulos A,Tonnel AB

更新日期：1994-10-01 00:00:00

abstract：:Type 3 von Willebrand disease (VWD) is a severe hemorrhagic defect in humans. We now identify the homozygous mutation in the Chapel Hill strain of canine type 3 VWD that results in premature termination of von Willebrand factor (VWF) protein synthesis. We cultured endothelium from VWD and normal dogs to study intracel...

journal_title：Blood

authors： Haberichter SL,Merricks EP,Fahs SA,Christopherson PA,Nichols TC,Montgomery RR

更新日期：2005-01-01 00:00:00

abstract：:Plasma glutathione peroxidase (GSHPx) (glutathione: H2O2 oxidoreductase) is a unique selenoglycoprotein. Treatment of this enzyme with glycopeptidase F partially deglycosylates it and establishes the presence of N-linked sugar moieties. Antibodies raised in a rabbit against the purified enzyme from plasma were found t...

journal_title：Blood

authors： Avissar N,Whitin JC,Allen PZ,Palmer IS,Cohen HJ

更新日期：1989-01-01 00:00:00

abstract：:Oxygen-induced retinopathy (OIR) is a well-characterized model for retinopathy of prematurity, a disorder that results from rapid microvascular proliferation after exposure of the retina to high oxygen levels. Here, we report that the proliferative phase of OIR requires transcriptional induction of the annexin A2 (A2)...

journal_title：Blood

authors： Huang B,Deora AB,He KL,Chen K,Sui G,Jacovina AT,Almeida D,Hong P,Burgman P,Hajjar KA

更新日期：2011-09-08 00:00:00

abstract：:Bortezomib (PS-341), a selective inhibitor of proteasomes, induces apoptosis in multiple myeloma (MM) cells; however, prolonged drug exposure may result in cumulative toxicity and the development of chemoresistance. Here we show that combining PK-11195 (PK), an antagonist to mitochondrial peripheral benzodiazepine rec...

journal_title：Blood

authors： Chauhan D,Li G,Podar K,Hideshima T,Mitsiades C,Schlossman R,Munshi N,Richardson P,Cotter FE,Anderson KC

更新日期：2004-10-15 00:00:00

abstract：:Male recipients of transplants from female (F-->M) hematopoietic stem cell donors represent a special group in whom donor T cells that are specific for recipient minor histocompatibility antigens encoded by Y-chromosome genes may contribute to a graft-versus-leukemia (GVL) effect and to graft-versus-host disease (GVHD...

journal_title：Blood

authors： Randolph SS,Gooley TA,Warren EH,Appelbaum FR,Riddell SR

更新日期：2004-01-01 00:00:00

abstract：:Emerging successful clinical data on gene therapy using adeno-associated viral (AAV) vector for hemophilia B (HB) showed that the risk of cellular immune response to vector capsid is clearly dose dependent. To decrease the vector dose, we explored AAV-8 (1-3 × 10(12) vg/kg) encoding a hyperfunctional factor IX (FIX-Pa...

journal_title：Blood

authors： Crudele JM,Finn JD,Siner JI,Martin NB,Niemeyer GP,Zhou S,Mingozzi F,Lothrop CD Jr,Arruda VR

更新日期：2015-03-05 00:00:00

abstract：:In this issue of Blood, Bagnara et al describe the development of a reliable and convincing xenograft model of CLL that recapitulates aspects of the leukemic microenvironment and gives intriguing insights into disease biology. ...

journal_title：Blood

authors： Devereux S

更新日期：2011-05-19 00:00:00

abstract：:One hundred fifty-one children with acute myelogenous leukemia (AML) entered the cooperative study BFM-78 between December 1978 and October 1982. The initial therapy consisted of an intensive induction and consolidation regimen over eight weeks with seven different drugs and cranial irradiation. It was followed by mai...

journal_title：Blood

authors： Creutzig U,Ritter J,Riehm H,Langermann HJ,Henze G,Kabisch H,Niethammer D,Jürgens H,Stollmann B,Lasson U

更新日期：1985-02-01 00:00:00

abstract：:Mice deficient in intercellular adhesion molecule-1 (ICAM-1), lacking membranous ICAM-1, show a normal development but abnormalities of inflammatory and immune functions. Although the membrane-bound form of ICAM-1 is not detectable in the mutant strain, circulating ICAM-1 (cICAM) is present in serum from ICAM-1-defici...

journal_title：Blood

authors： van Den Engel NK,Heidenthal E,Vinke A,Kolb H,Martin S

更新日期：2000-02-15 00:00:00

abstract：:Hemophilic bleeding into joints causes synovial and microvascular proliferation and inflammation (hemophilic synovitis) that contribute to end-stage joint degeneration (hemophilic arthropathy), the major morbidity of hemophilia. New therapies are needed for joint deterioration that progresses despite standard intraven...

journal_title：Blood

authors： Sun J,Hakobyan N,Valentino LA,Feldman BL,Samulski RJ,Monahan PE

更新日期：2008-12-01 00:00:00

abstract：:Dosing of enzyme replacement therapy (ERT) for Gaucher disease type 1 is still a subject of debate and varies from 15 to 130 U/kg/mo, making a huge economic difference of 70,000 US dollars to 380,000 US dollars(euro55,000-300,000) per patient per year. To investigate whether this difference in dosing ultimately transl...

journal_title：Blood

authors： de Fost M,Hollak CE,Groener JE,Aerts JM,Maas M,Poll LW,Wiersma MG,Häussinger D,Brett S,Brill N,vom Dahl S

更新日期：2006-08-01 00:00:00

abstract：:While investigating 2592 patients enrolled in multicenter myeloma trials, we found light chain-only (LCO) patients had worse median survival times (1.9 years) than patients with IgA and IgG paraproteins (2.3 and 2.5 years, respectively) (P < .001). However, IgA and IgG patients with levels of LC excretion similar to t...

journal_title：Blood

authors： Drayson M,Begum G,Basu S,Makkuni S,Dunn J,Barth N,Child JA

更新日期：2006-09-15 00:00:00