Abstract:
:Surprisingly little is known about the interaction of human blood mononuclear cells with viruses. Here, we show that monocytes are the predominant cell type infected when peripheral blood mononuclear cells are exposed to viruses ex vivo. Remarkably, infection with vesicular stomatitis virus, vaccinia virus, and a variety of influenza A viruses (including circulating swine-origin virus) induces monocytes to differentiate within 18 hours into CD16(-)CD83(+) mature dendritic cells with enhanced capacity to activate T cells. Differentiation into dendritic cells does not require cell division and occurs despite the synthesis of viral proteins, which demonstrates that monocytes counteract the capacity of these highly lytic viruses to hijack host cell biosynthetic capacity. Indeed, differentiation requires infectious virus and viral protein synthesis. These findings demonstrate that monocytes are uniquely susceptible to viral infection among blood mononuclear cells, with the likely purpose of generating cells with enhanced capacity to activate innate and acquired antiviral immunity.
journal_name
Bloodjournal_title
Bloodauthors
Hou W,Gibbs JS,Lu X,Brooke CB,Roy D,Modlin RL,Bennink JR,Yewdell JWdoi
10.1182/blood-2011-09-379479subject
Has Abstractpub_date
2012-03-29 00:00:00pages
3128-31issue
13eissn
0006-4971issn
1528-0020pii
blood-2011-09-379479journal_volume
119pub_type
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